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Our top choices for Commerce hotels

Rockwood Inn

Rockwood Inn
2.0 star property
Cape Girardeau
10.0 out of 10, Exceptional, (19)
"My stay was cozy, warm and inviting, and absolutely wonderful shower. I will definitely be returning! "
United States
Kim
The price is AU$255
includes taxes & fees
8 Jan - 9 Jan 2026
Rockwood Inn

Town House Inn Cape Giradreau

Town House Inn Cape Giradreau
2.5 star property
Cape Girardeau
6.0 out of 10, (206)
"This is a unique place, having a kitchen and clean and spacious rooms, very comfortable"
United States
Larry
Travelling for leisure
The price is AU$96
includes taxes & fees
4 Jan - 5 Jan 2026
Town House Inn Cape Giradreau

Drury Inn & Suites Cape Girardeau

Drury Inn & Suites Cape Girardeau
3.0 star property
Cape Girardeau
9.4 out of 10, Exceptional, (1003)
"Great room, free coffee and soda."
United States
Tara
Travelling for leisure
The price is AU$152
includes taxes & fees
4 Jan - 5 Jan 2026
Drury Inn & Suites Cape Girardeau

Tru By Hilton Cape Girardeau

Tru By Hilton Cape Girardeau
2.5 star property
Cape Girardeau
9.6 out of 10, Exceptional, (104)
"Easy parking. clean and safe lot and location. comfortable bed and decent shower"
United States
Timothy
Travelling for leisure
The price is AU$152
includes taxes & fees
7 Jan - 8 Jan 2026
Tru By Hilton Cape Girardeau

Candlewood Suites Cape Girardeau by IHG

Candlewood Suites Cape Girardeau by IHG
2.5 star property
Cape Girardeau
8.2 out of 10, Very good, (886)
"The hotel room was very, very spacious!!"
United States
Connie
Travelling for leisure
The price is AU$126
includes taxes & fees
25 Jan - 26 Jan 2026
Candlewood Suites Cape Girardeau by IHG

Hampton Inn Cape Girardeau I 55 East

Hampton Inn Cape Girardeau I 55 East
2.5 star property
Cape Girardeau
9.6 out of 10, Exceptional, (785)
"the hotel was clean and conveniently located to the sportsplex"
United States
Jaime
Travelling for leisure
The price is AU$178
includes taxes & fees
8 Jan - 9 Jan 2026
Hampton Inn Cape Girardeau I 55 East

Fairfield Inn & Suites by Marriott Cape Girardeau

Fairfield Inn & Suites by Marriott Cape Girardeau
2.5 star property
Cape Girardeau
9.4 out of 10, Exceptional, (145)
"Other than that the room was very clean and tidy."
United States
Hollis
Travelling for leisure
The price is AU$148
includes taxes & fees
8 Jan - 9 Jan 2026
Fairfield Inn & Suites by Marriott Cape Girardeau

Pear Tree Inn Cape Girardeau Near the Medical Center

Pear Tree Inn Cape Girardeau Near the Medical Center
2.5 star property
Cape Girardeau
9.0 out of 10, Wonderful, (1003)
"Very friendly people, clean rooms, comfortable bed, great breakfast,"
United States
Tammy
Travelling with family
The price is AU$118
includes taxes & fees
4 Jan - 5 Jan 2026
Pear Tree Inn Cape Girardeau Near the Medical Center

Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
2.5 star property
Cape Girardeau
9.4 out of 10, Exceptional, (1000)
"the room was very clean, accommodating all my needs"
United States
Frank
Travelling with family
The price is AU$153
includes taxes & fees
11 Jan - 12 Jan 2026
Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

The Riverview

The Riverview
4.0 star property
Cape Girardeau
9.4 out of 10, Exceptional, (479)
"Very nice rooms, hotel overall is clean"
United States
Courtney
Travelling for leisure
The price is AU$157
includes taxes & fees
4 Jan - 5 Jan 2026
The Riverview

Quality Inn Cape Girardeau North

Quality Inn Cape Girardeau North
2.5 star property
Cape Girardeau
7.2 out of 10, Good, (689)
"The breakfast was well stocked, however, and the pool was nice."
United States
WAYNE
Travelling for business
The price is AU$100
includes taxes & fees
8 Jan - 9 Jan 2026
Quality Inn Cape Girardeau North

Courtyard by Marriott Cape Girardeau Downtown

Courtyard by Marriott Cape Girardeau Downtown
3.0 star property
Cape Girardeau
9.6 out of 10, Exceptional, (469)
"Room was comfortable and clean"
United States
Richard
Travelling for leisure
The price is AU$205
includes taxes & fees
25 Jan - 26 Jan 2026
Courtyard by Marriott Cape Girardeau Downtown

