East Main Street Hotels, Grand Junction

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Check prices for these dates

Tonight
10 Dec - 11 Dec
Tomorrow
11 Dec - 12 Dec
This weekend
12 Dec - 14 Dec
Next weekend
19 Dec - 21 Dec

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Our top choices for East Main Street hotels

Restaurant
Tru by Hilton Grand Junction Downtown

Tru by Hilton Grand Junction Downtown

2.5 star property
Historic Grand Junction, 1.4 km from East Main Street
9.2 out of 10, Wonderful, (973)
"Spotless and modern rooms, great friendly staff. "
United States
Ruben
The price is AU$137
includes taxes & fees
21 Dec - 22 Dec
Tru by Hilton Grand Junction Downtown
Free continental breakfast
La Quinta Inn & Suites by Wyndham Grand Junction

La Quinta Inn & Suites by Wyndham Grand Junction

3.0 star property
Horizon Drive District, 5.4 km from East Main Street
8.8 out of 10, Excellent, (2708)
"Easy to check-in was a great quick stay"
United States
Stephanie
The price is AU$130
includes taxes & fees
14 Dec - 15 Dec
La Quinta Inn & Suites by Wyndham Grand Junction
Rooftop terrace
Hotel Maverick

Hotel Maverick

4.0 star property
Capitol Hill, 1.6 km from East Main Street
9.6 out of 10, Exceptional, (1004)
"Excellent place to stay in Grand Junction. "
United States
Steve
Hotel Maverick
Terrace/patio
Home2 Suites by Hilton Grand Junction Northwest

Home2 Suites by Hilton Grand Junction Northwest

3.0 star property
24 Road Corridor, 5.9 km from East Main Street
9.2 out of 10, Wonderful, (871)
"Great location, clean room, very pleasant staff "
United States
Allison
The price is AU$220
includes taxes & fees
21 Dec - 22 Dec
Home2 Suites by Hilton Grand Junction Northwest
Breakfast served
Grand Vista Hotel

Grand Vista Hotel

3.5 star property
Horizon Drive District, 5.5 km from East Main Street
8.2 out of 10, Very good, (3440)
"Good place to stay"
United States
Ramona
Grand Vista Hotel
Exterior
Holiday Inn & Suites Grand Junction by IHG

Holiday Inn & Suites Grand Junction by IHG

3.0 star property
Horizon Drive District, 5.4 km from East Main Street
8.6 out of 10, Excellent, (1000)
"Room clean and comfortable, staff was awesome and attentive "
United States
Kirstin
The price is AU$154
includes taxes & fees
5 Jan - 6 Jan 2026
Holiday Inn & Suites Grand Junction by IHG
Billiards
Clarion Inn Grand Junction

Clarion Inn Grand Junction

2.5 star property
Horizon Drive District, 5.3 km from East Main Street
8.4 out of 10, Very good, (1693)
"Very Clean, great beds, nice pool, great staff "
Canada
Deborah
The price is AU$124
includes taxes & fees
21 Dec - 22 Dec
Clarion Inn Grand Junction
Exterior
WoodSpring Suites Grand Junction

WoodSpring Suites Grand Junction

2.5 star property
24 Road Corridor, 5.9 km from East Main Street
6.4 out of 10, (892)
"I enjoy my stay here so much, I have decided to make it my long term resudence for a while. "
United States
Heather
The price is AU$93
includes taxes & fees
11 Dec - 12 Dec
WoodSpring Suites Grand Junction
Reception
Ramada by Wyndham Grand Junction

Ramada by Wyndham Grand Junction

2.5 star property
Horizon Drive District, 5.3 km from East Main Street
8.4 out of 10, Very good, (1854)
"We very much enjoyed our stay there!"
United States
Kathryn
The price is AU$101
includes taxes & fees
14 Dec - 15 Dec
Ramada by Wyndham Grand Junction
Property amenity
SpringHill Suites by Marriott Grand Junction Downtown/Historic Main St.

SpringHill Suites by Marriott Grand Junction Downtown/Historic Main St.

3.5 star property
Historic Grand Junction, 1.5 km from East Main Street
9.0 out of 10, Wonderful, (1002)
"Very nice family hotel with good breakfast."
United States
Margarita
The price is AU$201
includes taxes & fees
21 Dec - 22 Dec
SpringHill Suites by Marriott Grand Junction Downtown/Historic Main St.
Exterior
Hampton Inn Grand Junction Downtown/Historic Main Street

Hampton Inn Grand Junction Downtown/Historic Main Street

2.5 star property
Historic Grand Junction, 1.5 km from East Main Street
8.8 out of 10, Excellent, (1001)
"Love being in downtown Grand Junction. The hotel was very nice."
United States
Sherri
The price is AU$151
includes taxes & fees
21 Dec - 22 Dec
Hampton Inn Grand Junction Downtown/Historic Main Street
Lobby
Comfort Inn & Suites Fruita - Grand Junction

Comfort Inn & Suites Fruita - Grand Junction

2.5 star property
18.5 km from East Main Street
8.4 out of 10, Very good, (1002)
"The location was convenient and the staff was friendly. "
United States
Charles
The price is AU$117
includes taxes & fees
11 Dec - 12 Dec
Comfort Inn & Suites Fruita - Grand Junction
Terrace/patio
Courtyard by Marriott Grand Junction

Courtyard by Marriott Grand Junction

3.0 star property
Horizon Drive District, 5.6 km from East Main Street
8.4 out of 10, Very good, (1000)
"Friendly staff and clean room "
United States
Jennifer
The price is AU$161
includes taxes & fees
21 Dec - 22 Dec
Courtyard by Marriott Grand Junction
Lobby
Quality Inn Grand Junction near University

