An aerial view of a coastal landscape with a dam, farmland, and dense forests.

Search Best Resorts in Santee

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

Next weekend
2 Oct - 4 Oct
In two weeks
9 Oct - 11 Oct
In one month
23 Oct - 25 Oct
In two months
20 Nov - 22 Nov
No exact matches found, but these alternatives could be just right

Recommended hotels in Santee

A breakfast area with a self-service counter, refrigerated display, and a digital menu board.

1. Tru By Hilton Santee

Tru By Hilton Santee
2.5 star property
Santee
9.2 out of 10, Wonderful, (962 reviews)
"Great place to stay!"
United States
Connor
The price is AU$157
includes taxes & fees
4 Oct - 5 Oct
Tru By Hilton Santee
A hotel room with two beds, a grey armchair, a nightstand with a phone, and a cityscape picture on the wall.

2. Baymont by Wyndham Santee

Baymont by Wyndham Santee
2.5 star property
Santee
8.0 out of 10, Very good, (1,496 reviews)
"Very quiet, dog friendly, clean, breakfast included."
United States
Yomerys
The price is AU$125
includes taxes & fees
23 Sept - 24 Sept
Baymont by Wyndham Santee
A hotel dining area with multiple tables and chairs, a large flat-screen TV, and a patterned wall design.

3. Hampton Inn Santee-I-95

Hampton Inn Santee-I-95
2.5 star property
Santee
9.6 out of 10, Exceptional, (1,001 reviews)
"Great location, room and staff."
United States
Herbert
The price is AU$197
includes taxes & fees
15 Oct - 16 Oct
Hampton Inn Santee-I-95
A hotel entrance with a sign reading "Best Western PLISS."

4. Best Western Plus Santee Inn

Best Western Plus Santee Inn
2.5 star property
Santee
8.8 out of 10, Excellent, (1,005 reviews)
"My best stay yet in Santee!! Love this place"
United States
shannon
The price is AU$185
includes taxes & fees
4 Oct - 5 Oct
Best Western Plus Santee Inn
A water park with a pool, slides, and umbrellas.

5. Holiday Inn Santee by IHG

Holiday Inn Santee by IHG
3.0 star property
Santee
8.2 out of 10, Very good, (1,000 reviews)
"I stay here all the time when traveling with my dog. This place is super clean and the staff is excellent."
United States
Dennis
The price is AU$162
includes taxes & fees
18 Oct - 19 Oct
Holiday Inn Santee by IHG
A hotel room with a large bed, a desk, a chair, a desk lamp, and a wall-mounted lamp.

6. Comfort Inn & Suites Santee

Comfort Inn & Suites Santee
2.5 star property
Santee
8.0 out of 10, Very good, (1,005 reviews)
"Was a good place to stay"
United States
santa
The price is AU$167
includes taxes & fees
27 Sept - 28 Sept
Comfort Inn & Suites Santee
A hotel room with two beds, a desk, a mirror, and a wall-mounted TV.

7. Travelodge by Wyndham Santee

Travelodge by Wyndham Santee
2.0 star property
Santee
7.2 out of 10, Good, (776 reviews)
"Great service"
United States
Kunjan
The price is AU$100
includes taxes & fees
5 Oct - 6 Oct
Travelodge by Wyndham Santee
A modern kitchen with dark cabinets, a granite countertop, a ceiling fan, a flat-screen TV, and a breakfast bar with pastries.

8. Quality Inn & Suites Santee I-95

Quality Inn & Suites Santee I-95
2.5 star property
Santee
6.0 out of 10, (594 reviews)
"noisy AC unit overflowing trash cans broken vending machine"
United States
Mark
The price is AU$103
includes taxes & fees
27 Sept - 28 Sept
Quality Inn & Suites Santee I-95
A dining area with multiple tables and chairs, a ceiling fan, and large windows.

9. Super 8 by Wyndham Santee/I-95

Super 8 by Wyndham Santee/I-95
2.0 star property
Santee
6.8 out of 10, (475 reviews)
"An older fecility but certainly well maintained. Loved Mr. Patel!"
United States
William
The price is AU$99
includes taxes & fees
28 Sept - 29 Sept
Super 8 by Wyndham Santee/I-95
A hotel room with two beds, a desk, a chair, a lamp, and a window with curtains.

10. Econo Lodge Santee

Econo Lodge Santee
2.0 star property
Santee
6.4 out of 10, (316 reviews)
"The shops and restaurants are all within walking distance & it is only 4.2 miles to the Palmetto Resort where my sister & I met up with my nephew& his wife."
United States
Dorothy
The price is AU$98
includes taxes & fees
19 Oct - 20 Oct
Econo Lodge Santee
A church with a triangular roof, a central entrance, and a bell tower.

11. Red Roof Inn Santee

Red Roof Inn Santee
2.0 star property
Santee
6.6 out of 10, (665 reviews)
"Clean rooms and staff was great"
United States
Tiffany
The price is AU$98
includes taxes & fees
27 Sept - 28 Sept
Red Roof Inn Santee
A spacious living room with a large sofa, two coffee tables, and a potted plant.

12. Kindred Spirits Retreat at Lake Marion - Pet Friendly Getaway Minutes from I-95!

Kindred Spirits Retreat at Lake Marion - Pet Friendly Getaway Minutes from I-95!
Santee
10.0 out of 10, Exceptional, (46 reviews)
"This was our first long trip with our dog and she loved the place! Fenced in yard and home was cozy and dog friendly. Loved the farmhouse style and large bedrooms and baths. "
United States
Lori B.
The price is AU$493
includes taxes & fees
27 Sept - 28 Sept
Kindred Spirits Retreat at Lake Marion - Pet Friendly Getaway Minutes from I-95!
A wicker outdoor seating area with cushioned chairs and a matching ottoman on a porch.

