Lodging Image

Isle of Palms South Hotels, Jacksonville

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

This weekend
25 Sept - 27 Sept
Next weekend
2 Oct - 4 Oct

Filter by

Property class

Guest rating

Selecting then applying a filter from this group will update the results on a new page

Our top choices for Isle of Palms South hotels

A hotel lobby with a bar area, seating arrangements, and a reception desk.

1. Hampton Inn & Suites Jacksonville - Beach Blvd/Mayo Clinic

Hampton Inn & Suites Jacksonville - Beach Blvd/Mayo Clinic
2.5 star property
2.9 km from Isle of Palms South
9.0 out of 10, Wonderful, (1,000 reviews)
"Great place to stay."
United States
Patsy
The price is AU$177
includes taxes & fees
4 Oct - 5 Oct
Hampton Inn & Suites Jacksonville - Beach Blvd/Mayo Clinic
An outdoor seating area with stone fire pit, wicker furniture, and potted plants.

2. Courtyard by Marriott Jacksonville at Mayo Clinic Campus/Beaches

Courtyard by Marriott Jacksonville at Mayo Clinic Campus/Beaches
3.0 star property
1.5 km from Isle of Palms South
8.4 out of 10, Very good, (797 reviews)
"The staff was very helpful and the parking easy and, in parts, quite shady. It was within easy walking distance of the Mayo Clinic!"
United States
Patricia
The price is AU$245
includes taxes & fees
3 Oct - 4 Oct
Courtyard by Marriott Jacksonville at Mayo Clinic Campus/Beaches
A spacious living area with a high ceiling, a fireplace, and a bar area in the background.

3. Residence Inn By Marriott Jacksonville - Mayo Clinic Area

Residence Inn By Marriott Jacksonville - Mayo Clinic Area
3.0 star property
Isle of Palms, 2 km from Isle of Palms South
9.4 out of 10, Exceptional, (602 reviews)
"Great stay"
United States
Michaelanne
The price is AU$250
includes taxes & fees
18 Oct - 19 Oct
Residence Inn By Marriott Jacksonville - Mayo Clinic Area
A modern restaurant with a bar area, wooden ceiling, and large windows.

4. Hilton Jacksonville at Mayo Clinic near Beaches

Hilton Jacksonville at Mayo Clinic near Beaches
4.5 star property
1.9 km from Isle of Palms South
9.4 out of 10, Exceptional, (360 reviews)
"Excellent hotel and staff."
United States
Kristen
The price is AU$263
includes taxes & fees
10 Oct - 11 Oct
Hilton Jacksonville at Mayo Clinic near Beaches
A hotel room with two beds, a desk with a computer, a chair, and a colorful carpet.

5. Holiday Inn Express Jacksonville Beach by IHG

Holiday Inn Express Jacksonville Beach by IHG
3.0 star property
3.5 km from Isle of Palms South
9.2 out of 10, Wonderful, (1,001 reviews)
"The staff was nice, and the breakfast was very good,"
United States
Jose
The price is AU$190
includes taxes & fees
28 Sept - 29 Sept
Holiday Inn Express Jacksonville Beach by IHG
An outdoor seating area with a fire pit, wicker furniture, and a covered patio.

6. TownePlace Suites by Marriott Jacksonville East

TownePlace Suites by Marriott Jacksonville East
3.0 star property
2.9 km from Isle of Palms South
9.2 out of 10, Wonderful, (660 reviews)
"Great location close to the beach. Super well maintained facility. Everything was great!"
United States
gregory
The price is AU$192
includes taxes & fees
4 Oct - 5 Oct
TownePlace Suites by Marriott Jacksonville East
A spacious lobby with a glass floor, a reception desk, and a view of the ocean.

7. Margaritaville Jacksonville Beach

Margaritaville Jacksonville Beach
2.5 star property
Oceanfront, 4.8 km from Isle of Palms South
9.0 out of 10, Wonderful, (4,524 reviews)
"Great location with beautiful views, clean, beautiful rooms and lots to do around the area"
United States
Keisha
The price is AU$241
includes taxes & fees
28 Sept - 29 Sept
Margaritaville Jacksonville Beach
A beach with a sandy shore, waves, and buildings in the background.

8. Best Western Oceanfront

Best Western Oceanfront
3.0 star property
Oceanfront, 4.6 km from Isle of Palms South
9.0 out of 10, Wonderful, (1,004 reviews)
"This is one of the best kept Best Western hotels I’ve ever been in. The hotel is walkable to the beach, dining, and activities. Parking is easy. The staff are very friendly and breakfast was varied for everyone’s needs."
United States
Sonya
The price is AU$184
includes taxes & fees
1 Oct - 2 Oct
Best Western Oceanfront
A modern outdoor seating area with white wicker chairs, a glass fire pit with burning wood, and a view of palm trees and a building in the background.

