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Cheap Flights from Florence (FLO) to Knoxville (TYS)

Popular airlines from Florence, SC (FLO-Florence Regional) to Alcoa - Knoxville Airport (TYS)

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Frequently asked questions

How much does a flight from Florence, SC (FLO-Florence Regional) to Knoxville, TN (TYS-McGhee Tyson) cost?
You can find one-way and return flights from FLO to TYS with Expedia. Flight prices vary based on the month and day of the week you want to travel, as well as the airline and how far in advance you book your ticket. Filter your search on Expedia by "Price (lowest to highest)" to see our cheapest fares first, and use the Price Tracking tool to receive alerts when FLO to TYS ticket fares go up or down.
What is the cheapest month to fly from Florence, SC (FLO-Florence Regional) to Knoxville, TN (TYS-McGhee Tyson)?
The cheapest months to fly from FLO to TYS are typically during off-peak season when demand is low. Traveling in off-peak or shoulder months is usually a good way to secure cheap tickets, just remember to avoid flying during holidays if you are able to. Use the calendar view in your search to see which months have low fares on this route.
Which airlines fly direct from Florence, SC (FLO-Florence Regional) to Knoxville, TN (TYS-McGhee Tyson)?
Enter FLO to TYS and your travel dates, then apply the 'Nonstop' filter to see only direct flights.
What is the cheapest airline that flies from Florence, SC (FLO-Florence Regional) to Knoxville, TN (TYS-McGhee Tyson)?
American Airlines is one of the cheapest airlines offering connecting return flights from Florence Regional (FLO) to McGhee Tyson (TYS), with tickets starting from around AU$717 for flights that can be booked for departure within the next year. These flights typically include a layover in Charlotte-Douglas Intl. (CLT). Prices are per adult, for economy/coach class. Use Expedia's search tool to compare the prices and schedules of airlines that fly this route to find the best option for your plans and budget.
How do I find cheap flights from Florence, SC (FLO-Florence Regional) to Knoxville, TN (TYS-McGhee Tyson)?
To find a cheap flight from Florence, SC (FLO-Florence Regional) to Knoxville, TN (TYS-McGhee Tyson), be flexible with your dates. Traveling outside of peak vacation months and booking a mid-week flight can help you save. Early morning and late night flights are often more affordable, too. Expedia allows you to compare flight times, airlines and routes all in one place to find low fares. You can also set up Price Tracking and receive alerts when fares go up or down.
What is the best time to fly from Florence, SC (FLO-Florence Regional) to Knoxville, TN (TYS-McGhee Tyson)?
The best time to fly is usually mid-week (Tuesday or Wednesday) and during early morning hours as flights tend to be cheaper, less crowded, and generally more on-time. Avoid major holidays and peak vacation seasons for smoother travel. Combining off-peak days and hours often gives the best combination of cost, comfort, and convenience.
How many flights per day from Florence, SC (FLO-Florence Regional) to Knoxville, TN (TYS-McGhee Tyson)?
There are approximately 3 connecting flights per day from Florence Regional (FLO) to McGhee Tyson (TYS). A common connection point is Charlotte-Douglas Intl. (CLT).
What is the earliest flight from Florence, SC (FLO-Florence Regional) to Knoxville, TN (TYS-McGhee Tyson)?
The earliest flight from Florence Regional (FLO) to McGhee Tyson (TYS) typically departs around 5:10 AM local time. This flight is operated by American Airlines and is a seasonal service, active in October. An early departure like this can help you make the most of your time at your destination. To compare early flights on Expedia, select the "Early Morning" and "Morning" filters in your search.
What day of the week has the most flights from Florence, SC (FLO-Florence Regional) to Knoxville, TN (TYS-McGhee Tyson)?
You'll find the most flights from Florence Regional (FLO) to McGhee Tyson (TYS) on a Thursday, with around 3 flights available. This gives you several flight options for your travel plans. American Airlines is a major airline on this route. Flight schedules are consistent throughout the week, so you have a good selection of flights regardless of the day you choose to fly.
What are the most popular departure times for flights from Florence, SC (FLO-Florence Regional) to Knoxville, TN (TYS-McGhee Tyson)?
The most popular departure times for flights from Florence Regional (FLO) to McGhee Tyson (TYS) are in the early morning, from 3am to 6am. American Airlines offers flights during this window. Many travellers prefer this time as it allows for an early start to their journey.
How long does it take to fly from Florence, SC (FLO-Florence Regional) to Knoxville, TN (TYS-McGhee Tyson)?
There are no nonstop flights from Florence, SC (FLO-Florence Regional) to Knoxville, TN (TYS-McGhee Tyson). The distance between these two airports is approximately 428 kilometres. For flights with one stop, you can expect the journey to typically take around 3 hours 30 minutes. If your flight has two or more stops, the travel time will be significantly longer, usually around 11 hours 18 minutes. Keep in mind that actual flight times can vary due to factors like layover duration, routing, and weather conditions.
Can you fly business or first class from Florence, SC (FLO) to Knoxville, TN (TYS)?
Select the "Business class" and "First class" filters when looking for Florence, SC (FLO) to Knoxville, TN (TYS) flights on Expedia. This is the easiest way to compare prices, routes and flight times for your trip.
How do I earn miles on a Florence, SC (FLO-Florence Regional) to Knoxville, TN (TYS-McGhee Tyson) flight with Expedia?
It's easy to earn miles on a Florence, SC (FLO-Florence Regional) to Knoxville, TN (TYS-McGhee Tyson) flight when you book with Expedia. Before you confirm your booking, simply select your frequent flyer program and enter your program number. As a member of One Key™, you can also earn OneKeyCash™* on top of your airline miles when you book with Expedia.*Excludes taxes and fees. OneKeyCash is not redeemable for cash and can only be used on Expedia and other participating brands.
What airports do you fly into for Knoxville, TN (TYS) from Florence, SC (FLO)?
If you're planning to travel to Knoxville from Florence Regional (FLO), you can fly directly into McGhee Tyson (TYS) which offers domestic flights and connections. Some flights may connect through major hubs like Charlotte-Douglas Intl. (CLT) before reaching Knoxville. Compare routes and airports on Expedia to find the best flight options for your travel plans.
Is it cheaper to buy a plane ticket from Florence, SC (FLO-Florence Regional) to Knoxville, TN (TYS-McGhee Tyson) at the last minute?
Typically, booking a last minute flight from Florence, SC (FLO-Florence Regional) to Knoxville, TN (TYS-McGhee Tyson) will be more expensive than booking in advance. As the departure date approaches, there are usually fewer seats available which can drive up the cost. However, if there's some wiggle room with your travel dates and times, you could bag a cheap last-minute fare.
Is it cheaper to book a Florence, SC (FLO-Florence Regional) to Knoxville, TN (TYS-McGhee Tyson) flight and hotel package?
Securing a Florence, SC (FLO-Florence Regional) to Knoxville, TN (TYS-McGhee Tyson) flight and hotel package is usually cheaper than booking separately. With Expedia, you can enjoy the ease of organizing your travels all in one place. Select from our extensive range of stays and then add flights, activities and car rentals to your booking. Bundle everything together, and you could save hundreds of dollars.
Can I cancel or change the date of my flight from Florence, SC (FLO-Florence Regional) to Knoxville, TN (TYS-McGhee Tyson)?
If you booked your Florence, SC (FLO-Florence Regional) to Knoxville, TN (TYS-McGhee Tyson) flight within the last 24 hours, you may be able to modify or cancel it without any fees. Depending on the airline and the type of ticket you have, additional charges may apply for changes beyond this timeframe. Airline policies and contact information can be found in your itinerary or confirmation email. Or, head to our Customer Service portal if you'd like more information.

