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Cape Girardeau Holiday Rentals

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Holiday Rentals in Cape Girardeau

Serenity South -- Gardens, River-Views, and Refreshing Space
10.0 out of 10, Exceptional, (144)
"Beautiful house. Great stay. Would definitely stay again!"
United States
Vicki R.
The price is AU$380
includes taxes & fees
23 Oct - 24 Oct
Serenity South -- Gardens, River-Views, and Refreshing Space
The Twisted Sassafras Treehouse
10.0 out of 10, Exceptional, (24)
"We had a wonderful time at the Twisted Sassafras Treehouse. The cabin was secluded but conveniently located near many great restaurants and activities. The property was comfortable and clean. We'd be happy to stay again."
United States
Jessica L.
The price is AU$473
includes taxes & fees
4 Nov - 5 Nov
The Twisted Sassafras Treehouse
Little Blue Cottage on Spanish
8.6 out of 10, Excellent, (45)
"I would definitely stay here again!"
United States
Bonita
The price is AU$158
includes taxes & fees
23 Oct - 24 Oct
Little Blue Cottage on Spanish
Historical 'Kage House' Short Term Rental located in "Old Town Cape"
10.0 out of 10, Exceptional, (221)
"Property location was perfect.Deck view was great.Very clean and comfortable place."
United States
Robert M.
Historical 'Kage House' Short Term Rental located in "Old Town Cape"
Urban 2-bedroom Escape in Downtown Cape Girardeau
10.0 out of 10, Exceptional, (7)
"We had the best girls’ getaway here! The place was super clean and well decorated. We had everything we needed, and the host was friendly and quick to respond. The location was perfect—lots of shops, restaurants, and even a spa all within walking distance. We couldn’t have asked for a better spot!"
United States
Eric B.
Urban 2-bedroom Escape in Downtown Cape Girardeau
Charming Secluded Getaway Cabin within minutes of amenities
10.0 out of 10, Exceptional, (17)
"Nice little Cabin in a beautiful area. Blair and her family were wonderful!"
United States
Keegan C.
Charming Secluded Getaway Cabin within minutes of amenities
Downtown 4BR with 2 King Beds! Walking distance to SEMO and the River Front.
8.8 out of 10, Excellent, (19)
"Enjoyed by all! Relaxing and plenty to do. Very clean and comfortable!"
United States
Terresa V.
Downtown 4BR with 2 King Beds! Walking distance to SEMO and the River Front.
Artistic and Creative Vibe with Indoor Swing 2 Blocks to Downtown & near SEMO
9.6 out of 10, Exceptional, (41)
"Very clean and had everything we needed! Walking distance to campus and downtown. Definitely would recommend "
United States
michelle h.
The price is AU$215
includes taxes & fees
2 Nov - 3 Nov
Artistic and Creative Vibe with Indoor Swing 2 Blocks to Downtown & near SEMO
“Brickyard”-Recently Remodeled Dutch Colonial Revival in Downtown Cape Girardeau
10.0 out of 10, Exceptional, (25)
"Group of ladies came and loved this little gem. Chip was a wonderful and gracious host. Fresh flowers and snacks were waiting for us! The history that comes with the property is amazing. Can’t say enough good things and would definitely stay again."
United States
Anonymous traveller
“Brickyard”-Recently Remodeled Dutch Colonial Revival in Downtown Cape Girardeau
3+ acre Home: Pool Table, Putt-Putt, 4 miles to Downtown and SEMO, Summer Pool
8.8 out of 10, Excellent, (34)
"Abbie was an amazing hostess. She was great with communicating with our group and made our stay awesome. She was very accommodating and made sure we had everything we needed to make our trip perfect. The house and pool were great. We were very pleased. "
