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Our top choices for Seneca hotels

Best Western Seneca-Clemson

Best Western Seneca-Clemson
2.5 star property
Seneca
8.4 out of 10, Very good, (646 reviews)
"The stay was amazing "
United States
Tabatha
The price is AU$150
includes taxes & fees
4 Feb - 5 Feb
Best Western Seneca-Clemson

Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy

Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy
2.0 star property
Seneca
9.8 out of 10, Exceptional, (55 reviews)
"Excellent stay."
United States
Beonca
The price is AU$211
includes taxes & fees
22 Jan - 23 Jan
Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy

Fairfield Inn & Suites Seneca Clemson Univ Area

Fairfield Inn & Suites Seneca Clemson Univ Area
2.5 star property
Seneca
9.4 out of 10, Exceptional, (206 reviews)
"Spotless, friendly staff, great location. "
United States
Cari
The price is AU$204
includes taxes & fees
26 Jan - 27 Jan
Fairfield Inn & Suites Seneca Clemson Univ Area

Hampton Inn & Suites Seneca-Clemson Area

Hampton Inn & Suites Seneca-Clemson Area
2.5 star property
Seneca
9.2 out of 10, Wonderful, (672 reviews)
"Everything was excellent "
United States
Debby
The price is AU$194
includes taxes & fees
25 Jan - 26 Jan
Hampton Inn & Suites Seneca-Clemson Area

Quality Inn Seneca Clemson Area US-123

Quality Inn Seneca Clemson Area US-123
2.5 star property
Seneca
8.0 out of 10, Very good, (670 reviews)
"Our stay was very nice. Clean room. The outside was clean. "
United States
Gayle
The price is AU$136
includes taxes & fees
28 Jan - 29 Jan
Quality Inn Seneca Clemson Area US-123

Lakeside Lodge Clemson

Lakeside Lodge Clemson
2.5 star property
Seneca
9.0 out of 10, Wonderful, (1,005 reviews)
"Great place to stay. "
United States
Gene
The price is AU$201
includes taxes & fees
24 Jan - 25 Jan
Lakeside Lodge Clemson

Tru by Hilton Seneca Clemson

Tru by Hilton Seneca Clemson
2.5 star property
Seneca
9.2 out of 10, Wonderful, (803 reviews)
"Perfect stay for a weekend. Lots of shopping and restaurants nearby. Clean safe area annd the staff was wonderful!"
United States
Cindy
The price is AU$159
includes taxes & fees
1 Feb - 2 Feb
Tru by Hilton Seneca Clemson

Days Inn by Wyndham Seneca / Clemson Area

Days Inn by Wyndham Seneca / Clemson Area
2.0 star property
Seneca
6.8 out of 10, (724 reviews)
"Room was clean. Quiet place to rest. Lisa at the front desk was very helpful and very nice. "
United States
Teresa
The price is AU$114
includes taxes & fees
25 Jan - 26 Jan
Days Inn by Wyndham Seneca / Clemson Area

Liberty Hall Bed and Breakfast

Liberty Hall Bed and Breakfast
4.0 star property
Pendleton
10.0 out of 10, Exceptional, (78 reviews)
"The owners are amazing. Comfy rooms, stellar breakfast and good people. "
United States
Renee
The price is AU$244
includes taxes & fees
25 Jan - 26 Jan
Liberty Hall Bed and Breakfast

Quality Inn & Suites Easley - Greenville

Quality Inn & Suites Easley - Greenville
2.5 star property
Easley
7.0 out of 10, Good, (393 reviews)
"The staff was pleasant and facility was clean."
United States
Eric
The price is AU$86
includes taxes & fees
28 Jan - 29 Jan
Quality Inn & Suites Easley - Greenville

Baymont by Wyndham Easley/Greenville

Baymont by Wyndham Easley/Greenville
2.5 star property
Easley
7.4 out of 10, Good, (765 reviews)
"Easy access from the highway lot of restaurants around the hotel and staff is very friendly"
United States
brian
The price is AU$108
includes taxes & fees
13 Feb - 14 Feb
Baymont by Wyndham Easley/Greenville

Days Inn by Wyndham Easley/Greenville/Clemson Area

Days Inn by Wyndham Easley/Greenville/Clemson Area
2.0 star property
Easley
6.2 out of 10, (827 reviews)
"It was like always pretty ok"
United States
Sasha
The price is AU$101
includes taxes & fees
6 Feb - 7 Feb
Days Inn by Wyndham Easley/Greenville/Clemson Area

