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Check prices for these dates

Tonight
25 Sept - 26 Sept
Tomorrow
26 Sept - 27 Sept
This weekend
25 Sept - 27 Sept
Next weekend
2 Oct - 4 Oct

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Our top choices for Santa Cruz hotels

A reception area with a counter, pendant lights, a plant, and a glass wall.
A hotel room with two beds, a desk, a chair, a TV, and a large window with a city view.
A modern cafeteria with white tables and chairs, large windows with a view of greenery, and a counter with beverages.
A multi-story hotel with a flat facade, a sign reading 'CITY EXPRESS,' and a parking lot.

1. City Express by Marriott Cananea

City Express by Marriott Cananea
Cananea
United States
Erika
AU$165
includes taxes & fees
27 Sept - 28 Sept
City Express by Marriott Cananea
A cozy living room with a sofa, ottoman, and round coffee table, surrounded by potted plants and a mounted deer head.
A grand chandelier, a mirror, and a painting in a room with a wooden bench.
A restaurant with a cozy seating area, including a striped booth and tables with candles and flowers.
A bar area with a counter, bar stools, and a variety of bottles.

2. Hotel Fray Marcos

Hotel Fray Marcos
Nogales
United States
Viet
AU$138
includes taxes & fees
27 Sept - 28 Sept
Hotel Fray Marcos
A restaurant interior with booths, tables, and chairs.
A hotel room with a bed, a small table, a chair, a nightstand, and a window with curtains.
A multi-story motel with a sign reading 'Motel San Luis de Nogales.'
A bathroom with a white sink, mirror, and toilet.

3. Motel San Luis de Nogales

Motel San Luis de Nogales
Nogales
United States
Priscilla
AU$85
includes taxes & fees
29 Sept - 30 Sept
Motel San Luis de Nogales
A pathway flanked by neatly trimmed hedges and palm trees, leading to a building with a modern design and a red and blue sign.
A bar area with a TV, shelves of liquor, and a food display.
A hotel with a red and beige facade, a landscaped garden with pink flowers, and a sign indicating it is a Fiesta Inn.
A spacious dining area with multiple tables and chairs, large windows offering views of the outdoors, and a modern ceiling design with hanging lights.

4. Fiesta Inn Nogales

Fiesta Inn Nogales
Nueva Nogales
United States
Mario
AU$153
includes taxes & fees
27 Sept - 28 Sept
Fiesta Inn Nogales
A modern hotel lobby with a reception desk, seating area, and large windows offering a city view.
A modern living room with a blue sofa, a white coffee table, and a brick fireplace.
A hotel room with two beds, a desk, a TV, and a view of the outdoors.
A modern hotel room with a dining area, a kitchen counter with breakfast items, and a large fruit-themed mural on the wall.

5. Fairfield Inn & Suites by Marriott Nogales

Fairfield Inn & Suites by Marriott Nogales
Nogales
United States
David
AU$225
includes taxes & fees
4 Oct - 5 Oct
Fairfield Inn & Suites by Marriott Nogales
A building with a reception area and a staircase leading up to it.
A modern waiting area with two black leather sofas, a glass coffee table, and a large framed artwork on the wall.
A multi-story building with balconies, green lighting accents, and a red base.
A reception desk with a glass partition, a digital welcome screen displaying multiple languages, and a clean, modern interior with a tiled floor.

6. Hotel Marques De Cima

Hotel Marques De Cima
Nogales
United States
martin
AU$148
includes taxes & fees
27 Sept - 28 Sept
Hotel Marques De Cima
A bedroom with two beds, a wardrobe, and a door.
A modern building with a large window and a fire extinguisher mounted on the wall.
A bathroom with a glass bowl sink, white towels, and a mirror reflecting the room.
A hotel room with a bed, a chair, a small table, and a window with curtains.

7. Hotel Pedregal

Hotel Pedregal
Nogales
United States
Idaliee
AU$138
includes taxes & fees
27 Sept - 28 Sept
Hotel Pedregal
A modern living room with a blue sofa, a wooden dining table with black chairs, a flat-screen TV mounted on the wall, and a ceiling fan.
A bedroom with a bed, a ceiling fan, a window with blinds, a bedside table with a lamp, and a wooden cabinet.
A modern meeting room with a round table, grey chairs, a grey sofa, a ceiling fan, and a colorful abstract painting.

8. Departamento Kennedy Nogales

Departamento Kennedy Nogales
Nogales
AU$191
includes taxes & fees
27 Sept - 28 Sept
Departamento Kennedy Nogales
A modern lobby with a reception desk, seating area, and large windows offering a view of the outside.
A hotel room with two beds, a desk, a chair, and a TV.
A modern living room with a grey sofa, two armchairs, a coffee table with a flower vase, and two ottomans.
A CityExpress hotel with a modern design, featuring a flat facade, multiple windows, and a covered entrance.

