Search Saint Charles hotels

Start date: Check-in selected.
To Date
End date: Check-out
  • Change your mind

    Book hotels with free cancellation
  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

Next weekend
In two weeks

Filter by

Guest rating
Guest rating
Star rating

Top hotels and accommodation in Saint Charles

Lakeside Hotel Casino

3.0 star property
Osceola
8.0 out of 10, Very good, (1002)
"these rooms are big and comfortable"
Canada
ronald
Travelling for leisure
The price is AU$130
includes taxes & fees
15 Dec - 16 Dec
Lakeside Hotel Casino

Days Inn & Suites by Wyndham Des Moines Airport

2.0 star property
Greater South Side
8.6 out of 10, Excellent, (1674)
"Room was very clean and up-to-date"
United States
William
Travelling for leisure
The price is AU$106
includes taxes & fees
16 Dec - 17 Dec
Days Inn & Suites by Wyndham Des Moines Airport

Country Inn & Suites by Radisson, Indianola, IA

2.5 star property
Indianola
9.0 out of 10, Wonderful, (710)
"friendly rooms were super clean"
United States
Betty
The price is AU$185
includes taxes & fees
28 Dec - 29 Dec
Country Inn & Suites by Radisson, Indianola, IA

AmericInn by Wyndham Osceola

2.5 star property
Osceola
8.8 out of 10, Excellent, (595)
"Great clean hotel and friendly staff"
United States
Joseph
Travelling with family
The price is AU$182
includes taxes & fees
26 Dec - 27 Dec
AmericInn by Wyndham Osceola

Quality Inn Osceola

2.5 star property
Osceola
8.4 out of 10, Very good, (61)
"fresh towels and bed was made...always very quiet... enjoyed the stay!!"
United States
Roger
The price is AU$152
includes taxes & fees
1 Jan - 2 Jan 2026
Quality Inn Osceola

AmericInn by Wyndham Des Moines Airport

2.5 star property
Greater South Side
7.8 out of 10, Good, (1000)
"Friendly staff. beds are very firm"
United States
angela
Travelling for business
The price is AU$105
includes taxes & fees
14 Dec - 15 Dec
AmericInn by Wyndham Des Moines Airport

Baymont by Wyndham Des Moines Airport

2.5 star property
Southwestern Hills
9.4 out of 10, Exceptional, (1154)
"Room is clean and comfortable"
United States
Ken
The price is AU$144
includes taxes & fees
6 Jan - 7 Jan 2026
Baymont by Wyndham Des Moines Airport

Homewood Suites by Hilton Des Moines Airport

3.0 star property
Des Moines
9.4 out of 10, Exceptional, (606)
"Nice new and clean hotel."
United States
Lance
Travelling for leisure
The price is AU$194
includes taxes & fees
14 Dec - 15 Dec
Homewood Suites by Hilton Des Moines Airport

Hotel Fort Des Moines, Curio Collection by Hilton

4.5 star property
Downtown Des Moines
9.6 out of 10, Exceptional, (1055)
"Love the history and room was squeaky clean."
United States
Latoia
Travelling with small children
The price is AU$241
includes taxes & fees
4 Jan - 5 Jan 2026
Hotel Fort Des Moines, Curio Collection by Hilton

Embassy Suites Hotel Des Moines Downtown

3.5 star property
Downtown Des Moines
8.2 out of 10, Very good, (1066)
"Great hotel and a nice large room"
United States
Michelle
Travelling for business
The price is AU$215
includes taxes & fees
12 Dec - 13 Dec
Embassy Suites Hotel Des Moines Downtown

Fairfield Inn & Suites by Marriott Des Moines Downtown

4.0 star property
Downtown Des Moines
9.0 out of 10, Wonderful, (392)
"the room was very clean"
United States
Jessica
The price is AU$165
includes taxes & fees
14 Dec - 15 Dec
Fairfield Inn & Suites by Marriott Des Moines Downtown

Quality Inn Indianola

2.5 star property
Indianola
7.6 out of 10, Good, (512)
"The staff was kind and the hotel rooms clean"
United States
Stephanie
The price is AU$117
includes taxes & fees
4 Jan - 5 Jan 2026
Quality Inn Indianola

AC Hotel Des Moines East Village

3.0 star property
Downtown Des Moines
9.2 out of 10, Wonderful, (404)
"Great location to shopping and food."
United States
Darryl
Travelling for leisure and business
The price is AU$255
includes taxes & fees
16 Dec - 17 Dec
AC Hotel Des Moines East Village

Hampton Inn Des Moines-Airport

2.5 star property
Greater South Side
8.8 out of 10, Excellent, (1006)
"Very convenient location to the airport."
United States
Rui
Travelling solo
The price is AU$174
includes taxes & fees
14 Dec - 15 Dec
Hampton Inn Des Moines-Airport

