A gazebo with columns, a large tree with hanging roots, and a building in the background.

Santa Ana Hotels, Panama City

  • Change your mind

    Book hotels with free cancellation
  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

Filter by

Property class

Guest rating

Selecting then applying a filter from this group will update the results on a new page

Our top choices for Santa Ana hotels

1. Casco View Life Residences

Casco View Life Residences
4.0 star property
Santa Ana
9.0 out of 10, Wonderful, (111 reviews)
"It is a new place, an apartment was in pristine condition. The building is 2 blocks away from the old town."
United States
Arshak Andrew
The price is AU$160
includes taxes & fees
15 Oct - 16 Oct
Casco View Life Residences

2. Hotel Caracas - Casco Viejo

Hotel Caracas - Casco Viejo
3.0 star property
Santa Ana
8.0 out of 10, Very good, (20 reviews)
"great staff"
United States
Keith
The price is AU$54
includes taxes & fees
27 Oct - 28 Oct
Hotel Caracas - Casco Viejo

3. Hostal La Cigarra

Hostal La Cigarra
2.0 star property
Santa Ana
7.6 out of 10, Good, (75 reviews)
"Excellent staff, close to metro and embassies. A good location, good room for a great price. I would stay again. "
United Kingdom
Mark
The price is AU$41
includes taxes & fees
20 Oct - 21 Oct
Hostal La Cigarra

4. Casco View Apartments & Rooftop Pool

Casco View Apartments & Rooftop Pool
3.5 star property
Santa Ana
The price is AU$134
includes taxes & fees
20 Oct - 21 Oct
Casco View Apartments & Rooftop Pool

5. Hotel República

Hotel República
2.0 star property
Santa Ana
6.8 out of 10, (197 reviews)
"Good location. Walking distance to shops and public transport."
Canada
Danilo
The price is AU$130
includes taxes & fees
13 Nov - 14 Nov
Hotel República

6. La Manzana Barrio Vivo by Wynwood

La Manzana Barrio Vivo by Wynwood
3.0 star property
Santa Ana
7.6 out of 10, Good, (19 reviews)
"Very clean and safe property"
United States
Javier Alberto Lindauer
The price is AU$156
includes taxes & fees
14 Oct - 15 Oct
La Manzana Barrio Vivo by Wynwood

7. ART CASCO The Hotel

ART CASCO The Hotel
2.0 star property
Santa Ana
5.8 out of 10, (14 reviews)
"La habitación es 1000% publicidad engañosa o no sé como llamarlo, es UN MOTEL, cobran por mes, o por hora, el edificio huele a humedad, a humo de cigarro y olores un tanto desagradables, las almohadas de la cama viejas y con quemadas de cigarro, olian muy mal las habitaciones, la fachada se ve bien, en fotos bien pero si van a hospedarse ahí no es un lugar FAMILIAR, ceroo familiar, si, esta a 10 minutos de casco viejo caminando, pero.. esta en una zona que se percibe insegura y con mucha...
Mexico
KARINA YUNUEN
The price is AU$50
includes taxes & fees
21 Oct - 22 Oct
ART CASCO The Hotel

8. Hotel Riazor

Hotel Riazor
3.0 star property
Santa Ana
3.8 out of 10, (11 reviews)
"Rough neighborhood "
Canada
Del
The price is AU$39
includes taxes & fees
15 Oct - 16 Oct
Hotel Riazor

9. Hotel Magnolia Boutique

Hotel Magnolia Boutique
2.0 star property
San Felipe, 0.7 km from Santa Ana
8.8 out of 10, Excellent, (527 reviews)
"Safe and clean. Great service."
United States
Ronald
The price is AU$103
includes taxes & fees
14 Oct - 15 Oct
Hotel Magnolia Boutique