9. City Express by Marriott Nogales

City Express by Marriott Nogales
Nogales
United States
Carlos
AU$141
includes taxes & fees
4 Oct - 5 Oct
City Express by Marriott Nogales
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Top Santa Cruz Hotel Reviews

Recent Reviews in Santa Cruz

Hotel Fray Marcos

Hotel Fray Marcos

10/10 Excellent
"10/10"
Heriberto 1-night trip
Posted 2 days ago
Hotel Fray Marcos
City Express by Marriott Cananea

City Express by Marriott Cananea

10/10 Excellent
"Clean room and very friendly staff."
Erika 1-night trip
Posted 5 days ago
City Express by Marriott Cananea
Hotel Pedregal

Hotel Pedregal

10/10 Excellent
"A great experience at a price you'll never find in the US or at least in california. The rooms are very spacious and have everything up to date including a smart TV with cable, microwave, air conditioner, and refrigerator. The overall architecture is very high end and you get your own carport with no garage door but the hotel has a main gate and is very safe inside the property. I rarely ever need a hotel but if I ever end up in Nogales sonora again this is definitely gonna be my go to hotel. The staff also accepts US dollars or Mexican pesos."
Felipe 1-night trip
Posted 2 months ago
Hotel Pedregal
Motel San Luis de Nogales

Motel San Luis de Nogales

10/10 Excellent
"The view is nice.A lot of stores around you a great restaurant downstairs. Kid friendly too."
Priscilla 2-night trip
Posted 2 months ago
Motel San Luis de Nogales
Charming 2-bedroom house with WiFi, AC in beautiful Cananea

Charming 2-bedroom house with WiFi, AC in beautiful Cananea

10/10 Excellent
"Nice place. Very friendly and helpful host. Thank you."
Kendall 3-night trip
Posted 5 months ago
Charming 2-bedroom house with WiFi, AC in beautiful Cananea

Frequently asked questions

What is the best area to stay in Santa Cruz?
The best area to stay in Santa Cruz, Sonora, is the town centre, particularly around the main square, Plaza Zaragoza.This area is the heart of Santa Cruz, offering a convenient base for exploring. You'll find many of the town's key landmarks, including the historic Templo de Nuestra Señora de Guadalupe, within easy walking distance. The streets here are generally well-maintained and offer a pleasant stroll amongst local shops and eateries.Couples looking for a relaxed and authentic experience will find the town centre ideal. It provides opportunities to enjoy local cuisine, browse artisan crafts, and simply soak in the local way of life without needing to travel far. The evenings around Plaza Zaragoza often feature local gatherings, adding to the pleasant atmosphere.
When is the best time to go to Santa Cruz?
The best time to visit Santa Cruz, Sonora, Mexico is during the cooler, drier months from November to April.During this period, the weather is pleasantly warm with average temperatures ranging from 20°C to 28°C, and there's very little rainfall. This makes it ideal for exploring the outdoors, whether you're interested in hiking the Sierra Azul mountains or enjoying the local markets without the intense heat of summer.Couples looking for a relaxed getaway will appreciate the comfortable climate for leisurely strolls through the town's historic centre, perhaps visiting the Mission de Santa Cruz. The evenings are mild, superb for dining al fresco.
Can I cancel my hotel reservation on Expedia?
You can cancel your hotel reservation on Expedia, though it depends on the cancellation policy of your booking. Most bookings are refundable if cancelled within 24-48 hours of the scheduled arrival. Be sure to check your booking confirmation for the exact cancellation policy. If free cancellation is available, you can cancel directly through your Expedia account by logging in, going to "My Trips", and selecting your reservation. To find flexible deals, filter your search by "Fully refundable property" for hotels in Santa Cruz.
How can I save on a hotel booking in Santa Cruz with Expedia?
One Key™—Expedia's free travel rewards program—gives you instant access to discounts with Member Prices on Santa Cruz hotels. Plus, you'll earn OneKeyCash™* on eligible bookings to use on future trips. Booking an Expedia hotel and flight package is another great way to save, where bundling can result in significant savings. *Excludes taxes and fees. OneKeyCash is not redeemable for cash and can only be used on Expedia and other participating brands.
How much is the nightly rate for a hotel in Santa Cruz?
Prices for hotels in Santa Cruz often vary, but you can find a great deal on Expedia. All sorts of factors affect price, such as the time of year or the days of the week you choose for your stay. Find the best deals by being flexible with your dates, and sort search results by "Price: low to high" for our cheapest rates.

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