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Our top choices for Defiance hotels

Super 8 by Wyndham St. Clair MO

Super 8 by Wyndham St. Clair MO
2.0 star property
St. Clair
7.2 out of 10, Good, (953 reviews)
"Room was okay, definitely not the best but good for the price. "
United States
Mason
The price is AU$105
includes taxes & fees
26 Jan - 27 Jan
Super 8 by Wyndham St. Clair MO

Best Western Plus Washington Hotel

Best Western Plus Washington Hotel
2.5 star property
Washington
9.2 out of 10, Wonderful, (650 reviews)
"Isa a great place to stay I always enjoy it!"
United States
vicki
The price is AU$218
includes taxes & fees
26 Jan - 27 Jan
Best Western Plus Washington Hotel

Holiday Inn Express & Suites Wentzville St Louis West by IHG

Holiday Inn Express & Suites Wentzville St Louis West by IHG
2.5 star property
Wentzville
9.4 out of 10, Exceptional, (864 reviews)
"Beautiful hotel, friendly staff, good breakfast."
United States
Erika
The price is AU$232
includes taxes & fees
31 Jan - 1 Feb
Holiday Inn Express & Suites Wentzville St Louis West by IHG

Comfort Suites St Charles - St Louis

Comfort Suites St Charles - St Louis
2.5 star property
St. Charles
8.4 out of 10, Very good, (1,005 reviews)
"Great hotel for the money"
United States
Jere
The price is AU$133
includes taxes & fees
25 Jan - 26 Jan
Comfort Suites St Charles - St Louis

Drury Plaza Hotel St. Louis St. Charles

Drury Plaza Hotel St. Louis St. Charles
3.0 star property
St. Charles
9.6 out of 10, Exceptional, (1,000 reviews)
"Great hotel "
United States
John Christopher
The price is AU$198
includes taxes & fees
1 Feb - 2 Feb
Drury Plaza Hotel St. Louis St. Charles

Quality Inn Near Six Flags St. Louis

Quality Inn Near Six Flags St. Louis
2.5 star property
Pacific
8.4 out of 10, Very good, (365 reviews)
"Excellent staff & very clean room"
United States
Karen
The price is AU$168
includes taxes & fees
22 Jan - 23 Jan
Quality Inn Near Six Flags St. Louis

Embassy Suites by Hilton St. Louis St. Charles

Embassy Suites by Hilton St. Louis St. Charles
3.5 star property
St. Charles
8.8 out of 10, Excellent, (1,002 reviews)
"My favorite hotel"
United States
Edward
The price is AU$209
includes taxes & fees
1 Feb - 2 Feb
Embassy Suites by Hilton St. Louis St. Charles

Hilton St. Louis Frontenac

Hilton St. Louis Frontenac
4.0 star property
Frontenac
8.8 out of 10, Excellent, (1,000 reviews)
"Great room, great amenities!"
United States
Linda or James
The price is AU$226
includes taxes & fees
1 Feb - 2 Feb
Hilton St. Louis Frontenac

Hampton Inn & Suites St. Charles Old Town Area

Hampton Inn & Suites St. Charles Old Town Area
2.5 star property
St. Charles
9.2 out of 10, Wonderful, (643 reviews)
"The breakfast was delicious and contained a wide variety. The staff friendly and the rooms very clean. "
United States
Kim
The price is AU$203
includes taxes & fees
8 Feb - 9 Feb
Hampton Inn & Suites St. Charles Old Town Area

Fairfield Inn & Suites Wentzville

Fairfield Inn & Suites Wentzville
2.5 star property
Wentzville
9.0 out of 10, Wonderful, (649 reviews)
"Hotel staff was friendly and room was very clean "
United States
Danielle
The price is AU$217
includes taxes & fees
25 Jan - 26 Jan
Fairfield Inn & Suites Wentzville

Super 8 by Wyndham Washington

Super 8 by Wyndham Washington
2.0 star property
Washington
8.4 out of 10, Very good, (705 reviews)
"The staff was extremely nice & accommodating."
United States
Brenda
The price is AU$143
includes taxes & fees
28 Jan - 29 Jan
Super 8 by Wyndham Washington

Best Western Plus The Charles Hotel

Best Western Plus The Charles Hotel
3.0 star property
St. Charles
8.2 out of 10, Very good, (1,005 reviews)
"Very nice at service desk, room clean and comfortable, breakfast really good. Would recommend, would stay again!"
United States
Melisa
The price is AU$152
includes taxes & fees
26 Jan - 27 Jan
Best Western Plus The Charles Hotel

Holiday Inn Express & Suites St Peters by IHG

Holiday Inn Express & Suites St Peters by IHG
2.5 star property
St. Peters
9.2 out of 10, Wonderful, (383 reviews)
"Parking was easy and the room was nice."
United States
Martha
The price is AU$181
includes taxes & fees
26 Jan - 27 Jan
Holiday Inn Express & Suites St Peters by IHG