9. Element by Marriott Jacksonville Beach

Element by Marriott Jacksonville Beach
3.0 star property
Oceanfront, 4.4 km from Isle of Palms South
9.6 out of 10, Exceptional, (587 reviews)
"Nice lodging a block from the beach. Great food nearby."
United States
Nick
The price is AU$245
includes taxes & fees
1 Oct - 2 Oct
Element by Marriott Jacksonville Beach
A laptop on a wooden desk with a white mug, a spoon, and a smartphone.

10. Hyatt Studios Jacksonville/St Johns Town Center

Hyatt Studios Jacksonville/St Johns Town Center
2.5 star property
8.7 km from Isle of Palms South
9.4 out of 10, Exceptional, (214 reviews)
"Very nice stay, they have grab and go breakfast as complimentary."
United States
Phi
The price is AU$177
includes taxes & fees
3 Oct - 4 Oct
Hyatt Studios Jacksonville/St Johns Town Center
A covered entrance with a dark tiled floor, white columns, and a green bench.

11. Hampton Inn Jacksonville/Ponte Vedra Beach-Mayo Clinic Area

Hampton Inn Jacksonville/Ponte Vedra Beach-Mayo Clinic Area
2.5 star property
3.8 km from Isle of Palms South
9.0 out of 10, Wonderful, (1,234 reviews)
"Room was clean, staff were very pleasant and helpful. Will definitely stay here again when I come back to Jacksonville."
United States
Robert
The price is AU$190
includes taxes & fees
4 Oct - 5 Oct
Hampton Inn Jacksonville/Ponte Vedra Beach-Mayo Clinic Area

12. Four Points by Sheraton Jacksonville Beachfront

Four Points by Sheraton Jacksonville Beachfront
3.0 star property
Oceanfront, 4.5 km from Isle of Palms South
9.0 out of 10, Wonderful, (1,007 reviews)
"Awesome stay"
United States
Susan
The price is AU$286
includes taxes & fees
4 Oct - 5 Oct
Four Points by Sheraton Jacksonville Beachfront
A balcony with a view of the beach, a wooden walkway, and a chair.

13. Courtyard by Marriott Jacksonville Beach Oceanfront

Courtyard by Marriott Jacksonville Beach Oceanfront
3.0 star property
Oceanfront, 5.2 km from Isle of Palms South
8.4 out of 10, Very good, (1,001 reviews)
"Great hotel on the beach very good staff."
Canada
Marc
The price is AU$266
includes taxes & fees
1 Oct - 2 Oct
Courtyard by Marriott Jacksonville Beach Oceanfront
A modern dining area with wooden tables and chairs, pendant lighting, and artwork on the walls.

14. Fairfield Inn & Suites by Marriott Jacksonville Beach

Fairfield Inn & Suites by Marriott Jacksonville Beach
3.0 star property
Oceanfront, 5.2 km from Isle of Palms South
8.6 out of 10, Excellent, (986 reviews)
"clean room nice beach location"
United States
Anne
The price is AU$204
includes taxes & fees
4 Oct - 5 Oct
Fairfield Inn & Suites by Marriott Jacksonville Beach
A lobby with a reception desk, seating area, and a staircase.

15. Holiday Inn Express & Suites Jacksonville SE- Med Ctr Area by IHG

Holiday Inn Express & Suites Jacksonville SE- Med Ctr Area by IHG
2.5 star property
3.7 km from Isle of Palms South
9.0 out of 10, Wonderful, (1,010 reviews)
"wonderful breakfast and friendly staff"
United States
frances
The price is AU$150
includes taxes & fees
25 Oct - 26 Oct
Holiday Inn Express & Suites Jacksonville SE- Med Ctr Area by IHG
A terrace with wooden tables and chairs, overlooking a beach and a pier.

16. Springhill Suites By Marriott Jacksonville Beach Oceanfront

Springhill Suites By Marriott Jacksonville Beach Oceanfront
4.0 star property
Oceanfront, 4.7 km from Isle of Palms South
9.0 out of 10, Wonderful, (804 reviews)
"Excellent room and customer service."
United States
MELISSA
The price is AU$273
includes taxes & fees
1 Oct - 2 Oct
Springhill Suites By Marriott Jacksonville Beach Oceanfront
A pathway leading to a gated entrance with a sign reading "FEAHORSE."

