Top Hotels Near Fort Defiance State Park in Cairo from AU$102

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Our top choices for Fort Defiance State Park hotels

Lobby
Quality Inn Cairo I-57

Quality Inn Cairo I-57

Quality Inn Cairo I-57
2.5 star property
7.8 km from Fort Defiance State Park
6.6 out of 10, (273)
"Break fast was excellent "
United States
Uma
The price is AU$120
includes taxes & fees
10 Jan - 11 Jan 2026
Quality Inn Cairo I-57
Laptop workspace, blackout curtains, free cots/infant beds, free WiFi
Super 8 by Wyndham Charleston/Sikeston East MO

Super 8 by Wyndham Charleston/Sikeston East MO

Super 8 by Wyndham Charleston/Sikeston East MO
2.0 star property
17.5 km from Fort Defiance State Park
6.6 out of 10, (613)
"Staff was great! Room was nice. "
United States
Lana
The price is AU$104
includes taxes & fees
23 Dec - 24 Dec
Super 8 by Wyndham Charleston/Sikeston East MO
Room, 1 King Bed, Non Smoking | View from room
Eagle Inn Charleston

Eagle Inn Charleston

Eagle Inn Charleston
2.0 star property
16.2 km from Fort Defiance State Park
6.6 out of 10, (104)
"Middle of nowhere hotel was ok"
United States
David
The price is AU$102
includes taxes & fees
23 Dec - 24 Dec
Eagle Inn Charleston
Basic Double Room | Living area
La Center Motel

La Center Motel

La Center Motel
2.0 star property
17.5 km from Fort Defiance State Park
7.8 out of 10, Good, (17)
"Quiet and convenient."
United States
Alma
La Center Motel
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top Fort Defiance State Park Hotel Reviews

Drury Inn & Suites Sikeston, MO

Drury Inn & Suites Sikeston, MO

10/10 Excellent
"Everything was well done"
Sue 1-night trip
Posted 4 days ago
Drury Inn & Suites Sikeston, MO

Hotels near other Fort Defiance State Park attractions

Columbus-Belmont State Park

3.7/5 (18 reviews)
You can learn about the history of Columbus when you stop by Columbus-Belmont State Park.
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Ullin City Hall

After visiting Ullin City Hall, make a plan to see the other sights and activities in Ullin. Amble around the area's parks or experience its museums.
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Frequently asked questions

What's the area like around Fort Defiance State Park?
Fort Defiance State Park is located in Cairo. When you want to settle in and find a place to stay, take a look at some of the hotels and other accommodation options that Expedia offers in the area.
What's the best place to stay close to Fort Defiance State Park?
Quality Inn Charleston - Sikeston is one of the top choices for your stay based on our traveller data, and this hotel offers free breakfast and free parking. You'll find it 12.6 mi (20.2 km) from Fort Defiance State Park. Other good choices around the area include Super 8 by Wyndham Charleston/Sikeston East MO and Drury Inn & Suites Sikeston, MO.
If I need to cancel the hotel reservation for my stay near Fort Defiance State Park, will I receive a refund?
Yes! The majority of hotel room reservations are fully refundable if cancelled prior to the hotel's cancellation deadline, which is often 24 or 48 hours before your check-in date. If your reservation is non-refundable, you might be able to cancel it and get a refund within 24 hours of booking. Put your dates in and click on "Search", then filter by "fully refundable" to review the best deals available near Fort Defiance State Park.