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Our top choices for Defiance hotels

Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham

Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham
3.0 star property
Fenton
8.0 out of 10, Very good, (1,128 reviews)
"Great room, great people, great breakfast "
United States
Jaiden
The price is AU$144
includes taxes & fees
19 Mar - 20 Mar
Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham

Quality Inn Foristell

Quality Inn Foristell
2.5 star property
Foristell
8.2 out of 10, Very good, (949 reviews)
"Clean rooms, pleasant staff."
United States
Karen
The price is AU$108
includes taxes & fees
22 Mar - 23 Mar
Quality Inn Foristell

WoodSpring Suites St Peters-OFallon

WoodSpring Suites St Peters-OFallon
2.5 star property
St. Peters
9.0 out of 10, Wonderful, (49 reviews)
"Super clean , quiet place "
United States
Phoenix
The price is AU$148
includes taxes & fees
24 Mar - 25 Mar
WoodSpring Suites St Peters-OFallon

Drury Inn & Suites Southwest St. Louis

Drury Inn & Suites Southwest St. Louis
3.0 star property
Valley Park
9.6 out of 10, Exceptional, (1,013 reviews)
"Great stay"
United States
Maureen
The price is AU$189
includes taxes & fees
5 Apr - 6 Apr
Drury Inn & Suites Southwest St. Louis

Best Western Plus Fenton

Best Western Plus Fenton
2.5 star property
Fenton
9.2 out of 10, Wonderful, (222 reviews)
"Stay was great, and the pool was perfect for my daughter and her friend. Wonderful spot for an easy "stay cation" with the girls. "
United States
Melissa
The price is AU$148
includes taxes & fees
24 Mar - 25 Mar
Best Western Plus Fenton

Holiday Inn Express Warrenton by IHG

Holiday Inn Express Warrenton by IHG
2.5 star property
Warrenton
9.0 out of 10, Wonderful, (526 reviews)
"Very helpful and friendly staff"
United States
TONY
The price is AU$228
includes taxes & fees
15 Mar - 16 Mar
Holiday Inn Express Warrenton by IHG

Baymont by Wyndham Warrenton

Baymont by Wyndham Warrenton
2.5 star property
Warrenton
7.4 out of 10, Good, (1,000 reviews)
"Nice place and nice people "
United States
Columbus
The price is AU$147
includes taxes & fees
17 Mar - 18 Mar
Baymont by Wyndham Warrenton

Wingate by Wyndham St. Louis/Fenton Route 66

Wingate by Wyndham St. Louis/Fenton Route 66
3.0 star property
Fenton
8.0 out of 10, Very good, (1,154 reviews)
"Clean rooms, quiet, AC worked great and good breakfast "
United States
Karen
The price is AU$128
includes taxes & fees
19 Mar - 20 Mar
Wingate by Wyndham St. Louis/Fenton Route 66

Comfort Suites St Charles - St Louis

Comfort Suites St Charles - St Louis
2.5 star property
St. Charles
8.4 out of 10, Very good, (1,009 reviews)
"Great hotel for the money"
United States
Jere
The price is AU$141
includes taxes & fees
5 Apr - 6 Apr
Comfort Suites St Charles - St Louis

Super 8 by Wyndham St Charles

Super 8 by Wyndham St Charles
2.0 star property
St. Charles
8.0 out of 10, Very good, (1,008 reviews)
"Great place to stay for the $$$"
United States
Kale
The price is AU$129
includes taxes & fees
18 Mar - 19 Mar
Super 8 by Wyndham St Charles

Sleep Inn & Suites O'Fallon MO - Technology Drive

Sleep Inn & Suites O'Fallon MO - Technology Drive
2.5 star property
O'Fallon
9.0 out of 10, Wonderful, (1,002 reviews)
"Friendly staff, clean room, comfy bed, excellent breakfast buffet."
United States
Kathy
The price is AU$130
includes taxes & fees
15 Mar - 16 Mar
Sleep Inn & Suites O'Fallon MO - Technology Drive

Hampton Inn St. Louis Wentzville

Hampton Inn St. Louis Wentzville
2.5 star property
Wentzville
9.0 out of 10, Wonderful, (667 reviews)
"Prompt service, quick check in. "
United States
Emily
The price is AU$192
includes taxes & fees
6 Apr - 7 Apr
Hampton Inn St. Louis Wentzville

Best Western Plus Washington Hotel

Best Western Plus Washington Hotel
2.5 star property
Washington
9.2 out of 10, Wonderful, (664 reviews)
"Clean room and hotel with a nice breakfast, have stayed here two times while visiting family."
United States
Brooks
The price is AU$206
includes taxes & fees
16 Mar - 17 Mar
Best Western Plus Washington Hotel

Drury Inn & Suites St. Louis St. Peters

Drury Inn & Suites St. Louis St. Peters
3.0 star property
St. Peters
9.4 out of 10, Exceptional, (1,008 reviews)
"Comfortable room. Quiet even though next to interstate. Excellent food "
United States
Geo
The price is AU$178
includes taxes & fees
22 Mar - 23 Mar
Drury Inn & Suites St. Louis St. Peters

