A forested valley with autumn foliage, a rocky cliff, and a sunset.

Spa Hotels & Resorts in Southern Illinois

  • Change your mind

    Book hotels with free cancellation
  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
  • Be picky

    Search almost a million properties worldwide

Check availability on Southern Illinois Spa Hotels

This weekend
Next weekend

Our top choices for Southern Illinois hotels with a spa

1. Drury Plaza Hotel Mt. Vernon

Drury Plaza Hotel Mt. Vernon
3.5 star property
Mount Vernon
9.8 out of 10, Exceptional, (1,855 reviews)
"The breakfast was amazing"
United States
Angie
The price is AU$178
includes taxes & fees
8 Nov - 9 Nov
Drury Plaza Hotel Mt. Vernon

2. Holiday Inn Express & Suites Mount Vernon by IHG

Holiday Inn Express & Suites Mount Vernon by IHG
2.5 star property
Mount Vernon
8.8 out of 10, Excellent, (1,002 reviews)
"Great spacious room. Breakfast was awesome and the helper was outstanding! Great food and coffee."
United States
Doug
The price is AU$178
includes taxes & fees
30 Nov - 1 Dec
Holiday Inn Express & Suites Mount Vernon by IHG

3. Comfort Suites Mount Vernon

Comfort Suites Mount Vernon
2.5 star property
Mount Vernon
9.0 out of 10, Wonderful, (1,094 reviews)
"Great bathroom"
United States
Bruce and Robin
The price is AU$188
includes taxes & fees
15 Nov - 16 Nov
Comfort Suites Mount Vernon

4. Best Western Plus Centralia Hotel & Suites

Best Western Plus Centralia Hotel & Suites
2.5 star property
Centralia
9.6 out of 10, Exceptional, (686 reviews)
"We stayed here with 2 adults and 3 kids and it was perfect. We highly recommend staying here"
United States
Jeremy
The price is AU$221
includes taxes & fees
3 Nov - 4 Nov
Best Western Plus Centralia Hotel & Suites

5. DoubleTree by Hilton Mt. Vernon

DoubleTree by Hilton Mt. Vernon
4.0 star property
Mount Vernon
8.4 out of 10, Very good, (908 reviews)
"Nice clean and great staff"
United States
Kenneth
The price is AU$205
includes taxes & fees
7 Nov - 8 Nov
DoubleTree by Hilton Mt. Vernon

6. Quality Inn Mount Vernon, IL

Quality Inn Mount Vernon, IL
2.5 star property
Mount Vernon
7.8 out of 10, Good, (722 reviews)
"Clean rooms, complimentary breakfast, great value."
United States
Ryan
The price is AU$116
includes taxes & fees
8 Nov - 9 Nov
Quality Inn Mount Vernon, IL

7. Fairfield Inn & Suites by Marriott Mt. Vernon Rend Lake

Fairfield Inn & Suites by Marriott Mt. Vernon Rend Lake
3.0 star property
Mount Vernon
8.8 out of 10, Excellent, (729 reviews)
"Beautiful property very clean when you enter the lobby is very impressive in the staff was very helpful. Our room was clean in the morning. Breakfast was great."
United States
Susan
The price is AU$168
includes taxes & fees
27 Nov - 28 Nov
Fairfield Inn & Suites by Marriott Mt. Vernon Rend Lake

8. Super 8 by Wyndham Mt. Vernon IL

Super 8 by Wyndham Mt. Vernon IL
2.5 star property
Mount Vernon
7.8 out of 10, Good, (1,001 reviews)
"Everything was clean, nice hotel"
United States
Leslie
The price is AU$118
includes taxes & fees
8 Nov - 9 Nov
Super 8 by Wyndham Mt. Vernon IL

9. SureStay Hotel by Best Western Whittington Rend Lake

SureStay Hotel by Best Western Whittington Rend Lake
2.5 star property
Whittington
8.8 out of 10, Excellent, (1,001 reviews)
"Very clean and everything was perfect!"
United States
Tad
The price is AU$121
includes taxes & fees
1 Dec - 2 Dec
SureStay Hotel by Best Western Whittington Rend Lake

10. Cobblestone Inn & Suites - Altamont

Cobblestone Inn & Suites - Altamont
2.5 star property
Altamont
9.6 out of 10, Exceptional, (962 reviews)
"The hotel was very clean, nice bathrooms, and very quiet."
United States
Heidi
The price is AU$166
includes taxes & fees
3 Nov - 4 Nov
Cobblestone Inn & Suites - Altamont

11. Best Western U. S. Inn

Best Western U. S. Inn
2.5 star property
Nashville
8.6 out of 10, Excellent, (459 reviews)
"Worked well for our short stay."
United States
Steven
The price is AU$186
includes taxes & fees
3 Nov - 4 Nov
Best Western U. S. Inn

