Sanctuary Hotels, Sanibel

  • Change your mind

    Book hotels with free cancellation
  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

This weekend
Next weekend

Filter by

Guest rating
Guest rating
Star rating

Our top choices for Sanctuary hotels

Lani Kai Beachfront Resort

Lani Kai Beachfront Resort
3.5 star property
21.8 km from Sanctuary
9.0 out of 10, Wonderful, (1,448 reviews)
"Loved the resort and amenities"
United States
Steven
The price is AU$258
includes taxes & fees
6 May - 7 May
Lani Kai Beachfront Resort

The Palmetto Inn

The Palmetto Inn
3.0 star property
31.2 km from Sanctuary
8.2 out of 10, Very good, (117 reviews)
"Wonderful location in the center of Boca Grande. Easy walk to beachside. "
United States
Maria
The price is AU$216
includes taxes & fees
3 May - 4 May
The Palmetto Inn

The Bay Inn at Lani Kai

The Bay Inn at Lani Kai
3.0 star property
21.8 km from Sanctuary
7.6 out of 10, Good, (398 reviews)
"Excellent. We just enjoy so much !!Rooms very clean and just across de beach !!"
United States
Marie
The price is AU$211
includes taxes & fees
3 May - 4 May
The Bay Inn at Lani Kai

Pointe Estero Beach Resort

Pointe Estero Beach Resort
2.0 star property
27.3 km from Sanctuary
9.2 out of 10, Wonderful, (1,001 reviews)
"Love this place!!"
United States
Teneille
The price is AU$657
includes taxes & fees
4 May - 5 May
Pointe Estero Beach Resort

Sanibel Island Beach Resort

Sanibel Island Beach Resort
3.0 star property
Mid Island, 13.1 km from Sanctuary
9.2 out of 10, Wonderful, (1,846 reviews)
"Great restaurant and beach bar on premises. "
United States
Bruce
The price is AU$396
includes taxes & fees
31 May - 1 June
Sanibel Island Beach Resort

Pink Shell Beach Resort and Marina

Pink Shell Beach Resort and Marina
4.0 star property
20.4 km from Sanctuary
9.4 out of 10, Exceptional, (1,337 reviews)
"Wonderful stay overall. Breakfast buffet was tasty, staff was always attentive, abundant wait staff, beautiful views, adults only pool, and although a resort, didn’t feel penned in."
United States
William Mark
The price is AU$655
includes taxes & fees
18 May - 19 May
Pink Shell Beach Resort and Marina

1 Island Hideaway

1 Island Hideaway
3.0 star property
24.3 km from Sanctuary
8.6 out of 10, Excellent, (32 reviews)
"Clean and modern apartment and we stayed on first floor. Walking distance to beach with hot tub and pool. Not really walking distance to bars/restaurants so probably best to have a car. Worth the price."
United States
Howard
The price is AU$616
includes taxes & fees
5 May - 6 May
1 Island Hideaway

Holiday Inn Express Cape Coral-Fort Myers Area by IHG

Holiday Inn Express Cape Coral-Fort Myers Area by IHG
2.5 star property
23.9 km from Sanctuary
9.2 out of 10, Wonderful, (1,435 reviews)
"Love it here! Clean rooms, great staff, great breakfast!"
United States
Amy
The price is AU$163
includes taxes & fees
11 May - 12 May
Holiday Inn Express Cape Coral-Fort Myers Area by IHG

The Anchor Inn

The Anchor Inn
2.0 star property
Mid Island, 12.8 km from Sanctuary
10.0 out of 10, Exceptional, (31 reviews)
"Anchor Inn is not only in a great location but beautiful. We used the bikes every day!"
United States
Renee
The price is AU$363
includes taxes & fees
31 May - 1 June
The Anchor Inn

Latitude 26 Waterfront Resort & Marina

Latitude 26 Waterfront Resort & Marina
3.0 star property
22 km from Sanctuary
8.6 out of 10, Excellent, (1,000 reviews)
"Place is quiet and right down the street from the beach"
United States
Bryan
The price is AU$157
includes taxes & fees
3 May - 4 May
Latitude 26 Waterfront Resort & Marina

Best Western Plus Beach Resort

Best Western Plus Beach Resort
2.5 star property
20.9 km from Sanctuary
9.4 out of 10, Exceptional, (1,001 reviews)
"Free breakfast, clean room, beach view, chill parrot"
United States
Katie Ann
The price is AU$430
includes taxes & fees
1 June - 2 June
Best Western Plus Beach Resort

Sundial Beach Resort & Spa

Sundial Beach Resort & Spa
5.0 star property
Mid Island, 12.8 km from Sanctuary
8.6 out of 10, Excellent, (2,640 reviews)
"Everything was fantastic! The amenities and staff were great. The breakfast is a bit pricey, but you can cook in your room if need be. "
United States
Haley
The price is AU$663
includes taxes & fees
1 June - 2 June
Sundial Beach Resort & Spa

La Quinta Inn & Suites by Wyndham Ft. Myers-Sanibel Gateway

La Quinta Inn & Suites by Wyndham Ft. Myers-Sanibel Gateway
3.0 star property
19.9 km from Sanctuary
8.2 out of 10, Very good, (1,136 reviews)
"Clean room, nice pool, near beaches, good breakfast."
United States
Kenneth
The price is AU$124
includes taxes & fees
31 May - 1 June
La Quinta Inn & Suites by Wyndham Ft. Myers-Sanibel Gateway

