A forested valley with autumn foliage, a rocky cliff, and a sunset.

Search Southern Illinois Guest Houses

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

Next weekend
7 Aug - 9 Aug
In two weeks
14 Aug - 16 Aug
In one month
28 Aug - 30 Aug
In two months
25 Sept - 27 Sept

Our top choices for Southern Illinois guest houses

Smart TV

1. Cozy, Fun, and One-Of-A-Kind!

Cozy, Fun, and One-Of-A-Kind!
Shaw
9.4 out of 10, Exceptional, (139 reviews)
"Great place and location"
United States
Sam K.
The price is AU$207
includes taxes & fees
17 Aug - 18 Aug
Cozy, Fun, and One-Of-A-Kind!
Front of property

2. Grand Center Inn

Grand Center Inn
3.0 star property
Grand Center
9.4 out of 10, Exceptional, (105 reviews)
"Lovely room, easy check in, close to Fox, comfy bed"
United States
Leon and Janis
The price is AU$269
includes taxes & fees
12 Aug - 13 Aug
Grand Center Inn
Exterior

3. Charming Home with Country Views

Charming Home with Country Views
Grafton
9.8 out of 10, Exceptional, (45 reviews)
"Everything that was advertised and more. Charming, comfortable, very clean and we had a great stay. Perfect location for biking along the Great River Road. Highly recommend!"
United States
Cathy D.
The price is AU$546
includes taxes & fees
12 Aug - 13 Aug
Charming Home with Country Views
TV, video games

4. In the center of all Historic Main Street has to offer

In the center of all Historic Main Street has to offer
Grafton
7.0 out of 10, Good, (2 reviews)
"Such a great location! Very clean & cute house!"
United States
Janelle C.
The price is AU$871
includes taxes & fees
13 Aug - 14 Aug
In the center of all Historic Main Street has to offer
Private kitchen

5. The Mediterranean House 1858

The Mediterranean House 1858
2.0 star property
Perryville
The price is AU$1,147
includes taxes & fees
3 Aug - 4 Aug
The Mediterranean House 1858
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties
Save an average of 15% on thousands of hotels when you're signed in
Sign in
Sign up, it's free

Top Southern Illinois Hotel Reviews

Super 8 by Wyndham O'Fallon

Super 8 by Wyndham O'Fallon

10/10 Excellent
"Fine and clean room but they need more options for breakfast in the morning times"
Elizabeth 1-night trip
Posted 9 hours ago
Super 8 by Wyndham O'Fallon

Find out more about Southern Illinois

Southern Illinois Guest Houses information

Number of reviews
131
Accommodation
4 Guest Houses
Lowest Price
AU$269
Highest Price
AU$1,147