The best area to stay in Santa Fe De Antioquia is the historic centre, particularly around the main square, Plaza Mayor.This area is the heart of the town, characterised by its well-preserved historic architecture, cobblestone streets, and charming balconies. The Plaza Mayor is a central point, often bustling with local life, surrounded by the Cathedral Basilica and various shops and eateries. It's very walkable, making it easy to explore on foot.For couples looking for a romantic getaway, staying within the historic centre offers unparalleled convenience and atmosphere. You'll find boutique hotels tucked away in beautifully restored historic buildings, often with courtyards and pools. Being in the centre means you're just steps away from the town's best restaurants and cafes, superb for evening strolls and enjoying the local culture.For families, the historic centre also provides a practical base. Many hotels offer family-friendly amenities, and being close to the Plaza Mayor means children can enjoy the open space and watch local activities.