Photo by Michael True

Search Defiance hotels

    calendar shield illustration

    Change your mind

    Book hotels with free cancellation
    deals illustration

    Treat yourself

    Sign in to save 10% or more on thousands of hotels
    bed illustration

    Be picky

    Search almost a million properties worldwide

Check prices for these dates

Filter by

Guest rating
Guest rating
Property class

Top hotels and accommodation in Defiance

Our top choices for Defiance hotels

Drury Plaza Hotel St. Louis Chesterfield

3.0 star property
9.6 out of 10, Exceptional, (1011)
"Great place to stay! "
The price is AU$232
includes taxes & fees
24 Sept - 25 Sept
Drury Plaza Hotel St. Louis Chesterfield

Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham

3.0 star property
8.4 out of 10, Very good, (1007)
"Very good hotel for the price"
The price is AU$159
includes taxes & fees
31 Aug - 1 Sept
Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham

Quality Inn Near Six Flags St. Louis

2.5 star property
8.4 out of 10, Very good, (333)
"Pool was small. Staff was great. Room was very clean and well maintained. Overall very nice stay. "
The price is AU$175
includes taxes & fees
1 Sept - 2 Sept
Quality Inn Near Six Flags St. Louis

Super 8 by Wyndham St. Clair MO

2.0 star property
7.2 out of 10, Good, (896)
"Nice location amd staff were very nice would go there again!"
The price is AU$125
includes taxes & fees
27 Aug - 28 Aug
Super 8 by Wyndham St. Clair MO

Hampton Inn & Suites St. Louis/Chesterfield

3.5 star property
8.8 out of 10, Excellent, (806)
"Everything was wonderful!"
The price is AU$189
includes taxes & fees
1 Sept - 2 Sept
Hampton Inn & Suites St. Louis/Chesterfield

Comfort Inn St. Louis Airport

3.0 star property
8.6 out of 10, Excellent, (894)
"Good experience during our stay. "
The price is AU$166
includes taxes & fees
3 Sept - 4 Sept
Comfort Inn St. Louis Airport

Wingate by Wyndham St. Louis/Fenton Route 66

3.0 star property
8.2 out of 10, Very good, (1008)
"Good hotel! "
The price is AU$150
includes taxes & fees
31 Aug - 1 Sept
Wingate by Wyndham St. Louis/Fenton Route 66

Larkspur Landing Extended Stay Suites St. Louis Riverport - Airport West

3.0 star property
7.4 out of 10, Good, (1012)
"It's a beautiful place to stay "
The price is AU$145
includes taxes & fees
25 Sept - 26 Sept
Larkspur Landing Extended Stay Suites St. Louis Riverport - Airport West

Holiday Inn Express St. Louis West - O'Fallon by IHG

2.5 star property
8.6 out of 10, Excellent, (770)
"Friendly staff and clean, fresh smelling rooms."
The price is AU$191
includes taxes & fees
28 Aug - 29 Aug
Holiday Inn Express St. Louis West - O'Fallon by IHG

Super 8 by Wyndham St Charles

2.0 star property
8.0 out of 10, Very good, (1001)
"Great breakfast and awesome staff"
The price is AU$138
includes taxes & fees
1 Sept - 2 Sept
Super 8 by Wyndham St Charles

Super 8 by Wyndham Warrenton

2.0 star property
7.4 out of 10, Good, (583)
"Staff was extremely accommodating and friendly."
The price is AU$126
includes taxes & fees
1 Sept - 2 Sept
Super 8 by Wyndham Warrenton

Quality Inn

2.5 star property
8.2 out of 10, Very good, (837)
"Lovely clean room and comfortable bed, quiet area , nice breakfast … all the things i need."
The price is AU$164
includes taxes & fees
24 Sept - 25 Sept
Quality Inn

Sleep Inn & Suites O'Fallon MO - Technology Drive

2.5 star property
8.8 out of 10, Excellent, (1007)
"Perfect place to stay, very clean and quiet."
The price is AU$171
includes taxes & fees
14 Sept - 15 Sept
Sleep Inn & Suites O'Fallon MO - Technology Drive

Super 8 by Wyndham Washington

2.0 star property
8.4 out of 10, Very good, (667)
"It was clean and quaint for the price and was also close to where I was going the next morning. "
The price is AU$152
includes taxes & fees
1 Sept - 2 Sept
Super 8 by Wyndham Washington