United States
Julie H.
The price is AU$336
includes taxes & fees
26 Oct - 27 Oct
3+ acre Home: Pool Table, Putt-Putt, 4 miles to Downtown and SEMO, Summer Pool
Historic Victorian - Walkable to Downtown Cape Girardeau - King Bed - Fast Wifi
10.0 out of 10, Exceptional, (8)
"We thoroughly enjoyed the property. Very unique and fun. "
United States
Chris H.
Historic Victorian - Walkable to Downtown Cape Girardeau - King Bed - Fast Wifi
Quaint, Beautiful Home next to SEMO and Hospital
9.8 out of 10, Exceptional, (40)
"Great stay, great location! "
United States
Deana K.
Quaint, Beautiful Home next to SEMO and Hospital
4-Bedroom Home - 2 King Beds, Summer Pool, Pool Table, Air Hockey + More
9.6 out of 10, Exceptional, (7)
"Nice place, great times"
United States
Jace W.
The price is AU$682
includes taxes & fees
26 Oct - 27 Oct
4-Bedroom Home - 2 King Beds, Summer Pool, Pool Table, Air Hockey + More
Loft Apartment Across From Semo University Houch Field House. Walk To Events
10.0 out of 10, Exceptional, (92)
"Place is spacious and was great for a weekend in Cape. Walkable to nearby restaurants."
United States
Myles O.
The price is AU$283
includes taxes & fees
31 Oct - 1 Nov
Loft Apartment Across From Semo University Houch Field House. Walk To Events
Next Door to Mercy Hospital - Pet Friendly - Fast Wifi
8.0 out of 10, Very good, (5)
"Great place for our family to have a quick get together in short notice."
United States
Red Bear Den
Next Door to Mercy Hospital - Pet Friendly - Fast Wifi
2Bdrm Stay in Downtown Cape, Walkable, Laundry
2Bdrm Stay in Downtown Cape, Walkable, Laundry
Gorgeous 1856 Log Cabin, Completely Renovated
10.0 out of 10, Exceptional, (3)
"incredible place. I was there for work, but it was a really nice relaxing area to retreat too, and also get some work done in a serene environment. It would be an incredible place for an entire family. And, a good place for friends to get together."
United States
Chandler G.
The price is AU$490
includes taxes & fees
11 Nov - 12 Nov
Gorgeous 1856 Log Cabin, Completely Renovated
Steps to Southeast Hospital - Fast Wifi - King Bed
10.0 out of 10, Exceptional, (6)
"This was the perfect place for us to have a small group weekend getaway! All the beds were comfy! High quality sheets! Very clean! "
United States
Kim R.
Steps to Southeast Hospital - Fast Wifi - King Bed
The cabin in Eden
9.6 out of 10, Exceptional, (18)
"I stayed here with my teenage daughter and newborn son during the 2024 eclipse. It was very comfortable for us amd very clean. The property is in an excellent location. It is close to many antique stores and great eats! The river is close and we had the pleasure of visiting the Old St. Vincent's (across the street) for Divine Mercy Sunday with the prayers, adoration, and confession. It was lovely! Matt (the host) was clear on directions and we didn't have any trouble contacting him. Even though...
United States
Tina B.
The cabin in Eden
Rest, Relax and Renew. Our log cabin experience awaits your arrival.
10.0 out of 10, Exceptional, (399)
"Serene, well appointed cabin, front porch rocker back deck"
United States
Christine
The price is AU$314
includes taxes & fees
26 Oct - 27 Oct
Rest, Relax and Renew. Our log cabin experience awaits your arrival.
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top Cape Girardeau Hotel Reviews