WoodSpring Suites St Peters-OFallon

WoodSpring Suites St Peters-OFallon
2.5 star property
St. Peters
9.4 out of 10, Exceptional, (34 reviews)
"Super clean , quiet place "
United States
Phoenix
The price is AU$157
includes taxes & fees
22 Jan - 23 Jan
WoodSpring Suites St Peters-OFallon

Country Inn & Suites by Radisson, St. Charles Historic District

Country Inn & Suites by Radisson, St. Charles Historic District
2.5 star property
St. Charles Historic District
9.4 out of 10, Exceptional, (1,001 reviews)
"We had a great stay in a beautiful area. The staff were friendly, and Kay at the front desk was so kind and welcoming!"
United States
Audrey
The price is AU$202
includes taxes & fees
25 Jan - 26 Jan
Country Inn & Suites by Radisson, St. Charles Historic District

Quality Inn Foristell

Quality Inn Foristell
2.5 star property
Foristell
8.2 out of 10, Very good, (923 reviews)
"Clean rooms, pleasant staff."
United States
Karen
The price is AU$124
includes taxes & fees
25 Jan - 26 Jan
Quality Inn Foristell

River Sirens Hotel

River Sirens Hotel
2.5 star property
Washington
9.8 out of 10, Exceptional, (186 reviews)
"Great place"
United States
Herchel
River Sirens Hotel

Drury Inn & Suites St. Louis St. Peters

Drury Inn & Suites St. Louis St. Peters
3.0 star property
St. Peters
9.4 out of 10, Exceptional, (1,003 reviews)
"Awesome staff "
United States
John
The price is AU$188
includes taxes & fees
1 Feb - 2 Feb
Drury Inn & Suites St. Louis St. Peters

Days Inn by Wyndham St Peters/St Charles

Days Inn by Wyndham St Peters/St Charles
2.0 star property
St. Peters
6.2 out of 10, (1,000 reviews)
"Room was excellent and clean"
United States
catherine
The price is AU$96
includes taxes & fees
18 Feb - 19 Feb
Days Inn by Wyndham St Peters/St Charles

Hampton Inn St. Louis Wentzville

Hampton Inn St. Louis Wentzville
2.5 star property
Wentzville
9.0 out of 10, Wonderful, (645 reviews)
"Easy check in accessible room, comfortable bed and chairs"
United States
Maurine
The price is AU$205
includes taxes & fees
31 Jan - 1 Feb
Hampton Inn St. Louis Wentzville
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Stay near popular Defiance attractions

Learn more about Defiance

Nestled along the Missouri River, this historic village offers scenic hiking trails and access to nearby wine country. Visit the Daniel Boone Home in neighbouring Defiance Township or enjoy tastings at the family-owned wineries dotting the surrounding countryside.

A covered bridge at the Historic Daniel Boone Home Park in Defiance, Missouri

Top Defiance Hotel Reviews

Recent Reviews in Defiance

More cheap accommodation in Defiance

Frequently asked questions

What's the best place to stay in Defiance?
Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham, located 17.9 mi (28.8 km) from the heart of Defiance, is a top choice for your stay, based on our traveller data. Two other options for your visit to the area are The Wildwood Hotel and Ameristar Casino Resort and Spa. See all available top hotels, or vacation rentals in Defiance.
What are some of the best holiday rentals that Defiance has to offer?
The St. Charles Guest House, lovely historic home, fun for families and groups: This holiday home rental outside of Defiance is located on a river, and has a fireplace, a selection of games and air conditioning to put you at ease in your new surroundings. It has 3 bedrooms, as well as a kitchen with a dishwasher, a fridge and a stovetop, so that you can cook with friends or family. See all vacation rentals in Defiance.
If I need to cancel my hotel reservation in Defiance, will I receive a refund?
Yes! The majority of room reservations are fully refundable if you cancel before the accommodation's cancellation deadline, which often is within 24-48 hours of your check-in date. If you have a reservation that's non-refundable, you might be able to cancel it and receive a refund within a 24-hour period of your booking. Filter your search by fully refundable to find flexible hotel deals in Defiance.
What are some accommodation options with pools in Defiance?
Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham: Features an indoor pool, an outdoor pool and buffet. The Wildwood Hotel and Ameristar Casino Resort and Spa are two additional hotels with an on-site pool. View all hotels with pools in Defiance.
How is it staying in Defiance?
Visitors can enjoy all that Defiance has to offer, including the wineries and parks. Top sights in the area include St. Louis Union Station, Busch Stadium and Gateway Arch. In Defiance, there are 20 hotels and other accommodation options to choose from. Find out more about Defiance.
What should I do while I'm visiting Defiance?
Natural beauty is on display at August A. Busch Memorial Conservation Area, Missouri River and Matson Hill Park Trailhead. A couple of additional sights to add to your itinerary are Yellow Farmhouse Winery and Chandler Hill Vineyards. Take a look at what more there is to see and do in Expedia's Defiance guide.
What's the weather like in Defiance?
The hottest months are usually July and August, with an average temperature of 24°C, while the coldest months are January and February, with an average of 3°C. Average annual precipitation for Defiance is 1228 mm.

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