Default HTG hotel image

Luxury Hotels & Resorts in Santa Cruz from AU$71

  • Change your mind

    Book hotels with free cancellation
  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in
  • Be picky

    Search almost a million properties worldwide

Check availability on Santa Cruz Luxury Hotels

Tonight
1 Oct - 2 Oct
Tomorrow
2 Oct - 3 Oct
This weekend
2 Oct - 4 Oct
Next weekend
9 Oct - 11 Oct

Our top choices for Santa Cruz luxury hotels

1. Antigua Hotel Boutique

Antigua Hotel Boutique
Ciudad López Mateos
AU$128
includes taxes & fees
11 Oct - 12 Oct
Antigua Hotel Boutique

2. Fiesta Americana México Satélite

Fiesta Americana México Satélite
Tlalnepantla de Baz
  • Upscale luxury meets convenience at this Mexico Satélite hotel with Egyptian cotton sheets and 24-hour room service.
AU$191
includes taxes & fees
2 Oct - 3 Oct
Fiesta Americana México Satélite

3. Novotel Mexico City Toreo

Novotel Mexico City Toreo
Naucalpan
AU$150
includes taxes & fees
18 Oct - 19 Oct
Novotel Mexico City Toreo

4. Fiesta Americana México Toreo

Fiesta Americana México Toreo
Naucalpan
AU$276
includes taxes & fees
9 Oct - 10 Oct
Fiesta Americana México Toreo

5. Hyatt Regency Mexico City

Hyatt Regency Mexico City
Polanco
  • Experience luxury in Mexico City with an indoor pool, full-service spa, and 3 upscale restaurants just minutes from Chapultepec Park.
AU$459
includes taxes & fees
11 Oct - 12 Oct
Hyatt Regency Mexico City

6. Lamartine

Lamartine
Polanco
  • Polanco boutique luxury offers massages, premium bedding, and rainfall showers near Reforma.
AU$459
includes taxes & fees
18 Oct - 19 Oct
Lamartine

7. Ruben Dario by Capitalia

Ruben Dario by Capitalia
Polanco
AU$202
includes taxes & fees
4 Oct - 5 Oct
Ruben Dario by Capitalia

8. Isabella Boutique Stays by Viadora

Isabella Boutique Stays by Viadora
Polanco
AU$422
includes taxes & fees
5 Oct - 6 Oct
Isabella Boutique Stays by Viadora

9. Orchid House Mexico City

Orchid House Mexico City
Polanco
AU$443
includes taxes & fees
25 Oct - 26 Oct
Orchid House Mexico City

10. W Mexico City

W Mexico City
Polanco
  • Indulge in pillowtop beds and full-service spa treatments at this luxury Polanco hotel, steps from Chapultepec Park and cultural hotspots.
AU$607
includes taxes & fees
10 Oct - 11 Oct
W Mexico City
View all properties

Find out more about Santa Cruz

Santa Cruzand its attractions for luxury travelers

Santa Cruz in Tepotzotlán, State of Mexico, offers a luxurious retreat for discerning travellers. Begin your adventure at the stunning Ex Convento de San Francisco Javier, a UNESCO World Heritage site, where you can marvel at Baroque architecture and intricate frescoes that transport you to a bygone era. For those seeking a dash of nature, the nearby Parque Nacional de Tepotzotlán provides picturesque hiking trails, perfect for family outings or serene walks amidst lush greenery. Don't miss the enchanting Museo del Virreinato, showcasing historic art and history, which offers an immersive glimpse into the region's past. After a day of exploration, unwind at a luxurious hotel situated in the heart of the historic centre, where attentive service meets modern amenities, ensuring a pampered stay. Indulge in exquisite dining experiences at your hotel, featuring local gourmet cuisine, and relish in the convenience of being steps away from vibrant markets and artisan shops, making your stay both comfortable and culturally enriching.

Top Santa Cruz Hotel Reviews

Hyatt Regency Mexico City

Hyatt Regency Mexico City

10/10 Excellent
"Good"
Kevin 3-night trip
Posted 4 hours ago
Hyatt Regency Mexico City
InterContinental Presidente Mexico City by IHG

InterContinental Presidente Mexico City by IHG

8/10 Good
"The front desk staff was not as helpful for a hotel with such name recognition.when arrived bellhop did not help with luggage. many hotel staff were available but choose not to assist.the area of hotel is great the draw back of the location is the Mexico City traffic."
Mireya 4-night trip
Posted 1 day ago
InterContinental Presidente Mexico City by IHG
JW Marriott Hotel Mexico City Polanco

JW Marriott Hotel Mexico City Polanco

10/10 Excellent
"Excellent"
JOSE 3-night trip
Posted 13 days ago
JW Marriott Hotel Mexico City Polanco

Frequently asked questions

Are you looking for a luxury hotel for your Santa Cruz holiday?
Expedia can help you arrange a flight to Santa Lucía, Mexico (NLU-Felipe Ángeles Intl.) airport or Benito Juarez International Airport (MEX) airport, and then you can select from various places to stay that will deliver the luxury you'd like to find. Amenities are important when you plan a holiday, so we make it easy to find what you want to make your stay relaxing and comfortable. If you want an upscale hotel that has a spa, an indoor pool or luxury bedding, Expedia can help you find the best luxury hotel experience that Santa Cruz offers.
When can I expect good weather in Santa Cruz?
Planning for the weather is an important factor for making your trip to Santa Cruz a success, especially when you're splurging. The hottest months are usually April and May, with an average temperature of 18°C, while the coldest months are January and December, with an average of 14°C. The rainiest months in Santa Cruz are August, July, September and June, with each month seeing an average of 186 mm of rainfall.
What's there to see and do in Santa Cruz?
Enjoy all that Santa Cruz has to offer when you visit Hacienda La Concepcion, National Museum of the Viceroyalty and San Marcos Power Center. If you have a little extra time during your trip, you might want to make a stop at Xochitla Ecological Park and Arcos del Sitio.

Explore a world of travel with Expedia