What is Southhampton like?

Travellers to the Southhampton neighbourhood in St. Louis will be sure to enjoy their stay.

How many hotels should I expect to find in the Southhampton area?

If you're searching for places to stay in St. Louis, Expedia has something to meet your needs with 23 Southhampton hotels and other accommodation options to choose from.

If I need to cancel my hotel reservation in Southhampton, will I receive a refund?

Yes! The majority of hotel bookings are refundable provided that you cancel prior to the accommodation's cancellation deadline, which often is within 24-48 hours of your arrival date. If you booked a non-refundable reservation, you may still be able to cancel and be given a refund within a 24-hour period of your booking. Put your dates in and click on "Search", then you can filter by "fully refundable" to view the top deals on offer in Southhampton.

What can I see and do in this St. Louis neighbourhood?

A few places to visit in the area around Southhampton include Miniature Museum of Greater St. Louis, Lindenwood Park and River des Peres Greenway Trailhead. When you're sightseeing in St. Louis, Tower Grove Tennis Center and George Washington Carver Garden are also worth a stop.

Southhampton Hotels, St. Louis

Where to?

Dates

March 2026

4

April 2026

Change your mind
Book hotels with free cancellation
Treat yourself
Sign in to save 10% or more on thousands of hotels
Sign in
Be picky
Search almost a million properties worldwide

Our top choices for Southhampton hotels

Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham

16.6 km from Southhampton

Jaiden

includes taxes & fees

8 Mar - 9 Mar

Red Lion Inn & Suites Pontoon Beach

26.9 km from Southhampton

Saulius

includes taxes & fees

8 Mar - 9 Mar

The Principal Hotel

17.9 km from Southhampton

David

includes taxes & fees

22 Mar - 23 Mar

5 restaurants, breakfast, lunch, dinner served; American cuisine

River City Casino & Hotel

6.7 km from Southhampton

Theresa A

includes taxes & fees

8 Mar - 9 Mar

Best Western Plus Fenton

15 km from Southhampton

Melissa

includes taxes & fees

5 Mar - 6 Mar

Drury Plaza Hotel St. Louis at the Arch

Downtown St. Louis, 9.3 km from Southhampton

Brad

includes taxes & fees

8 Mar - 9 Mar

Wingate by Wyndham St. Louis/Fenton Route 66

16.7 km from Southhampton

Karen

includes taxes & fees

9 Mar - 10 Mar

Hyatt Regency St. Louis at The Arch

Downtown St. Louis, 9.5 km from Southhampton

Cynthia

includes taxes & fees

28 Mar - 29 Mar

The Wildwood Hotel

30 km from Southhampton

Shawn

Best Western St. Louis Inn

15.7 km from Southhampton

Marisa

includes taxes & fees

8 Mar - 9 Mar

Magnolia Hotel St. Louis, a Tribute Portfolio Hotel

Downtown St. Louis, 9.4 km from Southhampton

David

includes taxes & fees

22 Mar - 23 Mar

Casino Queen Hotel

10.4 km from Southhampton

Suzy

includes taxes & fees

29 Mar - 30 Mar

Holiday Inn Express & Suites St. Louis West - Fenton by IHG

17 km from Southhampton

Scott

includes taxes & fees

8 Mar - 9 Mar

Hollywood Casino & Hotel St. Louis

25.1 km from Southhampton

James

includes taxes & fees

2 Apr - 3 Apr

Hilton St. Louis Airport

17.8 km from Southhampton

Lisa

includes taxes & fees

15 Mar - 16 Mar

Hampton Inn By Hilton St Louis Airport

17.8 km from Southhampton

Allyn

includes taxes & fees

15 Mar - 16 Mar

Wingate by Wyndham St. Louis Airport

18.4 km from Southhampton

Sandra

includes taxes & fees

15 Mar - 16 Mar

Drury Inn & Suites St. Louis Fairview Heights

26 km from Southhampton

RANJITH

includes taxes & fees

1 Apr - 2 Apr

21C Museum Hotel St Louis

Downtown West, 8.7 km from Southhampton

Kimbriel

includes taxes & fees

1 Apr - 2 Apr

Moonrise Hotel

7.7 km from Southhampton

Jaden

includes taxes & fees

8 Mar - 9 Mar

View all properties

Our guide on where to stay in Southhampton

Find the best Southhampton areas for the activities you enjoy most.

Gateway Arch featuring a monument, night scenes and a park

Downtown St. Louis

Gourmet restaurants beloved sports teams and top sights from Gateway Arch to Busch Stadium – discover Downtown St. Louis, a destination also famous for its historic sites.

See properties

Clayton

Take time in Clayton to visit attractions like Chapel of St. Timothy And St. Titus, Concordia Seminary and Shaw Park Tennis Center. You might also appreciate the abundant dining options, and you can hop on the metro at Clayton Station to see more of the city.

See properties

Berkeley

Visitors highly recommend Berkeley for its abundant dining options, and you can make a stop by James S. McDonnell Prologue Room while you're in town.

See properties

Anheuser-Busch Brewery featuring heritage architecture and a garden

Soulard

You'll enjoy the bars and churches in Soulard. You might want to make time for a stop at Anheuser-Busch Brewery or Soulard Farmer's Market.

See properties

Downtown West

While visiting Downtown West, you might make a stop by sights like St. Louis Union Station and St. Louis Aquarium at Union Station.

See properties

Top Southhampton Hotel Reviews

Home2 Suites by Hilton St. Louis Downtown

6/10 Okay

"Water temp only gets a mild hot. Clean room. Walking distance to enterprise, bars, restraunts and more. Walked around till early morning hours. Never had any problems. Just mind your business. "