South Central Houston Hotels, Houston

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Check prices for these dates

Tonight
12 May - 13 May
Tomorrow
13 May - 14 May
This weekend
15 May - 17 May
Next weekend
22 May - 24 May

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Our top choices for South Central Houston hotels

Exterior detail

Sentral Forme Houston

Sentral Forme Houston
4.5 star property
South Central Houston
9.0 out of 10, Wonderful, (29 reviews)
"Verry nice and staff was very helpful. Will stay again"
United States
Carolyn
The price is AU$271
includes taxes & fees
14 May - 15 May
Sentral Forme Houston
Laptop workspace, blackout curtains, soundproofing, iron/ironing board

Downtowner Inns - Houston Downtown

Downtowner Inns - Houston Downtown
2.0 star property
South Central Houston
9.2 out of 10, Wonderful, (132 reviews)
"great stay "
United States
Jordan
The price is AU$141
includes taxes & fees
17 May - 18 May
Downtowner Inns - Houston Downtown
Terrace/patio

Hilton Houston Plaza/Medical Center

Hilton Houston Plaza/Medical Center
4.5 star property
South Central Houston
8.4 out of 10, Very good, (1,916 reviews)
"The staff was awesome and very friendly! Hotel very nice! I will stay again"
United States
Maria Guadalupe
The price is AU$178
includes taxes & fees
17 May - 18 May
Hilton Houston Plaza/Medical Center
Outdoor pool, free pool cabanas, pool umbrellas

The Westin Houston Medical Center/Museum District

The Westin Houston Medical Center/Museum District
4.0 star property
South Central Houston
9.2 out of 10, Wonderful, (1,155 reviews)
"Fantastic reasonably priced property."
United States
William
The price is AU$260
includes taxes & fees
22 May - 23 May
The Westin Houston Medical Center/Museum District
House | Private kitchen

Downtown Houston 3BR Bachelorette Escape

Downtown Houston 3BR Bachelorette Escape
2.0 star property
South Central Houston
9.8 out of 10, Exceptional, (6 reviews)
"Everything was great. Look no further and book this property. "
United States
Iesheal
The price is AU$561
includes taxes & fees
19 May - 20 May
Downtown Houston 3BR Bachelorette Escape
Reception

Americas Best Value Inn Medical Center Downtown

Americas Best Value Inn Medical Center Downtown
2.0 star property
South Central Houston
8.0 out of 10, Very good, (1,015 reviews)
"Convenient location and comfortable room."
United States
Rogelio
The price is AU$114
includes taxes & fees
14 May - 15 May
Americas Best Value Inn Medical Center Downtown
Reception

Wanderstay Boutique Hotel

Wanderstay Boutique Hotel
3.0 star property
South Central Houston
9.8 out of 10, Exceptional, (72 reviews)
"Solo trip and it was a perfect location staff was nice and it was nice and clean!! Would stay there again. "
United States
Sharon
The price is AU$194
includes taxes & fees
18 May - 19 May
Wanderstay Boutique Hotel
Premium bedding, pillow-top beds, minibar, in-room safe

Hotel Zaza Houston Museum District

Hotel Zaza Houston Museum District
4.5 star property
South Central Houston
9.0 out of 10, Wonderful, (1,022 reviews)
"It was a wonderful place to stay will be coming back again."
United States
Jesse
The price is AU$376
includes taxes & fees
25 May - 26 May
Hotel Zaza Houston Museum District
Breakfast and dinner served

DoubleTree by Hilton Houston Medical Center Hotel & Suites

DoubleTree by Hilton Houston Medical Center Hotel & Suites
4.0 star property
South Central Houston
8.4 out of 10, Very good, (577 reviews)
"Staff was wonderful "
United States
Lynn
The price is AU$173
includes taxes & fees
17 May - 18 May
DoubleTree by Hilton Houston Medical Center Hotel & Suites
American cuisine

Houston Marriott Medical Center/Museum District

Houston Marriott Medical Center/Museum District
4.0 star property
South Central Houston
9.0 out of 10, Wonderful, (1,003 reviews)
"Right in the center of the Medical District. Didn’t even have to go outside to get to my wife’s appointment. "
United States
Dominick
The price is AU$334
includes taxes & fees
23 May - 24 May
Houston Marriott Medical Center/Museum District
Exterior

