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Cape Girardeau Holiday Rentals

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Holiday Rentals in Cape Girardeau

The Twisted Sassafras Treehouse

Cape Girardeau
10.0 out of 10, Exceptional, (27)
"The place was awesome very clean the host was very accommodating. Nice a quiet for a relaxing stay highly recommend "
United States
Gary C.
The price is AU$459
includes taxes & fees
15 Dec - 16 Dec
The Twisted Sassafras Treehouse

4-Bedroom Home - 2 King Beds, Summer Pool, Pool Table, Air Hockey + More

Cape Girardeau
9.6 out of 10, Exceptional, (7)
"Nice place, great times"
United States
Jace W.
The price is AU$668
includes taxes & fees
10 Dec - 11 Dec
4-Bedroom Home - 2 King Beds, Summer Pool, Pool Table, Air Hockey + More

Gorgeous 1856 Log Cabin, Completely Renovated

Jackson
10.0 out of 10, Exceptional, (3)
"incredible place. I was there for work, but it was a really nice relaxing area to retreat too, and also get some work done in a serene environment. It would be an incredible place for an entire family. And, a good place for friends to get together."
United States
Chandler G.
The price is AU$472
includes taxes & fees
11 Dec - 12 Dec
Gorgeous 1856 Log Cabin, Completely Renovated

Artistic and Creative Vibe with Indoor Swing 2 Blocks to Downtown & near SEMO

Cape Girardeau
9.6 out of 10, Exceptional, (44)
"This place is AWESOME! It's clean, artsy, fun, and if we ever have a chance, we will certainly return!"
United States
Jordan S.
The price is AU$211
includes taxes & fees
17 Dec - 18 Dec
Artistic and Creative Vibe with Indoor Swing 2 Blocks to Downtown & near SEMO

Little Blue Cottage on Spanish

Cape Girardeau
8.6 out of 10, Excellent, (48)
"Some issues with check-in. Very nice area. Lot of history."
United States
Jeffrey M.
The price is AU$155
includes taxes & fees
15 Dec - 16 Dec
Little Blue Cottage on Spanish

Serenity South -- Gardens, River-Views, and Refreshing Space

Cape Girardeau
10.0 out of 10, Exceptional, (148)
"Such a great place and location"
United States
Tracy H.
The price is AU$373
includes taxes & fees
10 Dec - 11 Dec
Serenity South -- Gardens, River-Views, and Refreshing Space

The Cottage, Rusted Route Farms

Jackson
10.0 out of 10, Exceptional, (2)
"This Cottage was very nice and clean and well maintained. The meat tray that we ordered and the breakfast tray was beyond Fabulous!!! My husband is still talking about it. . .Rick & Renee Christman"
United States
Renee C.
The price is AU$297
includes taxes & fees
10 Dec - 11 Dec
The Cottage, Rusted Route Farms

3+ acre Home: Pool Table, Putt-Putt, 4 miles to Downtown and SEMO, Summer Pool

Cape Girardeau
8.6 out of 10, Excellent, (35)
"Very nice house. The pool and hot tub were perfect for a short getaway. Tons of activities and games to keep the fanily entertained. Will definitely come back! "
United States
Emily D.
The price is AU$326
includes taxes & fees
10 Dec - 11 Dec
3+ acre Home: Pool Table, Putt-Putt, 4 miles to Downtown and SEMO, Summer Pool

Luxury 4BR Log Cabin Near SIU & Wine Trail

Makanda
10.0 out of 10, Exceptional, (41)
"The cabin was beautiful and just as described. Location was relaxing and really enjoyed the firepit. Will definitely consider staying again when in the area."
United States
Marjorie H.
The price is AU$895
includes taxes & fees
10 Dec - 11 Dec
Luxury 4BR Log Cabin Near SIU & Wine Trail

Stones Throw from Giant City Park, Wineries, Hiking, Biking, Hunting and more.

Makanda
9.8 out of 10, Exceptional, (66)
"Nice place!"
United States
Laura
The price is AU$429
includes taxes & fees
13 Dec - 14 Dec
Stones Throw from Giant City Park, Wineries, Hiking, Biking, Hunting and more.

