Isle of Palms South Hotels, Jacksonville
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Our top choices for Isle of Palms South hotels
1. Residence Inn By Marriott Jacksonville - Mayo Clinic Area
Residence Inn By Marriott Jacksonville - Mayo Clinic AreaIsle of Palms, 2 km from Isle of Palms South
9.4 out of 10, Exceptional, (564 reviews)
"I stayed at this hotel for 3 days. It was super clean and comfortable to stay the night for vacation."
Devonta
The price is AU$227
includes taxes & fees
2 Aug - 3 Aug
2. Hampton Inn & Suites Jacksonville - Beach Blvd/Mayo Clinic
Hampton Inn & Suites Jacksonville - Beach Blvd/Mayo Clinic2.9 km from Isle of Palms South
9.0 out of 10, Wonderful, (1,001 reviews)
"Great location. 10 mins from the beach access. Nice clean hotel. Will stay again."
keilyn
The price is AU$185
includes taxes & fees
2 Aug - 3 Aug
3. Courtyard by Marriott Jacksonville at Mayo Clinic Campus/Beaches
Courtyard by Marriott Jacksonville at Mayo Clinic Campus/Beaches1.5 km from Isle of Palms South
8.4 out of 10, Very good, (788 reviews)
"Nice hotel for the money."
Troy
The price is AU$247
includes taxes & fees
8 Aug - 9 Aug
4. Hilton Jacksonville At Mayo Clinic
Hilton Jacksonville At Mayo Clinic1.9 km from Isle of Palms South
9.4 out of 10, Exceptional, (294 reviews)
"Great hotel and very convenient to Mayo."
Margaret
The price is AU$266
includes taxes & fees
15 Aug - 16 Aug
5. Holiday Inn Express & Suites Jacksonville SE- Med Ctr Area by IHG
Holiday Inn Express & Suites Jacksonville SE- Med Ctr Area by IHG3.7 km from Isle of Palms South
9.0 out of 10, Wonderful, (1,012 reviews)
"Staff was amazing, the shuttle bus was a huge help in this stay. Couldn’t ask for a better experience!"
Skylar
The price is AU$156
includes taxes & fees
16 Aug - 17 Aug
6. TownePlace Suites by Marriott Jacksonville East
TownePlace Suites by Marriott Jacksonville East2.9 km from Isle of Palms South
9.2 out of 10, Wonderful, (641 reviews)
"This is always a great place to stay especially because it’s close to the Mayo Clinic …a five minute drive"
Miriam
The price is AU$194
includes taxes & fees
2 Aug - 3 Aug
7. Hyatt Studios Jacksonville/St Johns Town Center
Hyatt Studios Jacksonville/St Johns Town Center8.7 km from Isle of Palms South
9.6 out of 10, Exceptional, (134 reviews)
"I really like this location and would definitely stay here again."
Althia
The price is AU$198
includes taxes & fees
20 Aug - 21 Aug
8. Margaritaville Jacksonville Beach
Margaritaville Jacksonville BeachOceanfront, 4.8 km from Isle of Palms South
8.8 out of 10, Excellent, (4,234 reviews)
"Excellent place to stay"
stephen
The price is AU$274
includes taxes & fees
4 Aug - 5 Aug
9. Best Western Oceanfront
Best Western OceanfrontOceanfront, 4.6 km from Isle of Palms South
9.0 out of 10, Wonderful, (1,003 reviews)
"Great place overall!!"
Harkirat
The price is AU$260
includes taxes & fees
13 Aug - 14 Aug
10. Element by Marriott Jacksonville Beach
Element by Marriott Jacksonville BeachOceanfront, 4.4 km from Isle of Palms South
9.6 out of 10, Exceptional, (572 reviews)
"Best hotel ever 😊"
Tablo
The price is AU$290
includes taxes & fees
2 Aug - 3 Aug
11. Four Points by Sheraton Jacksonville Beachfront
Four Points by Sheraton Jacksonville BeachfrontOceanfront, 4.5 km from Isle of Palms South
9.0 out of 10, Wonderful, (1,002 reviews)
"Very nice property and staff"
BONINA
The price is AU$290
includes taxes & fees
20 Aug - 21 Aug
12. Hampton Inn Jacksonville/Ponte Vedra Beach-Mayo Clinic Area
Hampton Inn Jacksonville/Ponte Vedra Beach-Mayo Clinic Area3.8 km from Isle of Palms South
9.0 out of 10, Wonderful, (1,186 reviews)
"Attentive and friendly staff, good location, generous breakfast"
Dagmar Maria
The price is AU$198
includes taxes & fees
16 Aug - 17 Aug
13. Courtyard by Marriott Jacksonville Beach Oceanfront
Courtyard by Marriott Jacksonville Beach OceanfrontOceanfront, 5.2 km from Isle of Palms South
8.6 out of 10, Excellent, (1,004 reviews)
"Beach was amazing! Love how close!"
