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Business Hotels & Resorts in Southern Illinois from AU$137

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Check availability on Southern Illinois Business Hotels

Our top choices for Southern Illinois business-friendly hotels

Lobby

Drury Inn & Suites Marion

Drury Inn & Suites Marion
3.0 star property
Marion
9.4 out of 10, Exceptional, (1,000 reviews)
"Clean room, great breakfast and evening drinks & food. Friendly staff."
United States
Brandy
The price is AU$202
includes taxes & fees
12 July - 13 July
Drury Inn & Suites Marion
Lobby lounge

Drury Plaza Hotel Mt. Vernon

Drury Plaza Hotel Mt. Vernon
3.5 star property
Mount Vernon
9.8 out of 10, Exceptional, (1,716 reviews)
"A nice stay"
United States
DAVID
The price is AU$204
includes taxes & fees
4 Aug - 5 Aug
Drury Plaza Hotel Mt. Vernon
Exterior

Holiday Inn Express & Suites Effingham by IHG

Holiday Inn Express & Suites Effingham by IHG
2.5 star property
Effingham
9.4 out of 10, Exceptional, (1,001 reviews)
"Breakfast was great!"
United States
Carol
The price is AU$198
includes taxes & fees
12 July - 13 July
Holiday Inn Express & Suites Effingham by IHG
Front of property – evening/night

Country Inn & Suites by Radisson, Effingham, IL

Country Inn & Suites by Radisson, Effingham, IL
2.5 star property
Effingham
8.8 out of 10, Excellent, (1,001 reviews)
"Wonderful stay. "
United States
Jennifer
The price is AU$143
includes taxes & fees
4 Aug - 5 Aug
Country Inn & Suites by Radisson, Effingham, IL
Exterior

Holiday Inn Express & Suites Murphysboro - Carbondale by IHG

Holiday Inn Express & Suites Murphysboro - Carbondale by IHG
2.5 star property
Murphysboro
9.4 out of 10, Exceptional, (559 reviews)
"Great place and folks!! Breakfast was on point, and the staff is very nice and friendly. Will be back!"
United States
Mark
The price is AU$189
includes taxes & fees
2 Aug - 3 Aug
Holiday Inn Express & Suites Murphysboro - Carbondale by IHG
Exterior

Holiday Inn Express & Suites Vandalia by IHG

Holiday Inn Express & Suites Vandalia by IHG
2.5 star property
Vandalia
8.8 out of 10, Excellent, (840 reviews)
"Easy access fro I70.. Hotel very full but breakfast dining was clean & stocked."
United States
Joyce
The price is AU$196
includes taxes & fees
12 July - 13 July
Holiday Inn Express & Suites Vandalia by IHG
Lobby

SureStay Hotel by Best Western Whittington Rend Lake

SureStay Hotel by Best Western Whittington Rend Lake
2.5 star property
Whittington
8.8 out of 10, Excellent, (987 reviews)
"Staff was friendly room was clean"
United States
Brandon
The price is AU$137
includes taxes & fees
23 July - 24 July
SureStay Hotel by Best Western Whittington Rend Lake
Exterior

Holiday Inn Effingham by IHG

Holiday Inn Effingham by IHG
3.5 star property
Effingham
9.2 out of 10, Wonderful, (695 reviews)
"Nice hotel. Great location on the Ohio River. Walking distance to the old downtown."
United States
Glenn
The price is AU$178
includes taxes & fees
12 July - 13 July
Holiday Inn Effingham by IHG
Exterior

La Quinta Inn & Suites by Wyndham Effingham

La Quinta Inn & Suites by Wyndham Effingham
3.0 star property
Effingham
9.2 out of 10, Wonderful, (1,000 reviews)
"Clean hotel, excellent staff, good breakfast"
United States
Alexis
The price is AU$169
includes taxes & fees
12 July - 13 July
La Quinta Inn & Suites by Wyndham Effingham
Indoor pool

Best Western Delta Inn

Best Western Delta Inn
2.5 star property
Effingham
9.0 out of 10, Wonderful, (1,002 reviews)
"Nice quick stay"
United States
Bri
The price is AU$144
includes taxes & fees
12 July - 13 July
Best Western Delta Inn
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top Southern Illinois Hotel Reviews

Comfort Inn Edwardsville - St. Louis

Comfort Inn Edwardsville - St. Louis

10/10 Excellent
"It was late by the time we went to the hotel and Seth was kind and helpful in speedy check-in. Great job!"
Murali 1-night trip
Posted 3 hours ago
Comfort Inn Edwardsville - St. Louis

Frequently asked questions

How much do business-friendly hotels in Southern Illinois cost?
Prices for business hotels in Southern Illinois range between AU$137 and AU$204 per night. Whatever your budget, Expedia will help you find the perfect space to complete the job. This price was available on Expedia within the past 7 days, for a hotel booking with a check-in date within the next year. Prices reflect current offers and availability is subject to change. Additional terms may apply.
How many business-friendly hotels are there in Southern Illinois?
Select from 149 business-friendly hotels in Southern Illinois. Wherever your job is taking you, Expedia will help you secure the ideal space with the amenities you want.
What is there to do in Southern Illinois near my business-friendly hotel?
Whether you're a fan of arts, culture, shopping or dining, Southern Illinois promises something for everyone! The top city of Casey has lots of attractions, including Worlds Largest Mailbox, Worlds Largest Wind Chime and Worlds Largest Bird Cage. If you're planning a business trip to Alton, National Great Rivers Museum, Fast Eddies Bon Air and Argosy Casino should be at the top of your to-do list.