Northeast Missouri Adults Only Holidays 2026

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Top Adults Only Northeast Missouri Hotels

Historic Iron Horse Inn

207 E. 4th Street Hermann MO

2 hours drive from St. Louis Union Station

Stay at this B&B in Hermann. Enjoy free breakfast, free parking and a garden. Popular attractions Tin Mill Brewery and Hermannhof Vineyards are located ...

8.4/10 Very good! (21 reviews)

"The inn keeper was fabulous. The rooms were clean and cozy. Will defiantly be back."

Reviewed on 30 Oct 2023

Moonrise Hotel

6177 Delmar Blvd St. Louis MO

10 min drive from St. Louis Union Station

Stay at this boutique hotel in St. Louis. Enjoy free Wi-Fi, free parking and 2 bars/lounges. Our guests praise the restaurant and the helpful staff in their ...

9/10 Wonderful! (2,031 reviews)

"The room could use a few more usb charging ports. But very nice"

Reviewed on 2 Oct 2026

See all 3,002 properties in Northeast Missouri

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.