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Top hotels and accommodation in Panacea

The Panacea Motel

2.0 star property
Panacea
9.0 out of 10, Wonderful, (136)
"The room was very clean, well kept"
United States
Shane
Travelling with family
The Panacea Motel

The Lodge at Wakulla Springs

3.0 star property
Crawfordville
9.4 out of 10, Exceptional, (1001)
"The rooms are charming and clean, with a cozy, old-Florida feel."
United States
Danay
Travelling with partner
The Lodge at Wakulla Springs

Wildwood Inn

3.0 star property
Crawfordville
8.6 out of 10, Excellent, (1003)
"Clean room and great staffs"
United States
Efeturi
The price is AU$199
includes taxes & fees
21 Dec - 22 Dec
Wildwood Inn

St James Bay Golf & Pickleball Resort

3.5 star property
Carrabelle
9.0 out of 10, Wonderful, (366)
"The other pool by the restaurant is amazing and the staff and the restaurant it is amazing."
United States
Linda
Travelling with small children
The price is AU$235
includes taxes & fees
1 Jan - 2 Jan 2026
St James Bay Golf & Pickleball Resort

Best Western Wakulla Inn & Suites

2.5 star property
Crawfordville
8.8 out of 10, Excellent, (946)
"Our room was clean and spacious."
United States
Laura
Travelling for leisure
The price is AU$187
includes taxes & fees
1 Jan - 2 Jan 2026
Best Western Wakulla Inn & Suites

The Moorings Hotel and Marina

2.5 star property
Carrabelle
8.4 out of 10, Very good, (39)
"Hotel was really nice and convenient to everything we wanted to do in the area. Very quiet and peaceful. Bed was a little uncomfortable, but that's a personal preference thing and I won't fault them for that. Really nice staff and easy check in and check out. Would definitely return!"
United States
Cheryl
The price is AU$214
includes taxes & fees
29 Dec - 30 Dec
The Moorings Hotel and Marina

The Old Carrabelle Hotel

2.0 star property
Carrabelle
The price is AU$226
includes taxes & fees
1 Jan - 2 Jan 2026
The Old Carrabelle Hotel

Franklin Inn

2.0 star property
Carrabelle
7.8 out of 10, Good, (453)
"The room came with a small refrigerator with a top freezer… just the right size"
United States
Katy
Travelling for leisure and business
The price is AU$131
includes taxes & fees
11 Dec - 12 Dec
Franklin Inn
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Great weekend hotel deals in Panacea, FL

Showing deals for:19 Dec - 21 Dec
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Stay near popular Panacea attractions

Learn more about Panacea

Kayak through pristine coastal marshes at Panacea's Woolley Park, where fishing piers and boardwalks offer prime spots for catching redfish. Nearby St. Marks National Wildlife Refuge invites visitors to spot migratory birds and explore the historic lighthouse along scenic hiking trails.

Sunset over a lake at Panacea, northern Florida, USA | NONE |

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Frequently asked questions

Where is the best place to stay in Panacea?
Expedia customers give high marks to The Panacea Motel. See all available top hotels, or vacation rentals in Panacea.
What are some of the best holiday rentals that Panacea has to offer?
Oceanfront on a Private Beach-Hot Tub-Beautifully Remodeled-Dog Friendly Beach: This highly rated holiday home rental in Panacea is located on the beach, and has a fireplace, a balcony and a BBQ to put you at ease in your new surroundings. It has 3 bedrooms, as well as a kitchen with a dishwasher, a fridge and a stovetop, so that you can cook with friends or family. It offers a garden, a selection of games and 1 hot tub so that you can immerse yourself in your holiday. Other favourite homes for rent in Panacea are 7 Bedroom Beach House with POOL!! Gulf Front and Bay Front and NEW LISTING!!! Welcome to Ohana Shack! 4BR/4.5BA Private Beachfront Property!. See all vacation rentals in Panacea.
If I need to cancel my hotel reservation in Panacea, will I receive a refund?
Yes, the majority of hotel bookings are refundable provided that you cancel before the hotel's cancellation deadline, which is usually within 24-48 hours of your scheduled arrival. If you have a reservation that's non-refundable, you may still be able to cancel and be given a refund within a 24-hour period of booking. Filter your search by fully refundable to find flexible hotel deals in Panacea.
What's the best dog-friendly place to stay in Panacea?
The Panacea Motel is a top dog-friendly option for your stay. See more pet-friendly hotel accommodations in Panacea.
What are some accommodation options with pools in Panacea?
7 Bedroom Beach House with POOL!! Gulf Front and Bay Front: Offers complimentary wireless Internet access, a pool and kitchens. View all hotels with pools in Panacea.
How is it to stay in Panacea?
Nature enthusiasts will enjoy exploring Panacea, and many visitors will definitely appreciate the beaches and seafood restaurants. The relaxing and secluded setting also entices those visiting the city. In Panacea, there are 212 hotels and other accommodation options to choose from. Find out more about Panacea.
What are the top places to visit in Panacea?
Natural beauty is on display at Mashes Sand Beach, Alligator Point Beach and Bald Point State Park. Dolphin viewing is a great activity, and Bayside Marina is one place to visit. A couple of additional sights to add to your itinerary are Wilson Beach and Public Beach Access. Take a look at what more there is to see and do in Expedia's Panacea guide.
What's the seasonal weather in Panacea?
The hottest months are usually July and August, with an average temperature of 27°C, while the coldest months are January and February, with an average of 14°C. The rainiest months in Panacea are August, July, June and September, with each month seeing an average of 201 mm of rainfall.

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