
Sikeston Holidays
Book a Hotel + Flight or Car together to unlock savings
Photo by Ryan Coleman
Your Sikeston Holiday
With a reputation for its rich history and rural countryside, Sikeston is an ideal getaway destination. Lock in one of our Sikeston holiday packages and discover all that this lively city has to offer. Fill your schedule with tours of The Book Bug, Sikeston Depot Museum and Central Park, some of the attractions you should see during a trip to Sikeston. Expedia can help you escape your routine. Tailor your holiday to Sikeston to suit your style of travel, whatever that may be!
Sikeston Holiday
Sikeston Essential Information
Language | English |
---|---|
Currency | U.S dollars |
Closest Airport | Cape Girardeau Municipal Airport (CGI) |
Population | 16,400 |
Max Temp Winter | 7ºC |
Max Temp Summer | 29ºC |
Top Sights | Sikeston Depot Museum, Central Park and The Book Bug |
Our pick of the best Sikeston Hotel Deals

Best Western Plus Sikeston
120 S Interstate Drive, Sikeston, MO
Fully refundableReserve now, pay when you stay
The price is AU$155 per night from 10 Aug to 11 Aug
AU$155
10 Aug - 11 Aug
includes taxes & fees
8.2/10 Very Good! (1,000 reviews)
"It was clean & nice, but the person greeting us was not very personable, just rattled off the lines of the hotel policies. It felt like they went cheap on things like toilet paper, kleenex, towels, bathroom sink drain didn't work, bathtub was slippery, and no charging ports for electronics, just ..."
Reviewed on 29 Jul. 2025

Drury Inn & Suites Sikeston, MO
2608 East Malone Ave, Miner, Sikeston, MO
Fully refundableReserve now, pay when you stay
The price is AU$160 per night from 17 Aug to 18 Aug
AU$160
17 Aug - 18 Aug
includes taxes & fees
9.4/10 Exceptional! (1,001 reviews)
"Enjoyed everything"
Reviewed on 19 Jul. 2025

Days Inn and Suites by Wyndham Sikeston
220 S Interstate Dr, Sikeston, MO
Fully refundableReserve now, pay when you stay
The price is AU$127 per night from 18 Aug to 19 Aug
AU$127
18 Aug - 19 Aug
includes taxes & fees
7.2/10 Good! (1,001 reviews)
Nice, comfortable
"The staff and room were nice. I did not like that they actually took a deposit out of my account and put it back instead of just held it like other hotels I've been at."
Reviewed on 26 Jul. 2025
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.