10. Principe Hotel and Suites

Principe Hotel and Suites
3.0 star property
El Cangrejo, 3.9 km from Santa Ana
9.0 out of 10, Wonderful, (2,099 reviews)
"Very large suites, comfortable beds, great A/C"
United States
Willis
The price is AU$93
includes taxes & fees
28 Oct - 29 Oct
Principe Hotel and Suites

11. The Executive Hotel

The Executive Hotel
3.5 star property
Campo Alegre, 3.2 km from Santa Ana
9.2 out of 10, Wonderful, (1,283 reviews)
"great location, great hotel"
United States
Sandra
The price is AU$126
includes taxes & fees
4 Nov - 5 Nov
The Executive Hotel

12. Hotel Riu Plaza Panama

Hotel Riu Plaza Panama
5.0 star property
Campo Alegre, 3.6 km from Santa Ana
9.0 out of 10, Wonderful, (6,079 reviews)
"Stayed here twice and enjoyed it both times! The staff are very friendly rooms are clean and that breakfast buffet amazing!!!"
United States
Yullando Abbigale
The price is AU$208
includes taxes & fees
25 Oct - 26 Oct
Hotel Riu Plaza Panama

13. Ramada Plaza by Wyndham Panama Punta Pacifica

Ramada Plaza by Wyndham Panama Punta Pacifica
4.0 star property
San Francisco, 5.1 km from Santa Ana
9.6 out of 10, Exceptional, (1,390 reviews)
"Great location and breakfast buffet was great"
United States
Luis
The price is AU$153
includes taxes & fees
9 Nov - 10 Nov
Ramada Plaza by Wyndham Panama Punta Pacifica

14. Riande Urban Hotel

Riande Urban Hotel
3.5 star property
El Cangrejo, 3.8 km from Santa Ana
8.8 out of 10, Excellent, (1,033 reviews)
"The breakfast was great"
Canada
Gary
The price is AU$126
includes taxes & fees
12 Nov - 13 Nov
Riande Urban Hotel

15. Tantalo Hotel

Tantalo Hotel
3.5 star property
San Felipe, 0.7 km from Santa Ana
8.8 out of 10, Excellent, (339 reviews)
"Great location, friendly and helpful staff, very spacious room, very clean, Great breakfast because we could order straight from the in-house restaurant’s menu. Would definitely stay again."
United States
Cassondra
The price is AU$122
includes taxes & fees
27 Oct - 28 Oct
Tantalo Hotel

16. Waymore Hotel Spa & Casino

Waymore Hotel Spa & Casino
4.0 star property
El Cangrejo, 3.5 km from Santa Ana
9.0 out of 10, Wonderful, (1,197 reviews)
"Breakfast, Cafe, was just perfect location"
United States
Bruno
The price is AU$209
includes taxes & fees
16 Oct - 17 Oct
Waymore Hotel Spa & Casino

17. TRYP by Wyndham Panamá Centro

TRYP by Wyndham Panamá Centro
3.5 star property
El Cangrejo, 3.5 km from Santa Ana
9.0 out of 10, Wonderful, (1,004 reviews)
"Room clean staff very welcoming and breakfast was fantastic also Dinner"
United States
Donna
The price is AU$152
includes taxes & fees
5 Nov - 6 Nov
TRYP by Wyndham Panamá Centro

18. Courtyard by Marriott Panama Multiplaza Mall

Courtyard by Marriott Panama Multiplaza Mall
4.0 star property
San Francisco, 4.5 km from Santa Ana
9.0 out of 10, Wonderful, (1,000 reviews)
"I enjoyed my stay at this hotel, great location , breakfast was fresh every morning, room was clean and the staff was friendly. I definitely would be staying here again.."
United States
SHARROW
The price is AU$186
includes taxes & fees
31 Oct - 1 Nov
Courtyard by Marriott Panama Multiplaza Mall

19. Decapolis Hotel Panama City

Decapolis Hotel Panama City
4.0 star property
Punta Paitilla, 3.6 km from Santa Ana
8.6 out of 10, Excellent, (1,726 reviews)
"Location is wonderful."
United States
Jorge Luis
The price is AU$138
includes taxes & fees
31 Oct - 1 Nov
Decapolis Hotel Panama City

