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Our top choices for Isle of Palms hotels
1. Residence Inn By Marriott Jacksonville - Mayo Clinic Area
Residence Inn By Marriott Jacksonville - Mayo Clinic AreaIsle of Palms
9.4 out of 10, Exceptional, (623 reviews)
"Great stay if you are going to Mayo"
Eladio
The price is AU$228
includes taxes & fees
27 Nov - 28 Nov
2. Holiday Inn Express Jacksonville Beach by IHG
Holiday Inn Express Jacksonville Beach by IHG3.3 km from Isle of Palms
9.2 out of 10, Wonderful, (1,002 reviews)
"Room really comfortable and staff so welcoming."
John
The price is AU$190
includes taxes & fees
23 Nov - 24 Nov
3. Hampton Inn & Suites Jacksonville - Beach Blvd/Mayo Clinic
Hampton Inn & Suites Jacksonville - Beach Blvd/Mayo Clinic3 km from Isle of Palms
9.0 out of 10, Wonderful, (1,003 reviews)
"Loved the room, and the little cheese omelets at breakfast were good!"
Kerry
The price is AU$212
includes taxes & fees
15 Nov - 16 Nov
4. TownePlace Suites by Marriott Jacksonville East
TownePlace Suites by Marriott Jacksonville East3 km from Isle of Palms
9.2 out of 10, Wonderful, (669 reviews)
"The room was very clean and comfortable. It would be nice to have the breakfast time last longer than 9:00am though."
Lana
The price is AU$205
includes taxes & fees
22 Nov - 23 Nov
5. Hilton Jacksonville at Mayo Clinic near Beaches
Hilton Jacksonville at Mayo Clinic near Beaches2.1 km from Isle of Palms
9.2 out of 10, Wonderful, (392 reviews)
"A beautiful place will stay there again"
Brandy
The price is AU$268
includes taxes & fees
22 Nov - 23 Nov
6. Best Western Oceanfront
Best Western OceanfrontOceanfront, 4.4 km from Isle of Palms
9.0 out of 10, Wonderful, (1,001 reviews)
"Would stay again"
Williams
The price is AU$204
includes taxes & fees
23 Nov - 24 Nov
7. Hyatt Place Jacksonville / St. Johns Town Center
Hyatt Place Jacksonville / St. Johns Town Center9.7 km from Isle of Palms
9.2 out of 10, Wonderful, (1,202 reviews)
"Great stay. Bed super comfy. Staff pleasant. Had a room facing lake."
Lashonda
The price is AU$184
includes taxes & fees
23 Nov - 24 Nov
8. Candlewood Suites Jacksonville - Mayport by IHG
Candlewood Suites Jacksonville - Mayport by IHG8 km from Isle of Palms
9.0 out of 10, Wonderful, (308 reviews)
"Room had all the amenities you need for a comfortable overnight stay."
Nasar
The price is AU$169
includes taxes & fees
14 Nov - 15 Nov
9. Hyatt Studios Jacksonville/St Johns Town Center
Hyatt Studios Jacksonville/St Johns Town Center8.9 km from Isle of Palms
9.4 out of 10, Exceptional, (254 reviews)
"Terrific location and accommodations to match!"
William
The price is AU$193
includes taxes & fees
18 Nov - 19 Nov
10. Holiday Inn Jacksonville E 295 Baymeadows by IHG
Holiday Inn Jacksonville E 295 Baymeadows by IHG9.8 km from Isle of Palms
8.6 out of 10, Excellent, (1,000 reviews)
"Great Hotel"
Josh
The price is AU$145
includes taxes & fees
13 Dec - 14 Dec
11. Fairfield Inn & Suites by Marriott Jacksonville Beach
Fairfield Inn & Suites by Marriott Jacksonville BeachOceanfront, 5 km from Isle of Palms
8.6 out of 10, Excellent, (1,005 reviews)
"friendly and helpful staff. Breakfast was very good."
Daniel
The price is AU$239
includes taxes & fees
19 Nov - 20 Nov
12. Holiday Inn Express & Suites Jacksonville SE- Med Ctr Area by IHG
Holiday Inn Express & Suites Jacksonville SE- Med Ctr Area by IHG3.9 km from Isle of Palms
9.0 out of 10, Wonderful, (1,035 reviews)
"Great stay"
Alfredo
The price is AU$183
includes taxes & fees
22 Nov - 23 Nov
13. Hampton Inn Jacksonville/Ponte Vedra Beach-Mayo Clinic Area
Hampton Inn Jacksonville/Ponte Vedra Beach-Mayo Clinic Area3.7 km from Isle of Palms
9.0 out of 10, Wonderful, (1,250 reviews)
"Excellent place to stay if spending time at Mayo"
Jeffrey
The price is AU$199
includes taxes & fees
23 Nov - 24 Nov
14. Aloft by Marriott Jacksonville Tapestry Park
Aloft by Marriott Jacksonville Tapestry Park12 km from Isle of Palms
9.0 out of 10, Wonderful, (1,000 reviews)
"Overall good stay"
Kaleah
The price is AU$210
includes taxes & fees
14 Nov - 15 Nov
15. Element by Marriott Jacksonville Beach
Element by Marriott Jacksonville BeachOceanfront, 4.2 km from Isle of Palms
9.6 out of 10, Exceptional, (597 reviews)
"The staff was very helpful to watch my dogs in their stroller while I got breakfast, and it was a wonderful breakfast."