Comfort Inn & Suites St. Louis - O'Fallon

Comfort Inn & Suites St. Louis - O'Fallon
2.5 star property
O'Fallon
7.6 out of 10, Good, (1,006 reviews)
"Nice room, good front desk help"
United States
jeffrey
The price is AU$135
includes taxes & fees
22 Mar - 23 Mar
Comfort Inn & Suites St. Louis - O'Fallon

Holiday Inn Express St. Louis West - O'Fallon by IHG

Holiday Inn Express St. Louis West - O'Fallon by IHG
2.5 star property
O'Fallon
8.6 out of 10, Excellent, (881 reviews)
"Service, cleanliness and breakfast were all very agreeable "
United States
James
The price is AU$144
includes taxes & fees
15 Mar - 16 Mar
Holiday Inn Express St. Louis West - O'Fallon by IHG

TownePlace Suites by Marriott Wentzville

TownePlace Suites by Marriott Wentzville
3.0 star property
Wentzville
9.4 out of 10, Exceptional, (50 reviews)
"Clean room and the suite was nice. "
United States
Elizabeth
The price is AU$241
includes taxes & fees
7 Apr - 8 Apr
TownePlace Suites by Marriott Wentzville

The Wildwood Hotel

The Wildwood Hotel
3.5 star property
Wildwood
9.2 out of 10, Wonderful, (1,623 reviews)
"Clean room and great breakfast "
United States
Shawn
The price is AU$144
includes taxes & fees
1 Apr - 2 Apr
The Wildwood Hotel

Drury Plaza Hotel St. Louis St. Charles

Drury Plaza Hotel St. Louis St. Charles
3.0 star property
St. Charles
9.6 out of 10, Exceptional, (1,001 reviews)
"Great hotel "
United States
John Christopher
The price is AU$235
includes taxes & fees
3 Apr - 4 Apr
Drury Plaza Hotel St. Louis St. Charles

Super 8 by Wyndham Warrenton

Super 8 by Wyndham Warrenton
2.0 star property
Warrenton
7.4 out of 10, Good, (633 reviews)
"It all went well . Room has been remodeled it was nice ."
United States
Charles
The price is AU$87
includes taxes & fees
23 Mar - 24 Mar
Super 8 by Wyndham Warrenton
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

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Stay near popular Defiance attractions

Learn more about Defiance

Nestled along the Missouri River, this historic village offers scenic hiking trails and access to nearby wine country. Visit the Daniel Boone Home in neighbouring Defiance Township or enjoy tastings at the family-owned wineries dotting the surrounding countryside.

A covered bridge at the Historic Daniel Boone Home Park in Defiance, Missouri

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Recent Reviews in Defiance

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Frequently asked questions

What's the best place to stay in Defiance?
Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham, located 17.9 mi (28.8 km) from the heart of Defiance, is a top choice for your stay, based on our traveller data. Two other options for your visit to the area are The Wildwood Hotel and Ameristar Casino Resort and Spa. See all available top hotels, or vacation rentals in Defiance.
What are some of the best holiday rentals that Defiance has to offer?
St. Charles 1860's Gem - Sleeps 6!: This holiday home rental outside of Defiance is located on a river, and has a garden, a selection of books and air conditioning to put you at ease in your new surroundings. Kitchen amenities include a dishwasher, a fridge and a stovetop. See all vacation rentals in Defiance.
If I need to cancel my hotel reservation in Defiance, will I receive a refund?
Yes! The majority of room reservations are fully refundable if you cancel before the accommodation's cancellation deadline, which often is within 24-48 hours of your check-in date. If you have a reservation that's non-refundable, you might be able to cancel it and receive a refund within a 24-hour period of your booking. Filter your search by fully refundable to find flexible hotel deals in Defiance.
What are some accommodation options with pools in Defiance?
Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham: Features an indoor pool, an outdoor pool and buffet. The Wildwood Hotel and Ameristar Casino Resort and Spa are two additional hotels with an on-site pool. View all hotels with pools in Defiance.
How is it staying in Defiance?
Visitors can enjoy all that Defiance has to offer, including the wineries and parks. Top sights in the area include St. Louis Union Station and Busch Stadium. In Defiance, there are 19 hotels and other accommodation options to choose from. Find out more about Defiance.
What should I do while I'm visiting Defiance?
Natural beauty is on display at August A. Busch Memorial Conservation Area, Missouri River and Matson Hill Park Trailhead. A couple of additional sights to add to your itinerary are Chandler Hill Vineyards and Sugar Creek Winery. Take a look at what more there is to see and do in Expedia's Defiance guide.
What's the weather like in Defiance?
The hottest months are usually July and August, with an average temperature of 24°C, while the coldest months are January and February, with an average of 3°C. Average annual precipitation for Defiance is 1228 mm.

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