A group of men in red uniforms with gold accents, holding rifles and wearing kilts.

Pet Friendly Hotels & Resorts in Southeast Missouri from AU$92

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check availability on Southeast Missouri Pet Friendly Hotels

Tonight
9 Oct - 10 Oct
Tomorrow
10 Oct - 11 Oct
This weekend
9 Oct - 11 Oct
Next weekend
16 Oct - 18 Oct

Our top choices for Southeast Missouri pet-friendly hotels

A hotel room with a bed, bedside tables, a desk, a chair, a lamp, and a window.

1. Hampton Inn & Suites By Hilton Festus

Hampton Inn & Suites By Hilton Festus
Festus
AU$147
includes taxes & fees
1 Nov - 2 Nov
Hampton Inn & Suites By Hilton Festus
A spacious lobby with a large sectional sofa, multiple armchairs, and a coffee table. There is a TV mounted on the wall and a large window providing a view of the outdoors.
A hotel room with two beds, a brick wall, and a wooden headboard.
A restaurant with a brick wall, a flat-screen TV, and a bar area.
An indoor swimming pool with a wooden ceiling, lounge chairs, and a lifeguard chair.

2. Drury Inn & Suites Jackson MO

Drury Inn & Suites Jackson MO
Jackson
United States
Debra S
AU$121
includes taxes & fees
18 Oct - 19 Oct
Drury Inn & Suites Jackson MO
A motel with a covered entrance, a flag, and a phone number.
A living room with a black leather sofa, a wooden coffee table with a vase of flowers, a green potted plant, and a lamp.
A reception desk with a wooden finish, a framed black and white cityscape, and a large framed Eiffel Tower picture.
A spacious kitchen with a dining area, featuring a ceiling fan, a TV mounted on the wall, and a large rug in the center.

3. Madison Inn Lodge

Madison Inn Lodge
Fredericktown
United States
Bawan
AU$127
includes taxes & fees
3 Nov - 4 Nov
Madison Inn Lodge
A living room with a blue wall, a fireplace, a sofa, and a chair.
A brick building with a sign reading "Mercantile & Hotel".
A bar area with stools and a counter where a bartender is serving drinks.
A sign for EC REED'S MERCANTILE & HOTEL with a geometric design.

4. EC Reed's Mercantile and Hotel

EC Reed's Mercantile and Hotel
Marble Hill
United States
JANEEN
AU$164
includes taxes & fees
11 Oct - 12 Oct
EC Reed's Mercantile and Hotel
A spacious dining area with multiple tables and chairs, a flat-screen TV mounted on the wall, and large windows providing natural light.
Terrace/patio
Pool
Snack bar

5. Hampton Inn Poplar Bluff

Hampton Inn Poplar Bluff
Poplar Bluff
United States
Rhonda
AU$146
includes taxes & fees
18 Oct - 19 Oct
Hampton Inn Poplar Bluff
A spacious lobby with a circular seating area, a stone fireplace, and modern lighting fixtures.
A spacious corridor with a high ceiling, recessed lighting, and a series of posters on the walls.
A Drury Plaza Hotel with a modern design, featuring a prominent entrance, multiple floors, and a clear sky.
An indoor swimming pool with clear blue water, surrounded by beige walls and large windows.

6. Drury Plaza Hotel Cape Girardeau Conference Center

Drury Plaza Hotel Cape Girardeau Conference Center
Cape Girardeau
United States
Curtis
AU$162
includes taxes & fees
18 Oct - 19 Oct
Drury Plaza Hotel Cape Girardeau Conference Center
A bedroom with a bed, a wooden headboard, a window with a view of greenery, and a tray with breakfast items.
Private kitchen
Property amenity
A cabin with two Adirondack chairs outside, a picnic table, and a small black structure with a window and a sign.

7. Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy

Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy
French Village
United States
cynthia
AU$230
includes taxes & fees
8 Nov - 9 Nov
Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy
A compact kitchen with wooden cabinets, a large TV, and various kitchen utensils hanging on the wall.
A log cabin interior with a wooden floor, two leather sofas, a refrigerator, and a door with windows.
A bedroom with a bunk bed, a single bed, a ceiling fan, and a wooden door.
A small cabin with a front porch, a covered deck area, and outdoor seating.

