Plan, book, travel with confidence
Better together
Save up to AU$2,500 when you book a flight and hotel together*
Find the right fit
With over 300,000 hotels worldwide, it's easy to create a perfect package
Rest easy
Plan, book, and manage your trip all in one place

Top Adults Only Charleston Hotels

86 Cannon Charleston - Adults Only

86 Cannon Street Charleston SC

5 min walk from Medical University of South Carolina

Stay at this luxury inn in Charleston. Enjoy free breakfast, free Wi-Fi and free bicycles on-site. Popular attractions Charleston City Market and South Carolina ...

Detached Guest Suite

Charleston SC

10 min drive from Medical University of South Carolina

Stay at this golf cottage in Charleston. Enjoy free Wi-Fi, a garden and laundry facilities. Our guests praise the pool and the helpful staff in their reviews. ...

10/10 Exceptional! (208 reviews)

Had a wonderful stay at this Vrbo. perfect for what we needed and the location to our event was close. would defiantly use this place again.

Reviewed on 6 May 2026

Downtown-One-of-a-Kind Romantic Luxury Residence 5BR, 3BA Sleeps 10 to 12

Charleston SC

8 min walk from Medical University of South Carolina

Stay at this apartment in Charleston. Enjoy laundry facilities, tennis courts and patios. Popular attractions South Carolina Aquarium and Charleston City Market ...

9.8/10 Exceptional! (69 reviews)

Everything was clean and organized. So nice to have a dedicated place to park. The host responded immediately to any questions we may have had. The kitchen was quite large and had a very nice porch if you chose to eat outside. Very nice stay

Reviewed on 23 Apr 2026

See all 5,043 properties in Charleston

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.