Charming 2BR/1B cabin - Winetrail, SIU, Shawnee Forest, Giant City, Cedar Lake

2.0 star property
Makanda
9.4 out of 10, Exceptional, (3)
"Quaint cottage very convenient to the Shawnee Wine Trail. The lack of an oven and stove did not hamper our foodie lifestyle as the grill and a camp stove (which we brought) met all our needs. "
United States
Patrick S.
The price is AU$429
includes taxes & fees
13 Dec - 14 Dec
Charming 2BR/1B cabin - Winetrail, SIU, Shawnee Forest, Giant City, Cedar Lake

Villa B offers peace and quiet with beautiful views of the countryside.

Jackson
10.0 out of 10, Exceptional, (11)
"Our stay was amazing. Everything was so clean organized, and anything you would possibly need was in the room. We will definitely be staying there again when in the area!!"
United States
Karen P.
The price is AU$280
includes taxes & fees
3 Jan - 4 Jan 2026
Villa B offers peace and quiet with beautiful views of the countryside.

Winetrail Cabin - SIU, Giant City SP, Shawnee Forest, & Cedar Lake minutes away!

Makanda
9.6 out of 10, Exceptional, (39)
"The cabin was perfect for our 5 nights in the area. There was plenty of room and everything we needed. The pictures online were nice but in real life, it was a real gem. Can't wait to visit again."
United States
Victoria H.
The price is AU$353
includes taxes & fees
13 Dec - 14 Dec
Winetrail Cabin - SIU, Giant City SP, Shawnee Forest, & Cedar Lake minutes away!

Rest, Relax and Renew. Our log cabin experience awaits your arrival.

Anna
10.0 out of 10, Exceptional, (403)
"Very clean, courteus staff. Beautiful area and quiet. Very relaxing."
United States
Tommy
The price is AU$308
includes taxes & fees
21 Dec - 22 Dec
Rest, Relax and Renew. Our log cabin experience awaits your arrival.

Minutes from Giant City - SIU - Shawnee Winetrail - Shawnee Forest - Cedar Lake

2.0 star property
Makanda
9.4 out of 10, Exceptional, (3)
"Check in was easy and the place was perfect for my stay. I came down for a fishing trip and was able to park my boat at my rental. The owner was very helpful when I had questions about my stay as well. I will definitely stay here again."
United States
Shannon M.
The price is AU$324
includes taxes & fees
13 Dec - 14 Dec
Minutes from Giant City - SIU - Shawnee Winetrail - Shawnee Forest - Cedar Lake

Beautiful location in the secluded woods

Pomona
10.0 out of 10, Exceptional, (60)
"It was very nice and clean. We really enjoyed staying there. We would love to rent this place again. "
United States
susan B.
The price is AU$257
includes taxes & fees
12 Dec - 13 Dec
Beautiful location in the secluded woods

Cozy cabins on beautiful Horseshoe Lake

Olive Branch
9.8 out of 10, Exceptional, (35)
"Beautiful place, host was kind and and quick to respond to messages "
United States
Melissa W.
The price is AU$234
includes taxes & fees
22 Dec - 23 Dec
Cozy cabins on beautiful Horseshoe Lake

Charming 2-bedroom apartment in fabulous Marble Hill with AC

Marble Hill
7.0 out of 10, Good, (4)
"Host was not properly notified of the booking, but made the accommodations made several trips to make sure we were checked in and comfortable. Also gave very good advice for local points of interest."
United States
Chrystine H.
The price is AU$204
includes taxes & fees
18 Dec - 19 Dec
Charming 2-bedroom apartment in fabulous Marble Hill with AC

Stones Throw from Giant City Park, Wineries, Hiking, Biking, Hunting and more.

Makanda
9.6 out of 10, Exceptional, (41)
"Wonderful. Great location, close to wineries, Shawnee National Forest, and Giant City State Park and Lodge. Steve was great to work with. Will definitely stay again!!!"
United States
Allan T.
The price is AU$353
includes taxes & fees
13 Dec - 14 Dec
Stones Throw from Giant City Park, Wineries, Hiking, Biking, Hunting and more.

