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Serenity South -- Gardens, River-Views, and Refreshing Space

Riverside holiday home with kitchen and balcony

Photo gallery for Serenity South -- Gardens, River-Views, and Refreshing Space

Fridge, microwave, oven, stovetop
Interior
Dining
Outdoor dining
Fridge, microwave, oven, stovetop
In the heart of Cape Girardeau Historic District, this beautifully renovated duplex offers a cozy living room and large dining room perfect for relaxation. Explore downtown's local restaurants, antique shops, and boutiques within walking distance or unwind on the balcony overlooking the shared yard.

Reviews

10 out of 10
Exceptional

Entire home

3 bedrooms2 bathroomsSleeps 5149 sq m

Popular amenities

  • Parking available
  • Kitchen
  • Fireplace
  • Outdoor space
The current price is AU$379
includes taxes & fees
7 Dec - 8 Dec

Add dates for prices

About this property

Entire place

You'll have the entire home to yourself and will only share it with other guests in your party.

Serenity South -- Gardens, River-Views, and Refreshing Space

Beautifully renovated duplex with large shared yard in Cape Girardeau Historic District. Cozy living room, large dining room, fully stocked kitchen, 3 second-story bedrooms with balcony at the end of the hall, and 1 1/2 bathes. Perfect for getting away for rejuvenation or exploring downtown. Within walking distance to local downtown restaurants, antique shops, and boutiques. Two blocks from the Mississippi River and many other attractions.

Property amenities

Internet

  • Available in the house: WiFi

Parking and transport

  • Car not required
  • Parking on site

Kitchen

  • Coffee grinder
  • Coffee/tea maker
  • Cookware, dishware, and utensils
  • Dishwasher
  • Hob
  • Ice maker
  • Microwave
  • Oven
  • Paper towels
  • Refrigerator
  • Spices
  • Toaster

Bedrooms

  • 3 bedrooms
  • Bedsheets provided

Bathroom

  • 1.5 bathrooms
  • Bathtub or shower
  • Hair dryer
  • Shampoo
  • Soap
  • Toilet paper
  • Towels provided

Living spaces

  • Fireplace
  • Living room
  • Separate dining area

Entertainment

  • Books
  • DVD player
  • Games
  • TV

Outdoor areas

  • Balcony
  • Garden
  • Outdoor furniture

Laundry

  • Laundromat nearby

Comfort

  • Air conditioning
  • Heating

Pets

  • No pets allowed

Suitability/Accessibility

  • Smoke-free property

Services and conveniences

  • Iron/ironing board

Location highlights

  • Near a health/beauty spa
  • Near a hospital
  • Near an outlet shopping centre
  • On a river

Things to do

  • Water park
  • Basketball nearby
  • Casino nearby
  • Cycling nearby
  • Fishing nearby
  • Golfing nearby
  • Hiking/biking trails nearby
  • Horseback riding nearby
  • Motor boating nearby
  • Swimming nearby
  • Wildlife walks nearby
  • Winery tours nearby

Safety features

  • Carbon monoxide detector (host has indicated there is a carbon monoxide detector on the property)
  • Smoke detector (host has indicated there is a smoke detector on the property)
  • Deadbolt lock

General

  • Garden
  • Unit size: 1,600 square feet

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Policies

Check-in

Check-in time starts at 4:00 PM
Minimum check-in age - 18

Check-out

Check-out before 11:00 AM

Special check-in instructions

You will receive an email from the host with check-in and check-out instructions

Rules

Back yard is shared with the other side of the duplex. Please respect their use of the common space.

Pets

Pets not allowed

Children and extra beds

Children are welcome
Note from host: Excellent fenced back yard.

Events

Events allowed: family gatherings, birthday parties, weddings
Parties or events must okayed before arrival.

