A calm lake surrounded by trees and vegetation.

Business Hotels & Resorts in Southwest Illinois from AU$110

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Check availability on Southwest Illinois Business Hotels

Our top choices for Southwest Illinois business-friendly hotels

Lobby lounge

Drury Plaza Hotel Mt. Vernon

Drury Plaza Hotel Mt. Vernon
3.5 star property
Mount Vernon
9.8 out of 10, Exceptional, (1,716 reviews)
"A nice stay"
United States
DAVID
The price is AU$184
includes taxes & fees
12 July - 13 July
Drury Plaza Hotel Mt. Vernon
Lobby

SureStay Hotel by Best Western Whittington Rend Lake

SureStay Hotel by Best Western Whittington Rend Lake
2.5 star property
Whittington
8.8 out of 10, Excellent, (987 reviews)
"Staff was friendly room was clean"
United States
Brandon
The price is AU$130
includes taxes & fees
12 July - 13 July
SureStay Hotel by Best Western Whittington Rend Lake
Lobby

Drury Inn & Suites Marion

Drury Inn & Suites Marion
3.0 star property
Marion
9.4 out of 10, Exceptional, (1,000 reviews)
"Clean room, great breakfast and evening drinks & food. Friendly staff."
United States
Brandy
The price is AU$202
includes taxes & fees
12 July - 13 July
Drury Inn & Suites Marion
5 restaurants; breakfast, lunch, dinner and brunch served

River City Casino & Hotel

River City Casino & Hotel
4.0 star property
St. Louis
9.2 out of 10, Wonderful, (1,646 reviews)
"Would stay again in a heartbeat!"
United States
Austin
The price is AU$180
includes taxes & fees
12 July - 13 July
River City Casino & Hotel
Exterior

Holiday Inn Express & Suites Murphysboro - Carbondale by IHG

Holiday Inn Express & Suites Murphysboro - Carbondale by IHG
2.5 star property
Murphysboro
9.4 out of 10, Exceptional, (559 reviews)
"Great place and folks!! Breakfast was on point, and the staff is very nice and friendly. Will be back!"
United States
Mark
The price is AU$189
includes taxes & fees
2 Aug - 3 Aug
Holiday Inn Express & Suites Murphysboro - Carbondale by IHG
Lobby

Drury Plaza Hotel Cape Girardeau Conference Center

Drury Plaza Hotel Cape Girardeau Conference Center
3.0 star property
Cape Girardeau
9.6 out of 10, Exceptional, (1,003 reviews)
"Wonderful room and food offerings were extra thoughtful."
United States
Jonna
The price is AU$163
includes taxes & fees
12 July - 13 July
Drury Plaza Hotel Cape Girardeau Conference Center
Sauna, hot tub, body treatments, hot stone massages

Walker's Bluff Casino Resort

Walker's Bluff Casino Resort
4.5 star property
Carterville
9.4 out of 10, Exceptional, (474 reviews)
"Nice hotel!"
United States
Monique
The price is AU$180
includes taxes & fees
14 July - 15 July
Walker's Bluff Casino Resort
Exterior

Holiday Inn Express & Suites Vandalia by IHG

Holiday Inn Express & Suites Vandalia by IHG
2.5 star property
Vandalia
8.8 out of 10, Excellent, (840 reviews)
"Easy access fro I70.. Hotel very full but breakfast dining was clean & stocked."
United States
Joyce
The price is AU$196
includes taxes & fees
12 July - 13 July
Holiday Inn Express & Suites Vandalia by IHG
Lobby sitting area

Baymont by Wyndham Marion

Baymont by Wyndham Marion
2.5 star property
Marion
8.4 out of 10, Very good, (1,072 reviews)
"Great stay…thank you!!"
United States
Brandi and michael
The price is AU$140
includes taxes & fees
5 July - 6 July
Baymont by Wyndham Marion
In-room safe, desk, iron/ironing board, cots/infant beds

Quality Inn & Suites Vandalia near I-70 and Hwy 51

Quality Inn & Suites Vandalia near I-70 and Hwy 51
2.5 star property
Vandalia
8.4 out of 10, Very good, (1,001 reviews)
"Place was great. Not to bad for a great place to crash after a day of fishing."
United States
Dawn
The price is AU$110
includes taxes & fees
26 July - 27 July
Quality Inn & Suites Vandalia near I-70 and Hwy 51
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top Southwest Illinois Hotel Reviews

Drury Inn & Suites St. Louis Collinsville

Drury Inn & Suites St. Louis Collinsville

10/10 Excellent
"We love the 530 kickback and drinks! Everyone was so kind and helpful. Very clean and well kept property."
Amanda 2-night trip
Posted 1 hour ago
Drury Inn & Suites St. Louis Collinsville

Frequently asked questions

How much do business-friendly hotels in Southwest Illinois cost?
Rates for business hotels in Southwest Illinois range between AU$110 and AU$202 per night. No matter your budget, Expedia will help you locate the best space to get the job done. This price was available on Expedia within the past 7 days, for a hotel booking with a check-in date within the next year. Prices reflect current offers and availability is subject to change. Additional terms may apply.
How many business-friendly hotels are there in Southwest Illinois?
Southwest Illinois has 105 business-friendly hotels to choose from. Whether you're hosting a conference or meeting or simply working remotely, these properties are equipped with the amenities you need to be productive.
What is there to do in Southwest Illinois near my business-friendly hotel?
Southwest Illinois has so much to do and see, it can be difficult to decide where to begin. If you're spending a few days in Alton for work, National Great Rivers Museum is a hit with travellers.

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