Search Southern Illinois hotels

  • Change your mind

    Book hotels with free cancellation
  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

Next weekend
In two weeks

Filter by

Guest rating
Guest rating
Star rating

Our top choices for Southern Illinois hotels

Drury Plaza Hotel Mt. Vernon

Drury Plaza Hotel Mt. Vernon
3.0 star property
Mount Vernon
9.6 out of 10, Exceptional, (1,660 reviews)
"Hotel is very clean, nicely furnished and the beds were so comfy!"
United States
Christina
The price is AU$179
includes taxes & fees
8 Mar - 9 Mar
Drury Plaza Hotel Mt. Vernon

La Quinta Inn & Suites by Wyndham Effingham

La Quinta Inn & Suites by Wyndham Effingham
3.0 star property
Effingham
9.2 out of 10, Wonderful, (1,004 reviews)
"Staff was amazing and the brekfast was good too!"
United States
Kevin
The price is AU$152
includes taxes & fees
8 Mar - 9 Mar
La Quinta Inn & Suites by Wyndham Effingham

Home2 Suites By Hilton Effingham

Home2 Suites By Hilton Effingham
3.0 star property
Effingham
9.8 out of 10, Exceptional, (39 reviews)
"Very kind staff, very clean, very pleased. "
United States
Erin
The price is AU$205
includes taxes & fees
8 Mar - 9 Mar
Home2 Suites By Hilton Effingham

Country Inn & Suites by Radisson, Effingham, IL

Country Inn & Suites by Radisson, Effingham, IL
2.5 star property
Effingham
8.8 out of 10, Excellent, (1,001 reviews)
"Clean, friendly staff and good breakfast. Location is excellent. "
United States
Maria
The price is AU$125
includes taxes & fees
8 Mar - 9 Mar
Country Inn & Suites by Radisson, Effingham, IL

Hampton Inn & Suites Effingham

Hampton Inn & Suites Effingham
2.5 star property
Effingham
9.6 out of 10, Exceptional, (716 reviews)
"Very clean, nice hot breakfast, and kind staff. "
United States
Erin
The price is AU$203
includes taxes & fees
15 Mar - 16 Mar
Hampton Inn & Suites Effingham

SureStay Hotel by Best Western Whittington Rend Lake

SureStay Hotel by Best Western Whittington Rend Lake
2.5 star property
Whittington
8.8 out of 10, Excellent, (933 reviews)
"Great place to stay."
United States
Stephen
The price is AU$112
includes taxes & fees
8 Mar - 9 Mar
SureStay Hotel by Best Western Whittington Rend Lake

Holiday Inn Express & Suites Effingham by IHG

Holiday Inn Express & Suites Effingham by IHG
2.5 star property
Effingham
9.4 out of 10, Exceptional, (1,005 reviews)
"Room was clean, staff was very pleasant, breakfast was delicious and plentiful and we were able to enjoy all amenities. "
United States
Laura
The price is AU$194
includes taxes & fees
8 Mar - 9 Mar
Holiday Inn Express & Suites Effingham by IHG

Best Western U. S. Inn

Best Western U. S. Inn
2.5 star property
Nashville
8.6 out of 10, Excellent, (403 reviews)
"Good staff "
United States
Jose Diego
The price is AU$135
includes taxes & fees
2 Mar - 3 Mar
Best Western U. S. Inn

Drury Inn & Suites Marion

Drury Inn & Suites Marion
3.0 star property
Marion
9.4 out of 10, Exceptional, (1,001 reviews)
"All of the above, enjoyed the evening meal and breakfast, also staff was very friendly. "
United States
Barbara
The price is AU$179
includes taxes & fees
15 Mar - 16 Mar
Drury Inn & Suites Marion

The Principal Hotel

The Principal Hotel
3.5 star property
Columbia
9.8 out of 10, Exceptional, (206 reviews)
"Great stay and very clean!"
United States
David
The price is AU$162
includes taxes & fees
10 Mar - 11 Mar
The Principal Hotel

Charleston House Bed & Breakfast Inn

Charleston House Bed & Breakfast Inn
4.0 star property
Charleston
10.0 out of 10, Exceptional, (2 reviews)
"Absolutely wonder comfortable stay and delicious breakfast. Stayed with my 2 kids and slept so well. Almost forgot I was at a college campus, felt like a resort"
United States
Mary
The price is AU$153
includes taxes & fees
9 Mar - 10 Mar
Charleston House Bed & Breakfast Inn