12. Holiday Inn Express & Suites Salem by IHG

Holiday Inn Express & Suites Salem by IHG
2.5 star property
Salem
9.4 out of 10, Exceptional, (808 reviews)
"Great location"
United States
John
The price is AU$167
includes taxes & fees
15 Nov - 16 Nov
Holiday Inn Express & Suites Salem by IHG

13. Hampton Inn & Suites Effingham

Hampton Inn & Suites Effingham
2.5 star property
Effingham
9.6 out of 10, Exceptional, (800 reviews)
"The property was very clean even just staying a quick overnight traveling the room felt very comfortable."
United States
Scott
The price is AU$200
includes taxes & fees
15 Nov - 16 Nov
Hampton Inn & Suites Effingham

14. Best Western Plus Parkside Inn & Suites

Best Western Plus Parkside Inn & Suites
2.5 star property
Olney
9.8 out of 10, Exceptional, (395 reviews)
"Very clean and friendly staff."
United States
Lynda
The price is AU$200
includes taxes & fees
8 Nov - 9 Nov
Best Western Plus Parkside Inn & Suites

15. La Quinta Inn & Suites by Wyndham Effingham

La Quinta Inn & Suites by Wyndham Effingham
3.0 star property
Effingham
9.2 out of 10, Wonderful, (1,001 reviews)
"Very nice stay!!!"
United States
Steve
The price is AU$173
includes taxes & fees
8 Nov - 9 Nov
La Quinta Inn & Suites by Wyndham Effingham

16. Rodeway Inn Mount Vernon, IL

Rodeway Inn Mount Vernon, IL
2.0 star property
Mount Vernon
7.2 out of 10, Good, (1,000 reviews)
"Good place to stay, we were traveling and the price was great, clean room, great staff we were very comfortable"
United States
Karalee
The price is AU$106
includes taxes & fees
3 Nov - 4 Nov
Rodeway Inn Mount Vernon, IL

17. Days Inn by Wyndham Mount Vernon

Days Inn by Wyndham Mount Vernon
2.0 star property
Mount Vernon
6.6 out of 10, (1,001 reviews)
"Checking in was very easy and quick. I have no complaints."
United States
Howard
The price is AU$103
includes taxes & fees
9 Nov - 10 Nov
Days Inn by Wyndham Mount Vernon

18. Quality Inn & Suites Vandalia near I-70 and Hwy 51

Quality Inn & Suites Vandalia near I-70 and Hwy 51
2.5 star property
Vandalia
8.2 out of 10, Very good, (1,002 reviews)
"It is an older property but I thought it was very nice"
United States
Colleen
The price is AU$112
includes taxes & fees
3 Nov - 4 Nov
Quality Inn & Suites Vandalia near I-70 and Hwy 51

19. Home2 Suites By Hilton Effingham

Home2 Suites By Hilton Effingham
3.0 star property
Effingham
9.6 out of 10, Exceptional, (67 reviews)
"The hotel was clean and room was fantastic in every way."
United States
Steve
The price is AU$205
includes taxes & fees
1 Dec - 2 Dec
Home2 Suites By Hilton Effingham

20. Walker's Bluff Casino Resort

Walker's Bluff Casino Resort
4.5 star property
Carterville
9.4 out of 10, Exceptional, (542 reviews)
"A great place to stay"
United States
Ron
The price is AU$232
includes taxes & fees
9 Nov - 10 Nov
Walker's Bluff Casino Resort
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Choose what matters most at spa hotels in Southern Illinois

Find out more about Southern Illinois

Top Southern Illinois attractions for a relaxing vacation

Southern Illinois offers a delightful mix of relaxation and adventure, perfect for travellers seeking hotel spas. Begin your journey in the stunning Shawnee National Forest, where you can explore breathtaking landscapes and enjoy activities like hiking the famed Garden of the Gods. After a day of adventure, unwind at one of the local spa hotels that offer rejuvenating treatments inspired by nature. Don't miss the chance to visit the charming town of Carbondale, known for its vibrant arts scene and a plethora of dining options that cater to all tastes, providing the perfect backdrop for a relaxing evening after a day of exploration. Wine enthusiasts will appreciate a visit to the nearby wineries of the Shawnee Hills Wine Trail, where you can indulge in tastings while soaking in the picturesque views. For a unique experience, take a leisurely boat ride on the serene waters of the Cache River State Natural Area, where you can reconnect with nature. Staying in the quaint town of Makanda, with its artisanal shops and laid-back vibe, allows you to enjoy a peaceful retreat, complemented by spa facilities that cater to your every need, ensuring you leave feeling pampered and revitalised.

Top Southern Illinois Hotel Reviews