13. Peaceful Condo on Lake Marion in Santee, SC. Time to play golf and go fishing!

Peaceful Condo on Lake Marion in Santee, SC. Time to play golf and go fishing!
Santee
10.0 out of 10, Exceptional, (15 reviews)
"Annual golf trip with old friends. Perfect accommodations & location. Hope to stay again"
United States
Greg M.
The price is AU$723
includes taxes & fees
28 Sept - 29 Sept
Peaceful Condo on Lake Marion in Santee, SC. Time to play golf and go fishing!
A covered patio with outdoor furniture, a view of a lake, and a sunset.

14. LuxuryGrndFloorCornerLakeViewPoolGolfFishBoatParks

LuxuryGrndFloorCornerLakeViewPoolGolfFishBoatParks
Santee
8.8 out of 10, Excellent, (6 reviews)
"We had a wonderful stay. Couldn't have asked for better location. It was beautiful, close to everything and perfect for our family."
United States
Michelle H.
The price is AU$719
includes taxes & fees
4 Oct - 5 Oct
LuxuryGrndFloorCornerLakeViewPoolGolfFishBoatParks
A bedroom with a dark wooden bed, white walls, a ceiling fan, and a window with blinds.

15. Lake Marion Condo, Boat Slip Included, Pet Friendly

Lake Marion Condo, Boat Slip Included, Pet Friendly
Santee
The price is AU$481
includes taxes & fees
23 Sept - 24 Sept
Lake Marion Condo, Boat Slip Included, Pet Friendly

16. Ramada by Wyndham Santee I-95

Ramada by Wyndham Santee I-95
2.0 star property
Santee
6.4 out of 10, (593 reviews)
"The price rate was great"
United States
Stevenson
The price is AU$129
includes taxes & fees
27 Sept - 28 Sept
Ramada by Wyndham Santee I-95
A Red Roof Inn with two red leather armchairs and a small wooden table in front of a stone-patterned wall.

17. Red Roof Inn Orangeburg

Red Roof Inn Orangeburg
2.0 star property
Orangeburg
5.8 out of 10, (744 reviews)
"Nice place to stay at an affordable price during our trip to Disney it was our halfway point"
United States
phyllis
The price is AU$91
includes taxes & fees
28 Sept - 29 Sept
Red Roof Inn Orangeburg
A hotel room with two beds, a desk, a chair, and a mirror.

18. SureStay Hotel by Best Western Manning

SureStay Hotel by Best Western Manning
2.5 star property
Manning
8.6 out of 10, Excellent, (1,002 reviews)
"Checking in was quick, rooms were very clean, Checking out was quick very good stay at Sure Stay 👌 👍"
United States
Bruce
The price is AU$141
includes taxes & fees
23 Sept - 24 Sept
SureStay Hotel by Best Western Manning
A tent with a view of a lake and boats, a wooden chair, and a potted plant.

19. Bells Marina & Resort

Bells Marina & Resort
2.5 star property
Eutawville
8.6 out of 10, Excellent, (101 reviews)
"Love it"
United States
Mark
The price is AU$120
includes taxes & fees
24 Sept - 25 Sept
Bells Marina & Resort
A buffet with various food items and utensils.

20. Sunset Inn Manning I 95

Sunset Inn Manning I 95
2.0 star property
Summerton
5.2 out of 10, (63 reviews)
"Creepy, property is not well kept, and need a complete renovation."
United States
James
The price is AU$79
includes taxes & fees
22 Oct - 23 Oct
Sunset Inn Manning I 95
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties
Save an average of 15% on thousands of hotels when you're signed in
Sign in
Sign up, it's free

Top Santee Hotel Reviews

Tru By Hilton Santee

Tru By Hilton Santee

10/10 Excellent
"The elevator was full of fingerprints. Old ones"
Dorothy 1-night trip
Posted 9 hours ago
Tru By Hilton Santee

Find out more about Santee

Santee Resort information

Number of reviews
9,882
Accommodation
1 Resort
Lowest Price
AU$79
Highest Price
AU$211

Frequently asked questions

What can I expect from a resort holiday in Santee?
You deserve a getaway, and a resort is just the place to treat yourself to the services and amenities you need for a relaxing time in Santee. One of the comfortable resorts in the surrounding area might be just what you're searching for, whether you want an amazing pool, blissful spa treatments or nightly entertainment options.
What's a favourite resort for my stay in Santee?
Here's our top-rated Santee resort: Waterfront Condo on Lake Marion - Golf resort. Features a fitness centre.
How many resorts are there in Santee?
Choose among Expedia's 5 resort hotels in Santee, where you'll find on-site spas, beautiful guest rooms and more.
What can I do in Santee?
Travellers enjoy the golfing and other activities in Santee, and also have good things to say about the dining options here. If you've packed your golf clubs, you can tee off at Santee Cooper Country Club or Santee National Golf Club. Additional attractions in the area include Santee State Park and Lake Marion.
What's the weather like in Santee?
The hottest months are usually July and August, with an average temperature of 26°C, while the coldest months are January and February, with an average of 11°C. Average annual precipitation for Santee is 1397 mm.
What's the best way to get to and around Santee?
Fly into Columbia, SC (CAE-Columbia Metropolitan), which is located 49 mi (78.8 km) away. If you'd like to venture out around the area, consider renting a car to explore more sights.

Explore a world of travel with Expedia