Photo by RVLuckyorWhat
Search Upstate South Carolina hotels
Change your mindBook hotels with free cancellation
Be pickySearch almost a million properties worldwide
Go beyond your typical stay in Upstate South Carolina
Check prices for these dates
Our top choices for Upstate South Carolina hotels
Inn on the Square, an Ascend Collection Hotel
Inn on the Square, an Ascend Collection HotelUptown Greenwood
9.2 out of 10, Wonderful, (710)
"Comfortable bed, nice fridge, tv, microwave."
Lindsay
Travelling for leisure
The price is AU$173
includes taxes & fees
25 Jan - 26 Jan 2026
Holiday Inn Express & Suites Greenwood Mall by IHG
Holiday Inn Express & Suites Greenwood Mall by IHGGreenwood
9.0 out of 10, Wonderful, (486)
"Our room was clean and very nice;"
Louie
Travelling with family
The price is AU$250
includes taxes & fees
2 Jan - 3 Jan 2026
9.4 out of 10, Exceptional, (686)
"Always a friendly welcome from professional and helpful staff, clean rooms and a good choice for breakfast in the morning."
John
Travelling with partner
The price is AU$228
includes taxes & fees
18 Jan - 19 Jan 2026
8.0 out of 10, Very good, (1002)
"Rooms are clean and well maintained"
Greg
Travelling with family
9.4 out of 10, Exceptional, (439)
"Rooms are quiet and clean"
Ashley
The price is AU$197
includes taxes & fees
1 Jan - 2 Jan 2026
9.6 out of 10, Exceptional, (416)
"Beautiful property, great staff, very nice rooms."
Heather
Travelling for leisure
The price is AU$226
includes taxes & fees
3 Jan - 4 Jan 2026
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Holiday Rentals in Upstate South Carolina
Cottage
9.8 out of 10, Exceptional, (9)
Save an average of 15% on thousands of hotels when you're signed in
Stay near popular Southeastern United States attractions
Learn more about Upstate South Carolina
Check out the local area in Upstate South Carolina—home to attractions like Discovery Island Water Park and Heritage Park.
Photo by Ryan Watts
Open Photo by Ryan Watts
Top Upstate South Carolina Hotel Reviews
Recent Reviews in Upstate South Carolina
La Quinta Inn & Suites by Wyndham Greenville Woodruff Rd.
10/10 Excellent
More cheap accommodation in Upstate South Carolina
Days Inn by Wyndham Anderson
1007 George Smith Mill Rd Anderson SC
The price is AU$104 per night from 4 Jan to 5 Jan
AU$104
4 Jan - 5 Jan 2026
includes taxes & fees
7.8/10 Good! (1,001 reviews)
Explore a world of travel with Expedia
- Pet Friendly Hotels in Boiling Springs
- Boiling Springs Hotels
- Cabin Rentals in Clinton
- Holiday Homes in Clinton
- Spartanburg County Hotels
- Drayton Hotels
- Caravan Parks in Duncan
- Cottages in Duncan
- Duncan Hotels
- Enoree Hotels
- Fingerville Hotels
- Five Forks Hotels
- Fountain Inn Hotels
- Gray Court Hotels
- Hotels near Greenville-Spartanburg Intl.
- Greer Hotels
- Hotels near Heritage Park
- Inman Hotels
- Laurens Hotels
- Lyman Hotels
- Mauldin Hotels
- Moore Hotels
- Holiday Homes in Pauline
- Pauline Hotels
- Caravan Parks in Roebuck
- Roebuck Hotels
- Lodges in Roebuck
- Hotels near Shipwreck Cove
- Caravan Parks in Southern Shops
- Cheap Hotels in Southern Shops
- All Inclusive Hotels in Spartanburg
- Spartanburg Hotels
- Hotels near Spartanburg Regional Hospital
- Startex Hotels
- Beach Hotels in Taylors
- Family Hotels in Taylors
- Taylors Hotels
- Hotels near Tyger River Park
- Una Hotels
- Upstate South Carolina Hotels
- Wellford Hotels
- Hotels near Wofford College
- Cheap Hotels in Woodruff
- Luxury Hotels in Woodruff
- Woodruff Hotels
- Flights to Buffalo
- Flights to Fairforest
- Flights to Five Forks
- Flights to Greenville-Spartanburg Intl.
- Flights to Laurens
- Flights to Roebuck
- Flights to Simpsonville
- Flights to Southern Shops
- Flights to Spartanburg
- Flights to Una
- Flights from Donaldson Center
- Flights from Greenville Downtown
- Flights from Greenville-Spartanburg Intl.
- Flights from Denver to Upstate South Carolina
- Flights from Philadelphia to Upstate South Carolina
- Flights from Startex
- Flights from Gray Court
- Flights from Wellford
- Flights from Boiling Springs
- Flights from Taylors
- Flights from Duncan
- Flights from Adelaide (ADL) to Greenville (GSP)
- Flights from Anderson (AND) to Greenville (GMU)
- Flights from Atlanta (ATL) to Greenville (GSP)
- Flights from Mobile (BFM) to Greenville (GMU)
- Flights from Brisbane (BNE) to Greenville (GSP)
- Flights from Charlotte (CLT) to Greenville (GSP)
- Flights from Coeur d'Alene (COE) to Greenville (GSP)
- Flights from Dallas (DFW) to Greenville (GSP)
- Flights from Dillon (DLL) to Greenville (GDC)
- Flights from Delta (DTA) to Greenville (GSP)
- Flights from Ankara (ESB) to Greenville (GSP)
- Flights from Gulfport (GPT) to Greenville (GDC)
- Flights from Greenwood (GRD) to Greenville (GMU)
- Flights from Honolulu (HNL) to Greenville (GSP)
- Flights from Houston (IAH) to Greenville (GSP)
- Flights from Indianapolis (IND) to Greenville (GDC)
- Flights from Los Angeles (LAX) to Greenville (GSP)
- Flights from New York (LGA) to Greenville (GSP)
- Flights from Orlando (MCO) to Greenville (GSP)
- Flights from Melbourne (MEL) to Greenville (GSP)
- Flights from Miami (MIA) to Greenville (GDC)
- Flights from Miami (MIA) to Greenville (GMU)
- Flights from Melbourne (MLB) to Greenville (GSP)
- Flights from Chicago (ORD) to Greenville (GMU)
- Flights from Perth (PER) to Greenville (GSP)
- Flights from Rota (ROP) to Greenville (GSP)
- Flights from San Francisco (SFO) to Greenville (GSP)
- Flights from Sydney (SYD) to Greenville (GSP)
- Flights from Varginha (VAG) to Greenville (GSP)
