Sanctuary Hotels, Sanibel

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Check prices for these dates

Tonight
5 Nov - 6 Nov
Tomorrow
6 Nov - 7 Nov
This weekend
6 Nov - 8 Nov
Next weekend
13 Nov - 15 Nov

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Our top choices for Sanctuary hotels

A resort with a central pool, multiple lounge areas, and a beach view.

1. Tween Waters Island Resort & Spa

Tween Waters Island Resort & Spa
3.0 star property
3.7 km from Sanctuary
8.6 out of 10, Excellent, (1,000 reviews)
"They could do better on the food for breakfast at the restaurant on the property"
United States
Carol
The price is AU$354
includes taxes & fees
6 Dec - 7 Dec
Tween Waters Island Resort & Spa
A spacious living room with a large flat-screen TV, a ceiling fan, and a view of the ocean through large windows.

2. South Seas

South Seas
3.5 star property
5.5 km from Sanctuary
8.4 out of 10, Very good, (1,000 reviews)
"Staff was super friendly and made my family feel so welcome. Standouts were our waiter Dale at the Beach House and Jocaleb, a worker at the pool. We had an awesome stay and will return."
United States
Jeremy
The price is AU$489
includes taxes & fees
11 Nov - 12 Nov
South Seas
A resort with multiple-story buildings, palm trees, and a well-maintained lawn.

3. Sanibel Island Beach Resort

Sanibel Island Beach Resort
3.0 star property
Mid Island, 13.1 km from Sanctuary
9.2 out of 10, Wonderful, (2,411 reviews)
"It was a wonderful stay. We really enjoyed it."
United States
Elina
The price is AU$357
includes taxes & fees
8 Nov - 9 Nov
Sanibel Island Beach Resort
A balcony with a wooden table and chairs, a hanging chair, and a view of palm trees and a pool.

4. Off the Charts Inn & Out Island Resort

Off the Charts Inn & Out Island Resort
2.5 star property
8.8 km from Sanctuary
9.6 out of 10, Exceptional, (165 reviews)
"Very good on everything I love the location"
United States
George
The price is AU$286
includes taxes & fees
5 Dec - 6 Dec
Off the Charts Inn & Out Island Resort
A covered outdoor area with a table and chairs, a ceiling fan, and a view of a beach with palm trees and a boat.

5. Island Inn

Island Inn
3.5 star property
West End, 9.6 km from Sanctuary
9.4 out of 10, Exceptional, (1,168 reviews)
"Great location"
United States
Nicole
The price is AU$428
includes taxes & fees
30 Nov - 1 Dec
Island Inn
Living area

6. The Anchor Inn

The Anchor Inn
2.0 star property
Mid Island, 12.8 km from Sanctuary
10.0 out of 10, Exceptional, (85 reviews)
"The whole place was wonderful."
United States
April
The price is AU$250
includes taxes & fees
6 Dec - 7 Dec
The Anchor Inn
A balcony with a table and chairs, large windows, and a view of the sea.

7. The Westin Cape Coral Resort At Marina Village

The Westin Cape Coral Resort At Marina Village
4.0 star property
18.1 km from Sanctuary
9.0 out of 10, Wonderful, (1,000 reviews)
"Very clean and nice place!"
United States
Charles
The price is AU$297
includes taxes & fees
15 Nov - 16 Nov
The Westin Cape Coral Resort At Marina Village
A hotel pool area with multiple lounge chairs and umbrellas, surrounded by a fence and palm trees.

8. La Quinta Inn & Suites by Wyndham Ft. Myers-Sanibel Gateway

La Quinta Inn & Suites by Wyndham Ft. Myers-Sanibel Gateway
3.0 star property
19.9 km from Sanctuary
8.2 out of 10, Very good, (1,401 reviews)
"The staff was very helpful during my stay."
United States
Samantha
The price is AU$127
includes taxes & fees
23 Nov - 24 Nov
La Quinta Inn & Suites by Wyndham Ft. Myers-Sanibel Gateway
A waterfront hotel with multiple buildings, a dock, and a calm body of water reflecting the structures.

9. Marriott Sanibel Harbour Resort & Spa

Marriott Sanibel Harbour Resort & Spa
4.0 star property
15.6 km from Sanctuary
8.6 out of 10, Excellent, (1,001 reviews)
"I love everything about this hotel"
United States
Yunior
The price is AU$380
includes taxes & fees
18 Nov - 19 Nov
Marriott Sanibel Harbour Resort & Spa
A spacious dining area with multiple tables and chairs, large windows, and a modern chandelier.

10. Residence Inn by Marriott Fort Myers Sanibel

Residence Inn by Marriott Fort Myers Sanibel
3.0 star property
19.3 km from Sanctuary
8.8 out of 10, Excellent, (1,001 reviews)
"Loved the balcony view, breakfast spread, hot tub and heated pool."
United States
Lora
The price is AU$162
includes taxes & fees
15 Nov - 16 Nov
Residence Inn by Marriott Fort Myers Sanibel
An outdoor patio with tables and chairs, umbrellas, and a pool in the background.

