A forested valley with autumn foliage, a rocky cliff, and a sunset.

Spa Hotels & Resorts in Southern Illinois from AU$177

  • Change your mind

    Book hotels with free cancellation
  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
  • Be picky

    Search almost a million properties worldwide

Check availability on Southern Illinois Spa Hotels

Next weekend
In two weeks

Our top choices for Southern Illinois hotels with a spa

1. Walker's Bluff Casino Resort

Walker's Bluff Casino Resort
4.5 star property
Carterville
9.4 out of 10, Exceptional, (490 reviews)
  • cleanliness
    Luxurious spa retreat with hot stone massages, sauna, and seasonal pools awaits at this casino resort with attentive staff and fine dining.
The price is AU$217
includes taxes & fees
4 Aug - 5 Aug
Walker's Bluff Casino Resort

2. Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
2.5 star property
Cape Girardeau
9.4 out of 10, Exceptional, (1,001 reviews)
  • cleanliness
    Luxurious spa sanctuary awaits with full-service treatments and indoor pool in this centrally located hotel.
The price is AU$177
includes taxes & fees
5 Aug - 6 Aug
Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

3. Arthur's Country Inn

Arthur's Country Inn
2.5 star property
Arthur
8.4 out of 10, Very good, (146 reviews)
The price is AU$189
includes taxes & fees
16 Aug - 17 Aug
Arthur's Country Inn

4. Ameristar Casino Resort and Spa

Ameristar Casino Resort and Spa
4.5 star property
St. Charles
8.6 out of 10, Excellent, (1,025 reviews)
  • cleanliness
    Riverside wellness oasis offers full-service spa with aromatherapy and hydrotherapy for a restorative retreat.
The price is AU$269
includes taxes & fees
16 Aug - 17 Aug
Ameristar Casino Resort and Spa

5. 21C Museum Hotel St Louis

21C Museum Hotel St Louis
4.5 star property
Downtown West
9.0 out of 10, Wonderful, (2,017 reviews)
  • cleanliness
    Discover spa services, a steam room, and an Olympic-sized indoor pool at this modern hotel, all designed for rejuvenating getaways.
The price is AU$246
includes taxes & fees
26 Aug - 27 Aug
21C Museum Hotel St Louis

6. Four Seasons Hotel St Louis

Four Seasons Hotel St Louis
5.0 star property
Downtown St. Louis
9.4 out of 10, Exceptional, (1,002 reviews)
  • cleanliness
    Discover a tranquil haven with 12 treatment rooms, outdoor pool, and breathtaking views at this rejuvenating spa retreat.
The price is AU$625
includes taxes & fees
3 Aug - 4 Aug
Four Seasons Hotel St Louis

7. 1895 Washington Hotel

1895 Washington Hotel
3.0 star property
Paducah
9.2 out of 10, Wonderful, (435 reviews)
  • cleanliness
    Unwind in a Victorian sanctuary with relaxing reflexology and soothing hydrotherapy treatments for total rejuvenation.
The price is AU$374
includes taxes & fees
9 Aug - 10 Aug
1895 Washington Hotel

8. The Ritz-Carlton, St. Louis

The Ritz-Carlton, St. Louis
5.0 star property
Clayton
9.2 out of 10, Wonderful, (577 reviews)
  • cleanliness
    Revel in a rejuvenating spa retreat with aromatherapy treatments and hot stone massages at this luxury St. Louis hotel.
The price is AU$1,013
includes taxes & fees
7 Aug - 8 Aug
The Ritz-Carlton, St. Louis

9. Truitt Hotel

Truitt Hotel
2.0 star property
Lafayette Square
The price is AU$310
includes taxes & fees
1 Sept - 2 Sept
Truitt Hotel
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Choose what matters most at spa hotels in Southern Illinois

Find out more about Southern Illinois

Top Southern Illinois attractions for a relaxing vacation

Southern Illinois offers a delightful mix of relaxation and adventure, perfect for travellers seeking hotel spas. Begin your journey in the stunning Shawnee National Forest, where you can explore breathtaking landscapes and enjoy activities like hiking the famed Garden of the Gods. After a day of adventure, unwind at one of the local spa hotels that offer rejuvenating treatments inspired by nature. Don't miss the chance to visit the charming town of Carbondale, known for its vibrant arts scene and a plethora of dining options that cater to all tastes, providing the perfect backdrop for a relaxing evening after a day of exploration. Wine enthusiasts will appreciate a visit to the nearby wineries of the Shawnee Hills Wine Trail, where you can indulge in tastings while soaking in the picturesque views. For a unique experience, take a leisurely boat ride on the serene waters of the Cache River State Natural Area, where you can reconnect with nature. Staying in the quaint town of Makanda, with its artisanal shops and laid-back vibe, allows you to enjoy a peaceful retreat, complemented by spa facilities that cater to your every need, ensuring you leave feeling pampered and revitalised.

Top Southern Illinois Hotel Reviews