Spa Hotels & Resorts in Southern Illinois from AU$160

  • Change your mind

    Book hotels with free cancellation
  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
  • Be picky

    Search almost a million properties worldwide

Check availability on Southern Illinois Spa Hotels

This weekend
Next weekend

Our top choices for Southern Illinois hotels with a spa

Walker's Bluff Casino Resort

Walker's Bluff Casino Resort
4.5 star property
Carterville
9.4 out of 10, Exceptional, (441 reviews)
  • cleanliness
    Luxurious spa retreat with hot stone massages, sauna, and seasonal pools awaits at this casino resort with attentive staff and fine dining.
"The hot tub we enjoyed ...."
United States
Matthew J
The price is AU$178
includes taxes & fees
12 May - 13 May
Walker's Bluff Casino Resort

Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
2.5 star property
Cape Girardeau
9.4 out of 10, Exceptional, (1,002 reviews)
  • cleanliness
    Luxurious spa sanctuary awaits with full-service treatments and indoor pool in this centrally located hotel.
"Our stay was wonderful. The rooms are so nice. Bed was comfortable. The jaccuzi tub is excellent. The free breakfast was lovely. Even had healthy options with turkey sausage and egg white omelets. Delicious. "
United States
Laura
The price is AU$165
includes taxes & fees
17 May - 18 May
Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

Ameristar Casino Resort and Spa

Ameristar Casino Resort and Spa
4.5 star property
St. Charles
8.6 out of 10, Excellent, (1,001 reviews)
  • cleanliness
    Riverside wellness oasis offers full-service spa with aromatherapy and hydrotherapy for a restorative retreat.
"The spa was great and all the staff were perfect very polite!"
United States
Charlotte
The price is AU$281
includes taxes & fees
25 May - 26 May
Ameristar Casino Resort and Spa

1895 Washington Hotel

1895 Washington Hotel
3.0 star property
Paducah
9.2 out of 10, Wonderful, (411 reviews)
  • cleanliness
    Unwind in a Victorian sanctuary with relaxing reflexology and soothing hydrotherapy treatments for total rejuvenation.
"Jacuzzi tub clean and powerful."
United States
Celina
The price is AU$160
includes taxes & fees
3 May - 4 May
1895 Washington Hotel

21C Museum Hotel St Louis

21C Museum Hotel St Louis
4.5 star property
Downtown West
9.0 out of 10, Wonderful, (1,806 reviews)
  • cleanliness
    Discover spa services, a steam room, and an Olympic-sized indoor pool at this modern hotel, all designed for rejuvenating getaways.
"Beautiful, repurposed hotel with gorgeous lobby, amazing art museum, top-notch pool and spa facilities, central location, and very comfortable and compact room."
United States
Natalie
The price is AU$281
includes taxes & fees
10 May - 11 May
21C Museum Hotel St Louis

Four Seasons Hotel St Louis

Four Seasons Hotel St Louis
5.0 star property
Downtown St. Louis
9.4 out of 10, Exceptional, (1,000 reviews)
  • cleanliness
    Discover a tranquil haven with 12 treatment rooms, outdoor pool, and breathtaking views at this rejuvenating spa retreat.
"I would definitely come back here to rest and recharge."
United States
Lynne
The price is AU$544
includes taxes & fees
7 May - 8 May
Four Seasons Hotel St Louis
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Choose what matters most at spa hotels in Southern Illinois

Find out more about Southern Illinois

Top Southern Illinois attractions for a relaxing vacation

Southern Illinois offers a delightful mix of relaxation and adventure, perfect for travellers seeking hotel spas. Begin your journey in the stunning Shawnee National Forest, where you can explore breathtaking landscapes and enjoy activities like hiking the famed Garden of the Gods. After a day of adventure, unwind at one of the local spa hotels that offer rejuvenating treatments inspired by nature. Don't miss the chance to visit the charming town of Carbondale, known for its vibrant arts scene and a plethora of dining options that cater to all tastes, providing the perfect backdrop for a relaxing evening after a day of exploration. Wine enthusiasts will appreciate a visit to the nearby wineries of the Shawnee Hills Wine Trail, where you can indulge in tastings while soaking in the picturesque views. For a unique experience, take a leisurely boat ride on the serene waters of the Cache River State Natural Area, where you can reconnect with nature. Staying in the quaint town of Makanda, with its artisanal shops and laid-back vibe, allows you to enjoy a peaceful retreat, complemented by spa facilities that cater to your every need, ensuring you leave feeling pampered and revitalised.

Top Southern Illinois Hotel Reviews

Explore a world of travel with Expedia