InterContinental Houston by IHG

InterContinental Houston by IHG
4.0 star property
South Central Houston
9.2 out of 10, Wonderful, (1,013 reviews)
"The food was excellent and the staff friendly and helpful. "
United States
Andrea
The price is AU$271
includes taxes & fees
17 May - 18 May
InterContinental Houston by IHG
Outdoor pool

Houston Towers Inn Downtown Museum District Med. Ctr NRG - Adults Only

Houston Towers Inn Downtown Museum District Med. Ctr NRG - Adults Only
3.5 star property
South Central Houston
9.6 out of 10, Exceptional, (212 reviews)
"Beautiful place and wonderful management. Would definitely stay again! "
United States
Shelly
The price is AU$355
includes taxes & fees
18 May - 19 May
Houston Towers Inn Downtown Museum District Med. Ctr NRG - Adults Only
Lobby

Hilton University of Houston

Hilton University of Houston
3.5 star property
South Central Houston
9.0 out of 10, Wonderful, (941 reviews)
"The hotel was clean, staff were friendly and the location was perfect for our event. I will definitely stay there again. "
United States
Ricardo
The price is AU$222
includes taxes & fees
19 May - 20 May
Hilton University of Houston
Exterior

La Maison in Midtown an urban B&B

La Maison in Midtown an urban B&B
3.5 star property
South Central Houston
9.8 out of 10, Exceptional, (571 reviews)
"We felt welcome from the moment we walked in. The owners are so hospitable and the place such a delight. Loved the generous breakfast and ambiance- great parking as well!"
United States
Carolina
The price is AU$286
includes taxes & fees
17 May - 18 May
La Maison in Midtown an urban B&B
House

Posh Dtwn Midtown Home w Stunning Roof-topterrace

Posh Dtwn Midtown Home w Stunning Roof-topterrace
3.0 star property
South Central Houston
The price is AU$868
includes taxes & fees
26 May - 27 May
Posh Dtwn Midtown Home w Stunning Roof-topterrace
Standard Room, 1 King Bed

Southmore Boulevard Motel

Southmore Boulevard Motel
2.0 star property
South Central Houston
5.6 out of 10, (238 reviews)
"I enjoyed my stay at this hotel."
United States
Tamela
The price is AU$91
includes taxes & fees
15 May - 16 May
Southmore Boulevard Motel
Lobby

Extended Stay America Suites Houston Med Ctr Braeswood Bl

Extended Stay America Suites Houston Med Ctr Braeswood Bl
2.5 star property
South Central Houston
5.8 out of 10, (1,018 reviews)
"Love the pet friendly property"
United States
Nelda
The price is AU$117
includes taxes & fees
14 May - 15 May
Extended Stay America Suites Houston Med Ctr Braeswood Bl
Reception

Golden Motel Near Houston Medical Center

Golden Motel Near Houston Medical Center
2.5 star property
South Central Houston
2.0 out of 10, (1 review)
"Room smelt like cigarettes burnt wholes in the wall and bed sheet all 6 walls had stains toilet seat look like someone stood on it "
United States
Jacari
The price is AU$92
includes taxes & fees
13 May - 14 May
Golden Motel Near Houston Medical Center
Interior

Wanderstay Houston Hostel

Wanderstay Houston Hostel
2.0 star property
South Central Houston
8.2 out of 10, Very good, (200 reviews)
"it was a great experience, staff was kind and helpful. "
United States
James
The price is AU$99
includes taxes & fees
14 May - 15 May
Wanderstay Houston Hostel
House

Paradise Palace Best Rooftop in HTX w Hot Tub

Paradise Palace Best Rooftop in HTX w Hot Tub
3.0 star property
South Central Houston
The price is AU$946
includes taxes & fees
19 May - 20 May
Paradise Palace Best Rooftop in HTX w Hot Tub
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties

