A beach with people walking, a sandy shore, and a city skyline with tall buildings in the background.

Luxury Hotels & Resorts in Panama City from AU$182

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Check availability on Panama City Luxury Hotels

Tonight
29 Sept - 30 Sept
Tomorrow
30 Sept - 1 Oct
This weekend
2 Oct - 4 Oct
Next weekend
9 Oct - 11 Oct

Our top choices for Panama City luxury hotels

1. 308 Regency Towers Panama City Beach FL

308 Regency Towers Panama City Beach FL
Lower Grand Lagoon
AU$888
includes taxes & fees
17 Oct - 18 Oct
308 Regency Towers Panama City Beach FL

2. Octa Collection on Front Beach

Octa Collection on Front Beach
Long Beach
AU$630
includes taxes & fees
30 Sept - 1 Oct
Octa Collection on Front Beach

3. Calypso Beach Resort Tower 1

Calypso Beach Resort Tower 1
Panama City Beach
AU$800
includes taxes & fees
30 Sept - 1 Oct
Calypso Beach Resort Tower 1

4. Boutique-Style Gulf-Front Retreat - 1BR + Bunks- Beach Chairs & Fees Included

Boutique-Style Gulf-Front Retreat - 1BR + Bunks- Beach Chairs & Fees Included
Panama City Beach
Boutique-Style Gulf-Front Retreat - 1BR + Bunks- Beach Chairs & Fees Included

5. Family Favorite Oceanfront Condo Newly Redecorated

Family Favorite Oceanfront Condo Newly Redecorated
Panama City Beach
AU$751
includes taxes & fees
26 Oct - 27 Oct
Family Favorite Oceanfront Condo Newly Redecorated

6. Private Balconies Sleeps Sept 26 - Oct 3

Private Balconies Sleeps Sept 26 - Oct 3
Lower Grand Lagoon
AU$1,027
includes taxes & fees
30 Sept - 1 Oct
Private Balconies Sleeps Sept 26 - Oct 3

7. Tidewater - Breathtaking first-line ocean views! Walking distance to Pier Park

Tidewater - Breathtaking first-line ocean views! Walking distance to Pier Park
Panama City Beach
AU$609
includes taxes & fees
1 Oct - 2 Oct
Tidewater - Breathtaking first-line ocean views! Walking distance to Pier Park

8. Coastal Condo 607 | Beachfront!

Coastal Condo 607 | Beachfront!
Panama City
AU$708
includes taxes & fees
27 Oct - 28 Oct
Coastal Condo 607 | Beachfront!

9. BeachFront - Ocean View- Majestic Beach Resort 709

BeachFront - Ocean View- Majestic Beach Resort 709
Long Beach
AU$830
includes taxes & fees
20 Oct - 21 Oct
BeachFront - Ocean View- Majestic Beach Resort 709

10. Crown of 30A – Pool, Pets & Golf Cart

Crown of 30A – Pool, Pets & Golf Cart
Dune Allen Beach
AU$5,463
includes taxes & fees
9 Oct - 10 Oct
Crown of 30A – Pool, Pets & Golf Cart
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Top Panama City Hotel Reviews

La Quinta Inn & Suites by Wyndham Panama City

La Quinta Inn & Suites by Wyndham Panama City

10/10 Excellent
"The staff was amazing. My child was in the hospital and they were so caring! I appreciated this so much. I will definitely be going back there to stay. Thank you so much."
Sandra 2-night trip
Posted 6 hours ago
La Quinta Inn & Suites by Wyndham Panama City

Frequently asked questions

Are you looking for a luxury hotel for your stay in Panama City?
Use Expedia and let us help you arrange a flight to Panama City, FL (ECP-Northwest Florida Beaches Intl.) airport, and then select from different places to stay that will deliver the luxury you want. Amenities are important when you plan a holiday, so we make it easy to find what you want to make your stay relaxing and comfortable. If you want an upscale hotel that has a spa, an indoor pool or luxury bedding, Expedia can assist you in finding the best luxury hotel experience that Panama City has to offer. During your visit, you might want to enjoy the beaches and sunsets which Panama City is known for.
When can I expect good weather in Panama City?
Planning for the weather is an important factor for making your trip to Panama City a success, especially when you're splurging. The hottest months are usually August and July, with an average temperature of 28°C, while the coldest months are January and February, with an average of 15°C. The rainiest months in Panama City are August, July, September and June, with each month seeing an average of 176 mm of rainfall.
What's there to see and do in Panama City?
Enjoy all that Panama City has to offer when you visit Panama City Marina, Port Panama City and St. Andrews State Park. If you have a little extra time during your trip, you might want to make a stop at Naval Support Activity Panama City and Tyndall Air Force Base.

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