Weather will likely play an important role when you plan your trip to Santa Fe de Antioquia, but bear in mind that cheaper options are usually available when the weather isn't as good. The hottest months are usually August and July, with an average temperature of 19°C, while the coldest months are December and January, with an average of 18°C. The rainiest months in Santa Fe de Antioquia are May, April, October and November, with each month seeing an average of 406 mm of rainfall.