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Check prices for these dates

Tonight
19 Jan - 20 Jan
Tomorrow
20 Jan - 21 Jan
This weekend
23 Jan - 25 Jan
Next weekend
30 Jan - 1 Feb

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Our top choices for Cairo hotels

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Quality Inn Cairo I-57

Quality Inn Cairo I-57
2.5 star property
Cairo
6.6 out of 10, (275 reviews)
"The quality was not what I expected for a "Quality Inn". It felt more light a Motel 6. I was not satisfied at all."
United States
ReShena
The price is AU$118
includes taxes & fees
31 Jan - 1 Feb
Quality Inn Cairo I-57
Basic Double Room | Living area

La Center Motel

La Center Motel
2.0 star property
La Center
7.8 out of 10, Good, (17 reviews)
"Quiet and convenient."
United States
Alma
La Center Motel
Laptop workspace, blackout curtains, free cots/infant beds, free WiFi

Super 8 by Wyndham Charleston/Sikeston East MO

Super 8 by Wyndham Charleston/Sikeston East MO
2.0 star property
Charleston
6.8 out of 10, (620 reviews)
"Staff was great! Room was nice. "
United States
Lana
The price is AU$103
includes taxes & fees
21 Jan - 22 Jan
Super 8 by Wyndham Charleston/Sikeston East MO
Room, 1 King Bed, Non Smoking | View from room

Eagle Inn Charleston

Eagle Inn Charleston
2.0 star property
Charleston
6.6 out of 10, (105 reviews)
"Middle of nowhere hotel was ok"
United States
David
The price is AU$100
includes taxes & fees
21 Jan - 22 Jan
Eagle Inn Charleston
House (2 Bedrooms) | Interior

Quiet Country Stay: Modern Home Near Paducah

Quiet Country Stay: Modern Home Near Paducah
3.0 star property
Cunningham
The price is AU$434
includes taxes & fees
25 Jan - 26 Jan
Quiet Country Stay: Modern Home Near Paducah
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Stay near popular Cairo attractions

Fort Defiance State Park

Where the mighty Mississippi and Ohio rivers converge, Fort Defiance Park offers a rare view of this natural phenomenon. Explore the historic grounds where Lewis and Clark once trained the Corps of Discovery in 1803.
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Learn more about Cairo

At the confluence of the Mississippi and Ohio rivers, explore Cairo's historic Fort Defiance Park with its sweeping water views. History buffs shouldn't miss the Custom House Museum, where you can discover artefacts from this once-thriving river port town.

See all hotels in Cairo
Cairo Ohio River Bridge traversing over the Ohio River at sunset

Top Cairo Hotel Reviews

Recent Reviews in Cairo

Charming 3-bedroom house near ball park in quiet neighborhood

Charming 3-bedroom house near ball park in quiet neighborhood

10/10 Excellent
"This was our second time staying at this property. Everything was clean and just as advertised. We especially love the nice little touches to make this feel like home away from home for the night that we were there. The host was a great communicator. The check-in process was smooth."
Landon A. 1-night trip
Posted 8 days ago
Charming 3-bedroom house near ball park in quiet neighborhood

More cheap accommodation in Cairo

Eagle Inn Charleston

Eagle Inn Charleston

2811 East Marshall Street Charleston MO
The price is AU$100 per night from 21 Jan to 22 Jan
AU$100
21 Jan - 22 Jan
includes taxes & fees
6.6/10 (105 reviews)

Frequently asked questions

Where is the best place for a stay in Cairo?
Based on our traveller data, Quality Inn Cairo I-57 is one of the top choices for your stay. This hotel offers free breakfast and free parking. Two other choices for your stay in the area are Super 8 by Wyndham Charleston/Sikeston East MO and Eagle Inn Charleston. See all available top hotels, or vacation rentals in Cairo.
What are some of the best holiday rentals that Cairo has to offer?
Quiet Country Stay: Modern Home Near Paducah: This holiday home rental outside of Cairo offers a garden, a selection of games and a BBQ to help you feel perfectly comfortable in your new surroundings. Kitchen amenities include a fridge, a stovetop and a microwave. See all vacation rentals in Cairo.
If I need to cancel my hotel reservation in Cairo, will I receive a refund?
Yes, the majority of room reservations are refundable if you cancel before the accommodation's cancellation deadline, which is usually within 24-48 hours of your scheduled arrival. If you have a reservation that's non-refundable, you might be able to cancel it and receive a refund within 24 hours of your booking. Filter your search by fully refundable to find flexible hotel deals in Cairo.
What is staying in Cairo like?
Visitors can enjoy all that Cairo has to offer, including the restaurants, entertainment choices and riverfront. This city also attracts tourists with its small-town vibe. There are 25 hotels and other accommodation options in the surrounding area. Find out more about Cairo.
What should I do while I'm visiting Cairo?
The picturesque setting of Mississippi River and Ohio River Valley exemplify the area's natural beauty. Additionally, you might want to add Fort Defiance State Park to your itinerary. Take a look at what more there is to see and do in Expedia's Cairo guide.
What's the seasonal weather like in Cairo?
The hottest months are usually July and August, with an average temperature of 24°C, while the coldest months are January and February, with an average of 5°C. Average annual precipitation for Cairo is 1540 mm.

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