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Check prices for these dates

Tonight
8 May - 9 May
Tomorrow
9 May - 10 May
This weekend
8 May - 10 May
Next weekend
15 May - 17 May

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Our top choices for Defiance hotels

Indoor pool

Baymont by Wyndham Warrenton

Baymont by Wyndham Warrenton
2.5 star property
Warrenton
7.6 out of 10, Good, (1,003 reviews)
"Excellent place to stay!"
United States
Steven
The price is AU$117
includes taxes & fees
13 May - 14 May
Baymont by Wyndham Warrenton
Exterior

WoodSpring Suites St Peters-OFallon

WoodSpring Suites St Peters-OFallon
2.5 star property
St. Peters
8.6 out of 10, Excellent, (104 reviews)
"Nice hotel with good staff."
United States
Michael
The price is AU$128
includes taxes & fees
27 May - 28 May
WoodSpring Suites St Peters-OFallon
Reception

Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham

Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham
3.0 star property
Fenton
8.0 out of 10, Very good, (1,262 reviews)
"Nice room, comfortable bed, good breakfast."
United States
John
The price is AU$143
includes taxes & fees
17 May - 18 May
Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham
Exterior

Holiday Inn Express St. Louis West - O'Fallon by IHG

Holiday Inn Express St. Louis West - O'Fallon by IHG
2.5 star property
O'Fallon
8.6 out of 10, Excellent, (920 reviews)
"Clean friendly staff"
United States
Kayla
The price is AU$165
includes taxes & fees
17 May - 18 May
Holiday Inn Express St. Louis West - O'Fallon by IHG
Standard Room, 2 Queen Beds

Super 8 by Wyndham Warrenton

Super 8 by Wyndham Warrenton
2.0 star property
Warrenton
7.4 out of 10, Good, (646 reviews)
"The parking was easy, the room was verry clean."
United States
Gary
The price is AU$89
includes taxes & fees
21 May - 22 May
Super 8 by Wyndham Warrenton
Lobby

Quality Inn Foristell

Quality Inn Foristell
2.5 star property
Foristell
8.2 out of 10, Very good, (978 reviews)
"Clean and comfortable. Just what you need for an affordable place to sleep, when you're on the road."
United States
Amy
The price is AU$131
includes taxes & fees
11 May - 12 May
Quality Inn Foristell
Premium bedding, desk, iron/ironing board, free WiFi

Sleep Inn & Suites O'Fallon MO - Technology Drive

Sleep Inn & Suites O'Fallon MO - Technology Drive
2.5 star property
O'Fallon
9.0 out of 10, Wonderful, (1,008 reviews)
"Everything was excellent, location amenities, food.."
United States
FERNANDO
The price is AU$137
includes taxes & fees
25 May - 26 May
Sleep Inn & Suites O'Fallon MO - Technology Drive
43-inch LED TV with digital channels, TV

Comfort Inn & Suites St. Louis - O'Fallon

Comfort Inn & Suites St. Louis - O'Fallon
2.5 star property
O'Fallon
7.6 out of 10, Good, (1,003 reviews)
"Good spot and great location to visit with family "
United States
Ernest
The price is AU$132
includes taxes & fees
7 June - 8 June
Comfort Inn & Suites St. Louis - O'Fallon
Terrace/patio

Courtyard by Marriott St. Louis St. Peters

Courtyard by Marriott St. Louis St. Peters
3.0 star property
St. Peters
9.0 out of 10, Wonderful, (714 reviews)
"Great stay"
United States
Anna
The price is AU$191
includes taxes & fees
31 May - 1 June
Courtyard by Marriott St. Louis St. Peters
Room, 2 Queen Beds, Non Smoking

Wingate by Wyndham St. Louis/Fenton Route 66

Wingate by Wyndham St. Louis/Fenton Route 66
3.0 star property
Fenton
7.8 out of 10, Good, (1,207 reviews)
"Clean and a safe place to stay"
United States
Cindy
The price is AU$136
includes taxes & fees
13 May - 14 May
Wingate by Wyndham St. Louis/Fenton Route 66
Lobby