Frank Howard 111 Farmhouse

Frank Howard 111 Farmhouse
3.0 star property
Clemson
9.8 out of 10, Exceptional, (10 reviews)
"Great stay "
United States
Johnny
The price is AU$397
includes taxes & fees
18 Feb - 19 Feb
Frank Howard 111 Farmhouse

Inn @ Clemson

Inn @ Clemson
2.5 star property
Clemson
8.2 out of 10, Very good, (1,004 reviews)
"Love this hotel. It’s a little home away from home for me ❤️❤️❤️"
United States
Stacey
Inn @ Clemson

Best Western Plus Clemson Hotel & Conference Center

Best Western Plus Clemson Hotel & Conference Center
2.5 star property
Clemson
8.2 out of 10, Very good, (1,000 reviews)
"Rooms are clean. Staff was very pleasant. "
United States
Regina
The price is AU$156
includes taxes & fees
25 Jan - 26 Jan
Best Western Plus Clemson Hotel & Conference Center

The Shepherd Hotel Downtown Clemson

The Shepherd Hotel Downtown Clemson
4.0 star property
Clemson
9.8 out of 10, Exceptional, (752 reviews)
"Awesome hotel and very convenient for visiting Clemson."
United States
Nina
The price is AU$312
includes taxes & fees
22 Jan - 23 Jan
The Shepherd Hotel Downtown Clemson

Courtyard Marriott Clemson

Courtyard Marriott Clemson
3.0 star property
Clemson
9.0 out of 10, Wonderful, (528 reviews)
"Overall, great stay!"
United States
Lynn
The price is AU$206
includes taxes & fees
28 Jan - 29 Jan
Courtyard Marriott Clemson

Holiday Inn Express & Suites Clemson by IHG

Holiday Inn Express & Suites Clemson by IHG
2.5 star property
Clemson
8.8 out of 10, Excellent, (955 reviews)
"Staff"
United States
barry
The price is AU$203
includes taxes & fees
15 Feb - 16 Feb
Holiday Inn Express & Suites Clemson by IHG

Clemson University's James F. Martin Inn

Clemson University's James F. Martin Inn
3.0 star property
Clemson
9.6 out of 10, Exceptional, (964 reviews)
"Great place to stay!"
United States
Mindi
The price is AU$246
includes taxes & fees
22 Jan - 23 Jan
Clemson University's James F. Martin Inn

Comfort Inn & Suites Clemson - University Area

Comfort Inn & Suites Clemson - University Area
2.5 star property
Clemson
8.2 out of 10, Very good, (1,000 reviews)
"Clean room. Friendly staff. Convenient location."
United States
Anita
The price is AU$156
includes taxes & fees
28 Jan - 29 Jan
Comfort Inn & Suites Clemson - University Area
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Our guide on where to stay in Seneca

Find the best Seneca areas for the activities you enjoy most. Learn more about Seneca
Learn more about Seneca

Downtown

City centre Seneca captures the essence of small-town Southern charm with its well-preserved railway heritage and historic brick buildings. Tree-lined streets lead to charming shops and local eateries housed in structures dating back to the 1800s. Ram Cat Alley's colourful murals tell stories of local history while the old courthouse square hosts community gatherings. This walkable district offers a peaceful retreat from big city life. Visitors can browse antique stores for railway memorabilia, sample authentic Southern comfort food, or explore the cultural exhibits at the Bertha Lee Strickland Museum. The nearby Lake Keowee provides outdoor recreation just minutes away.

Serenity Bay

Serenity Bay offers a peaceful retreat within Saxony Forest's coastal embrace. The quiet residential streets wind through mature trees, creating a tranquil atmosphere away from tourist crowds. Nature lovers can explore nearby Lake Keowee or enjoy the neighborhood's forest trails. The area perfectly balances woodland serenity with beach proximity. Visitors should plan for self-contained holiday rentals rather than hotels. While dining options are limited within the area, the natural surroundings provide ideal conditions for relaxation and outdoor recreation.

Pine Ridge Point

Lake Keowee's serene waters lap against the shores of Pine Ridge Point, a tranquil residential haven in Seneca. Private docks stretch into crystal-clear waters where boats gently bob. Towering pines create natural privacy between lakefront homes. Visitors enjoy peaceful mornings watching mist rise over the water. This area offers an authentic lakeside living experience without tourist crowds. Holiday rentals range from cosy cabins to luxury estates with private boat slips. Days revolve around swimming, fishing, and water sports on Lake Keowee. Nature trails wind through mature forests for hiking and birdwatching.