Smoking

Smoking is not permitted

Important information

You need to know

Extra-person charges may apply and vary depending on property policy
Government-issued photo identification and a credit card, debit card or cash deposit may be required at check-in for incidental charges
Special requests are subject to availability upon check-in and may incur additional charges; special requests cannot be guaranteed
Parties and events (including family gatherings, birthday parties and weddings) are allowed on site. Maximum attendees: 50
Note from host: Parties or events must okayed before arrival.
Host has indicated that there is a carbon monoxide detector on the property
Host has indicated that there is a smoke detector on the property
Safety features at this property include a deadlock
This property is managed through our partner, Vrbo. You will receive an email from Vrbo with a link to a Vrbo account, where you can change or cancel your reservation

We should mention

A car is not required for transport to and from this property

About the area

Map
Cape Girardeau, MO

What's nearby

  • eDen Spa & Salon - 2 min walk - 0.2 km
  • Riverfront Park - 2 min walk - 0.2 km
  • Riverfront Bridge Park - 5 min walk - 0.4 km
  • Isle Casino Cape Girardeau - 16 min walk - 1.4 km
  • Southeast Missouri State University - 2 min drive - 1.8 km

Getting around

  • Cape Girardeau, MO (CGI-Cape Girardeau Municipal) - 12 min drive

Restaurants

  • ‪Sand's Pancake House - ‬11 min walk
  • ‪Katy O'Ferrell's Publick House - ‬9 min walk
  • ‪Hotshots Sports Bar & Grill - ‬5 min walk
  • ‪Minglewood Brewery - ‬7 min walk
  • ‪The Library - ‬3 min walk

Frequently asked questions

Is Serenity South -- Gardens, River-Views, and Refreshing Space pet-friendly?

No, pets are not allowed at this property.

How much does it cost to stay at Serenity South -- Gardens, River-Views, and Refreshing Space?

As of 14 Nov 2025, prices found for a 1-night stay for 2 adults at Serenity South -- Gardens, River-Views, and Refreshing Space on 7 Dec 2025 start from AU$379.16, including taxes and fees. This price is based on the lowest nightly price found in the last 24 hours for stays in the next 30 days. Prices are subject to change. Choose your dates for more accurate prices.

How much is parking at Serenity South -- Gardens, River-Views, and Refreshing Space?

On-site parking is available at the property.

What time is check-in at Serenity South -- Gardens, River-Views, and Refreshing Space?

Check-in begins at 4:00 PM.

What time is check-out at Serenity South -- Gardens, River-Views, and Refreshing Space?

Checkout is at 11:00 AM.

Where is Serenity South -- Gardens, River-Views, and Refreshing Space located?

This family-friendly Cape Girardeau holiday home is located on a river, steps away from eDen Spa & Salon, Shawnee National Forest and Mississippi River. Riverfront Park and Riverfront Bridge Park are also within 5 minutes.

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Reviews

Serenity South -- Gardens, River-Views, and Refreshing Space Reviews

10

Exceptional

10

Cleanliness

9.8

Location

10

Property conditions & facilities
Rating 10 - Excellent. 142 out of 146 reviews
Rating 8 - Good. 4 out of 146 reviews
Rating 6 - Okay. 0 out of 146 reviews
Rating 4 - Poor. 0 out of 146 reviews
Rating 2 - Terrible. 0 out of 146 reviews

Reviews

10/10 Excellent

Linden S.

Liked: Cleanliness, check-in, communication, location, listing accuracy

A Beautiful Retreat for Three Generations

Three generations found rest,beauty,& joy at Serenity South. Thoughtful touches,beautiful gardens and Cape charm made this more than a stay-it became a treasured memory. We were so appreciative of the details, the fresh flowers, homemade cookies, the coffeemaker upstairs and the books and games. The beds were all comfortable. We enjoyed this historical home and our stay.
Stayed 2 nights in May 2025

10/10 Excellent

Tim B.

Liked: Cleanliness, check-in, communication, location, listing accuracy

Homecoming

As always, a fantastic place to stay.
Stayed 2 nights in Oct 2023

10/10 Excellent

Nichole C.

Liked: Cleanliness, check-in, communication, location, listing accuracy
Serenity south was welcoming comfortable and very clean. Impeccably maintained historic home. Comfortable beds, great water pressure and shower head, easy to maintain consistent temperature. Good vibes throughout. Not haunted. Beautiful outdoor space but it was too hot to use it much while we were there. Recommend stopping by the olive oil store William and Water across the street.
Stayed 3 nights in Jul 2025

10/10 Excellent

Michelle A B.

