All hotels in Southern Illinois, Illinois
Change your mindBook hotels with free cancellation
Be pickySearch almost a million properties worldwide
All hotels in Southern Illinois, Illinois
We have found 1135 Southern Illinois Hotels
- Drury Inn & Suites St. Louis Fairview Heights
- Drury Plaza Hotel Mt. Vernon
- Super 8 by Wyndham O'Fallon
- Welcome Suites
- Baymont by Wyndham Effingham
- Drury Inn & Suites Marion
- Comfort Suites Mount Vernon
- Drury Inn & Suites St. Louis O'Fallon, IL
- The Principal Hotel
- Quality Inn & Suites Metropolis I-24
- Comfort Inn Edwardsville - St. Louis
- Drury Inn & Suites St. Louis Collinsville
- Quality Inn Carbondale University area
- Ramada by Wyndham Effingham
- Super 8 by Wyndham Troy IL/St. Louis Area
- Walker's Bluff Casino Resort
- Comfort Suites Fairview Heights - St. Louis
- Quality Inn O'Fallon IL - St. Louis
- Radisson Hotel Fairview Heights - St. Louis
- Best Western Marion Hotel
- Holiday Inn Express Metropolis by IHG
- Quality Inn & Suites near St. Louis and I-255
- Best Western Delta Inn
- Best Western St. Louis Fairview Heights
- Best Western Troy Hotel
- Holiday Inn Express & Suites Murphysboro - Carbondale by IHG
- Best Western Plus MidAmerica Hotel
- Motel 6 Caseyville, IL - Caseyville Il
- Red Lion Inn & Suites Pontoon Beach
- Days Inn by Wyndham Mount Vernon
- Quality Inn & Suites Vandalia near I-70 and Hwy 51
- Country Inn & Suites by Radisson, Effingham, IL
- Home2 Suites by Hilton Carbondale
- Best Western Saluki Inn
- Super 8 by Wyndham Mt. Vernon IL
- Super 8 by Wyndham Fairview Heights-St. Louis
- DoubleTree by Hilton Collinsville - St. Louis
- Holiday Inn Express & Suites Edwardsville by IHG
- Baymont by Wyndham Marion
- Holiday Inn Express & Suites Carbondale - University Area by IHG
- Cobblestone Inn & Suites - Altamont
- Super 8 by Wyndham Metropolis
- Days Inn by Wyndham Collinsville/St. Louis
- Super 8 by Wyndham Marion
- Baymont by Wyndham O'Fallon St. Louis Area
- Days Inn & Suites by Wyndham Casey
- Comfort Inn Collinsville near St. Louis
- Holiday Inn Express & Suites Mattoon by IHG
- Sleep Inn O'Fallon near I-64
- Best Western Heartland Inn
- Quality Inn Effingham North
- Comfort Inn & Suites O'Fallon - St. Louis Area
- La Quinta Inn & Suites by Wyndham Collinsville - St. Louis
- Quality Inn & Suites Marion
- Baymont by Wyndham Chester IL
- Holiday Inn Effingham by IHG
- Country Inn & Suites by Radisson, Fairview Heights, IL
- Holiday Inn Express Troy by IHG
- Country Inn & Suites by Radisson, Marion, IL
- SureStay Hotel by Best Western Whittington Rend Lake
- La Quinta Inn & Suites by Wyndham Effingham
- Best Western Plus Pontoon Beach
- Red Lion Inn & Suites Caseyville
- Harrah's Metropolis Hotel & Casino - A Caesars Rewards Destination
- Quality Inn Mount Vernon, IL
- Comfort Inn & Suites Marion I-57
- Indian Mound Motel
- Super 8 by Wyndham Collinsville St. Louis
- Holiday Inn Express & Suites Effingham by IHG
- Red Roof Inn St Louis - Troy, IL
- Hampton Inn St. Louis - Columbia
- Economy Inn & Suites
- Fairfield Inn by Marriott St. Louis Collinsville, IL
- Extended Stay America Select Suites - St. Louis - O' Fallon, IL
- Comfort Suites Mattoon East
- Comfort Suites Effingham Central
- Days Inn by Wyndham Salem, Illinois
- Country View Inn & Suites
- Super 8 by Wyndham Carbondale
- Holiday Inn Express & Suites Vandalia by IHG
- Hilton Garden Inn Mattoon, Il
- Unique Suites Hotel
- Hampton Inn O'Fallon
- Country Hearth Inn & Suites Edwardsville St. Louis
- Holiday Inn Express & Suites O'Fallon/Shiloh by IHG
- Eighteen-Ninety Sleepover
- Motel 6 Mount Vernon, IL
- Budget Host Inn Greenup
- Fairfield Inn & Suites St. Louis Pontoon Beach/Granite City
- Super 8 by Wyndham Belleville St. Louis Area
- Hampton Inn Collinsville
- Seasons Inn & Suites Highland
- Hampton Inn Carbondale
- Bel Air Motel
- Motel 6 Marion, IL
Let Expedia take you to the best Hotels in Southern Illinois. You'll find the largest selection of hotel deals, discount prices, and cheap hotel rates on reservations anywhere in the world. Expedia, the leader in world travel, gives you customer reviews, maps, and the best selection of hotels near landmarks and attractions.