Compare popular hotels in South Central Houston

Property
Property class
Guest rating
Breakfast included
Pool
Spa
Pet-friendly
WiFi included
Reception
Wanderstay Boutique Hotel
3.0 star property
9.8
Exceptional
72 reviews
View
Exterior
La Maison in Midtown an urban B&B
3.5 star property
9.8
Exceptional
571 reviews
View
Outdoor pool
Houston Towers Inn Downtown Museum District Med. Ctr NRG - Adults Only
3.5 star property
9.6
Exceptional
212 reviews
View
Laptop workspace, blackout curtains, soundproofing, iron/ironing board
Downtowner Inns - Houston Downtown
2.0 star property
9.2
Wonderful
132 reviews
View
Outdoor pool, free pool cabanas, pool umbrellas
The Westin Houston Medical Center/Museum District
4.0 star property
9.2
Wonderful
1,155 reviews
View

Our guide on where to stay in South Central Houston

Find the best South Central Houston areas for the activities you enjoy most.

Downtown Houston

Tour the beautiful green spaces, buzzing theater district and professional sports arenas nestled beneath a dramatic cityscape of gleaming skyscrapers.

The Galleria

Travellers to The Galleria praise its popular shops. If you've got some more time to explore, be sure to stop by The Galleria and Williams Tower.

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Texas Medical Center

Well liked for its restaurants, museums and shopping, there's plenty to explore in Texas Medical Center. Attractions like Houston Zoo are a major draw, and you can hop on the metro at TMC Transit Center or Dryden/TMC Station to see more of the city.

Montrose

Unique features of Montrose include the theatres and museums. Make a stop by Rothko Chapel or Menil Collection while you're exploring the area.

Photo by George Zimzores
Open Photo by George Zimzores

Houston Central Business District

If you're spending time in Houston Central Business District, check out sights like Toyota Center or House of Blues Houston and hop on the metro to see more of the city at Bell Station or Downtown Transit Center Station.

Top South Central Houston Hotel Reviews

Americas Best Value Inn Medical Center Downtown

Americas Best Value Inn Medical Center Downtown

10/10 Excellent
"I was so pleasantly surprised.we came for the medical center. Our flight arrived early and we were able to check into our room early anyway. The room was clean and spacious and it looked to be newly remodeled. I would definitely stay here again. The front desk was incredibly friendly. "
Erika 1-night trip
Posted 14 hours ago
Americas Best Value Inn Medical Center Downtown

Frequently asked questions

What's it like in South Central Houston?
Travellers are sure to enjoy a stay in Houston's South Central Houston neighbourhood. Make sure that you visit Continental Club and Children's Museum of Houston as part of your South Central Houston travel plans.
What's the best accommodation in South Central Houston?
Based on our traveller data, Hilton Houston Plaza/Medical Center is one of the top choices for your stay in South Central Houston. This hotel is a short 9-minute walk from MD Anderson Cancer Center, and it offers 2 restaurants and 2 bars. Other good options for your stay in the area include Hotel Zaza Houston Museum District and InterContinental Houston by IHG.
How many hotels can I expect to find in the South Central Houston area?
Expedia has 1133 hotels and other accommodation options in South Central Houston to choose from, making this an ideal home base for exploring the greater Houston area.
If I need to cancel my hotel reservation in South Central Houston, will I receive a refund?
Yes! Most room reservations are fully refundable as long as you cancel prior to the accommodation's cancellation deadline, which often is within 24-48 hours of the scheduled arrival. If your reservation is non-refundable, you might still have the option to cancel and get a refund within a 24-hour period of your booking. Add dates, click "Search", then you can filter by "fully refundable" to view the best deals available in South Central Houston.
What is there to do around this Houston neighbourhood?
Spend some time exploring the great outdoors at Hermann Park, Cullen Sculpture Garden and Bagby Dog Park. Continental Club and Children's Museum of Houston are some other stops worth a visit in the neighbourhood. Toyota Center and Daikin Park are some popular places to visit in the area around South Central Houston. Shape Community Center and Project Row Houses are also worth a visit when you're out sightseeing in Houston.
How can I get around South Central Houston and the greater Houston area?
For a quick way to explore the city, catch a ride on metro transit at Elgin/Third Ward Station, TSU/UH Athletics District Station or Ensemble/HCC Station. If you want to venture out of town, M. D. Anderson Station is the closest train station. You can also catch a ride at Kinder Station.

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