The Wildwood Hotel

3.5 star property
9.2 out of 10, Wonderful, (1562)
"Great place to stay."
The Wildwood Hotel

Comfort Inn & Suites St. Louis - O'Fallon

2.5 star property
7.6 out of 10, Good, (1002)
"And nice hotel at a nice price "
The price is AU$155
includes taxes & fees
7 Sept - 8 Sept
Comfort Inn & Suites St. Louis - O'Fallon

Holiday Inn Express & Suites St Peters by IHG

2.5 star property
9.2 out of 10, Wonderful, (341)
"Very nice place. Clean... quiet and very friendly staff!! We will definitely stay here again!!"
The price is AU$160
includes taxes & fees
1 Sept - 2 Sept
Holiday Inn Express & Suites St Peters by IHG

Drury Plaza Hotel St. Louis Creve Coeur

3.0 star property
9.2 out of 10, Wonderful, (1005)
"The staff and hotel were great. The provided hot breakfast and diner buffet was great!"
The price is AU$205
includes taxes & fees
31 Aug - 1 Sept
Drury Plaza Hotel St. Louis Creve Coeur

Hampton Inn St. Louis Southwest

2.5 star property
9.0 out of 10, Wonderful, (940)
"The hotel was nice and clean. The staff were friendly and helpful. The breakfast was great. I highly recommend the hotel."
The price is AU$195
includes taxes & fees
7 Sept - 8 Sept
Hampton Inn St. Louis Southwest

Comfort Suites St Charles - St Louis

2.5 star property
8.4 out of 10, Very good, (1009)
"Everything was great, clean, close to the places we were going too. "
The price is AU$178
includes taxes & fees
31 Aug - 1 Sept
Comfort Suites St Charles - St Louis
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Save an average of 15% on thousands of hotels when you're signed in

Stay near top Defiance attractions

Learn more about Defiance

Nestled along the Missouri River, this historic village offers scenic hiking trails and access to nearby wine country. Visit the Daniel Boone Home in neighbouring Defiance Township or enjoy tastings at the family-owned wineries dotting the surrounding countryside.

Top Defiance Hotel Reviews

More cheap accommodation in Defiance

More cheap accommodation in Defiance

Explore a world of travel with Expedia

Explore a world of travel with Expedia

Frequently asked questions

What's the best place to stay in Defiance?

Hollywood Casino & Hotel St. Louis, located 18.1 mi (29.2 km) from the heart of Defiance, is a top choice for your stay, based on our traveller data. Two other options for your visit to the area are Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham and Larkspur Landing Extended Stay Suites St. Louis Riverport - Airport West. See all available top hotels, or vacation rentals in Defiance.

What are some of the best holiday rentals that Defiance has to offer?

St. Charles 1860's Gem - Sleeps 6!: This holiday home rental outside of Defiance is located on a river, and has a garden, a selection of books and air conditioning to put you at ease in your new surroundings. Kitchen amenities include a dishwasher, a fridge and a stovetop. See all vacation rentals in Defiance.

If I need to cancel my hotel reservation in Defiance, will I receive a refund?

Yes! The majority of room reservations are fully refundable if you cancel before the accommodation's cancellation deadline, which often is within 24-48 hours of your check-in date. If you have a reservation that's non-refundable, you might be able to cancel it and receive a refund within a 24-hour period of your booking. Filter your search by fully refundable to find flexible hotel deals in Defiance.

What are some accommodation options with pools in Defiance?
How is it staying in Defiance?

Visitors can enjoy all that Defiance has to offer, including the wineries and parks. Top sights in the area include St. Louis Union Station, Busch Stadium and Gateway Arch. In Defiance, there are 20 hotels and other accommodation options to choose from. Find out more about Defiance.

What should I do while I'm visiting Defiance?

Natural beauty is on display at August A. Busch Memorial Conservation Area, Missouri River and Matson Hill Park Trailhead. A couple of additional sights to add to your itinerary are Yellow Farmhouse Winery and Chandler Hill Vineyards. Take a look at what more there is to see and do in Expedia's Defiance guide.

What's the weather like in Defiance?

The hottest months are usually July and August, with an average temperature of 24°C, while the coldest months are January and February, with an average of 3°C. Average annual precipitation for Defiance is 1228 mm.