Downtown Hotels, Seneca

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Check prices for these dates

Tonight
31 Dec - 1 Jan
Tomorrow
1 Jan - 2 Jan
This weekend
2 Jan - 4 Jan
Next weekend
9 Jan - 11 Jan

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Our top choices for Downtown hotels

Free daily on-the-go breakfast
Quality Inn Seneca Clemson Area US-123

Quality Inn Seneca Clemson Area US-123

Quality Inn Seneca Clemson Area US-123
2.5 star property
Downtown
8.0 out of 10, Very good, (666)
"Good available parking. Room clean. Breakfast was minimal, but good. The tub was slippery and needed a mat. I almost fell a couple of times. I would stay here again."
United States
Denise
The price is AU$130
includes taxes & fees
11 Jan - 12 Jan 2026
Quality Inn Seneca Clemson Area US-123
Signature Cottage, 2 Bedrooms, Non Smoking, Patio | Private kitchen
Frank Howard 111 Farmhouse

Frank Howard 111 Farmhouse

Frank Howard 111 Farmhouse
3.0 star property
12.7 km from Downtown
9.8 out of 10, Exceptional, (10)
"Great stay "
United States
Johnny
The price is AU$355
includes taxes & fees
11 Jan - 12 Jan 2026
Frank Howard 111 Farmhouse
Lobby lounge
Inn @ Clemson

Inn @ Clemson

Inn @ Clemson
2.5 star property
11.6 km from Downtown
8.0 out of 10, Very good, (1002)
"Staff and hotel was amazing "
United States
Keren
Inn @ Clemson
Gazebo
Days Inn by Wyndham Clemson

Days Inn by Wyndham Clemson

Days Inn by Wyndham Clemson
3.5 star property
12.5 km from Downtown
7.0 out of 10, Good, (199)
"Great stay. Nice staff. "
United States
Daniel
The price is AU$140
includes taxes & fees
3 Jan - 4 Jan 2026
Days Inn by Wyndham Clemson
Reception hall
The Inn at Patrick Square

The Inn at Patrick Square

The Inn at Patrick Square
3.5 star property
15.2 km from Downtown
9.8 out of 10, Exceptional, (786)
"Everything was clean staff was courteous and accommodating. "
United States
Stewart
The price is AU$247
includes taxes & fees
4 Jan - 5 Jan 2026
The Inn at Patrick Square
Meeting facility
The Abernathy of Clemson

The Abernathy of Clemson

The Abernathy of Clemson
4.0 star property
10.1 km from Downtown
9.6 out of 10, Exceptional, (559)
"location is amazing! "
United States
colleen
The Abernathy of Clemson
Fireplace
Courtyard Marriott Clemson

Courtyard Marriott Clemson

Courtyard Marriott Clemson
3.0 star property
12.9 km from Downtown
9.2 out of 10, Wonderful, (525)
"Overall, great stay!"
United States
Lynn
The price is AU$196
includes taxes & fees
5 Jan - 6 Jan 2026
Courtyard Marriott Clemson
View from property
Clemson University's James F. Martin Inn

Clemson University's James F. Martin Inn

Clemson University's James F. Martin Inn
3.0 star property
10.3 km from Downtown
9.6 out of 10, Exceptional, (961)
"Great place to stay!"
United States
Mindi
The price is AU$247
includes taxes & fees
1 Jan - 2 Jan 2026
Clemson University's James F. Martin Inn
Free daily buffet breakfast
Hampton Inn Clemson-University Area

Hampton Inn Clemson-University Area

Hampton Inn Clemson-University Area
2.5 star property
9.7 km from Downtown
8.8 out of 10, Excellent, (624)
"Room was awesome and great breakfast "
United States
Guy
The price is AU$182
includes taxes & fees
8 Jan - 9 Jan 2026
Hampton Inn Clemson-University Area
Lobby
Comfort Inn & Suites Clemson - University Area

Comfort Inn & Suites Clemson - University Area

Comfort Inn & Suites Clemson - University Area
2.5 star property
11.7 km from Downtown
8.2 out of 10, Very good, (1000)
"Great area behind the hotel to walk my dog!!"
United States
Connie
The price is AU$170
includes taxes & fees
11 Jan - 12 Jan 2026
Comfort Inn & Suites Clemson - University Area
Room, 1 King Bed, Accessible, Non Smoking
Econo Lodge Clemson - University Area

Econo Lodge Clemson - University Area

Econo Lodge Clemson - University Area
2.0 star property
13.1 km from Downtown
7.2 out of 10, Good, (147)
"Enjoyed the stay! "
United States
Lawrence
The price is AU$142
includes taxes & fees
7 Jan - 8 Jan 2026
Econo Lodge Clemson - University Area
In-room safe, blackout curtains, soundproofing, iron/ironing board
The Shepherd Hotel Downtown Clemson

The Shepherd Hotel Downtown Clemson

The Shepherd Hotel Downtown Clemson
4.0 star property
10.6 km from Downtown
9.8 out of 10, Exceptional, (745)
"Staff was amazing and our room was clean and comfortable. "
United States
Amanda R
The price is AU$294
includes taxes & fees
1 Jan - 2 Jan 2026
The Shepherd Hotel Downtown Clemson
Signature Cottage, 2 Bedrooms | Living room
Clemson Memorabilia House

Clemson Memorabilia House

Clemson Memorabilia House
3.0 star property
12.7 km from Downtown
9.8 out of 10, Exceptional, (9)
"We enjoyed our stay, it was the perfect size for our family of four. "
United States
Ashley
The price is AU$355
includes taxes & fees
1 Jan - 2 Jan 2026
Clemson Memorabilia House
Exterior
Holiday Inn Express & Suites Clemson by IHG