Vance
The price is AU$303
includes taxes & fees
5 Aug - 6 Aug
14. Hilton Garden Inn Jacksonville Ponte Vedra Sawgrass
Hilton Garden Inn Jacksonville Ponte Vedra Sawgrass8.8 km from Isle of Palms South
9.0 out of 10, Wonderful, (1,008 reviews)
"Very polite and helpful staff, very clean and comfortable room, very nice location."
Rodney
The price is AU$216
includes taxes & fees
6 Aug - 7 Aug
15. Holiday Inn Express Jacksonville Beach by IHG
Holiday Inn Express Jacksonville Beach by IHG3.5 km from Isle of Palms South
9.2 out of 10, Wonderful, (1,003 reviews)
"Great staff and location"
Tiffany
The price is AU$179
includes taxes & fees
10 Aug - 11 Aug
16. Hyatt Place Jacksonville / St. Johns Town Center
Hyatt Place Jacksonville / St. Johns Town Center9.5 km from Isle of Palms South
9.2 out of 10, Wonderful, (1,144 reviews)
"Clean rooms, welcoming staff, and good breakfast/coffee."
Rana
The price is AU$316
includes taxes & fees
15 Aug - 16 Aug
17. Springhill Suites By Marriott Jacksonville Beach Oceanfront
Springhill Suites By Marriott Jacksonville Beach OceanfrontOceanfront, 4.7 km from Isle of Palms South
9.0 out of 10, Wonderful, (753 reviews)
"Great location, room was nice and we really enjoyed the pool and restaurant. Staff was helpful and can’t beat beachfront location."
STEPHEN
The price is AU$348
includes taxes & fees
9 Aug - 10 Aug
18. Fairfield Inn & Suites by Marriott Jacksonville Beach
Fairfield Inn & Suites by Marriott Jacksonville BeachOceanfront, 5.2 km from Isle of Palms South
8.6 out of 10, Excellent, (961 reviews)
"Clean room friendly staff"
Dorian
The price is AU$241
includes taxes & fees
2 Aug - 3 Aug
19. Sheraton Jacksonville Hotel
Sheraton Jacksonville Hotel10.5 km from Isle of Palms South
9.0 out of 10, Wonderful, (1,001 reviews)
"Great breakfast"
ericca
The price is AU$201
includes taxes & fees
1 Aug - 2 Aug
20. Casa Marina Hotel
Casa Marina HotelOceanfront, 4.8 km from Isle of Palms South
8.6 out of 10, Excellent, (1,006 reviews)
"The bed is old, and the towels are too old and rough. Breakfast is ok. Good beach view."
Grace
The price is AU$205
includes taxes & fees
2 Aug - 3 Aug
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Our guide on where to stay in Isle of Palms South
Find the best Isle of Palms South areas for the activities you enjoy most.
Photo by Ryan Ketterman
Open Photo by Ryan Ketterman
Downtown Jacksonville
The picturesque St. Johns River meanders through the center of this hub of skyscrapers, cultural landmarks and exciting nightlife.
Oceanfront
While visiting Oceanfront, you might make a stop by sights like Oceanfront Park and Northeast Florida Beaches.
Amelia City
While visiting Amelia City, you might make a stop by sights like American Beach and Fernandina Beach.
Southside
If you're spending some time in Southside, St. Johns Town Center and Orange Park Place Shopping Center are top sights worth seeing.
Sawgrass
Beaches and riverfront are just a few things travellers like about Sawgrass. A stop by Mickler Beach is also recommended if you've got time to explore the area.
Top Isle of Palms South Hotel Reviews
Recent Reviews in Isle of Palms South
Hampton Inn Jacksonville Beach/Oceanfront
10/10 Excellent