Indian Oaks

Indian Oaks offers a tranquil retreat in suburban Seneca where mature oak trees create natural canopies over peaceful residential streets. This family-oriented community provides an authentic glimpse into American suburban living without tourist crowds. Landscaped yards and community green spaces showcase South Carolina's native beauty. Visitors can enjoy quiet morning walks on spacious pavements while listening to birdsong. Lake Keowee lies just beyond the area boundaries for those seeking water activities. With minimal commercial presence, Indian Oaks delivers a genuinely restful experience away from urban bustle.

Stay near popular Seneca attractions

Learn more about Seneca

Nestled along Lake Keowee's shoreline, this charming town offers spectacular waterfront activities from kayaking to fishing at South Cove County Park. Nearby Stumphouse Tunnel and Issaqueena Falls provide fascinating historical exploration and refreshing natural beauty, especially during summer's humid afternoons.

Lake Keowee South Carolina

Top Seneca Hotel Reviews

Recent Reviews in Seneca

More cheap accommodation in Seneca

Frequently asked questions

Where is the best place for a stay in Seneca?
Tru by Hilton Seneca Clemson is ranked highly by Expedia customers. This hotel offers free breakfast and free parking. Traveller reviews also recommend Lakeside Lodge Clemson and Hampton Inn & Suites Seneca-Clemson Area as top choices for your visit. See all available top hotels, or vacation rentals in Seneca.
What are some of the best holiday rentals that Seneca has to offer?
Quiet cove, deep water, minutes to Clemson, pet friendly, easy path to the dock: This highly rated holiday home rental in Seneca is located on a lake, and has a patio, a private garden and a BBQ to put you at ease in your new surroundings. It has 4 bedrooms, as well as a kitchen with a dishwasher, a fridge and a stovetop, so that you can cook with friends or family. You and your friends and family can relax into your holiday with amenities such as a selection of games. Some other homes for rent in Seneca include Luxury 4BR/4BA Lake Keowee Retreat- Mountain Cabin Vibes + Private Dock and Beautiful waterfront home on a private cove in Lake Keowee w/ hot tub. See all vacation rentals in Seneca.
If I need to cancel my hotel reservation in Seneca, will I receive a refund?
Yes! You'll find that most room reservations are fully refundable if cancelled before the accommodation's cancellation deadline, which is often 24 or 48 hours before the scheduled arrival. If you have a reservation that's non-refundable, you might still have the option to cancel and get a refund within 24 hours of your booking. Filter your search by fully refundable to find flexible hotel deals in Seneca.
What's the best family accommodation in Seneca?
Fairfield Inn & Suites Seneca Clemson Univ Area is a hotel with an outdoor pool and free parking, and it's a top choice on Expedia for families. Also, attractions in the area such as Ultimate Action Sports are fun for the whole family. Find more child-friendly accommodations in Seneca.
What is the top LGBTQ-friendly accommodation in Seneca?
Hampton Inn & Suites Seneca-Clemson Area is a top LGBTQ-friendly hotel that features free breakfast and free Wi-Fi. Tru by Hilton Seneca Clemson is another good choice for your trip. See all available hotels listed as LGBTQ-friendly in Seneca.
What's the best dog-friendly hotel in Seneca?
Lakeside Lodge Clemson is a top hotel for people travelling with their pets, and offers a restaurant and a seasonal outdoor pool for its human guests. Other good choices for you and your pet's trip include Days Inn by Wyndham Seneca / Clemson Area and Tru by Hilton Seneca Clemson. See more pet-friendly hotel accommodations in Seneca.
What are some hotels with pools in Seneca?
Lakeside Lodge Clemson: Hotel located near Clemson University. Features free self parking, a seasonal outdoor pool and complimentary wireless Internet access. Quality Inn Seneca Clemson Area US-123 and Hampton Inn & Suites Seneca-Clemson Area are two additional hotels that feature an on-site pool. View all hotels with pools in Seneca.
What is staying in Seneca like?
Visitors to Seneca will definitely enjoy the sporting events, lakeside setting and university setting. Welcoming and scenic, this city also attracts tourists with its cafes. In Seneca, there are 289 hotels and other accommodation options to choose from. Find out more about Seneca.
What should I see while I'm in Seneca?
Cultural venues include The Gauntlet and Oconee Community Theatre. Natural beauty is on display at Keowee Reservoir, Lake Keowee and Lake Hartwell. Exploring the waterfront is a great activity, and Keowee Key Golf Course is one place to visit. Take a look at what more there is to see and do in Expedia's Seneca guide.
What's the seasonal weather in Seneca?
The hottest months are usually July and August, with an average temperature of 25°C, while the coldest months are January and February, with an average of 8°C. Average annual precipitation for Seneca is 1565 mm.

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