Travel information

Origin airport
Florence Regional
Destination airport
McGhee Tyson
Distance
424 km

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Your quick guide to flights from Florence to Knoxville

Pick up great flights from Florence to Knoxville

With Expedia, you have your pick of flights a day with airlines covering flights from Florence to Knoxville. Whether you’re on a business trip, a family holiday or a luxury break, just enter your travel dates, hit search then check out your choice of flights. Select from return, one way or multi-city flights, and use the advance search tool if you want a direct or refundable flight. You can narrow your search to show you just your preferred cabin class and airline, too. It’s all easy. You can book direct flights from Florence to Knoxville that take around hours.

Find cheap flights from Florence to Knoxville

From the great flight deals with prices currently ranging from to , you can choose to see the cheapest flights first. Generally, you can book the cheapest flights from Florence to Knoxville around 4 to 6 weeks in advance. If your travel dates are flexible, try to avoid weekends and peak seasons – when you are more likely to grab the lowest prices. Even last minute, there are some impressive deals. The cheapest time to fly to Knoxville is normally in .

Reasons to book your flight from Florence to Knoxville with Expedia

Expedia makes it easy to find, book, and travel, with everything you need all in one place. When you enter your travel details, find fantastic deals just for you on flight tickets from Florence to Knoxville across all the main airline carriers, so you can save time, dollars, and hassle finding the perfect flight. If you think your plans could change, choose refundable flights so any changes won’t cost you more. Book your flight to Knoxville right now and, if you join Expedia Rewards, you earn points this time and every time you travel with Expedia.

Your quick guide to flights from Florence to Knoxville

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