11. Holiday Inn Express & Suites Ft Myers Beach-Sanibel Gateway by IHG

Holiday Inn Express & Suites Ft Myers Beach-Sanibel Gateway by IHG
2.5 star property
23.1 km from Sanctuary
9.2 out of 10, Wonderful, (1,001 reviews)
"Clean Hotel! Convenient for one night stay, close to airport and beaches."
United States
Kimberly
The price is AU$148
includes taxes & fees
8 Nov - 9 Nov
Holiday Inn Express & Suites Ft Myers Beach-Sanibel Gateway by IHG
A spacious lobby with a high ceiling, a seating area with a sofa and chairs, a small round table, and a decorative wall with artwork.

12. Hampton Inn & Suites Fort Myers Beach/Sanibel Gateway

Hampton Inn & Suites Fort Myers Beach/Sanibel Gateway
3.0 star property
22.9 km from Sanctuary
8.8 out of 10, Excellent, (1,000 reviews)
"Overall great experience at my stay."
United States
Chris
The price is AU$129
includes taxes & fees
11 Nov - 12 Nov
Hampton Inn & Suites Fort Myers Beach/Sanibel Gateway
A modern living room with a TV, dining table, and chairs. There is a balcony with a view of palm trees.

13. Casa Ybel Resort

Casa Ybel Resort
2.5 star property
Ybel, 11.6 km from Sanctuary
9.0 out of 10, Wonderful, (478 reviews)
"We loved our 1 night stay at Casa Ybel - next time it will hopefully be a longer getaway!"
United States
Sydney
The price is AU$413
includes taxes & fees
6 Nov - 7 Nov
Casa Ybel Resort
A balcony with wicker furniture, a view of a beach, and a clear sky.

14. Lani Kai Beachfront Resort

Lani Kai Beachfront Resort
3.5 star property
21.8 km from Sanctuary
8.8 out of 10, Excellent, (2,179 reviews)
"It was great to be right on the beach! The restaurants were also good."
United States
Tanya
The price is AU$238
includes taxes & fees
3 Dec - 4 Dec
Lani Kai Beachfront Resort
A poolside area with lounge chairs and umbrellas, surrounded by palm trees and a white fence.

15. Sunshine Island Inn

Sunshine Island Inn
2.5 star property
East End, 14.3 km from Sanctuary
9.0 out of 10, Wonderful, (310 reviews)
"Wonderful stay."
United States
Brooke
The price is AU$326
includes taxes & fees
8 Nov - 9 Nov
Sunshine Island Inn
A large, clear swimming pool with multiple lounge areas and palm trees.

16. Margaritaville Beach Resort Fort Myers

Margaritaville Beach Resort Fort Myers
4.0 star property
21.6 km from Sanctuary
9.0 out of 10, Wonderful, (2,737 reviews)
"Everything about the resort was excellent"
United States
Lance
The price is AU$354
includes taxes & fees
29 Nov - 30 Nov
Margaritaville Beach Resort Fort Myers
A resort with multiple buildings featuring blue roofs, a beach, and a clear view of the ocean.

17. Shalimar Beach Resort

Shalimar Beach Resort
3.5 star property
West End, 10.3 km from Sanctuary
9.8 out of 10, Exceptional, (109 reviews)
"Clean, quiet, perfect location. Easy access to the beach ⛱️."
United States
Mauricio
The price is AU$500
includes taxes & fees
9 Nov - 10 Nov
Shalimar Beach Resort
A pathway leading to a pool area with lounge chairs and umbrellas, surrounded by tropical plants and a thatched-roof structure.

18. Sanibel Inn

Sanibel Inn
3.0 star property
East End, 13.8 km from Sanctuary
9.2 out of 10, Wonderful, (1,001 reviews)
"Staff was amazingly friendly"
United States
Tamara
The price is AU$547
includes taxes & fees
6 Dec - 7 Dec
Sanibel Inn
Lobby lounge

19. Fairfield Inn & Suites by Marriott Ft. Myers/Cape Coral

Fairfield Inn & Suites by Marriott Ft. Myers/Cape Coral
3.0 star property
30.1 km from Sanctuary
8.8 out of 10, Excellent, (940 reviews)
"The staff took great care of us ! The room was perfect and breakfast was very good."
United States
Rick
The price is AU$126
includes taxes & fees
22 Nov - 23 Nov
Fairfield Inn & Suites by Marriott Ft. Myers/Cape Coral
An outdoor patio area with a fire pit table, wicker furniture, and a white fence in the background.

20. Tarpon Tale Inn

Tarpon Tale Inn
3.0 star property
East End, 14.8 km from Sanctuary
9.6 out of 10, Exceptional, (413 reviews)
"Makes you feel at home. Impeccably kept. Joe and Maureen give attention to details and think of guest convenience and hospitality. Excellent location. Steps from beach and little stores. Sanibel is gorgeous and chill, and so is Tarpon Tales Inn."
United States
Marianella
The price is AU$365
includes taxes & fees
7 Nov - 8 Nov
Tarpon Tale Inn
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties

Compare top hotels in Sanctuary

A resort with a central pool, multiple lounge areas, and a beach view.