Drury Inn & Suites St. Louis St. Peters

Drury Inn & Suites St. Louis St. Peters
3.0 star property
St. Peters
9.4 out of 10, Exceptional, (1,007 reviews)
"Great location and clean hotel!"
United States
Admir
The price is AU$176
includes taxes & fees
24 May - 25 May
Drury Inn & Suites St. Louis St. Peters
Lobby

Country Inn & Suites by Radisson, St. Peters, MO

Country Inn & Suites by Radisson, St. Peters, MO
2.5 star property
St. Charles
8.0 out of 10, Very good, (1,008 reviews)
"Amazing! Would definitely stay here again "
United States
Joe
The price is AU$146
includes taxes & fees
25 May - 26 May
Country Inn & Suites by Radisson, St. Peters, MO
Lobby

Best Western Plus St. Louis West-Westport

Best Western Plus St. Louis West-Westport
2.5 star property
Maryland Heights
8.0 out of 10, Very good, (1,068 reviews)
"Nice place comfortable and close to hospital and Dr appts "
United States
Teresa
The price is AU$136
includes taxes & fees
10 May - 11 May
Best Western Plus St. Louis West-Westport
Exterior

Holiday Inn Express & Suites St Peters by IHG

Holiday Inn Express & Suites St Peters by IHG
2.5 star property
St. Peters
9.2 out of 10, Wonderful, (406 reviews)
"Great breakfast nice bed"
United States
Carl
The price is AU$190
includes taxes & fees
7 June - 8 June
Holiday Inn Express & Suites St Peters by IHG
Room, Accessible

Super 8 by Wyndham O'Fallon MO/St. Louis Area

Super 8 by Wyndham O'Fallon MO/St. Louis Area
2.0 star property
O'Fallon
6.8 out of 10, (1,003 reviews)
"Property is most definitely dated. Linens were clean and comfortable for a night."
United States
Ashley
The price is AU$116
includes taxes & fees
25 May - 26 May
Super 8 by Wyndham O'Fallon MO/St. Louis Area
Terrace/patio

Holiday Inn St. Louis Arpt West-Earth City by IHG

Holiday Inn St. Louis Arpt West-Earth City by IHG
3.5 star property
Earth City
7.6 out of 10, Good, (1,004 reviews)
"Happy with our stay"
United States
MICHELLE
The price is AU$162
includes taxes & fees
7 June - 8 June
Holiday Inn St. Louis Arpt West-Earth City by IHG
Lobby

Days Inn by Wyndham St Peters/St Charles

Days Inn by Wyndham St Peters/St Charles
2.0 star property
St. Peters
6.2 out of 10, (1,005 reviews)
"Parking was good"
United States
raul
The price is AU$115
includes taxes & fees
20 May - 21 May
Days Inn by Wyndham St Peters/St Charles
Property entrance

The Wildwood Hotel

The Wildwood Hotel
3.5 star property
Wildwood
9.2 out of 10, Wonderful, (1,643 reviews)
"The hotel is really nice and close to good restaurants."
United States
Jackie
The price is AU$142
includes taxes & fees
25 May - 26 May
The Wildwood Hotel
Studio, 2 Double Beds, Accessible, Non Smoking

Extended Stay America Suites St Louis St Peters

Extended Stay America Suites St Louis St Peters
2.5 star property
St. Peters
7.0 out of 10, Good, (642 reviews)
"Breakfast is average one for quick grab and go type. Hotel is bit old and requires more maintenance and staffs are welcoming and helpful overall family friendly stay for a week in there. Easy commute to Walmart, Costco and Indian restaurants nearby"
United States
Karpaga Vinayagam
The price is AU$129
includes taxes & fees
10 May - 11 May
Extended Stay America Suites St Louis St Peters
Fridge, microwave, stovetop, dishwasher