Quality Inn Grand Junction near University

3.0 star property
Horizon Drive District, 4.9 km from East Main Street
8.6 out of 10, Excellent, (1000)
"Great staff."
United States
Manford
The price is AU$109
includes taxes & fees
21 Dec - 22 Dec
Quality Inn Grand Junction near University
Terrace/patio
Doubletree Hotel Grand Junction

Doubletree Hotel Grand Junction

4.0 star property
Horizon Drive District, 5 km from East Main Street
8.0 out of 10, Very good, (1000)
"Good value, nice big room, convenient"
United States
Kathy
The price is AU$154
includes taxes & fees
4 Jan - 5 Jan 2026
Doubletree Hotel Grand Junction
Dinner served
Wine Country Inn Palisade

Wine Country Inn Palisade

3.5 star property
17.1 km from East Main Street
9.6 out of 10, Exceptional, (1001)
"We loved the location near the wineries. Great place to stay!!"
United States
Sara
Wine Country Inn Palisade
Lobby
Comfort Inn Grand Junction I-70

Comfort Inn Grand Junction I-70

2.5 star property
Horizon Drive District, 5.4 km from East Main Street
8.6 out of 10, Excellent, (1004)
"Manager was wonderful at check in, breakfast was good. "
United States
Dean
The price is AU$128
includes taxes & fees
14 Dec - 15 Dec
Comfort Inn Grand Junction I-70
Exterior
Holiday Inn Express & Suites Grand Junction by IHG

Holiday Inn Express & Suites Grand Junction by IHG

2.5 star property
24 Road Corridor, 5.9 km from East Main Street
8.6 out of 10, Excellent, (1000)
"The room was great and the staff was very nice. "
United States
Clarissa
The price is AU$269
includes taxes & fees
9 Jan - 10 Jan 2026
Holiday Inn Express & Suites Grand Junction by IHG
Free daily continental breakfast
Super 8 by Wyndham Fruita

Super 8 by Wyndham Fruita

2.0 star property
18.5 km from East Main Street
8.4 out of 10, Very good, (1001)
"Nice place with lots of food choices within a walkable block."
United States
Daniel
The price is AU$110
includes taxes & fees
11 Dec - 12 Dec
Super 8 by Wyndham Fruita
Property entrance
Best Western Grande River Inn & Suites

Best Western Grande River Inn & Suites

2.5 star property
8.7 km from East Main Street
8.8 out of 10, Excellent, (791)
"Room and breakfast was typucal, ut bummed the pool and hot tub were closed."
United States
Phil
The price is AU$147
includes taxes & fees
22 Dec - 23 Dec
Best Western Grande River Inn & Suites
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Our guide on where to stay in East Main Street

Find the best East Main Street areas for the activities you enjoy most.

Redlands

You'll enjoy the mountain views and wineries in Redlands. You might want to make time for a stop at Colorado National Monument or Redlands Mesa Golf Club.

Downtown

Though Downtown may not have many top sights, you can venture to the surrounding area to see attractions like Western Colorado Botanical Gardens and Bananas Fun Park.

Pear Park

While visiting Pear Park, you might make a stop by sights like Colorado River and James M. Robb – Colorado River State Park.

Historic Grand Junction

Visitors highly recommend Historic Grand Junction for its abundant dining options, and you can make a stop by Museum of the West while you're in town.

Horizon Drive District

Horizon Drive District might not have many top sights, but Grand Junction Motor Speedway and Canyon View Park are two attractions nearby that you can check out.

Top East Main Street Hotel Reviews

La Quinta Inn & Suites by Wyndham Grand Junction

La Quinta Inn & Suites by Wyndham Grand Junction

10/10 Excellent
"Ebjoyed our stay with our dog aswell very pet friendly no extra charge"
jaaron 1-night trip
Posted 1 day ago
La Quinta Inn & Suites by Wyndham Grand Junction

Frequently asked questions

What's it like in East Main Street?
Travellers will be sure to enjoy their time in Grand Junction's East Main Street neighbourhood.
Where is the best hotel for a stay in East Main Street?
Based on our traveller data, Downtown craftsman home with hot tub. 3 blocks from restaurants, shops and bars. is one of the top choices for your stay in East Main Street. This guest house offers private balconies and a fitness centre. Other good choices for your stay in the area include Grand Junction Vacation Rental w/ Fire Pit! and Launch your Colorado adventures – Historic Downtown convenience.
How many hotels can I expect to find in the East Main Street area?
If you're searching for places to stay in Grand Junction, Expedia has something to meet your needs with 22 East Main Street hotels and other accommodation options to choose from.
If I need to cancel my hotel reservation in East Main Street, will I receive a refund?
Yes! You'll find that most hotel bookings are fully refundable provided that you cancel prior to the hotel's cancellation deadline, which is often 24 or 48 hours before the scheduled arrival. If you have a non-refundable reservation, it might still be possible to cancel it and be given a refund within 24 hours of your booking. Enter your dates, click on "Search", then you can filter by "fully refundable" to get the best deals in East Main Street.
What is there to do around this Grand Junction neighbourhood?
A few places to visit in the area around East Main Street include Museum of the West, Western Colorado Botanical Gardens and Elliott Tennis Center. While you're out sightseeing, Western Colorado Center for the Arts and Tennis Junction Indoor Center are a couple of additional sights to visit in Grand Junction.