20. Hotel Milan

Hotel Milan
3.0 star property
El Cangrejo, 3.6 km from Santa Ana
9.0 out of 10, Wonderful, (591 reviews)
"Very nice and kind staff. Walkable area"
United States
Arshak Andrew
The price is AU$63
includes taxes & fees
23 Oct - 24 Oct
Hotel Milan
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Compare popular hotels in Santa Ana

Property
Property class
Guest rating
Breakfast included
Pool
Spa
Pet-friendly
WiFi included
A modern indoor pool area with clear blue water, lounge chairs, and a wall of plants.
Casco View Life Residences
4.0 star property
9.0
Wonderful
111 reviews
View
A hotel corridor with wooden doors, a central white reception desk, and a staircase leading to an upper level.
Hotel Caracas - Casco Viejo
3.0 star property
8.0
Very good
20 reviews
View
An indoor dining area with tables and chairs, a mural on the wall, and hanging plants.
Hostal La Cigarra
2.0 star property
7.6
Good
75 reviews
View
A hotel room with a large bed, a window with curtains, a city view, and a lamp.
Hotel República
2.0 star property
6.8
197 reviews
View
A hotel entrance with a green facade and a metal fence.
ART CASCO The Hotel
2.0 star property
5.8
14 reviews
View

Our guide on where to stay in Santa Ana

Find the best Santa Ana areas for the activities you enjoy most.

Casco Viejo

Unique features of Casco Viejo include the historical sites and bars. Make a stop by Independence Square or Interoceanic Canal Museum while you're exploring the area.

Bella Vista

Travellers love Bella Vista for its popular shops, and you can see more of Panama City by jumping on the metro at Iglesia del Carmen Station or Vía Argentina Station. You might spend time checking out top sights like Via Espana and Iglesia del Carmen.

El Cangrejo

The ample dining options and casino gaming are top of the list for many visitors to El Cangrejo. A stop by Via Espana or Crown Casino might round out your trip.

San Francisco

San Francisco is noteworthy for its restaurants, and you can make a stop at top attractions like Multiplaza Pacific Mall and Calle 50.

San Felipe

While visiting San Felipe, you might make a stop by sights like Independence Square and Interoceanic Canal Museum.

Top Santa Ana Hotel Reviews

Recent Reviews in Santa Ana

Find out more about Santa Ana

Top reasons to visit Santa Ana

  • Vibrant Shopping: Santa Ana boasts lively shopping malls and centres, perfect for retail therapy.
  • Cultural Attractions: Explore local cathedrals and history museums for a taste of Panama's rich heritage.
  • Outdoor Activities: Enjoy family-friendly outings at Santa Ana Beach and the nearby Santa Ana Zoo.
  • Natural Beauty: Take advantage of unique bird watching opportunities in the picturesque surroundings.
  • Diverse Accommodation: Choose from a range of options, from budget hotels to apartment-style stays, catering to all travellers.

Find great hotels near Santa Ana

Discover a range of accommodation options in Santa Ana, Panama City, tailored to suit every traveler's needs. From budget-friendly hotels to apartment-style stays, you'll find the perfect spot for your city-themed getaway. Enjoy pet-friendly amenities and business facilities, ensuring a comfortable experience whether you're on holiday or a work trip. Explore the best hotels in Santa Ana and make your stay memorable.

