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Our top choices for Santee hotels

Hampton Inn Santee-I-95

Hampton Inn Santee-I-95
2.5 star property
Santee
9.6 out of 10, Exceptional, (1,000 reviews)
"Very clean & the breakfast staff was very courteous."
United States
Helen
The price is AU$215
includes taxes & fees
10 May - 11 May
Hampton Inn Santee-I-95

Comfort Inn & Suites Santee

Comfort Inn & Suites Santee
2.5 star property
Santee
8.0 out of 10, Very good, (1,006 reviews)
"Staff was friendly, room was clean, pleasant stay. "
United States
Joseph
The price is AU$180
includes taxes & fees
5 May - 6 May
Comfort Inn & Suites Santee

Fairfield Inn & Suites by Marriott Santee

Fairfield Inn & Suites by Marriott Santee
3.0 star property
Santee
9.8 out of 10, Exceptional, (1,000 reviews)
"Excellent hotel, clean rooms, great breakfast "
United States
Roberta
The price is AU$215
includes taxes & fees
10 May - 11 May
Fairfield Inn & Suites by Marriott Santee

Best Western Plus Santee Inn

Best Western Plus Santee Inn
2.5 star property
Santee
8.8 out of 10, Excellent, (1,000 reviews)
"Great breakfast bar - beautiful location in golf course and easy parking. "
United States
Nicole
The price is AU$187
includes taxes & fees
5 May - 6 May
Best Western Plus Santee Inn

Baymont by Wyndham Santee

Baymont by Wyndham Santee
2.5 star property
Santee
8.0 out of 10, Very good, (1,441 reviews)
"Location was great for a one night stay over "
Canada
Silvana
The price is AU$116
includes taxes & fees
23 Apr - 24 Apr
Baymont by Wyndham Santee

Tru By Hilton Santee

Tru By Hilton Santee
2.5 star property
Santee
9.2 out of 10, Wonderful, (799 reviews)
"Great stay!"
United States
Preston
The price is AU$189
includes taxes & fees
5 May - 6 May
Tru By Hilton Santee

Holiday Inn Santee by IHG

Holiday Inn Santee by IHG
3.0 star property
Santee
8.2 out of 10, Very good, (1,000 reviews)
"Staff was amazing — but they were very short staffed so the one person at the bar/restaurant (Dee) and the one person at the desk did the job of 3 people each!! Place is being renovated so not quite there yet but clean and good stay. And again incredible staff!!! "
United States
Deborah
The price is AU$210
includes taxes & fees
10 May - 11 May
Holiday Inn Santee by IHG

Travelodge by Wyndham Santee

Travelodge by Wyndham Santee
2.0 star property
Santee
7.2 out of 10, Good, (721 reviews)
"Good location for amenities and walking and driving distance "
United States
Gezeall
The price is AU$97
includes taxes & fees
7 May - 8 May
Travelodge by Wyndham Santee

Quality Inn & Suites Santee I-95

Quality Inn & Suites Santee I-95
2.5 star property
Santee
6.0 out of 10, (514 reviews)
"Easy parking, good breakfast, nice atmosphere, clean "
United States
Barbara
The price is AU$92
includes taxes & fees
13 May - 14 May
Quality Inn & Suites Santee I-95

Super 8 by Wyndham Santee

Super 8 by Wyndham Santee
2.0 star property
Santee
6.8 out of 10, (454 reviews)
"The beds are super comfy. I liked how quiet it was in the room and the staff was very friendly "
United States
Kathy
The price is AU$116
includes taxes & fees
26 Apr - 27 Apr
Super 8 by Wyndham Santee

Ramada by Wyndham Santee I-95

Ramada by Wyndham Santee I-95
2.0 star property
Santee
6.4 out of 10, (555 reviews)
"Clean room and good staff"
United States
Herbert
The price is AU$115
includes taxes & fees
3 May - 4 May
Ramada by Wyndham Santee I-95

Econo Lodge Santee

Econo Lodge Santee
2.0 star property
Santee
6.4 out of 10, (312 reviews)
"Very clean room, fast staff, a lot of food spots nearby! "
United States
Santiana
The price is AU$106
includes taxes & fees
6 May - 7 May
Econo Lodge Santee

Red Roof Inn Santee

Red Roof Inn Santee
2.0 star property
Santee
6.6 out of 10, (653 reviews)
"Very clean and well kept up room. It was quiet despite having people in rooms on both sides of us. Highly recommend this place for the value. "
United States
Kimberly
The price is AU$95
includes taxes & fees
29 Apr - 30 Apr
Red Roof Inn Santee

Southern Lodge 601

Southern Lodge 601
Orangeburg
7.6 out of 10, Good, (4 reviews)
"The room smelled. The tub leaked water all over the floor and it didn’t work. There were dead and living bugs on the floor. "
United States
Edward
The price is AU$117
includes taxes & fees
27 Apr - 28 Apr
Southern Lodge 601

SpringHill Suites by Marriott Orangeburg

SpringHill Suites by Marriott Orangeburg
2.5 star property
Orangeburg
8.8 out of 10, Excellent, (740 reviews)
"Fabulous hotel you will enjoy you stay and love the staff "
United States
Cordasha
The price is AU$185
includes taxes & fees
23 Apr - 24 Apr
SpringHill Suites by Marriott Orangeburg

Hampton Inn Manning

Hampton Inn Manning
2.5 star property
Manning
8.4 out of 10, Very good, (1,000 reviews)
"Available, very clean and the staff was very nice."
United States
richard k
The price is AU$209
includes taxes & fees
3 May - 4 May
Hampton Inn Manning