Residence Inn by Marriott Fort Myers Sanibel

Residence Inn by Marriott Fort Myers Sanibel
3.0 star property
19.3 km from Sanctuary
8.8 out of 10, Excellent, (1,000 reviews)
"Loved having two bedrooms, two bathrooms, and a full sized refrigerator. Breakfast was fantastic! Lots of choices!"
United States
Sheila Margaret
The price is AU$160
includes taxes & fees
4 May - 5 May
Residence Inn by Marriott Fort Myers Sanibel

DiamondHead Beach Resort

DiamondHead Beach Resort
3.5 star property
22.3 km from Sanctuary
9.2 out of 10, Wonderful, (1,152 reviews)
"Great room, great staff and great beach! Really enjoyed the location as well. Would stay here again"
United States
Kristen
The price is AU$326
includes taxes & fees
10 May - 11 May
DiamondHead Beach Resort

Shalimar Beach Resort

Shalimar Beach Resort
2.0 star property
West End, 10.3 km from Sanctuary
9.8 out of 10, Exceptional, (49 reviews)
"Fantastic location, updated, clean and spacious rooms."
United States
Keith
The price is AU$633
includes taxes & fees
4 May - 5 May
Shalimar Beach Resort

MALU LANI Inn & Marina

MALU LANI Inn & Marina
3.5 star property
24.7 km from Sanctuary
10.0 out of 10, Exceptional, (6 reviews)
"Beautiful property, peaceful, clean rental. Super responsive owner and all the things you need. Perfect location for boaters. Loved this stay and would definitely rent again! "
United States
April
The price is AU$560
includes taxes & fees
13 May - 14 May
MALU LANI Inn & Marina

Holiday Inn Express & Suites Ft Myers Beach-Sanibel Gateway by IHG

Holiday Inn Express & Suites Ft Myers Beach-Sanibel Gateway by IHG
2.5 star property
23.1 km from Sanctuary
9.2 out of 10, Wonderful, (1,001 reviews)
"Great place, good location "
United States
Christy
The price is AU$150
includes taxes & fees
17 May - 18 May
Holiday Inn Express & Suites Ft Myers Beach-Sanibel Gateway by IHG

Latitude 26 Waterfront Boutique Resort - Fort Myers Beach

Latitude 26 Waterfront Boutique Resort - Fort Myers Beach
2.5 star property
21.5 km from Sanctuary
8.8 out of 10, Excellent, (1,004 reviews)
"Amazing place to stay! "
United States
Kristen
The price is AU$180
includes taxes & fees
3 May - 4 May
Latitude 26 Waterfront Boutique Resort - Fort Myers Beach

Sanibel Inn

Sanibel Inn
3.0 star property
East End, 13.8 km from Sanctuary
9.2 out of 10, Wonderful, (1,001 reviews)
"Beautiful rooms, fantastic beach access. "
United States
Brenda
The price is AU$678
includes taxes & fees
1 June - 2 June
Sanibel Inn
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Our guide on where to stay in Sanctuary

Find the best Sanctuary areas for the activities you enjoy most.

Mid Island

If you're spending some time in Mid Island, Periwinkle Way and Sanibel Island Southern Beach are top sights worth seeing.

West End

If you're spending some time in West End, J. N. Ding Darling National Wildlife Refuge and Bowman's Beach are top sights worth seeing.

East End

While visiting East End, you might make a stop by sights like Sanibel Island Northern Beach and Sanibel Island Lighthouse.

Beachview Country Club Estates

While visiting Beachview Country Club Estates, you might make a stop by sights like Periwinkle Way and Sanibel Island Golf Club.

Shell Harbor

While Shell Harbor isn't home to many top sights, Sanibel Moorings Botanical Gardens and Sanibel Sea School are some notable places to visit nearby.

Top Sanctuary Hotel Reviews

Frequently asked questions

What is Sanctuary like?
Travellers are sure to enjoy a stay in Sanibel's Sanctuary neighbourhood. Consider a visit to J. N. Ding Darling National Wildlife Refuge as part of your Sanctuary travel plans.
How many hotels will I be able to find in the Sanctuary area?
When you want to find places to stay in Sanibel, start by booking one of Expedia's 9 hotels and other accommodation options in Sanctuary.
If I need to cancel my hotel reservation in Sanctuary, will I receive a refund?
Yes, the majority of hotel room reservations are fully refundable if you cancel prior to the hotel's cancellation deadline, which often is within 24-48 hours of your scheduled arrival. If your reservation is non-refundable, you may still be able to cancel and receive a refund within a 24-hour period of booking. Enter dates in and click on "Search", then you can filter by "fully refundable" to get the best deals available in Sanctuary.
What is there to do around this Sanibel neighbourhood?
J. N. Ding Darling National Wildlife Refuge is an attraction you might want to check out while you're in Sanctuary. Castaways Marina and Blind Pass Beach are also worth a visit when you're out sightseeing in Sanibel.

Explore a world of travel with Expedia