A forested valley with autumn foliage, a rocky cliff, and a sunset.

Business Hotels & Resorts in Southern Illinois from AU$109

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check availability on Southern Illinois Business Hotels

Tonight
8 Oct - 9 Oct
Tomorrow
9 Oct - 10 Oct
This weekend
9 Oct - 11 Oct
Next weekend
16 Oct - 18 Oct

Our top choices for Southern Illinois business-friendly hotels

A bar area with a long counter, multiple chairs, and hanging light fixtures.
A spacious lobby with a reception desk, seating area, and glass doors leading outside.
A hotel lobby with a Kitchen+Bar area, seating arrangements, and a view to the outside.
An indoor swimming pool with a metal ladder, a warning sign about cold weather, and a view of the outside.

1. Drury Plaza Hotel Mt. Vernon

Drury Plaza Hotel Mt. Vernon
Mount Vernon
United States
Susan
AU$180
includes taxes & fees
18 Oct - 19 Oct
Drury Plaza Hotel Mt. Vernon
A Holiday Inn Express & Suites building with a modern design, featuring a covered entrance and illuminated pillars.
An indoor swimming pool with clear lane markings, a lifeguard chair, and a window providing natural light.
A hotel room with two beds, a large window, and a wall-mounted lamp.
A modern kitchen with a wooden cabinet, coffee maker, and storage shelves.

2. Holiday Inn Express & Suites Mount Vernon by IHG

Holiday Inn Express & Suites Mount Vernon by IHG
Mount Vernon
United States
John
AU$180
includes taxes & fees
8 Nov - 9 Nov
Holiday Inn Express & Suites Mount Vernon by IHG
A hotel lobby with a large sofa, armchairs, a Christmas tree, and a patterned carpet.
A Fairfield Inn & Suites by Marriott hotel with a parking lot and a clear sky.
A modern dining area with round tables and chairs, a green booth seating area, and artwork on the walls.
A hotel room with a large bathtub, a desk with a chair, and a bed.

3. Fairfield Inn & Suites by Marriott Mt. Vernon Rend Lake

Fairfield Inn & Suites by Marriott Mt. Vernon Rend Lake
Mount Vernon
United States
Susan
AU$162
includes taxes & fees
17 Oct - 18 Oct
Fairfield Inn & Suites by Marriott Mt. Vernon Rend Lake
A hotel lobby with a reception desk, seating area, and a large screen TV.
A hotel room with a marble bathtub, a wooden dining table with chairs, a bed with a headboard, and a nightstand with lamps.
A Comfort Suites hotel with a spacious parking lot and a modern brick facade.
A brick building with a patio area featuring wicker furniture and a table.

4. Comfort Suites Mount Vernon

Comfort Suites Mount Vernon
Mount Vernon
United States
Lori
AU$197
includes taxes & fees
11 Oct - 12 Oct
Comfort Suites Mount Vernon
A spacious lobby with a stone fireplace, a seating area with a sofa and chairs, and a television mounted on the wall.
A hotel room with two beds, a desk, a chair, a TV, and a window with curtains.
A hallway with vending machines and a carpeted floor.
A dining area with round tables and chairs, a kitchen with a countertop and appliances, and a hallway leading to another room.

5. SureStay Hotel by Best Western Whittington Rend Lake

SureStay Hotel by Best Western Whittington Rend Lake
Whittington
United States
MARK
AU$136
includes taxes & fees
14 Oct - 15 Oct
SureStay Hotel by Best Western Whittington Rend Lake
A spacious lobby with a beige sectional sofa, a fireplace, and a view of the outside through large glass doors.
A treats section with a variety of snacks and beverages, including a refrigerated display and shelves stocked with items like Welch's and Bonde.
A modern hotel lobby with a long dining table, bar stools, a sofa, and a fireplace.
A hotel lobby with a large indoor pool, a reception desk, and a seating area.

6. Hampton Inn & Suites Effingham

Hampton Inn & Suites Effingham
Effingham
United States
Marjorie
AU$201
includes taxes & fees
1 Nov - 2 Nov
Hampton Inn & Suites Effingham
A modern living room with a fireplace, a bookshelf, a large wall clock, and a cozy seating area.
A modern living room with a sofa, coffee table, and a dining area with chairs.
A reception area with a wooden counter, a welcome mat, and framed artwork on the wall.
An indoor swimming pool with clear water, surrounded by white lounge chairs and tables, with a high ceiling and natural light from windows.

7. Country Inn & Suites by Radisson, Marion, IL

Country Inn & Suites by Radisson, Marion, IL
Marion
United States
Lisa
AU$143
includes taxes & fees
8 Nov - 9 Nov
Country Inn & Suites by Radisson, Marion, IL
An indoor swimming pool with a clear view of the surrounding area, including a seating area with chairs and a view of the outdoors through large windows.
A hotel room with a desk, two monitors, a keyboard, and a mouse.
A spacious dining area with a long wooden table, multiple chairs, and pendant lighting.
A Best Western hotel with a modern facade, a parking lot, and a clear sky.