Liked: Cleanliness, check-in, communication, location, listing accuracy

Adorable house

Our stay at Serenity South was very nice. The house is so adorable. The whole process was easy. Highly recommend!
Stayed 1 night in Dec 2023

10/10 Excellent

Debra B., MOUNT ZION

Liked: Cleanliness, check-in, communication, location, listing accuracy

Wonderful home!

We needed a place to stay and most of the hotel had no vacancy. Booked 2 nights at this lovely quaint older home and couldn’t have been more pleased. Definitely worth booking again.
Stayed 2 nights in Feb 2023

10/10 Excellent

Brittany W.

Liked: Cleanliness, check-in, communication, location, listing accuracy

Father/daughter weekend getaway

What a wonderful weekend we had! The house was everything it said it was and more (blueberry scones)! All in all it was a great place to stay with plenty of room. We'll be back again, next time we're in town!
Stayed 2 nights in Jun 2023

10/10 Excellent

Stephanie F.

Liked: Cleanliness, check-in, communication, location, listing accuracy

Positive Experience

The property was clean and the home had a lot of historical character.
Stayed 1 night in Jun 2022

10/10 Excellent

Cheryl R.

Liked: Cleanliness, check-in, communication, location, listing accuracy

Repeat customer

Second time to stay. Perfect location and size for us. Always clean, always responsive. We’ll be back.
Stayed 2 nights in Apr 2023

10/10 Excellent

Melissa M.

Liked: Cleanliness, check-in, communication, location, listing accuracy

Charming, beautifully maintained home

Lovely house, well maintained and stocked. Nice bed linens and towels. Lots of thoughtful features like a coffee and tea station upstairs with the bedrooms. The host even left fresh cookies for us in the kitchen. Beautiful gardens with cut flowers. Fantastic location just blocks from shopping, restaurants and bars. Highly recommend.
Stayed 2 nights in Apr 2024

10/10 Excellent

Alicia S.

Liked: Cleanliness, check-in, communication, location, listing accuracy

Great house and amazing location!

I stayed at Jo’s place with my sister and father. We absolutely loved it!! The location was truly amazing and close to so many restaurants and shops. The setup was perfect for us with the 3 bedrooms and full bath upstairs and it was great to have the 1/2 bath off the living space. We didn’t cook while we were there but the kitchen was huge and seemed well stocked with dishes. Communication with our host was easy and she was very helpful. The house was gorgeous and had tons of historical details. Would love to stay here again!
Stayed 1 night in Mar 2024

10/10 Excellent

Michael D.

Liked: Cleanliness, check-in, communication, location, listing accuracy

Beautiful Property, Amazing Town

We were looking for a place to stop overnight on our way back from our trip and we wish we could have stayed longer! The property was amazing. The backyard we good for my children to run around and play in. The house was well decorated and stocked. The surrounding town is beautiful. The downtown is within walking distance. We stumbled upon the Saturday morning Farmers market. This is definitely a place that we would come back to. Jo was great at keeping us in the loop.
Stayed 1 night in May 2023

10/10 Excellent

Ronald D.

Liked: Cleanliness, check-in, communication, location, listing accuracy

Perfect stay, perfect day!

We stayed at Serenity South as we visited the area for the total solar eclipse. The property was clean, comfortable, well maintained and furnished. When we booked it, we had no idea how convenient to downtown and the riverbank it actually was. We were within walking distance to the eclipse activities for the day. Jo was very attentive and responsive to any questions or needs we had. Check in and checkout instructions were very clear. Thank you for helping make our eclipse adventure absolutely perfect!
Stayed 3 nights in Apr 2024

10/10 Excellent

Sonia K.

Liked: Cleanliness, check-in, communication, location, listing accuracy

Girls weekend

Second time staying for a girls weekend. Always clean. Wondering if someone was staying/living in the basement? There was a child crying and it sounded like that is where it was coming from. Expected someone next door as it is a duplex. Also time for new mattresses.
Stayed 2 nights in Apr 2023

10/10 Excellent

Jennifer K.

Liked: Cleanliness, check-in, communication, location, listing accuracy

This property is excellent

This is an older home (1920’s?) with so much charm. It’s exceptionally well cared for - the floors are clean and in excellent condition, the walls are clean, paint job is beautiful, etc. The air is clean (no smell of mold) bathroom fans work, etc! In short, one of the best maintained rentals we’ve stayed in. The beds are comfy. Oh - and the landscaping is also beautiful! It is winter - would love to see the gardens in the spring. Jo was easy to contact, check in was easy. The trains do run 1 or 2 times per night and are close and on Friday night there were some people having fun running their loud cars through town but otherwise it is quiet and peaceful. The walk to town is only a few blocks. We would definitely stay here again!
Stayed 4 nights in Dec 2024

10/10 Excellent

Paul W.