Find out more about Cape Girardeau

Everything you need to know about Cape Girardeau holiday rentals

Whether you’re excited for the perfect family holiday, a romantic getaway for two, or the ultimate city break, we’ve got the Cape Girardeau holiday rental for you. At Expedia, you can take your pick from private holiday homes, apartments, cottages, cabins, villas... The list goes on, and on… and on!

There’s just as wide a choice of amenities, too. Maybe you’re dreaming of your own pool, long evenings in a hot tub, or watching the kids laugh through the day at a waterpark. Maybe you just want a quiet retreat in a pet-friendly apartment. Well, we can help you find it. Hunt out the perfect Cape Girardeau holiday rental for you by simply entering your desired dates. Then check your favourite filters to narrow down your search. 

Cape Girardeau holiday rentals: An excellent choice for every season

Whenever you want to travel, a warm welcome awaits you in Cape Girardeau. If you’re looking for a little peace, consider booking during the quieter months, such as  . For more hustle and bustle, you may prefer to visit in . 

Prices vary throughout the year and depend on the property type. Your chosen location and amenities will impact the cost of your trip, too. A Cape Girardeau holiday rental often works out to be a fantastic, cost-effective option for groups and families visiting for a few nights or longer. And if a hotel room is just too small, get a holiday rental with multiple bedrooms and shared living spaces to kick back in.  The selection of Cape Girardeau holiday rentals we have selected for you start as low as AU$158 per night. Entering your travel dates in the search wizard might find you even better deals!

How to find incredible deals on Cape Girardeau rentals

At Expedia, we put the best Cape Girardeau holiday rentals in one place. All you need to do is take your pick. And as we offer book now, pay later options, as well as free cancellation on some properties, you can plan your trip with total peace of mind. You’ll always find a great deal with Expedia. 

To find some top Cape Girardeau rental deals, enter your travel dates, and sort your search results by price. You can also filter by budget, so you only see accommodation in your ballpark. Next, add any filters you want—and just like that, you’ve built your dream Cape Girardeau holiday.

If you’re looking for a little inspiration, browse our latest incredible offers, or use the map to view all accommodation in and around Cape Girardeau. And to unlock even more fantastic deals, bundle your accommodation, flights, and car rental together to save and book with Expedia in complete confidence. 

Frequently asked questions

Can I find holiday rentals in Cape Girardeau?

Yes, there are holiday rentals in Cape Girardeau close to Cape Splash Family Aquatic Center, or you can select a more secluded option if you're looking for a relaxing stay. Visitors like the top-notch restaurants and shops in Cape Girardeau. Make sure you allow time to enjoy the riverfront during your holiday.

What are some of the best holiday rentals that Cape Girardeau has to offer?

Serenity South -- Gardens, River-Views, and Refreshing Space: This highly rated holiday home rental in Cape Girardeau is located on a river, and has a fireplace, a balcony and air conditioning to put you at ease in your new surroundings. It has 3 bedrooms, as well as a kitchen with a dishwasher, a fridge and a stovetop, so that you can cook with friends or family. Kick off your shoes and enjoy yourself with a garden and a selection of games. Some other homes for rent in Cape Girardeau include Little Blue Cottage on Spanish and “Brickyard”-Recently Remodeled Dutch Colonial Revival in Downtown Cape Girardeau.

How many holiday rentals will I find in Cape Girardeau?

Choose from 23 Expedia holiday rentals in Cape Girardeau for a memorable holiday.

What can I see and do in Cape Girardeau?

Family-friendly attractions include Cape Splash Family Aquatic Center and Cape Girardeau Conservation Nature Center, whereas Shawnee National Forest and Mississippi River are a couple of great spots to enjoy the outdoors. While here, Isle Casino Cape Girardeau and Show Me Center are other places worth a visit.

What are holiday rentals like in Cape Girardeau?

Holiday rentals are privately owned properties you can book for a few days, or a quick weekend, in Cape Girardeau. Holiday rentals offer amenities such as laundry facilities and kitchens so you'll feel just like you're staying in your own home. If you're concerned about cleanliness, a holiday rental can provide a sense of security away from public hotel lifts and busy front desks while still allowing you the experience of travel. You'll also find more space in a holiday rental than in a hotel, which is another reason why a holiday rental is an attractive choice for a small group gathering.