Tru by Hilton Orangeburg

Tru by Hilton Orangeburg
2.5 star property
Orangeburg
9.2 out of 10, Wonderful, (1,005 reviews)
"Great stay! "
Canada
Julie
The price is AU$177
includes taxes & fees
18 May - 19 May
Tru by Hilton Orangeburg

Comfort Inn & Suites Orangeburg

Comfort Inn & Suites Orangeburg
2.5 star property
Orangeburg
8.0 out of 10, Very good, (599 reviews)
"Great accommodations, friendly and kind staff plus the bonus daily breakfast options for their guest as well."
United States
Sharnitta
The price is AU$183
includes taxes & fees
19 May - 20 May
Comfort Inn & Suites Orangeburg

Travelodge by Wyndham Orangeburg

Travelodge by Wyndham Orangeburg
2.0 star property
Orangeburg
8.2 out of 10, Very good, (1,001 reviews)
"Staff was nice and parking near room was convenient. Plenty of food options nearby. "
United States
CARL
The price is AU$110
includes taxes & fees
30 Apr - 1 May
Travelodge by Wyndham Orangeburg

Sleep Inn Orangeburg

Sleep Inn Orangeburg
2.5 star property
Orangeburg
7.8 out of 10, Good, (423 reviews)
"Very clean, comfortable beds, friendly staff. would stay here again."
United States
Michele
The price is AU$128
includes taxes & fees
18 May - 19 May
Sleep Inn Orangeburg
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Stay near popular Santee attractions

Learn more about Santee

Nestled along Lake Marion, this charming town offers prime fishing and boating opportunities for outdoor enthusiasts. Visitors can tee off at Santee National Golf Club or explore nearby Santee State Park's hiking trails and campsites.

Cypress Trees with Spanish Moss growing on them. In Lake Marion at Santee State Park, Santee, Orangeburg County, South Carolina

Top Santee Hotel Reviews

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Frequently asked questions

Where is the best place for a stay in Santee?
Based on our traveller data, Baymont by Wyndham Santee is one of the top choices for your stay. This hotel offers free breakfast and free parking. Other good choices for your visit include Tru By Hilton Santee and Best Western Plus Santee Inn. See all available top hotels, or vacation rentals in Santee.
What are some of the best holiday rentals that Santee has to offer?
Kindred Spirits Retreat at Lake Marion - Pet Friendly Getaway Minutes from I-95!: This highly rated holiday home rental in Santee is located on a lake, and has a patio, a selection of games and a BBQ to put you at ease in your new surroundings. It has 3 bedrooms, as well as a kitchen with a dishwasher, a fridge and a stovetop, so that you can cook with friends or family. See all vacation rentals in Santee.
If I need to cancel my hotel reservation in Santee, will I receive a refund?
Yes, you'll find most room reservations are fully refundable as long as you cancel before the hotel's cancellation deadline, which is usually within 24-48 hours of check in. If your reservation is non-refundable, you might be able to cancel it and get a refund within a 24-hour period of your booking. Filter your search by fully refundable to find flexible hotel deals in Santee.
What's the best place to stay on a budget in Santee?
Based on reviews, Baymont by Wyndham Santee is a popular hotel for our travellers who want a more economical choice, and features free breakfast and free Wi-Fi. View all budget hotels in Santee.
What's the best family accommodation in Santee?
Comfort Inn & Suites Santee is a hotel with free parking and free buffet breakfast, and it's a top choice on Expedia for families. Fairfield Inn & Suites by Marriott Santee is another good option for your stay with the kids. Find more child-friendly accommodations in Santee.
What is the top LGBTQ-friendly accommodation in Santee?
Fairfield Inn & Suites by Marriott Santee is a top LGBTQ-friendly hotel, and features free breakfast and free WiFi. Hampton Inn Santee-I-95 and Holiday Inn Santee by IHG are two other good choices for your trip. See all available hotels listed as LGBTQ-friendly in Santee.
What's the best dog-friendly hotel in Santee?
Baymont by Wyndham Santee is a top hotel for people travelling with their pets, and offers concierge services and free WiFi for its human guests. Two other good options for you and your pet include Tru By Hilton Santee and Best Western Plus Santee Inn. See more pet-friendly hotel accommodations in Santee.
What's the best accommodation for a golf trip to Santee?
Holiday Inn Santee by IHG is a top hotel that has an adjacent golf course and features free WiFi. Other good options to stay near a golf course include Super 8 by Wyndham Santee and Ramada by Wyndham Santee I-95. Visit Santee Cooper Country Club or Santee National Golf Club to perfect your golf swing. See more golf hotels in Santee.
What are some accommodation options with pools in Santee?
Fairfield Inn & Suites by Marriott Santee is a top hotel with a pool, free buffet breakfast and free WiFi. Quality Inn & Suites Santee I-95 is an additional hotel with an on-site pool. View all hotels with pools in Santee.
What is staying in Santee like?
Families will find child-friendly activities in Santee, and visitors give high marks for the top-notch restaurants. This welcoming city also attracts tourists with its golf courses and cafes. In Santee, there are 128 hotels and other accommodation options to choose from. Find out more about Santee.
What are the top places to visit in Santee?
Favourite places to visit include Santee Cooper Country Club, Santee National Golf Club and Santee State Park. A couple of additional sights to add to your itinerary are Lake Marion and Santee Town Hall. Take a look at what more there is to see and do in Expedia's Santee guide.
What's the seasonal weather like in Santee?
The hottest months are usually July and August, with an average temperature of 26°C, while the coldest months are January and February, with an average of 11°C. Average annual precipitation for Santee is 1397 mm.

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