Drury Plaza Hotel Cape Girardeau Conference Center

Drury Plaza Hotel Cape Girardeau Conference Center
3.0 star property
Cape Girardeau
9.6 out of 10, Exceptional, (1000)
"Our room was clean and comfortable."
United States
John
Travelling for leisure
The price is AU$152
includes taxes & fees
4 Jan - 5 Jan 2026
Drury Plaza Hotel Cape Girardeau Conference Center

La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau

La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau
3.0 star property
Jackson
8.8 out of 10, Excellent, (680)
"But the hotel was clean and the front desk lady was very nice"
United States
Rosie
Travelling for leisure
The price is AU$131
includes taxes & fees
4 Jan - 5 Jan 2026
La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau

Drury Inn & Suites Sikeston, MO

Drury Inn & Suites Sikeston, MO
3.0 star property
Sikeston
9.4 out of 10, Exceptional, (1005)
"Clean room, great location and friendly staff"
United States
Mark
The price is AU$155
includes taxes & fees
4 Jan - 5 Jan 2026
Drury Inn & Suites Sikeston, MO

Comfort Suites Jackson-Cape Girardeau

Comfort Suites Jackson-Cape Girardeau
2.5 star property
Jackson
8.2 out of 10, Very good, (740)
"Room was clean and affordable for one night"
United States
Lori
Travelling solo
The price is AU$129
includes taxes & fees
4 Jan - 5 Jan 2026
Comfort Suites Jackson-Cape Girardeau

Country Yard Inn and Suite

Country Yard Inn and Suite
2.0 star property
Sikeston
6.8 out of 10, (121)
"Great spot en route home from Mississippi. Staff put me in a room that ended up being in a quiet section of the hotel. Great sleep."
United States
Andrew
The price is AU$95
includes taxes & fees
31 Dec - 1 Jan 2026
Country Yard Inn and Suite

Pear Tree Inn Cape Girardeau West

Pear Tree Inn Cape Girardeau West
2.5 star property
Cape Girardeau
9.0 out of 10, Wonderful, (1004)
"Staff very good, clean room and easy access to shopping near by."
United States
William
Travelling with pet
The price is AU$118
includes taxes & fees
4 Jan - 5 Jan 2026
Pear Tree Inn Cape Girardeau West

Super 8 by Wyndham Charleston/Sikeston East MO

Super 8 by Wyndham Charleston/Sikeston East MO
2.0 star property
Charleston
6.6 out of 10, (615)
"the bathroom is also very clean"
United States
Yan Robby
Travelling for business
The price is AU$103
includes taxes & fees
30 Jan - 31 Jan 2026
Super 8 by Wyndham Charleston/Sikeston East MO

Quality Inn Cairo I-57

Quality Inn Cairo I-57
2.5 star property
Cairo
6.6 out of 10, (275)
"The only good thing about the stay is the beds were comfortable"
United States
NICOLE
Travelling for business
The price is AU$118
includes taxes & fees
17 Jan - 18 Jan 2026
Quality Inn Cairo I-57
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top Commerce Hotel Reviews

Recent Reviews in Commerce

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Frequently asked questions

What's the best place to stay in Commerce?
Drury Plaza Hotel Cape Girardeau Conference Center, located 12.6 mi (20.3 km) from the heart of Commerce, is a top choice for your stay, based on our traveller data. Two other choices for your visit to the area are The Riverview and La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau. See all available top hotels, or vacation rentals in Commerce.
What are some of the best holiday rentals that Commerce has to offer?
Little Blue Cottage on Spanish: This holiday home rental outside of Commerce comes with WiFi so that you can feel at home during your trip. See all vacation rentals in Commerce.
If I need to cancel my hotel reservation in Commerce, will I receive a refund?
Yes! The majority of hotel bookings are refundable provided that you cancel prior to the accommodation's cancellation deadline, which often is within 24-48 hours of your arrival date. If your reservation is non-refundable, you might be able to cancel it and be given a refund within a 24-hour period of booking. Filter your search by fully refundable to find flexible hotel deals in Commerce.
How is it to stay in Commerce?
Travellers to Commerce will find plenty to explore and enjoy. There are 79 hotels and other accommodation options in the surrounding area. Find out more about Commerce.
What should I see while I'm in Commerce?
A favourite place to visit is Mississippi River. You'll also find Isle Casino Cape Girardeau and Show Me Center in the area. Take a look at what more there is to see and do in Expedia's Commerce guide.
What's the seasonal weather in Commerce?
The hottest months are usually July and August, with an average temperature of 25°C, while the coldest months are January and February, with an average of 5°C. Average annual precipitation for Commerce is 1491 mm.

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