Building at Cape Girardeau Regional Airport

Scott City
The price is AU$931
includes taxes & fees
10 Dec - 11 Dec
Building at Cape Girardeau Regional Airport
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top Cape Girardeau Hotel Reviews

Find out more about Cape Girardeau

Everything you need to know about Cape Girardeau holiday rentals

Whether you’re excited for the perfect family holiday, a romantic getaway for two, or the ultimate city break, we’ve got the Cape Girardeau holiday rental for you. At Expedia, you can take your pick from private holiday homes, apartments, cottages, cabins, villas... The list goes on, and on… and on!

There’s just as wide a choice of amenities, too. Maybe you’re dreaming of your own pool, long evenings in a hot tub, or watching the kids laugh through the day at a waterpark. Maybe you just want a quiet retreat in a pet-friendly apartment. Well, we can help you find it. Hunt out the perfect Cape Girardeau holiday rental for you by simply entering your desired dates. Then check your favourite filters to narrow down your search. 

Cape Girardeau holiday rentals: An excellent choice for every season

Whenever you want to travel, a warm welcome awaits you in Cape Girardeau. If you’re looking for a little peace, consider booking during the quieter months, such as  . For more hustle and bustle, you may prefer to visit in . 

Prices vary throughout the year and depend on the property type. Your chosen location and amenities will impact the cost of your trip, too. A Cape Girardeau holiday rental often works out to be a fantastic, cost-effective option for groups and families visiting for a few nights or longer. And if a hotel room is just too small, get a holiday rental with multiple bedrooms and shared living spaces to kick back in.  The selection of Cape Girardeau holiday rentals we have selected for you start as low as AU$155 per night. Entering your travel dates in the search wizard might find you even better deals!

How to find incredible deals on Cape Girardeau rentals

At Expedia, we put the best Cape Girardeau holiday rentals in one place. All you need to do is take your pick. And as we offer book now, pay later options, as well as free cancellation on some properties, you can plan your trip with total peace of mind. You’ll always find a great deal with Expedia. 

To find some top Cape Girardeau rental deals, enter your travel dates, and sort your search results by price. You can also filter by budget, so you only see accommodation in your ballpark. Next, add any filters you want—and just like that, you’ve built your dream Cape Girardeau holiday.

If you’re looking for a little inspiration, browse our latest incredible offers, or use the map to view all accommodation in and around Cape Girardeau. And to unlock even more fantastic deals, bundle your accommodation, flights, and car rental together to save and book with Expedia in complete confidence. 

Frequently asked questions

Can I find holiday rentals in Cape Girardeau?

Yes, there are holiday rentals in Cape Girardeau close to Cape Splash Family Aquatic Center, or you can select a more secluded option if you're looking for a relaxing stay. Visitors like the top-notch restaurants and shops in Cape Girardeau. Make sure you allow time to enjoy the riverfront during your holiday.

What are some of the best holiday rentals that Cape Girardeau has to offer?

Little Blue Cottage on Spanish: This highly rated holiday home rental in Cape Girardeau comes with WiFi so that you can feel at home during your trip. Some other homes for rent in Cape Girardeau include “Brickyard”-Recently Remodeled Dutch Colonial Revival in Downtown Cape Girardeau and Serenity South -- Gardens, River-Views, and Refreshing Space.

How many holiday rentals will I find in Cape Girardeau?

Choose from 22 Expedia holiday rentals in Cape Girardeau for a memorable holiday.

What can I see and do in Cape Girardeau?

Family-friendly attractions include Cape Splash Family Aquatic Center and Cape Girardeau Conservation Nature Center, whereas Shawnee National Forest and Mississippi River are a couple of great spots to enjoy the outdoors. While here, Isle Casino Cape Girardeau and Show Me Center are other places worth a visit.

What are holiday rentals like in Cape Girardeau?

Holiday rentals are privately owned properties you can book for a few days, or a quick weekend, in Cape Girardeau. Holiday rentals offer amenities such as laundry facilities and kitchens so you'll feel just like you're staying in your own home. If you're concerned about cleanliness, a holiday rental can provide a sense of security away from public hotel lifts and busy front desks while still allowing you the experience of travel. You'll also find more space in a holiday rental than in a hotel, which is another reason why a holiday rental is an attractive choice for a small group gathering.