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Top Adventure Southeast Minnesota Hotels

Kahler Grand Hotel

20 2nd Ave Sw Rochester MN

2 min walk from Mayo Clinic

Stay at this business-friendly hotel in Rochester. Enjoy free Wi-Fi, 2 restaurants and breakfast (surcharge). Our guests praise the helpful staff and the clean ...

8.4/10 Very good! (2,165 reviews)

"I loved it was right across the street from Mayo Clinic. On Thursday evenings downtown they have a marvelous festival with music and so many vendors. You have to check out the fudge. The staff was great and I received immediate results from questions and requests."

Reviewed on 26 June 2026

Willow Inn Suites Rochester

4323 Highway 52 North, West Frontage Rd Rochester MN

10 min drive from Mayo Clinic

Stay at this business-friendly hotel in Rochester. Enjoy free Wi-Fi, free parking and a 24-hour front desk. Our guests praise the helpful staff in their reviews. ...

Hotel Indigo Rochester – Mayo Clinic Area by IHG

220 S Broadway Rochester MN

6 min walk from Mayo Clinic

Stay at this business-friendly hotel in Rochester. Enjoy free Wi-Fi, a rooftop terrace and breakfast (surcharge). Our guests praise the restaurant and the helpful ...

8.8/10 Excellent! (1,002 reviews)

"This is a well located property, close to restaurants, shopping, and Mayo Clinic. The staff was very understanding of the fluidity of my stay due to appointments at Mayo Clinic. The property doesn't have some of the amenities of other more expensive hotels in the area, but it is a great value for ..."

Reviewed on 25 June 2026

See all 915 properties in Southeast Minnesota

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.