  • Central Hotel Panama Casco Viejo: Experience a romantic escape at the Central Hotel Panama Casco Viejo, a luxurious 4-star hotel located a short 805m from Santa Ana. This city-themed oasis offers an enchanting spa experience, perfect for couples looking to unwind together. Guests can indulge in exclusive romance packages, featuring 24-hour room service and champagne service for intimate moments. The full-service spa includes manicures, pedicures, body treatments, and massages, all designed to enhance relaxation and connection. Located in the heart of the city, this hotel combines modern comfort with historical charm, making it an ideal choice for a memorable getaway.
  • Innfiniti Hotel & Suites: Ideal for business travellers, Innfiniti Hotel & Suites is a 3.5-star property located 1.4km from Santa Ana. This city-themed hotel boasts a range of amenities specifically tailored for professionals on the go. With a focus on convenience and comfort, guests can enjoy a productive stay with well-equipped facilities and a central location that provides easy access to Panama City’s bustling business district. The contemporary design and attentive service make this hotel a great choice for those seeking a blend of work and leisure during their visit.
  • American Trade Hotel: Step into luxury at the American Trade Hotel, a 4.5-star accommodation just 644m from Santa Ana. This family-friendly and pet-friendly hotel offers an array of amenities, including complimentary cribs for little ones and a welcoming pet policy that allows you to bring your furry friends along. The hotel combines elegance with warmth, making it perfect for families seeking a luxurious stay. With exceptional service and a vibrant atmosphere, guests can enjoy a delightful experience that caters to both relaxation and family fun.

Where to stay near Santa Ana

Santa Ana, a vibrant neighbourhood in Panama City, offers a delightful blend of family-friendly attractions and business atmosphere. Explore hidden gems, relax at nearby surf resorts, and experience the warmth of friendly locals. With its unique charm, Santa Ana serves as an ideal base for discovering the rich culture and history of Panama, making it perfect for both leisure and business travellers seeking a memorable vacation.

  • Panama City: As the bustling capital of Panama, Panama City is a vibrant metropolis that offers a unique mix of modernity and history. Situated around Santa Ana, this city is a hub for family, business, and city-themed experiences. The year-round warm climate makes it an ideal destination for shopping at its many centres and exploring local parks and beaches. Key highlights include the iconic Panama Canal, historic sites, and a lively nightlife scene that caters to all tastes.
  • Casco Viejo: Located a mere 644m from Santa Ana, Casco Viejo is a charming neighbourhood known for its cobblestone streets and colonial architecture. This UNESCO World Heritage site is perfect for families and city explorers alike, attracting visitors with its mix of historical landmarks, shops, and beach access. Popular activities include visiting local markets and enjoying the vibrant street art. The area is especially lively in January and during the March to April period, making it a great time to soak in the local culture.
  • San Felipe: Also situated 644m from Santa Ana, San Felipe offers a unique blend of history and modern amenities. This neighbourhood attracts tourists seeking family-friendly activities and a taste of local culture. The area is home to several shopping centres and historic monuments, making it an ideal spot for both relaxation and exploration. With peak visitor numbers from February to March, it's a fantastic time to experience the local festivities and discover the rich history of this vibrant community.

Things to do near Santa Ana

Santa Ana, located in Panama City, is perfect for families and business travellers alike. Visitors can explore vibrant shopping malls and centres, while also enjoying unique bird watching opportunities nearby. This blend of urban charm and natural beauty makes Santa Ana a delightful destination for anyone looking to experience the local culture and leisure activities.

Shopping

In Santa Ana, explore Avenida Central, a vibrant shopping mall centre just 483m away, offering a mix of business and entertainment. Albrook Shopping Mall, 1.6km away, boasts family-friendly vibes. If you're up for a drive, visit Uruguay Street, located 3.2km away, for a local shopping experience.

Recreation

In Santa Ana, visit Maracana Stadium for a lively sports atmosphere, just 1.3km away, where you can enjoy local events. Estadio Rommel Fernandez, 11.3km away, also offers a vibrant sports scene, while Estadio Nacional Rod Carew, 9.7km away, hosts thrilling games and activities.

Adventure

The Honeycreeper Ridge Trail, located 43.5km from Santa Ana, offers stunning scenery and adventure vibes for hiking enthusiasts. Meanwhile, Gatun Eco Adventures, situated 48.3km away, presents an exhilarating zipline ropes course, perfect for those seeking outdoor thrills and an adrenaline rush amidst lush surroundings.