Lisa
The price is AU$253
includes taxes & fees
22 Nov - 23 Nov
16. Tru By Hilton Jacksonville St Johns Town Center
Tru By Hilton Jacksonville St Johns Town Center9.7 km from Isle of Palms
9.2 out of 10, Wonderful, (986 reviews)
"The staff was very welcoming,and friendly ."
Janice
The price is AU$172
includes taxes & fees
22 Nov - 23 Nov
17. Hilton Garden Inn Jacksonville Ponte Vedra Sawgrass
Hilton Garden Inn Jacksonville Ponte Vedra Sawgrass8.7 km from Isle of Palms
9.0 out of 10, Wonderful, (1,012 reviews)
"Great hotel and staff"
Timothy
The price is AU$207
includes taxes & fees
22 Nov - 23 Nov
18. Seahorse Oceanfront Inn
Seahorse Oceanfront Inn6.6 km from Isle of Palms
8.8 out of 10, Excellent, (858 reviews)
"Great location, but we were sad the pool was closed for maintenance, if we had known that, we would've found somewhere else. Loved the location and being near everything."
William
The price is AU$217
includes taxes & fees
8 Dec - 9 Dec
19. Springhill Suites By Marriott Jacksonville Beach Oceanfront
Springhill Suites By Marriott Jacksonville Beach OceanfrontOceanfront, 4.5 km from Isle of Palms
9.0 out of 10, Wonderful, (819 reviews)
"great location"
emily
The price is AU$282
includes taxes & fees
22 Nov - 23 Nov
20. Sheraton Jacksonville Hotel
Sheraton Jacksonville Hotel10.7 km from Isle of Palms
9.0 out of 10, Wonderful, (1,000 reviews)
"Staff was real nice rooms were clean. Bartender was real nice facilities looked amazing."
Jarvon
The price is AU$181
includes taxes & fees
23 Nov - 24 Nov
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Compare popular hotels in Isle of Palms
Property | Property class | Guest rating | Breakfast included | Pool | Spa | Pet-friendly | WiFi included | |
|---|---|---|---|---|---|---|---|---|
 Residence Inn By Marriott Jacksonville - Mayo Clinic Area | 9.4 Exceptional 623 reviews | View | ||||||
 Hampton Inn & Suites Jacksonville - Beach Blvd/Mayo Clinic | 9.0 Wonderful 1,003 reviews | View | ||||||
 Holiday Inn Express Jacksonville Beach by IHG | 9.2 Wonderful 1,002 reviews | View | ||||||
 Hilton Jacksonville at Mayo Clinic near Beaches | 9.2 Wonderful 392 reviews | View | ||||||
 TownePlace Suites by Marriott Jacksonville East | 9.2 Wonderful 669 reviews | View |
Our guide on where to stay in Isle of Palms
Find the best Isle of Palms areas for the activities you enjoy most.
Photo by Ryan Ketterman
Open Photo by Ryan Ketterman
Downtown Jacksonville
The picturesque St. Johns River meanders through the center of this hub of skyscrapers, cultural landmarks and exciting nightlife.
Amelia City
While visiting Amelia City, you might make a stop by sights like American Beach and Fernandina Beach.
Oceanfront
While visiting Oceanfront, you might make a stop by sights like Oceanfront Park and Northeast Florida Beaches.
Southside
If you're spending some time in Southside, St. Johns Town Center and Orange Park Place Shopping Center are top sights worth seeing.
Sawgrass
Beaches and riverfront are just a few things travellers like about Sawgrass. A stop by Mickler Beach is also recommended if you've got time to explore the area.
Top Isle of Palms Hotel Reviews
Holiday Inn Express & Suites Jacksonville - Town Center by IHG
Holiday Inn Express & Suites Jacksonville - Town Center by IHGSouthside
10/10 Excellent
Nice Motel, good room, Hot, sumptuous breakfast, good amenities, free onsite parking, fast internet, helpful, lovely reception staff, heater and A/C quiet and good, but a little bit of traffic noise, as windows are single pane, but we slept well because of, after a long drive.
Ranjana