Clarion Inn Des Moines Airport

3.0 star property
Watrous South
7.0 out of 10, Good, (128)
"Conveniently located near the airport and also provides a free shuttle to the airport"
United States
Debra
Travelling solo
The price is AU$92
includes taxes & fees
28 Dec - 29 Dec
Clarion Inn Des Moines Airport

Super 8 by Wyndham Osceola IA

2.0 star property
Osceola
8.6 out of 10, Excellent, (231)
"Pleasantly surprised by how spacious and up to date the room was."
United States
Karen L
Travelling with family
The price is AU$137
includes taxes & fees
1 Jan - 2 Jan 2026
Super 8 by Wyndham Osceola IA

Quality Inn & Suites Des Moines Airport

2.5 star property
Greater South Side
7.4 out of 10, Good, (1003)
"Used the pool and hot tub and both were clean and staff even had extra towels out available to use"
United States
Debra
Travelling with partner
The price is AU$106
includes taxes & fees
14 Dec - 15 Dec
Quality Inn & Suites Des Moines Airport

Econo Lodge Inn & Suites Fairgrounds

2.0 star property
Fairground
7.2 out of 10, Good, (1001)
"The bed was the most comfortable bed we have slept in on a long time."
United States
Tanika
Travelling with partner
The price is AU$97
includes taxes & fees
1 Jan - 2 Jan 2026
Econo Lodge Inn & Suites Fairgrounds

Surety Hotel, Autograph Collection

4.0 star property
Downtown Des Moines
9.4 out of 10, Exceptional, (1000)
"the room was very clean"
United States
Luisa
Travelling for leisure and business
The price is AU$272
includes taxes & fees
19 Dec - 20 Dec
Surety Hotel, Autograph Collection

Hampton Inn & Suites Des Moines Downtown

2.5 star property
Downtown Des Moines
8.6 out of 10, Excellent, (1003)
"Would recommend if you are wanting to be downtown it was a great location for that."
United States
Chrisshanna
Travelling with family
The price is AU$147
includes taxes & fees
14 Dec - 15 Dec
Hampton Inn & Suites Des Moines Downtown
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Save an average of 15% on thousands of hotels when you're signed in

Stay near popular Saint Charles attractions

Learn more about Saint Charles

Venture to sights like Imes Bridge as you discover the local area in Saint Charles.

cuttler-donahoe covered bridge, iowa

Top Saint Charles Hotel Reviews

Recent Reviews in Saint Charles

More cheap accommodation in Saint Charles

Frequently asked questions

Where is the best place for a stay in Saint Charles?
Hotel Fort Des Moines, Curio Collection by Hilton, located 22.5 mi (36.2 km) from the heart of Saint Charles, is a top choice for your stay, based on our traveller data. Other good options for your visit to the area are Home2 Suites by Hilton Des Moines at Drake University and Days Inn & Suites by Wyndham Des Moines Airport. See all available top hotels, or vacation rentals in Saint Charles.
What are some of the best holiday rentals that Saint Charles has to offer?
LUXURY GETAWAY! ARCADE, POOL TBL, PING PONG, HOT TUB, DECK! ACCESS TO POOLS!: This holiday home rental outside of Saint Charles is located next to a golf course, and has a fireplace, a balcony and a BBQ to put you at ease in your new surroundings. It has 5 bedrooms, as well as a kitchen with a dishwasher, a fridge and a stovetop, so that you can cook with friends or family. It offers a garden, a selection of games and 1 hot tub so that you can immerse yourself in your holiday. See all vacation rentals in Saint Charles.
If I need to cancel my hotel reservation in Saint Charles, will I receive a refund?
Yes, most hotel room reservations are fully refundable provided that you cancel prior to the accommodation's cancellation deadline, which is often 24 or 48 hours before your check-in date. If you have a non-refundable reservation, you might still have the option to cancel and be given a refund within 24 hours of booking. Filter your search by fully refundable to find flexible hotel deals in Saint Charles.
What is staying in Saint Charles like?
Travellers to Saint Charles will find plenty to explore and enjoy. In Saint Charles, there are 2 hotels and other accommodation options to choose from. Find out more about Saint Charles.
What are the top places to visit in Saint Charles?
A favourite place to visit is Imes Bridge. You'll also find Clark Tower and John Wayne Birthplace Museum in the area. Take a look at what more there is to see and do in Expedia's Saint Charles guide.
What's the seasonal weather like in Saint Charles?
The hottest months are usually July and August, with an average temperature of 22°C, while the coldest months are January and February, with an average of -2°C. The snowiest months in Saint Charles are January, December, November and February, with each month seeing an average of 14 cm of snowfall.

Explore a world of travel with Expedia