Nightlife

In Santa Ana, the National Theater offers a delightful mix of entertainment and culture, located a mere 966m away. The National Institute of Culture and Anita Villalaz Theater, both 1.3km from Santa Ana, provide captivating performances, ideal for family nights or romantic outings.

Booking tips and Expedia advantages for Santa Ana

To save money on your trip to Santa Ana, consider visiting between September and November for the lowest accommodation rates. Tuesdays are the cheapest days to book, while Saturdays tend to be pricier. Use Expedia’s search tool to find budget-friendly hotels and consider package deals that combine your flight and accommodation for extra savings. Additionally, explore free activities in the area and utilise public transport to keep costs down while enjoying your visit.

  • The most and least expensive months on average to stay in a hotel: The cheapest months to stay around Santa Ana are September to November, where the prices are slightly lower. This is in comparison to January and March to April, where prices are slightly higher.
  • The most and least expensive days on average to stay in a hotel: The least expensive day to stay around Santa Ana is Tuesday. The most expensive day to stay around Santa Ana is Saturday.
  • Find cheap hotels on Expedia: Utilise Expedia’s search tool to refine your preferences, such as your budget, desired location, and the type of accommodation you’re looking for. To find the best prices and offers, simply sort the price filter from lowest to highest.
  • Consider bundling your trip: You can save some dollars by combining your Santa Ana hotel reservation with your flights and activities through an Expedia package deal.

Find the best attractions near Santa Ana

Santa Ana in Panama City is an excellent destination for family, business, or city-themed vacations. Visitors can explore attractions like the Santa Ana Hill, local cathedrals, and history museums, offering a rich cultural experience amid beautiful scenery. For outdoor enthusiasts, Santana Beach and the Santa Ana Zoo provide fun-filled activities. Don't miss the chance to discover the top attractions and hidden gems around Santa Ana for a memorable holiday.

  • Metropolitan Cathedral of Panama: Nestled 805m from Santa Ana, this stunning cathedral showcases a blend of Spanish colonial architecture and local artistry. Its intricate details and serene atmosphere provide a perfect backdrop for cultural exploration and reflection.
  • Ancon Hill: Located 966m from Santa Ana, Ancon Hill offers breathtaking panoramic views of Panama City and the surrounding rainforest. Ideal for outdoor enthusiasts, the hike to the summit is rewarding and allows for a peaceful escape into nature.
  • Independence Square: Just 805m from Santa Ana, this vibrant piazza is rich in history and culture. Surrounded by important buildings, it serves as a gathering place for locals and tourists alike, making it a perfect spot to soak in the city's lively atmosphere.

Best time to go to Santa Ana

The best time to visit Santa Ana can depend on the weather and when visitor numbers rise and fall. The hottest average temperature around Santa Ana falls in April, when visitor numbers are average and weather is mostly sunny with light rain. The coolest average temperature around Santa Ana falls in November, visitor numbers are average and weather is mostly cloudy with frequent rain.

calendarCalendar MonthtemperatureTemperaturerainPrecipitationmostlyCloudinessoccupationOccupancypricePricing
January78.8°F (26.0°C)No Rain (Dry)Mostly SunnyAverageSlightly High
February79.2°F (26.2°C)No Rain (Dry)Mostly SunnySlightly HighAverage
March79.7°F (26.5°C)No Rain (Dry)Mostly SunnySlightly HighSlightly High
April80.4°F (26.9°C)Light RainMostly SunnyAverageSlightly High
May80.2°F (26.8°C)Frequent RainMostly CloudySlightly LowAverage
June79.9°F (26.6°C)Frequent RainMostly CloudySlightly LowAverage
July79.3°F (26.3°C)Frequent RainMostly CloudyAverageAverage
August79.2°F (26.2°C)Frequent RainMostly CloudyAverageAverage
September79.3°F (26.3°C)Frequent RainMostly CloudySlightly LowSlightly Low
October78.6°F (25.9°C)Frequent RainMostly CloudyAverageSlightly Low
November78.3°F (25.7°C)Frequent RainMostly CloudyAverageSlightly Low
December78.6°F (25.9°C)Light RainMostly CloudySlightly HighAverage