8. FS Rental #4 Annapolis, MO Black River

FS Rental #4 Annapolis, MO Black River
Annapolis
United States
Corey M.
AU$302
includes taxes & fees
10 Oct - 11 Oct
FS Rental #4 Annapolis, MO Black River
Property amenity
A modern hotel room with a large window, a gray sofa, a small round table, a white chair, and a bed.
A modern hotel with a sign reading "Towneplace Suites by Marriott Fairfield." It features a flat roof, large windows, and a well-lit entrance.
A modern lobby with a green sofa, two armchairs, a wooden coffee table, and a patterned rug.

9. TownePlace Suites by Marriott Sikeston

TownePlace Suites by Marriott Sikeston
Sikeston
United States
Stacy
AU$165
includes taxes & fees
18 Oct - 19 Oct
TownePlace Suites by Marriott Sikeston
A hotel room with a blue sofa, an orange ottoman, a desk with a lamp, a television, and a window with curtains.
A reception area with a wooden reception desk, two blue armchairs with orange cushions, a patterned side table, and a wall-mounted lamp.
A hotel room with two beds, a window with curtains, an air conditioning unit, and a lamp on a nightstand.
A modern dining area with wooden tables and chairs, a kitchen area with a tiled backsplash, and framed pictures on the wall.

10. Pear Tree Inn Cape Girardeau West

Pear Tree Inn Cape Girardeau West
Cape Girardeau
United States
Elizabeth
AU$117
includes taxes & fees
18 Oct - 19 Oct
Pear Tree Inn Cape Girardeau West
View all properties

Top Southeast Missouri Hotel Reviews

Drury Inn & Suites Sikeston, MO

Drury Inn & Suites Sikeston, MO

10/10 Excellent
"The pillows were too hard. Maybe have 1 or 2 soft pillows in each room. Otherwise, my cousins & friend, on a girl's trip, really like Drury & will use them again. The staff working the kitchen were wonderful. Kudos to all. ☺️ Thank you."
Cynthia 1-night trip
Posted less than an hour ago
Drury Inn & Suites Sikeston, MO
Days Inn and Suites by Wyndham Sikeston

Days Inn and Suites by Wyndham Sikeston

8/10 Good
"We were traveling through and wanted a quiet clean place to sleep. This was quiet clean although it is a bit dated. Only issue with maintenance was the outlet in the bathroom did not work which did not bother us but it should be attended to. We actually had a suite so it was very spacious. It was about $30 less than other rooms that were available in the area so it was quite a value in my opinion."
Richard 1-night trip
Posted 1 hour ago
Days Inn and Suites by Wyndham Sikeston
Drury Inn & Suites Cape Girardeau

Drury Inn & Suites Cape Girardeau

10/10 Excellent
"The whole experience here during our stay was wonderful. Staff was friendly, everything was clean and well maintained. We would definitely stay here again."
Austin 1-night trip
Posted 3 hours ago
Drury Inn & Suites Cape Girardeau
Drury Inn & Suites Hayti Caruthersville

Drury Inn & Suites Hayti Caruthersville

8/10 Good
"Great place, little expensive!"
Richard 1-night trip
Posted 12 hours ago
Drury Inn & Suites Hayti Caruthersville
Candlewood Suites Cape Girardeau by IHG

Candlewood Suites Cape Girardeau by IHG

8/10 Good
"I usually stay here if I need to because I travel back and forth from northern IL and I usually have a lot of food to take home to southern MS. The full size fridge and freezer is very nice to have available and you don’t have to book a super fancy room to get one. Housekeeping can be hard work, but missing a rather large blood stain on the wall behind the door is disturbing. Thankfully I always travel with Lysol wipes and cleaned it up."
Jacqueline 1-night trip
Posted 7 days ago
Candlewood Suites Cape Girardeau by IHG
Motel 6 Poplar Bluff, MO

Motel 6 Poplar Bluff, MO

10/10 Excellent
"Terrific base accommodation. Clean, efficient. I use this place whenever I’m in the area. I’m"
Herman 1-night trip
Posted 7 days ago
Motel 6 Poplar Bluff, MO

Explore a world of travel with Expedia