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Business Hotels & Resorts in Upstate South Carolina from AU$113

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Check availability on Upstate South Carolina Business Hotels

Tonight
25 Dec - 26 Dec
Tomorrow
26 Dec - 27 Dec
This weekend
26 Dec - 28 Dec
Next weekend
2 Jan - 4 Jan

Our top choices for Upstate South Carolina business-friendly hotels

Free daily full breakfast
Holiday Inn Express Gaffney by IHG

Holiday Inn Express Gaffney by IHG

Holiday Inn Express Gaffney by IHG
2.5 star property
Gaffney
8.6 out of 10, Excellent, (424)
"Great place to stay"
United States
Timothy
The price is AU$127
includes taxes & fees
31 Dec - 1 Jan 2026
Holiday Inn Express Gaffney by IHG
Free daily buffet breakfast
Hampton Inn Spartanburg-North I-85

Hampton Inn Spartanburg-North I-85

Hampton Inn Spartanburg-North I-85
2.5 star property
Spartanburg
8.8 out of 10, Excellent, (1000)
"The staff was courteous in the room was spotless!"
United States
Kimberly
The price is AU$129
includes taxes & fees
9 Jan - 10 Jan 2026
Hampton Inn Spartanburg-North I-85
Free daily continental breakfast
Best Western Plus Greenville I-385 Inn & Suites

Best Western Plus Greenville I-385 Inn & Suites

Best Western Plus Greenville I-385 Inn & Suites
2.5 star property
Greenville
9.0 out of 10, Wonderful, (1418)
"Clean room, great selection for breakfast, easy check in and check out"
United States
Angelica
The price is AU$125
includes taxes & fees
28 Dec - 29 Dec
Best Western Plus Greenville I-385 Inn & Suites
Exterior
DoubleTree by Hilton Greenville Woodruff Road

DoubleTree by Hilton Greenville Woodruff Road

DoubleTree by Hilton Greenville Woodruff Road
3.0 star property
Greenville
9.4 out of 10, Exceptional, (1000)
"Clean modern comfortable convenient location great cookie "
United States
Jimmy
The price is AU$180
includes taxes & fees
28 Dec - 29 Dec
DoubleTree by Hilton Greenville Woodruff Road
Terrace/patio
Embassy Suites Greenville Golf Resort & Conference Center

Embassy Suites Greenville Golf Resort & Conference Center

Embassy Suites Greenville Golf Resort & Conference Center
3.5 star property
Greenville
9.0 out of 10, Wonderful, (1002)
"Great room, staff and location. "
United States
Neil
The price is AU$161
includes taxes & fees
11 Jan - 12 Jan 2026
Embassy Suites Greenville Golf Resort & Conference Center
Seasonal outdoor pool
Super 8 by Wyndham Greer/Spartanburg Area

Super 8 by Wyndham Greer/Spartanburg Area

Super 8 by Wyndham Greer/Spartanburg Area
2.0 star property
Greer
7.2 out of 10, Good, (525)
"My stay at Super 8 was quite remarkable . I really enjoyed the place."
United States
Rick
The price is AU$113
includes taxes & fees
1 Jan - 2 Jan 2026
Super 8 by Wyndham Greer/Spartanburg Area
Free daily on-the-go breakfast
Quality Inn Seneca Clemson Area US-123

Quality Inn Seneca Clemson Area US-123

Quality Inn Seneca Clemson Area US-123
2.5 star property
Downtown
8.0 out of 10, Very good, (665)
"Friendly check in, clean room."
United States
connie
The price is AU$129
includes taxes & fees
4 Jan - 5 Jan 2026
Quality Inn Seneca Clemson Area US-123
Exterior
Woodspring Suites Greenville Airport

Woodspring Suites Greenville Airport

Woodspring Suites Greenville Airport
2.5 star property
Greenville
8.2 out of 10, Very good, (304)
"Clean room, friendly staff, I would definitely stay here again!"
United States
Melissa
The price is AU$130
includes taxes & fees
26 Dec - 27 Dec
Woodspring Suites Greenville Airport
Free daily on-the-go breakfast
Comfort Inn & Suites Greer - Greenville

Comfort Inn & Suites Greer - Greenville

Comfort Inn & Suites Greer - Greenville
2.5 star property
Greer
8.6 out of 10, Excellent, (730)
"Staff very friendly, clean spacious room"
United States
Arthur
The price is AU$152
includes taxes & fees
1 Jan - 2 Jan 2026
Comfort Inn & Suites Greer - Greenville
Exterior
Comfort Suites Clinton near Presbyterian College

Comfort Suites Clinton near Presbyterian College

Comfort Suites Clinton near Presbyterian College
2.5 star property
Clinton
8.2 out of 10, Very good, (753)
"Room veey clean"
United States
Ulysses
The price is AU$173
includes taxes & fees
29 Dec - 30 Dec
Comfort Suites Clinton near Presbyterian College
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top Upstate South Carolina Hotel Reviews

Aloft Greenville Downtown

Aloft Greenville Downtown

10/10 Excellent
"The hospitality and all amenities were top notch! We will definitely be staying there again with our dog."
Joseph 2-night trip
Posted 3 days ago
Aloft Greenville Downtown

Frequently asked questions

How much do business-friendly hotels in Upstate South Carolina cost?
Prepare to pay between AU$113 and AU$180 per night for business-friendly hotels in Upstate South Carolina. Epic deals on stays that are suitable for work-related travellers are a click away on Expedia. This price was available on Expedia within the past 7 days, for a hotel booking with a check-in date within the next year. Prices reflect current offers and availability is subject to change. Additional terms may apply.
How many business-friendly hotels are there in Upstate South Carolina?
When your job takes you on the road in Upstate South Carolina, there are 144 business-friendly hotels to choose from.
What is there to do in Upstate South Carolina near my business-friendly hotel?
There are tons of things to see and do in Upstate South Carolina. If you're off to Greenville, check out Greenville Zoo, The Children's Museum of the Upstate and Greenville County Museum of Art. Planning a stay in Spartanburg? Spartanburg Regional History Museum, Wofford College and Spartanburg Memorial Auditorium are among the top sights in this city.

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