Liked: Cleanliness, check-in, communication, location, listing accuracy

Perfect For Family Getaway

Our family of 5 (3 children-8, 9 & 12) enjoyed a brief getaway to Cape and was thrilled to find this wonderful place to stay. Everything was just as it was described and the home was very comfortable and clean. The location was perfect for getting out and enjoying the downtown area as we were able to shop the flea markets, enjoy the restaurants and see the historical sights without having to drive to them. The hosts were wonderful and made the stay a special experience for our kids. As for all the practical things you’d look for in a home to make a comfortable stay, they have it all and more. The beds were excellent, the kitchen was stocked and everything you would need was thought of and provided. If you’re looking for restaurant suggestions, Broussard’s Cajun Cuisine (best catfish ever) & Pagliai’s Pizza were excellent choices. We will certainly be back to enjoy this wonderful home… “thank you” to the hosts who made our stay a memorable, pleasant and comfortable experience!
Stayed 3 nights in May 2023

10/10 Excellent

Donna D.

Liked: Cleanliness, check-in, communication, location, listing accuracy

Lovely as always

Moving our daughter in to the dorm at SEMO for yr 2. Been coming to this location since our trip here during her senior year of HS when she visited SEMO to audition for the musical theatre program. It is a great place to stay when you have more than 2 people.
Stayed 1 night in Aug 2025

10/10 Excellent

Tracy H.

Liked: Cleanliness, check-in, communication, location, listing accuracy
Such a great place and location
Stayed 2 nights in Jul 2025

10/10 Excellent

Jodie F.

Liked: Cleanliness, check-in, communication, location, listing accuracy
Enjoyed everything! Great location!
Stayed 4 nights in Jul 2025

10/10 Excellent

Bryan P.

Liked: Cleanliness, check-in, communication, location, listing accuracy

Comfortable & Clean

Great Location short walking distance to the Downtown Area with lots do do, Restaurants, Water Park, Shopping. This is the 2nd time I have stayed and it is a true delight. Very spacious and comfortable. Easy to communicate with the Owner/Manager. I will be staying there again in the future. I recommend it with 5 Stars!
Stayed 1 night in Jun 2025

10/10 Excellent

Vicki R.

Liked: Cleanliness, check-in, communication, location, listing accuracy
Beautiful house. Great stay. Would definitely stay again!
Stayed 1 night in Jun 2025

10/10 Excellent

STEPHANIE L.

Liked: Cleanliness, check-in, communication, location, listing accuracy

In town for one day

Its was different, but over all it was on point.I will rebook this summer
Stayed 1 night in May 2025

10/10 Excellent

Sam E.

Liked: Cleanliness, check-in, communication, location, listing accuracy

Downtown home with great character

My son and two brothers stayed a night in this lovely home. I travel to Cape frequently to visit my son and will definitely stay here again.
Stayed 1 night in Apr 2025

10/10 Excellent

Michelle K.

Liked: Cleanliness, check-in, communication, location, listing accuracy

Perfect home for college visit

When looking for a VRBO for our daughter's college visit, we knew the perfect place to stay! This is our second stay at Serenity South and it was just as incredible as the first visit. Clean, inviting and cozy. Thanks Jo for another beautiful stay.
Stayed 1 night in Feb 2025

10/10 Excellent

Penny F.

Liked: Cleanliness, check-in, communication, location, listing accuracy

Beautiful getaway!

The property was exactly as listed with so many little touches that made it special. Communication was great and we were close to downtown shops and the casino. We will definitely stay again when we are in the area.
Stayed 2 nights in Mar 2025

10/10 Excellent

Rhonda S.

Liked: Cleanliness, check-in, communication, location, listing accuracy

Smith Women’s Weekend

We had a wonderful time at Serenity South! The house is quiet and very clean, in walking distance of fantastic shops and fun places to eat. We look forward to returning next year!
Stayed 2 nights in Feb 2025