The nearest major airports for your trip to Santa Ana

Travelling to Santa Ana, Panama is convenient with three major airports nearby. Tocumen International Airport (PTY) is approximately 20.9km from Santa Ana, with excellent hotels like JW Marriott Panama and The Santa Maria, both offering easy access to the airport. Marcos A. Gelabert International Airport (PAC) is closer, at about 3.2km away; nearby luxury options include Sofitel Legend Casco Viejo and Waldorf Astoria Panama, providing various shuttle services. Lastly, Panama Pacifico International Airport (BLB) is around 6.4km from Santa Ana, with top choices like Hilton Panama and Bristol Panama, which also offer transport services. Each airport provides ample access to Santa Ana accommodations and attractions.

Frequently asked questions

What are the best hotels in Santa Ana that travellers recommend?
For a popular hotel in Santa Ana, consider Hostal La Cigarra.

Hostal La Cigarra, with a rating of 7.6, is particularly noted by guests for its convenient location and comfortable rooms. This property features a traditional design and is situated within a historical district, close to a shopping district. It is also very convenient for visiting local attractions, being only 0.6 km from the Museum of History Panama and the Mola Museum. Other nearby points of interest include Cinta Costera, 1.6 km away, and Avenida Balboa, 3.6 km away.
What are the top pet-friendly hotels in Santa Ana?
For a top pet-friendly hotel in Santa Ana, you should consider Hostal La Cigarra.

Hostal La Cigarra, with a 7.6 rating, is a pet-friendly accommodation that permits pets and charges a cleaning amount for them. It is located in a historical district, making it convenient for exploring sites like the Museum of History Panama and the Mola Museum, both just 0.6 km away. Guests have frequently commented on its convenient location and comfortable rooms.
What are the best budget hotels in Santa Ana?
For budget-friendly accommodation in Santa Ana, you might consider Hostal La Cigarra, Hotel República, or ART CASCO The Hotel.

Hostal La Cigarra, with a rating of 7.6, provides free WiFi and is located in a historical district, close to the Amador Theater and the Museum of History Panama. Guests often comment on its convenient location and comfortable rooms.

Hotel República offers free WiFi and a lovely terrace, including a rooftop terrace, for guests to enjoy. It is also situated within a historical district.

ART CASCO The Hotel provides free WiFi and is conveniently located near museums and a historical district. It also offers nearby offsite parking with a discount.
Can I cancel my hotel reservation on Expedia?
Many Expedia hotel reservations are refundable, provided that you cancel before the hotel's cancellation deadline − this is often within 24 to 48 hours of your scheduled arrival. If you have a non-refundable booking, it might still be possible to receive a refund if you cancel it within 24 hours of booking. Be sure to check your booking confirmation for the exact cancellation policy. For maximum flexibility, use our 'Fully refundable property' filter during your search to find the right Santa Ana hotel for you.
How can I save on a hotel booking in Santa Ana with Expedia?
One Key™—Expedia's free travel rewards program—gives you instant access to discounts with Member Prices on Santa Ana hotels. Plus, you'll earn OneKeyCash™* on eligible bookings to use on future trips. Booking an Expedia hotel and flight package is another great way to save, where bundling can result in significant savings. *Excludes taxes and fees. OneKeyCash is not redeemable for cash and can only be used on Expedia and other participating brands.
How much is the nightly rate for a hotel in Santa Ana?
Hotel prices in Santa Ana often vary, but you can find a great deal on Expedia. Different factors affect nightly hotel rates, such as the time of year or the days of the week you want to book. To find the best deals for your stay, be flexible with your dates and sort search results by 'Price: low to high' for our cheapest rates.