Antofagasta Region Holidays

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Your Antofagasta Region Holiday

Answer the call of adventure with a tailor-made holiday package to Antofagasta Region. Wherever your travels take you and whatever you plan to do, prepare to experience a destination that'll make you truly feel alive. The easiest way to organise your trip to Antofagasta Region is to begin with its most popular cities, which include San Pedro de Atacama, Antofagasta and Historical District. Expedia has flights, hotels, car rentals and more to help you organise your very own customised Antofagasta Region holiday today.

Top destinations in Antofagasta Region

San Pedro de Atacama as well as a small group of people
FlightsFlightsHotelsHotels

San Pedro de Atacama

San Pedro de Atacama
El Tatio Geyser Field featuring animals, tranquil scenes and a pond
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Calama

Calama

Antofagasta Region Essential Information

Language
Spanish
Currency
Chilean pesos
Local Welcome
¡Hola!
Local Goodbye
Adiós
Closest Airport
Calama Airport (CJC)
Population
309,800
Top Sights
Valley of the Moon, Piedra del Coyote Overlook and Arco Iris Valley

Our pick of the best Antofagasta Region Hotel Deals

Diego de Almagro San Pedro de Atacama

Diego de Almagro San Pedro de Atacama

3 out of 5
Toconao 460, San Pedro de Atacama, Antofagasta
Fully refundableReserve now, pay when you stay
8/10 Very Good! (300 reviews)
"The hotel is in an excellent location with the main pedestrian street half block away. Is a charming property but is quite old, don’t expect luxury or even high comfort (to an American standard), but to be fair, is quiet good compared with other hotels in the area. There are other more modern hotels ..."

Reviewed on 23 Aug 2025

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Diego de Almagro San Pedro de Atacama
Noi Casa Atacama

Noi Casa Atacama

4.5 out of 5
Tocopilla E-8, San Pedro de Atacama, Antofagasta
The price is AU$430 per night from 16 Oct to 17 Oct
AU$430
16 Oct - 17 Oct
8.6/10 Excellent! (236 reviews)
"Clean, quiet, good food and staff that are friendly and a pleasure to interact with. I loved visiting San Pedro and Noi Casa Atacama was part of the unforgettable experience, hope to visit again someday."

Reviewed on 1 Sept 2025

Noi Casa Atacama
Hotel La Casa de Don Tomas

Hotel La Casa de Don Tomas

3 out of 5
Calle Tocopilla Sitio 18, San Pedro de Atacama
Fully refundableReserve now, pay when you stay
The price is AU$319 per night from 12 Oct to 13 Oct
AU$319
12 Oct - 13 Oct
9.2/10 Wonderful! (357 reviews)
"This hotel is a beautiful property located in an amazing town. The property is immaculate, well maintained and very comfortable. We love the minimalist aspect of the room including the pleasing absence of a television. The staff is very professional and very helpful. Each days activities required ..."

Reviewed on 10 June 2025

Hotel La Casa de Don Tomas
See all 268 properties in Antofagasta Region
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Frequently asked questions

How much does an Antofagasta Region holiday package cost?
From as low as . Yes, you read that right. Our Antofagasta Region packages are the best way to stretch your budget. Combine your hotels, flights and car rentals and discover this lively destination.
How do I get a cheap travel package to Antofagasta Region?
Our Antofagasta Region holiday packages promise plenty of savings for the savvy traveller. For the best deals, simply bundle your hotel, flights and activities into an affordable package. But impressive bargains are only the start of your next unforgettable adventure. Book with Expedia and you'll have more than 550 airlines and 1 000 000 properties throughout the world to pick from. Whatever your budget, there's a package that's perfect for you.
What are the top hotels in Antofagasta Region?
Have a look at ibis Antofagasta and NH Antofagasta. They're the first choice for lots of travellers to Antofagasta. If San Pedro de Atacama is on your travel itinerary, Park Hotel Calama and Noi Casa Atacama are cosy options.
How far in advance should I book my Antofagasta Region holiday?
It can be tricky to know when is the ideal time to book your trip to Antofagasta Region. But typically the earlier you book, the better the prices. Sometimes, you can reserve your flights and hotels up to a year before your departure date. If you're considering a last-minute getaway, no need to stress! There are fabulous deals featured on Expedia every single day.
What does an Expedia Antofagasta Region travel package include?
From hotels and airfares to rental cars, Expedia can help you shape an Antofagasta Region package that's perfect for you. Holidaying for a week or two? Consider a rental car, hotel and flight bundle. If you're taking a short break, a flight and hotel deal could be more your style. Activities can also be added once you've made your booking. Our holiday packages make it simple to save and plan.
What should I know before booking an Antofagasta Region travel package?
Tailor deals to suit your budget with an Expedia package. Airfares, hotels, rental cars — we're a one-stop shop for all of them. You'll save precious dollars just for bundling your bookings. Whether you're embarking on a skiing adventure or drinking cocktails on a beach, your perfect getaway is just clicks away.
Can I choose my airline with an Antofagasta Region Expedia holiday package?
Expedia has access to more than 550 airline partners worldwide, so you sure can! Simply select your preferred carrier and put together the perfect Antofagasta Region trip.
If I'm not able to travel, can I cancel my Antofagasta Region holiday package?
Whether it's your flight or hotel, you can cancel and rebook it. Locked in your Antofagasta Region holiday package in the last 24 hours? You may be able to make changes at no cost. For bookings older than that, you may be charged a fee by your hotel, airline or car rental company. For further information, visit our Customer Service Portal. We'll help you every step of the way.

Discover the most popular places to visit in Antofagasta Region

Valle de la Luna which includes desert views

Valley of the Moon

Treat your eyes to the variety of colors in a deserted valley that looks like a scene from a science fiction movie.

Valley of the Moon
Piedra del Coyote Overlook

Piedra del Coyote Overlook

Explore the great outdoors at Piedra del Coyote Overlook, a lovely green space in San Pedro de Atacama. You can seek out the local tours in this quaint area.

Piedra del Coyote Overlook
Cejar Lagoon showing swimming and a beach as well as an individual male

Cejar Lagoon

Float effortlessly in the salt water of this extraordinary lagoon situated in the heart of Atacama’s salt plains.

Cejar Lagoon

What to do in Antofagasta Region

Half Day Tour to Geysers del Tatio

Half Day Tour to Geysers del Tatio

AU$73
per adult
Half Day Tour to Geysers del Tatio
San Pedro de Atacama: Stargazing Experience with Transfer

San Pedro de Atacama: Stargazing Experience

AU$60
per adult
San Pedro de Atacama: Stargazing Experience
Stargazing Tour in San Pedro de Atacama

Stargazing Tour in San Pedro de Atacama

AU$54
per adult
80% of travellers recommend
Stargazing Tour in San Pedro de Atacama
See all activities in Antofagasta Region

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* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.