Default HTG hotel image

Search Byron hotels

  • Change your mind

    Book hotels with free cancellation
  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

Filter by

Property class

Guest rating

Selecting then applying a filter from this group will update the results on a new page

Our top choices for Byron hotels

1. Sleep Inn & Suites West-Near Medical Center

Sleep Inn & Suites West-Near Medical Center
2.5 star property
Rochester
9.0 out of 10, Wonderful, (730 reviews)
"Just a pleasant hotel a few hours from NYC"
United States
Christopher
The price is AU$125
includes taxes & fees
11 Dec - 12 Dec
Sleep Inn & Suites West-Near Medical Center

2. Comfort Inn & Suites West - Medical Center

Comfort Inn & Suites West - Medical Center
3.0 star property
Rochester
8.8 out of 10, Excellent, (670 reviews)
"Great stay"
United States
Angela
The price is AU$140
includes taxes & fees
11 Dec - 12 Dec
Comfort Inn & Suites West - Medical Center

3. Baymont by Wyndham Kasson Rochester Area

Baymont by Wyndham Kasson Rochester Area
2.5 star property
Kasson
6.6 out of 10, (425 reviews)
"Although dated, it was a good stay with a helpful staff"
United States
Dana
The price is AU$104
includes taxes & fees
22 Nov - 23 Nov
Baymont by Wyndham Kasson Rochester Area

4. Hampton Inn & Suites Rochester-North

Hampton Inn & Suites Rochester-North
2.5 star property
Rochester
9.2 out of 10, Wonderful, (1,000 reviews)
"Clean room great facilities."
United States
Mark
The price is AU$164
includes taxes & fees
11 Dec - 12 Dec
Hampton Inn & Suites Rochester-North

5. Staybridge Suites Rochester - Commerce Dr NW by IHG

Staybridge Suites Rochester - Commerce Dr NW by IHG
3.0 star property
Rochester
8.8 out of 10, Excellent, (579 reviews)
"Highly recommend, repeat stays always been great experience"
United States
MATTHEW
The price is AU$177
includes taxes & fees
22 Nov - 23 Nov
Staybridge Suites Rochester - Commerce Dr NW by IHG

6. Quality Inn near Medical Center

Quality Inn near Medical Center
2.5 star property
Rochester
7.8 out of 10, Good, (993 reviews)
"Always a good experience. I highly recommend them"
United States
B. Alice
The price is AU$107
includes taxes & fees
5 Dec - 6 Dec
Quality Inn near Medical Center

7. Microtel Inn & Suites by Wyndham Rochester North Mayo Clinic

Microtel Inn & Suites by Wyndham Rochester North Mayo Clinic
2.0 star property
Rochester
8.0 out of 10, Very good, (1,001 reviews)
"Clean room and nice shuttle!"
United States
John
The price is AU$119
includes taxes & fees
17 Nov - 18 Nov
Microtel Inn & Suites by Wyndham Rochester North Mayo Clinic

8. TownePlace Suites by Marriott Rochester

TownePlace Suites by Marriott Rochester
3.0 star property
Rochester
8.8 out of 10, Excellent, (624 reviews)
"This is my go to hotel when visiting Rochester! Perfect for families, lots of room space and breakfast is always hot and fresh. Highly recommend!"
United States
Christina
The price is AU$167
includes taxes & fees
22 Nov - 23 Nov
TownePlace Suites by Marriott Rochester

9. Hyatt House Rochester/Mayo Clinic Area

Hyatt House Rochester/Mayo Clinic Area
3.0 star property
Downtown Rochester
9.0 out of 10, Wonderful, (1,003 reviews)
"Great stay."
Canada
Robert Blaise
The price is AU$189
includes taxes & fees
27 Nov - 28 Nov
Hyatt House Rochester/Mayo Clinic Area

10. Best Western Rochester Hotel Mayo Clinic Area/St. Mary's

Best Western Rochester Hotel Mayo Clinic Area/St. Mary's
2.5 star property
Rochester
8.2 out of 10, Very good, (1,002 reviews)
"clean room, great breakfast and nice we can walk to bar and grill for dinner at night."
United States
jill
The price is AU$169
includes taxes & fees
19 Nov - 20 Nov
Best Western Rochester Hotel Mayo Clinic Area/St. Mary's

11. Extended Stay America Suites Rochester North

Extended Stay America Suites Rochester North
2.5 star property
Rochester
7.6 out of 10, Good, (747 reviews)
"Great rooms for a great Price"
United States
Chase
The price is AU$109
includes taxes & fees
16 Nov - 17 Nov
Extended Stay America Suites Rochester North

12. Holiday Inn Express & Suites Rochester – Mayo Clinic Area by IHG

Holiday Inn Express & Suites Rochester – Mayo Clinic Area by IHG
2.5 star property
Kutzky Park
8.6 out of 10, Excellent, (852 reviews)
"This is our 4th stay here. We keep coming back for our visits at the Mayo Clinic because of its location, very nice rooms and good breakfast,"
United States
walt
The price is AU$179
includes taxes & fees
27 Nov - 28 Nov
Holiday Inn Express & Suites Rochester – Mayo Clinic Area by IHG

13. Econo Lodge Mayo Clinic Area

Econo Lodge Mayo Clinic Area
2.0 star property
Rochester
9.0 out of 10, Wonderful, (1,001 reviews)
"Clean room and breakfast area was very clean."
United States
Britta
The price is AU$114
includes taxes & fees
12 Dec - 13 Dec
Econo Lodge Mayo Clinic Area

14. Hampton Inn Rochester-South

Hampton Inn Rochester-South
2.5 star property
Rochester
9.0 out of 10, Wonderful, (1,002 reviews)
"Great stay"
United States
Susan
The price is AU$165
includes taxes & fees
12 Dec - 13 Dec
Hampton Inn Rochester-South

