Cheap Flights from Des Moines (DSM) to Chicago (ORD)

View AU$329 flight on Sat, 6 Sep. 2025Opens in a new window

Popular airlines from Des Moines International Airport (DSM) to Chicago O'Hare International Airport (ORD)

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Cheap Flights from Des Moines (DSM) to Chicago (ORD)

Prices were available within the past 7 days for one-way flights and round trip tickets for the period specified. Prices and availability are subject to change. Additional terms apply.

American Airlines
Wed, 10 Sep. - Wed, 17 Sep.
DSM
Des Moines
ORD
Chicago
AU$287 Return, found 2 days ago
AU$287
Return
found 2 days ago
Select American Airlines flight, departing Wed, 10 Sep. from Des Moines to Chicago, returning Wed, 17 Sep., priced at AU$287 found 2 days ago
American Airlines
Fri, 12 Sep. - Fri, 19 Sep.
DSM
Des Moines
ORD
Chicago
AU$289 Return, found 1 day ago
AU$289
Return
found 1 day ago
Select American Airlines flight, departing Fri, 12 Sep. from Des Moines to Chicago, returning Fri, 19 Sep., priced at AU$289 found 1 day ago
American Airlines
Sat, 6 Sep. - Sat, 13 Sep.
DSM
Des Moines
ORD
Chicago
AU$290 Return, found 6 days ago
AU$290
Return
found 6 days ago
Select American Airlines flight, departing Sat, 6 Sep. from Des Moines to Chicago, returning Sat, 13 Sep., priced at AU$290 found 6 days ago
Delta
Wed, 10 Sep. - Wed, 17 Sep.
DSM
Des Moines
ORD
Chicago
AU$316 Return, found 2 days ago
AU$316
Return
found 2 days ago
Select Delta flight, departing Wed, 10 Sep. from Des Moines to Chicago, returning Wed, 17 Sep., priced at AU$316 found 2 days ago
Delta
Sat, 6 Sep. - Sat, 13 Sep.
DSM
Des Moines
ORD
Chicago
AU$320 Return, found 6 days ago
AU$320
Return
found 6 days ago
Select Delta flight, departing Sat, 6 Sep. from Des Moines to Chicago, returning Sat, 13 Sep., priced at AU$320 found 6 days ago
American Airlines
Wed, 10 Sep. - Wed, 17 Sep.
DSM
Des Moines
ORD
Chicago
AU$348 Return, found 2 days ago
AU$348
Return
found 2 days ago
Select American Airlines flight, departing Wed, 10 Sep. from Des Moines to Chicago, returning Wed, 17 Sep., priced at AU$348 found 2 days ago
American Airlines
Fri, 12 Sep. - Fri, 19 Sep.
DSM
Des Moines
ORD
Chicago
AU$349 Return, found 1 day ago
AU$349
Return
found 1 day ago
Select American Airlines flight, departing Fri, 12 Sep. from Des Moines to Chicago, returning Fri, 19 Sep., priced at AU$349 found 1 day ago
American Airlines
Sat, 6 Sep. - Sat, 13 Sep.
DSM
Des Moines
ORD
Chicago
AU$352 Return, found 6 days ago
AU$352
Return
found 6 days ago
Select American Airlines flight, departing Sat, 6 Sep. from Des Moines to Chicago, returning Sat, 13 Sep., priced at AU$352 found 6 days ago
Delta
Wed, 10 Sep. - Wed, 17 Sep.
DSM
Des Moines
ORD
Chicago
AU$363 Return, found 2 days ago
AU$363
Return
found 2 days ago
Select Delta flight, departing Wed, 10 Sep. from Des Moines to Chicago, returning Wed, 17 Sep., priced at AU$363 found 2 days ago
United
Wed, 10 Sep. - Wed, 17 Sep.
DSM
Des Moines
ORD
Chicago
AU$378 Return, found 2 days ago
AU$378
Return
found 2 days ago
Select United flight, departing Wed, 10 Sep. from Des Moines to Chicago, returning Wed, 17 Sep., priced at AU$378 found 2 days ago

Find the cheapest month to fly from Des Moines (DSM) to Chicago (ORD)

September is typically the cheapest month to fly

From AU$212 - AU$451 per traveller.