17. Seahorse Oceanfront Inn

Seahorse Oceanfront Inn
2.5 star property
6.8 km from Isle of Palms South
8.8 out of 10, Excellent, (805 reviews)
"This was a great weekend trip we loved the property and the views from the room."
United States
Steven
The price is AU$192
includes taxes & fees
1 Oct - 2 Oct
Seahorse Oceanfront Inn
An outdoor patio area with wicker furniture, a fire feature, and string lights.

18. Sheraton Jacksonville Hotel

Sheraton Jacksonville Hotel
4.0 star property
10.5 km from Isle of Palms South
9.2 out of 10, Wonderful, (1,001 reviews)
"Good location, clean"
United States
Kerrie
The price is AU$199
includes taxes & fees
25 Sept - 26 Sept
Sheraton Jacksonville Hotel
A hotel room with a large bed, a desk with a chair, a television, and a mirror.

19. Holiday Inn Jacksonville E 295 Baymeadows by IHG

Holiday Inn Jacksonville E 295 Baymeadows by IHG
3.0 star property
9.6 km from Isle of Palms South
8.6 out of 10, Excellent, (999 reviews)
"Great Hotel"
United States
Josh
The price is AU$134
includes taxes & fees
25 Oct - 26 Oct
Holiday Inn Jacksonville E 295 Baymeadows by IHG
A spacious lobby with a reception desk, seating area, and large windows.

20. Hilton Garden Inn Jacksonville Ponte Vedra Sawgrass

Hilton Garden Inn Jacksonville Ponte Vedra Sawgrass
3.0 star property
8.8 km from Isle of Palms South
9.2 out of 10, Wonderful, (1,002 reviews)
"Great in every way!! Very comfortable and clean and friendly"
United States
Joyce
The price is AU$197
includes taxes & fees
18 Oct - 19 Oct
Hilton Garden Inn Jacksonville Ponte Vedra Sawgrass
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties

Our guide on where to stay in Isle of Palms South

Find the best Isle of Palms South areas for the activities you enjoy most.
A city skyline with modern skyscrapers, a prominent Wells Fargo building, and a blue bridge over a river.
Photo by Ryan Ketterman
Open Photo by Ryan Ketterman

Downtown Jacksonville

The picturesque St. Johns River meanders through the center of this hub of skyscrapers, cultural landmarks and exciting nightlife.

A coastal cityscape at dusk with a prominent clock tower, waterfront, and historic buildings.

Amelia City

While visiting Amelia City, you might make a stop by sights like American Beach and Fernandina Beach.

A sunset over a beach with waves and a pier.

Oceanfront

While visiting Oceanfront, you might make a stop by sights like Oceanfront Park and Northeast Florida Beaches.

A city skyline at night with illuminated buildings and a bridge reflecting on the water.

Southside

If you're spending some time in Southside, St. Johns Town Center and Orange Park Place Shopping Center are top sights worth seeing.

A sunset over a beach with fallen trees and a distant shoreline.

American Beach

If you're spending some time in American Beach, American Beach and Spanish Quarter Village are top sights worth seeing.

Top Isle of Palms South Hotel Reviews

Recent Reviews in Isle of Palms South

Margaritaville Jacksonville Beach

Margaritaville Jacksonville Beach

8/10 Good
"Our room had a beautiful beach view. Convenient walking distance to the beach, pier and restaurants. The only issue was that people who live in the Margaritaville communities are confused about discounts that are available to them if booked directly with the resort/hotel. The GM got this fixed for us. Very nice."
Phil 3-night trip
Posted 3 hours ago
Margaritaville Jacksonville Beach

Frequently asked questions

What is Isle of Palms South like?
Travellers will be sure to find plenty to entertain them in Jacksonville Beach's Isle of Palms South neighbourhood.
How many hotels can I expect to find in Isle of Palms South?
Expedia has 7 Isle of Palms South hotels and other accommodation options, and one might make a good home base for venturing out into the greater Jacksonville Beach area.
If I need to cancel my hotel reservation in Isle of Palms South, will I receive a refund?
Yes, the majority of hotel reservations are fully refundable if you cancel before the accommodation's cancellation deadline, which is often 24 or 48 hours before the scheduled arrival. If you have a non-refundable reservation, you might be able to still cancel and receive a refund within a 24-hour period of booking. Enter dates in and click on "Search", then you can filter by "fully refundable" to view the best deals in Isle of Palms South.
What are the top things to see and do in Isle of Palms South?
Cradle Creek Preserve, Windsor Parke Golf Club and Jacksonville Beach Golf Club are just a few of the places to visit in and around Isle of Palms South. Windsor Commons Shopping Center and Harbor City Municipal Golf Course are also worth a visit when you're out sightseeing in Jacksonville Beach.