Cape Girardeau Travel Guide

Tourist Guide

Photo by Skyy
Photo by Skyy
Photo by Jessica King
Photo by Jessica King
Photo by Skyy
Photo by Skyy
Photo by Alice Burghart
Photo by Alice Burghart
Drury Plaza Hotel Cape Girardeau Conference Center

Drury Plaza Hotel Cape Girardeau Conference Center

3 out of 5
3351 Percy Drive, Cape Girardeau, MO
The price is AU$156 per night from 26 Oct to 27 Oct
AU$156
26 Oct - 27 Oct
includes taxes & fees
Stay at this 3-star business-friendly hotel in Cape Girardeau. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
9.4/10 Exceptional! (1,017 reviews)
Excellent service and clean hotel !
"Stayed at the same Drury we’ve been staying at for several years when traveling fro lower Alabama to Kansas City. We always plan our travel times to stay here. Clean, friendly people working and nice rooms."

Reviewed on 15 Oct 2025

Drury Plaza Hotel Cape Girardeau Conference Center
The Riverview

The Riverview

4 out of 5
777 Main St, Cape Girardeau, MO
The price is AU$188 per night from 28 Oct to 29 Oct
AU$188
28 Oct - 29 Oct
includes taxes & fees
Stay at this 4-star business-friendly hotel in Cape Girardeau. Enjoy free WiFi, free parking, and 2 restaurants. Popular attractions Isle Casino Cape Girardeau ...
9.2/10 Wonderful! (433 reviews)
"Newer hotel so clean. Walk-in shower with no door but works. Control is on opposite side of shower head so alittle awkward. Starbucks was nice. Front desk very accommodating. Close to old downtown but too far to walk. Railroad tracks on east side but didn’t reallly hear."

Reviewed on 7 Oct 2025

The Riverview
Pear Tree Inn Cape Girardeau Near the Medical Center

Pear Tree Inn Cape Girardeau Near the Medical Center

2.5 out of 5
3248 William St, Cape Girardeau, MO
The price is AU$121 per night from 26 Oct to 27 Oct
AU$121
26 Oct - 27 Oct
includes taxes & fees
Stay at this hotel in Cape Girardeau. Enjoy free WiFi, a 24-hour front desk, and daily housekeeping. Our guests praise the helpful staff and the clean rooms ...
8.8/10 Excellent! (1,009 reviews)
"Room was a bit on the small side, but comfortable."

Reviewed on 13 Oct 2025

Pear Tree Inn Cape Girardeau Near the Medical Center
See all 169 properties in Cape Girardeau
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Serenity South -- Gardens, River-Views, and Refreshing Space

Serenity South -- Gardens, River-Views, and Refreshing Space

Cape Girardeau
Book a stay at this family-friendly vacation home in Cape Girardeau. Enjoy a water park, a garden, and patios. Popular attractions eDen Spa & Salon and The Glenn ...
10/10 Exceptional! (144 reviews)
"Nice property near downtown in the river. This was the perfect location for our 50th high school reunion."

Reviewed on 14 Oct 2025

Serenity South -- Gardens, River-Views, and Refreshing Space
The Twisted Sassafras Treehouse

The Twisted Sassafras Treehouse

Cape Girardeau
Stay at this cabin in Cape Girardeau. Enjoy a garden, patios, and an in-room coffeemaker. Popular attractions Cape Girardeau Conservation Nature Center and Cape ...
10/10 Exceptional! (24 reviews)
"Amazing space. So nice being up in the trees. Had an amazing, relaxing time!!!"

Reviewed on 20 Sept 2025

The Twisted Sassafras Treehouse
Little Blue Cottage on Spanish

Little Blue Cottage on Spanish

Cape Girardeau
Stay at this vacation home in Cape Girardeau. Popular attractions eDen Spa & Salon and The Glenn House are located nearby.
8.4/10 Very Good! (44 reviews)
All I needed
"Perfect location, close enough to walk to food and drink, and exactly one block off the main cruising route so I could watch and not be on the route. The fridge could be colder, and there's no oven, and the A/C is loud. But that was stuff I knew. The place was clean, and easy to find. The little ..."

Reviewed on 22 July 2025

Little Blue Cottage on Spanish
See all properties in Cape Girardeau
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Popular places to visit

Southeast Missouri State University

Take a campus tour or just explore the area of Southeast Missouri State University during your trip to Cape Girardeau. While in this family-friendly area, you can savour the top-notch restaurants.

Southeast Missouri State University

Isle Casino Cape Girardeau

Why not roll the dice with a visit to Isle Casino Cape Girardeau during your time in Cape Girardeau? While in this family-friendly area, you can savour the top-notch restaurants.

Isle Casino Cape Girardeau

Riverfront Bridge Park

Riverfront Bridge Park is just one of the places to see in Cape Girardeau, so why not enjoy the other things to explore during your travels? While in this family-friendly area, you can savour the top-notch restaurants.

Riverfront Bridge Park

Show Me Center

Catch an event at Show Me Center during your trip to Cape Girardeau. While in this family-friendly area, you can savour the top-notch restaurants.

Show Me Center

Saint Francis Medical Center

If Saint Francis Medical Center is what brings you to town, hopefully you'll have a chance to explore more of Cape Girardeau.

Saint Francis Medical Center

Riverfront Park

Riverfront Park is just one of the places to see in Cape Girardeau, so why not enjoy the other things to explore during your travels? While in this family-friendly area, you can savour the top-notch restaurants.

Riverfront Park