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Top Adults Only Southeastern United States Hotels

Shoreline Island Resort - Exclusively Adult

14200 Gulf Boulevard Madeira Beach FL

4 hours drive from Walt Disney World® Resort

Stay at this beach aparthotel in Madeira Beach. Enjoy free Wi-Fi, free parking and a beach locale. Our guests praise the helpful staff in their reviews. Popular ...

9.2/10 Wonderful! (1,488 reviews)

"Good deal for the money good deal for the money"

Reviewed on 28 June 2026

The Southernmost Inn - Adults Only

525 United Street Key West FL

11 hours drive from Walt Disney World® Resort

Stay at this hotel in Key West. Enjoy free breakfast, 2 outdoor pools and parking (surcharge). Our guests praise the breakfast and the pool in their reviews. ...

8.4/10 Very good! (1,398 reviews)

"We were told we would have housecleaning every other day, we did not get it even one day. We had to keep going to the desk to get new towels, toilet paper soap. We even hung the sign on the door stating that we wanted it cleaned, and it was never cleaned. They messed up our parking and when we returned ..."

Reviewed on 3 July 2026

Paradise Inn Key West - Adults Only

819 Simonton Street Key West FL

11 hours drive from Walt Disney World® Resort

Stay at this business-friendly hotel in Key West. Enjoy free breakfast, parking (surcharge) and a garden. Our guests praise the breakfast and the pool in their ...

9.2/10 Wonderful! (1,000 reviews)

"Great boutique hotel close to every thing. Very impressed with the king suite it was so large and overlooked the pool. Nicely updated. Air conditioning was ice cold worked very well. Great happy hour with wine cheese and crackers. The girl at the front office goes out of her way to make sure you ..."

Reviewed on 1 July 2026

See all 475,603 properties in Southeastern United States

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.