All hotels in Southwest Illinois, Illinois
Change your mindBook hotels with free cancellation
Be pickySearch almost a million properties worldwide
All hotels in Southwest Illinois, Illinois
We have found 745 Southwest Illinois Hotels
- Courtyard St. Louis Airport/Earth City
- Super 8 by Wyndham St. Louis North
- Best Western St. Louis Airport North Hotel & Suites
- Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
- Candlewood Suites Cape Girardeau by IHG
- Holiday Inn St. Louis Arpt West-Earth City by IHG
- Best Western Plus Parkway Hotel
- Drury Inn & Suites St. Louis Arnold
- Harrah's Metropolis Hotel & Casino - A Caesars Rewards Destination
- La Quinta Inn & Suites by Wyndham Festus - St. Louis South
- Quality Inn Cape Girardeau North
- Courtyard by Marriott Cape Girardeau Downtown
- Studio 6 Extended stay - St Louis, MO - Westport/Craig Road
- Holiday Inn Express and Suites Alton St Louis Area by IHG
- Courtyard by Marriott St. Louis West County
- Hampton Inn & Suites St. Louis/Alton
- Comfort Inn Alton near I-255
- Fairfield Inn & Suites by Marriott Cape Girardeau
- Extended Stay America Suites St Louis Westport Central
- SpringHill Suites by Marriott St. Louis Airport/Earth City
- Hampton Inn & Suites St. Louis/South I-55
- Quality Inn Florissant - St Louis
- Embassy Suites by Hilton St. Louis Airport
- HomeTowne Studios by Red Roof St. Louis - Airport/ N Lindbergh
- Red Roof Inn St Louis - Westport/ Maryland Heights
- Best Western Plus Sikeston I-55
- Comfort Inn Festus - St Louis South
- Spark by Hilton St. Louis Southwest
- The Lodge at Grant's Trail
- Americas Best Value Inn St. Louis Downtown
- Fairfield Inn & Suites by Marriott St. Louis South
- Days Inn and Suites by Wyndham Sikeston
- Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)
- Residence Inn By Marriott St. Louis Clayton
- Holiday Inn Express & Suites Perryville by IHG
- Tru By Hilton Cape Girardeau
- Microtel Inn & Suites by Wyndham Sainte Genevieve
- Comfort Inn & Suites Hazelwood - St. Louis
- Hampton Inn St. Louis/Westport
- Comfort Inn St. Louis Airport
- Seven Gables, St. Louis West, a Tribute Portfolio Hotel
- Baymont by Wyndham Festus
- Super 8 by Wyndham Metropolis
- Extended Stay America Select Suites - St. Louis - Airport - Central
- Super 8 by Wyndham St. Louis Airport
- Sheraton Westport Plaza Hotel St. Louis
- Hampton Inn Cape Girardeau I 55 East
- Economy Inn & Suites
- The Lodge Hotel and Banquets
- Comfort Suites Jackson-Cape Girardeau
- The Last Hotel
- Residence Inn by Marriott St. Louis West County
- Holiday Inn Express & Suites Litchfield West by IHG
- Beautiful, Rehabbed Unit in Shaw Community 4228a
- Extended Stay America Select Suites - St. Louis - Westport - E Lackland Rd
- Extended Stay America Select Suites St Louis Earth City
- Amazing Soulard STL Unit, 713a
- Super 8 by Wyndham Staunton
- Country Yard Inn and Suite
- Town House Inn Cape Giradreau
- Homewood Suites by Hilton St. Louis Westport
- Super 8 by Wyndham Perryville
- Cozy, Fun, and One-Of-A-Kind!
- Super 8 by Wyndham Sikeston/Miner Area
- Welcome Suites Hazelwood
- WoodSpring Suites St. Louis Arnold
- MainStay Suites St Louis Airport
- Ultramodern 2BR Corner Loft w/Designer Features
- Cobblestone Inn & Suites - Altamont
- Amazing Lakeside hot tub, A-frame 3 King Beds, Shawnee Forest sleeps 2-6 Firepit
- Benton Park Inn
- Beautiful, Rehabbed Unit in Shaw Community - 4226b
- Sheraton Westport Chalet Hotel St. Louis
- Indoor Heated Pool pontoon boat fish 3 full baths sleeps 17 in beds 2026 SALE!!!
- Gorgeous Ultramodern 2BR Loft + Patio
- STL, Tower Grove, Cozy 2-Story Townhome - A
- Quality Inn Litchfield Route 66
- The West End - Futon with Queen
- Entire building in The Grove, Perfect for Groups!
- Radisson Hotel St. Louis Downtown Convention Center
- Motel 6 Metropolis, IL
- STL, Tower Grove, 2-Story Townhome - B
- Hampton Inn by Hilton Litchfield
- Super 8 by Wyndham Pevely
- Residence Inn St Louis Westport
- Intown Suites Extended Stay St. Louis Mo - Hazelwood
- OYO Hotel St. Louis Downtown City Center MO
- Chic Ultramodern Loft Suite w/ Designer Features
- Central West End B&B
- Super 8 by Wyndham Harrisburg
- Days Inn by Wyndham Perryville
- Hotel 7 Vienna
- Super 8 by Wyndham Charleston/Sikeston East MO
Let Expedia take you to the best Hotels in Southwest Illinois. You'll find the largest selection of hotel deals, discount prices, and cheap hotel rates on reservations anywhere in the world. Expedia, the leader in world travel, gives you customer reviews, maps, and the best selection of hotels near landmarks and attractions.