15. Fairfield Inn & Suites Rochester Mayo Clinic Area/St. Marys

Fairfield Inn & Suites Rochester Mayo Clinic Area/St. Marys
3.0 star property
Kutzky Park
9.6 out of 10, Exceptional, (755 reviews)
"The staff was extremely helpful making for a comfortable stay."
United States
Brien
The price is AU$190
includes taxes & fees
22 Nov - 23 Nov
Fairfield Inn & Suites Rochester Mayo Clinic Area/St. Marys

16. Med City Inn & Suites - Mayo Clinic Area

Med City Inn & Suites - Mayo Clinic Area
2.5 star property
Kutzky Park
7.8 out of 10, Good, (1,056 reviews)
"Great stay for the price. Will stay here again when visiting Rochester MN."
United States
Stephanie
The price is AU$125
includes taxes & fees
16 Dec - 17 Dec
Med City Inn & Suites - Mayo Clinic Area

17. Comfort Inn & Suites Rochester South Mayo Clinic

Comfort Inn & Suites Rochester South Mayo Clinic
2.0 star property
Rochester
8.8 out of 10, Excellent, (1,000 reviews)
"Great place to stay."
United States
LeeAnn
The price is AU$127
includes taxes & fees
11 Dec - 12 Dec
Comfort Inn & Suites Rochester South Mayo Clinic

18. Spark by Hilton Rochester South

Spark by Hilton Rochester South
3.0 star property
Rochester
9.2 out of 10, Wonderful, (611 reviews)
"Great value"
United States
Jen
The price is AU$114
includes taxes & fees
22 Nov - 23 Nov
Spark by Hilton Rochester South

19. AmericInn by Wyndham Rochester Near Mayo Clinic

AmericInn by Wyndham Rochester Near Mayo Clinic
3.0 star property
Rochester
8.2 out of 10, Very good, (1,597 reviews)
"Great stay, we were only there for one night, but the staff was very nice and helpful!"
United States
Madelyn
The price is AU$124
includes taxes & fees
6 Dec - 7 Dec
AmericInn by Wyndham Rochester Near Mayo Clinic

20. Hotel Indigo Rochester – Mayo Clinic Area by IHG

Hotel Indigo Rochester – Mayo Clinic Area by IHG
3.5 star property
Downtown Rochester
8.8 out of 10, Excellent, (1,003 reviews)
"We have stayed at Hotel Indigo multiple times and have always enjoyed our stay. It is in the perfect location in downtown Rochester."
United States
brittany
The price is AU$165
includes taxes & fees
28 Nov - 29 Nov
Hotel Indigo Rochester – Mayo Clinic Area by IHG
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Save an average of 15% on thousands of hotels when you're signed in

Stay near popular Byron attractions

Top Byron Hotel Reviews

Recent Reviews in Byron

More cheap accommodation in Byron

Frequently asked questions

What is the best area to stay in Byron?
The best area to stay in Byron is near the US-14 corridor, particularly around the Byron Business Park, as this offers the most convenient access and amenities.

This area is the commercial hub of Byron. It's characterised by modern developments and easy access to major roads, making it simple to navigate. You'll find a selection of dining options and local services here, all designed for convenience.

For business travellers, staying in this area is ideal due to its proximity to local businesses and the main arterial routes. The hotels here often cater to this audience with facilities like meeting rooms and high-speed internet, ensuring a productive stay.

Families visiting Byron will also find this area practical. The accessibility to US-14 means less time travelling and more time enjoying local activities or exploring nearby Rochester.
When is the best time to go to Byron?
The best time to visit Byron, Minnesota, is during the late spring, summer, and early autumn months, from May to October, when the weather is most pleasant for outdoor activities.

May and June offer mild temperatures, generally ranging from 10°C to 25°C, making it pleasant for exploring the local parks and trails. The greenery is lush, and it's a good time for those who enjoy hiking or cycling without the peak summer heat.

July and August are the warmest months, with average temperatures usually between 20°C and 30°C. This is ideal for enjoying the nearby lakes and rivers, such as those found in Whitewater State Park, which is a short drive away. Families often find these months great for a holiday due to the warm weather and school breaks.

September and October bring cooler temperatures, typically between 5°C and 20°C, and the stunning autumn foliage. This period is excellent for scenic drives and enjoying the vibrant colours of the changing leaves. It's a wonderful time for couples seeking a peaceful getaway and picturesque views.
Can I cancel my hotel reservation on Expedia?
You can cancel your hotel reservation on Expedia, though it depends on the cancellation policy of your booking. Most bookings are refundable if cancelled within 24-48 hours of the scheduled arrival. Be sure to check your booking confirmation for the exact cancellation policy. If free cancellation is available, you can cancel directly through your Expedia account by logging in, going to "My Trips", and selecting your reservation. To find flexible deals, filter your search by "Fully refundable property" for hotels in Byron.
How can I save on a hotel booking in Byron with Expedia?
One Key™—Expedia's free travel rewards program—gives you instant access to discounts with Member Prices on Byron hotels. Plus, you'll earn OneKeyCash™* on eligible bookings to use on future trips. Booking an Expedia hotel and flight package is another great way to save, where bundling can result in significant savings. *Excludes taxes and fees. OneKeyCash is not redeemable for cash and can only be used on Expedia and other participating brands.
How much is the nightly rate for a hotel in Byron?
Prices for hotels in Byron often vary, but you can find a great deal from AU$93 on Expedia. All sorts of factors affect price, such as the time of year or the days of the week you choose for your stay. Find the best deals by being flexible with your dates, and sort search results by "Price: low to high" for our cheapest rates.