Country Hearth Inn & Suites Edwardsville St. Louis

Country Hearth Inn & Suites Edwardsville St. Louis
2.5 star property
Edwardsville
8.6 out of 10, Excellent, (670 reviews)
"Room was great,staff friendly! All together a great stay."
United States
Zachary
The price is AU$208
includes taxes & fees
2 Mar - 3 Mar
Country Hearth Inn & Suites Edwardsville St. Louis

Holiday Inn Effingham by IHG

Holiday Inn Effingham by IHG
3.5 star property
Effingham
9.0 out of 10, Wonderful, (663 reviews)
"Nice place with bar and restaurant on site."
United States
Steve
The price is AU$171
includes taxes & fees
8 Mar - 9 Mar
Holiday Inn Effingham by IHG

Comfort Suites Mount Vernon

Comfort Suites Mount Vernon
2.5 star property
Mount Vernon
9.0 out of 10, Wonderful, (1,015 reviews)
"Very clean and safe stay!"
United States
Dale
The price is AU$172
includes taxes & fees
2 Mar - 3 Mar
Comfort Suites Mount Vernon

Best Western Plus Parkside Inn & Suites

Best Western Plus Parkside Inn & Suites
2.5 star property
Olney
9.8 out of 10, Exceptional, (332 reviews)
"Awesome staff, room and breakfast "
United States
Marjorie
The price is AU$184
includes taxes & fees
8 Mar - 9 Mar
Best Western Plus Parkside Inn & Suites

Hilton Garden Inn Mattoon, Il

Hilton Garden Inn Mattoon, Il
3.0 star property
Mattoon
9.0 out of 10, Wonderful, (223 reviews)
"Great hotel with a pool, fitness center, bar and restaurant. "
United States
william
The price is AU$203
includes taxes & fees
7 Mar - 8 Mar
Hilton Garden Inn Mattoon, Il

Holiday Inn Express & Suites Murphysboro - Carbondale by IHG

Holiday Inn Express & Suites Murphysboro - Carbondale by IHG
2.5 star property
Murphysboro
9.4 out of 10, Exceptional, (527 reviews)
"Yes, very clean and service was great."
United States
allen
The price is AU$192
includes taxes & fees
8 Mar - 9 Mar
Holiday Inn Express & Suites Murphysboro - Carbondale by IHG

Best Western Delta Inn

Best Western Delta Inn
2.5 star property
Effingham
9.2 out of 10, Wonderful, (1,001 reviews)
"Staff very friendly!"
United States
C. Mark
The price is AU$132
includes taxes & fees
11 Mar - 12 Mar
Best Western Delta Inn

Comfort Inn & Suites Marion I-57

Comfort Inn & Suites Marion I-57
2.5 star property
Marion
9.4 out of 10, Exceptional, (1,001 reviews)
"Nice room, friendly staff, solid breakfast. It's our second time staying. Quiet location. "
United States
Shelly
The price is AU$197
includes taxes & fees
15 Mar - 16 Mar
Comfort Inn & Suites Marion I-57

Days Inn & Suites by Wyndham Casey

Days Inn & Suites by Wyndham Casey
2.0 star property
Casey
7.4 out of 10, Good, (839 reviews)
"Nice place, quiet, clean, and I would stay there again."
United States
Kym
The price is AU$105
includes taxes & fees
2 Mar - 3 Mar
Days Inn & Suites by Wyndham Casey
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

The Annual Holiday Sale

Members save up to 40% on hotels and homes. Plan this year’s big trip and save.

Holiday Rentals in Southern Illinois

Save an average of 15% on thousands of hotels when you're signed in

Stay near popular Southern Illinois attractions

Learn more about Southern Illinois

Discover the culture and history of this region shaped by indigenous and pioneering communities and spend time in its peaceful, picturesque landscapes.

Southern Illinois which includes landscape views, forests and a sunset
Photo by Southernmost Illinois Tourism Bureau
Open Photo by Southernmost Illinois Tourism Bureau

Top Southern Illinois Hotel Reviews

Recent Reviews in Southern Illinois

More cheap accommodation in Southern Illinois

Explore a world of travel with Expedia