Sonesta Simply Suites St Louis Earth City

Sonesta Simply Suites St Louis Earth City
2.0 star property
Earth City
8.8 out of 10, Excellent, (876 reviews)
"Clean room, staff is friendly"
United States
Angela
The price is AU$134
includes taxes & fees
10 May - 11 May
Sonesta Simply Suites St Louis Earth City
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Stay near popular Defiance attractions

Photo by Pages of Travel
Open Photo by Pages of Travel

Chandler Hill Vineyards

3.9/5 (7 reviews)
This elegant Missouri winery showcases local and California wines from its hillside setting. Savour varietals on the expansive terrace while enjoying vineyard views and seasonal cuisine from their full-service kitchen.
See properties

Learn more about Defiance

Nestled along the Missouri River, this historic village offers scenic hiking trails and access to nearby wine country. Visit the Daniel Boone Home in neighbouring Defiance Township or enjoy tastings at the family-owned wineries dotting the surrounding countryside.

See all hotels in Defiance
A covered bridge at the Historic Daniel Boone Home Park in Defiance, Missouri

Top Defiance Hotel Reviews

Recent Reviews in Defiance

Larkspur Landing Extended Stay Suites St. Louis Riverport - Airport West

Larkspur Landing Extended Stay Suites St. Louis Riverport - Airport West

6/10 Okay
"Not much selection for Breakfast to choose from."
Anthony 1-night trip
Posted 4 hours ago
Larkspur Landing Extended Stay Suites St. Louis Riverport - Airport West

More cheap accommodation in Defiance

Days Inn and Suites by Wyndham St. Louis/Westport Plaza

Days Inn and Suites by Wyndham St. Louis/Westport Plaza

1970 Craig Rd Maryland Heights MO
The price is AU$109 per night from 20 May to 21 May
AU$109
20 May - 21 May
includes taxes & fees
4.6/10 (1,006 reviews)

Frequently asked questions

What's the best place to stay in Defiance?
Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham, located 17.9 mi (28.8 km) from the heart of Defiance, is a top choice for your stay, based on our traveller data. Two other options for your visit to the area are Hollywood Casino & Hotel St. Louis and Ameristar Casino Resort and Spa. See all available top hotels, or vacation rentals in Defiance.
What are some of the best holiday rentals that Defiance has to offer?
🌟 Adorable Historic 🏠 in the ❤️ of St. Charles 🌟: This holiday home rental outside of Defiance offers a patio, a garden and air conditioning to help you feel perfectly comfortable in your new surroundings. Kitchen amenities include a dishwasher, a fridge and a stovetop. See all vacation rentals in Defiance.
If I need to cancel my hotel reservation in Defiance, will I receive a refund?
Yes! The majority of room reservations are fully refundable if you cancel before the accommodation's cancellation deadline, which often is within 24-48 hours of your check-in date. If you have a reservation that's non-refundable, you might be able to cancel it and receive a refund within a 24-hour period of your booking. Filter your search by fully refundable to find flexible hotel deals in Defiance.
What are some accommodation options with pools in Defiance?
Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham: Features an indoor pool, an outdoor pool and buffet. Ameristar Casino Resort and Spa and The Wildwood Hotel are two additional hotels with an on-site pool. View all hotels with pools in Defiance.
How is it staying in Defiance?
Visitors can enjoy all that Defiance has to offer, including the wineries and parks. Top sights in the area include St. Louis Union Station, Busch Stadium and Gateway Arch. In Defiance, there are 19 hotels and other accommodation options to choose from. Find out more about Defiance.
What should I do while I'm visiting Defiance?
Natural beauty is on display at August A. Busch Memorial Conservation Area, Missouri River and Matson Hill Park Trailhead. A couple of additional sights to add to your itinerary are Chandler Hill Vineyards and Sugar Creek Winery. Take a look at what more there is to see and do in Expedia's Defiance guide.
What's the weather like in Defiance?
The hottest months are usually July and August, with an average temperature of 24°C, while the coldest months are January and February, with an average of 3°C. Average annual precipitation for Defiance is 1228 mm.

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