Holiday Inn Express & Suites Clemson by IHG

Holiday Inn Express & Suites Clemson by IHG
2.5 star property
12.4 km from Downtown
8.8 out of 10, Excellent, (950)
"Had a great stay at this hotel. Conveniently located near restaurants. "
United States
Kelly
The price is AU$196
includes taxes & fees
9 Jan - 10 Jan 2026
Holiday Inn Express & Suites Clemson by IHG
Property amenity
Best Western Plus Clemson Hotel & Conference Center

Best Western Plus Clemson Hotel & Conference Center

Best Western Plus Clemson Hotel & Conference Center
2.5 star property
11.8 km from Downtown
8.2 out of 10, Very good, (1000)
"Clean room and staff were great’"
United States
Audrey
The price is AU$154
includes taxes & fees
4 Jan - 5 Jan 2026
Best Western Plus Clemson Hotel & Conference Center
Balcony
Fairfield Inn & Suites Seneca Clemson Univ Area

Fairfield Inn & Suites Seneca Clemson Univ Area

Fairfield Inn & Suites Seneca Clemson Univ Area
2.5 star property
2 km from Downtown
9.4 out of 10, Exceptional, (205)
"Nice hotel by the lake"
United States
Mike
The price is AU$204
includes taxes & fees
1 Jan - 2 Jan 2026
Fairfield Inn & Suites Seneca Clemson Univ Area
Aerial view
Lakeside Lodge Clemson

Lakeside Lodge Clemson

Lakeside Lodge Clemson
2.5 star property
8.6 km from Downtown
9.0 out of 10, Wonderful, (1000)
"Great place to stay. "
United States
Gene
The price is AU$202
includes taxes & fees
1 Jan - 2 Jan 2026
Lakeside Lodge Clemson
Lobby
Best Western Seneca-Clemson

Best Western Seneca-Clemson

Best Western Seneca-Clemson
2.5 star property
1.7 km from Downtown
8.4 out of 10, Very good, (643)
"The stay was amazing "
United States
Tabatha
The price is AU$147
includes taxes & fees
7 Jan - 8 Jan 2026
Best Western Seneca-Clemson
Terrace/patio
Hampton Inn & Suites Lavonia

Hampton Inn & Suites Lavonia

Hampton Inn & Suites Lavonia
2.5 star property
30.7 km from Downtown
9.0 out of 10, Wonderful, (380)
"Room was very clean & the staff was great."
United States
Kaye
The price is AU$224
includes taxes & fees
31 Jan - 1 Feb 2026
Hampton Inn & Suites Lavonia
Lobby
Super 8 by Wyndham Lavonia

Super 8 by Wyndham Lavonia

Super 8 by Wyndham Lavonia
2.0 star property
30.6 km from Downtown
6.6 out of 10, (498)
"clean room and staff really. "
United States
Kaylyn
The price is AU$115
includes taxes & fees
6 Jan - 7 Jan 2026
Super 8 by Wyndham Lavonia
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Our guide on where to stay in Downtown

Find the best Downtown areas for the activities you enjoy most.

Serenity Bay

When in Serenity Bay, you can plan a visit to Keowee Key Golf Course and Lake Keowee, some noteworthy sights in the nearby area.

Pine Ridge Point

If you're looking for some top things to see and do in Pine Ridge Point and surrounding area, you can visit Lake Keowee and Keowee Key Golf Course.

Indian Oaks

While Indian Oaks may not have many sights to explore, venturing just a little farther will lead you to top things to see and do like Keowee Reservoir and Oconee County Library Seneca Branch.

Keowee Plantation

While Keowee Plantation isn't home to many top sights, Keowee Reservoir and Oconee County Library Seneca Branch are some notable places to visit nearby.

Top Downtown Hotel Reviews

The Shepherd Hotel Downtown Clemson

The Shepherd Hotel Downtown Clemson

10/10 Excellent
"."
DEL 2-night trip
Posted 2 weeks ago
The Shepherd Hotel Downtown Clemson

Frequently asked questions

What is Downtown like?
Travellers to the Downtown neighbourhood in Seneca will be sure to enjoy their stay. Make sure that you visit Seneca Historic District and Oconee County Library Seneca Branch as part of your Downtown travel plans.
Where is the best place to stay in Downtown?
Based on Expedia customer reviews, Quality Inn Seneca Clemson Area US-123 is the highest ranked property in Downtown. This hotel offers free breakfast and free parking.
How many hotels will I be able to find in Downtown?
Expedia has 9 Downtown hotels and other accommodation options, and one might make a good home base for venturing out into the greater Seneca area.
If I need to cancel my hotel reservation in Downtown, will I receive a refund?
Yes! You'll find that most room reservations are refundable if you cancel prior to the hotel's cancellation deadline, which is usually within 24-48 hours of your check-in date. If your reservation is non-refundable, you might be able to still cancel and receive a refund within 24 hours of booking. Enter your dates, click on "Search", then use the filter option "fully refundable" to review the best deals in Downtown.
What can I see and do in this Seneca neighbourhood?
Seneca Historic District, Oconee County Library Seneca Branch and Bertha Lee Strickland Cultural Museum are just a few attractions to check out in Downtown. As you're discovering the neighbourhood, The Gauntlet and Seneca City Hall are some other places worth a visit. Golden Corner Plaza, Oconee Community Theatre and Applewood Shopping Center are just a few of the places to visit in and around Downtown. While you're out sightseeing in Seneca, make sure that you visit other sights such as Wyndham Plaza or Cross Creek Plantation Golf.