Graph displaying average flight prices per month

Flight from Des Moines to Chicago route information
Origin airport
Des Moines Intl.
Destination airport
O'Hare Intl.
Airlines serving
American Airlines, Delta, United
Return price
AU$286
Distance
476 km
Average flight time
1 hour 30 mins

Your quick guide to flights from Des Moines to Chicago

Pick up great flights from Des Moines to Chicago

With Expedia, you have your pick of 46 flights a day with 20 airlines covering flights from Des Moines to Chicago. Whether you’re on a business trip, a family holiday or a luxury break, just enter your travel dates, hit search then check out your choice of flights. Select from return, one way or multi-city flights, and use the advance search tool if you want a direct or refundable flight. You can narrow your search to show you just your preferred cabin class and airline, too. It’s all easy. You can book direct flights from Des Moines to Chicago that take around 1 hours.

Find cheap flights from Des Moines to Chicago

From the great flight deals with prices currently ranging from AU$287 to AU$481, you can choose to see the cheapest flights first. Generally, you can book the cheapest flights from Des Moines to Chicago around 4 to 6 weeks in advance. If your travel dates are flexible, try to avoid weekends and peak seasons – when you are more likely to grab the lowest prices. Even last minute, there are some impressive deals. The cheapest time to fly to Chicago is normally in September.

Reasons to book your flight from Des Moines to Chicago with Expedia

Expedia makes it easy to find, book, and travel, with everything you need all in one place. When you enter your travel details, find fantastic deals just for you on flight tickets from Des Moines to Chicago across all the main airline carriers, so you can save time, dollars, and hassle finding the perfect flight. If you think your plans could change, choose refundable flights so any changes won’t cost you more. Book your flight to Chicago right now and, if you join Expedia Rewards, you earn points this time and every time you travel with Expedia.

Frequently asked questions

How much is a flight from Des Moines Intl. Airport (DSM) to ORD?
Round-trip flights from Des Moines Intl. Airport (DSM) to O'Hare Airport start from AU$287. This figure is based on fares available within the last 7 days on Expedia for flights departing within the next year — book now to avoid missing out. Prices and availability are subject to change. Additional terms apply.
Do I need to pay a cancellation fee if I cancel my flight from Des Moines Intl. Airport to O'Hare Airport?
We understand that things crop up unexpectedly, so we've made it as easy as possible for you to cancel your flight online. Just head to the Customer Service Portal and follow the instructions.
How do I find cheap flights from DSM to O'Hare Airport that have flexible change policies?
Many airlines offer the option to reschedule your flight without a change fee. All you pay is the difference between the original flight and the new flight. When you're searching for DSM to O'Hare Airport flights, you'll see a "no change fees" filter for you to select.
How far is the flight from Des Moines Intl. Airport to O'Hare Airport?
That movie you've been desperate to see will have to wait — the flight distance between Des Moines Intl. Airport (DSM) and ORD (ORD) is only 480 kilometres. The captain will be asking you to put your seat upright for landing before you know it.
Which airlines fly direct from DSM to O'Hare Intl. Airport (ORD)?
With 117 monthly flights operating from Des Moines Intl. Airport to ORD, United Airlines (UA) is a top choice. American Airlines (AA) is also worth considering. It offers 91 flights per month. Between these two airlines, you'll be able to find a great deal from Des Moines to Chicago.
Are DSM to O'Hare Intl. Airport (ORD) flight tickets cheaper when they're purchased at the last minute?
Flight tickets from Des Moines Intl. Airport to O'Hare Intl. Airport (ORD) are available up to 12 months prior to departure on Expedia. And although you may nab a great last-minute deal, it's not something you should count on. Also, booking your flights ahead of time means you'll have more options — and you can avoid getting caught in the dreaded middle seat! We regularly update our fares to bring you the biggest bargains, so check back often for all the latest specials.

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