Tween Waters Island Resort & Spa

3.0 star property
3.7 km from Sanctuary
View
A spacious living room with a large flat-screen TV, a ceiling fan, and a view of the ocean through large windows.

South Seas

3.5 star property
5.5 km from Sanctuary
View
A resort with multiple-story buildings, palm trees, and a well-maintained lawn.

Sanibel Island Beach Resort

3.0 star property
Mid Island, 13.1 km from Sanctuary
View
A balcony with a wooden table and chairs, a hanging chair, and a view of palm trees and a pool.

Off the Charts Inn & Out Island Resort

2.5 star property
8.8 km from Sanctuary
View
A covered outdoor area with a table and chairs, a ceiling fan, and a view of a beach with palm trees and a boat.

Island Inn

3.5 star property
West End, 9.6 km from Sanctuary
View
8.6
Excellent
1,000 reviews
8.4
Very good
1,000 reviews
9.2
Wonderful
2,411 reviews
9.6
Exceptional
165 reviews
9.4
Exceptional
1,168 reviews
The price is AU$354
includes taxes & fees
6 Dec - 7 Dec
The price is AU$489
includes taxes & fees
11 Nov - 12 Nov
The price is AU$357
includes taxes & fees
8 Nov - 9 Nov
The price is AU$286
includes taxes & fees
5 Dec - 6 Dec
The price is AU$428
includes taxes & fees
30 Nov - 1 Dec
  • No Breakfast included
  • Yes, Pool
  • Yes, Spa
  • Yes, Pet-friendly
  • No WiFi included
  • Yes, Parking
  • No Breakfast included
  • Yes, Pool
  • No Spa
  • No Pet-friendly
  • No WiFi included
  • No Parking
  • No Breakfast included
  • Yes, Pool
  • No Spa
  • Yes, Pet-friendly
  • Yes, WiFi included
  • Yes, Parking
  • No Breakfast included
  • No Pool
  • No Spa
  • Yes, Pet-friendly
  • Yes, WiFi included
  • Yes, Parking
  • No Breakfast included
  • No Pool
  • No Spa
  • No Pet-friendly
  • Yes, WiFi included
  • Yes, Parking

Our guide on where to stay in Sanctuary

Find the best Sanctuary areas for the activities you enjoy most.
A coastal scene with a lighthouse, beach, and ocean.

Mid Island

If you're spending some time in Mid Island, Periwinkle Way and Sanibel Island Southern Beach are top sights worth seeing.

A coastal scene with a lighthouse, beach, and ocean.

West End

If you're spending some time in West End, J. N. Ding Darling National Wildlife Refuge and Bowman's Beach are top sights worth seeing.

A coastal scene with a lighthouse, beach, and ocean.

East End

While visiting East End, you might make a stop by sights like Sanibel Island Northern Beach and Sanibel Island Lighthouse.

A street lined with palm trees and a sign for Periwinkle Place Shops.

Beachview Country Club Estates

While visiting Beachview Country Club Estates, you might make a stop by sights like Periwinkle Way and Sanibel Island Golf Club.

A beach with clear turquoise water, a sandy shore, and a weathered driftwood structure.

Gulf Shores

When in Gulf Shores, you can plan a visit to Bowman's Beach and J. N. Ding Darling National Wildlife Refuge, some noteworthy sights in the nearby area.

Top Sanctuary Hotel Reviews

A covered outdoor area with a table and chairs, a ceiling fan, and a view of a beach with palm trees and a boat.
Island Inn

Island Inn

Island Inn
West End

8/10 Good

The hotel and the area it was in was beautiful, perfectly situated, the staff were all incredibly welcoming, helpful, friendly. The room was spacious, beautiful and well appointed with full kitchenette, huge bathroom and screened-in porch with a gorgeous view of the ocean. The restaurant is a bit pricey and the breakfast is a little heavy on the pastries but that's not a big deal. I'd definitely stay here again and will. Loved it!
Australia
Joie
Reviewed August 30, 2015
Island Inn

Frequently Asked Questions

What is Sanctuary like?

Travellers are sure to enjoy a stay in Sanibel's Sanctuary neighbourhood. Consider a visit to J. N. Ding Darling National Wildlife Refuge as part of your Sanctuary travel plans.

How many hotels will I be able to find in the Sanctuary area?

When you want to find places to stay in Sanibel, start by booking one of Expedia's 8 hotels and other accommodation options in Sanctuary.

If I need to cancel my hotel reservation in Sanctuary, will I receive a refund?

Yes, the majority of hotel room reservations are fully refundable if you cancel prior to the hotel's cancellation deadline, which often is within 24-48 hours of your scheduled arrival. If your reservation is non-refundable, you may still be able to cancel and receive a refund within a 24-hour period of booking. Enter dates in and click on "Search", then you can filter by "fully refundable" to get the best deals available in Sanctuary.

What is there to do around this Sanibel neighbourhood?

J. N. Ding Darling National Wildlife Refuge is an attraction you might want to check out while you're in Sanctuary. Castaways Marina and Blind Pass Beach are also worth a visit when you're out sightseeing in Sanibel.

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