8. Best Western Delta Inn

Best Western Delta Inn
Effingham
United States
Susan
AU$133
includes taxes & fees
25 Oct - 26 Oct
Best Western Delta Inn
A modern breakfast bar with a coffee machine, cereal, and fruit display.
A hotel room with two beds, a desk, a chair, a TV, and a window with curtains.
A coffee station with multiple coffee dispensers, a hot water station, and a variety of coffee products on display.
A conference room with a patterned carpet, multiple tables, and chairs arranged for meetings.

9. Holiday Inn Express Hotel & Suites Marion Northeast by IHG

Holiday Inn Express Hotel & Suites Marion Northeast by IHG
Marion
United States
Jennifer
AU$179
includes taxes & fees
8 Nov - 9 Nov
Holiday Inn Express Hotel & Suites Marion Northeast by IHG
A La Quinta hotel with a stone facade, a covered entrance, and a parking lot.
A modern hotel lobby with a large sun-shaped artwork, multiple seating areas, and a patterned rug.
A hotel room with a large bed, a desk with a chair, a flat-screen TV, a bathtub, and framed pictures on the wall.
An indoor swimming pool with lounge chairs and a clear view of the pool area.

10. La Quinta Inn & Suites by Wyndham Effingham

La Quinta Inn & Suites by Wyndham Effingham
Effingham
United States
Sarah
AU$190
includes taxes & fees
8 Nov - 9 Nov
La Quinta Inn & Suites by Wyndham Effingham
View all properties

Top Southern Illinois Hotel Reviews

Holiday Inn Express Metropolis by IHG

Holiday Inn Express Metropolis by IHG

10/10 Excellent
"Great hotel! Lovely staff, spacious room, and my husband liked the breakfast so much we drove an extra 1.5 hours just to stay there again on our return trip!"
Rachael 1-night trip
Posted 12 hours ago
Holiday Inn Express Metropolis by IHG
Comfort Suites Mount Vernon

Comfort Suites Mount Vernon

8/10 Good
"The front desk staff Kim is very helpful and accommodating, she’s a hard worker too, we had good service from Kim"
Cristino 1-night trip
Posted 2 days ago
Comfort Suites Mount Vernon
Drury Inn & Suites Marion

Drury Inn & Suites Marion

8/10 Good
"friendly and helpful staff. Great food with many options to choose from. Great hot tub"
Carolyn 1-night trip
Posted 3 days ago
Drury Inn & Suites Marion
Comfort Inn Edwardsville - St. Louis

Comfort Inn Edwardsville - St. Louis

10/10 Excellent
"Nice location."
James 4-night trip
Posted 3 days ago
Comfort Inn Edwardsville - St. Louis
Quality Inn & Suites Metropolis I-24

Quality Inn & Suites Metropolis I-24

8/10 Good
"Motel is close to the interstate and has a bar and grill next door. Staff was very pleasant and helpful. Lobby and room were clean and neat. The hallway to the room had a musty mildew smell to it. Shower pressure was adequate but weak. TV and Air conditioning were both working well."
Paul 1-night trip
Posted 8 days ago
Quality Inn & Suites Metropolis I-24
Country Inn & Suites by Radisson, Marion, IL

Country Inn & Suites by Radisson, Marion, IL

10/10 Excellent
"This is an excellent hotel to stay at. Updated, easy parking, staff is very friendly, breakfast is great, will stay at this hotel again."
Lisa 3-night trip
Posted 11 days ago
Country Inn & Suites by Radisson, Marion, IL

Frequently asked questions

How much do business-friendly hotels in Southern Illinois cost?
Prices for business hotels in Southern Illinois range between AU$109 and AU$190 per night. Whatever your budget, Expedia will help you find the perfect space to complete the job. This price was available on Expedia within the past 7 days, for a hotel booking with a check-in date within the next year. Prices reflect current offers and availability is subject to change. Additional terms may apply.
How many business-friendly hotels are there in Southern Illinois?
Select from 149 business-friendly hotels in Southern Illinois. Wherever your job is taking you, Expedia will help you secure the ideal space with the amenities you want.
What is there to do in Southern Illinois near my business-friendly hotel?
Whether you're a fan of arts, culture, shopping or dining, Southern Illinois promises something for everyone! The top city of Casey has lots of attractions, including Worlds Largest Mailbox, Worlds Largest Wind Chime and Worlds Largest Bird Cage. If you're planning a business trip to Alton, National Great Rivers Museum, Fast Eddies Bon Air and Argosy Casino should be at the top of your to-do list.

Explore a world of travel with Expedia