A large eye sculpture in a park surrounded by trees.

Holiday Homes in Northeast Missouri

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

In two weeks
13 Nov - 15 Nov
In two months
25 Dec - 27 Dec
In three months
22 Jan - 24 Jan
In four months
19 Feb - 21 Feb

Our top choices for Northeast Missouri holiday homes

A modern kitchen with white cabinets, stainless steel appliances, and a wooden floor.

1. Spacious & Modern 2BR Home with Attached Garage

Spacious & Modern 2BR Home with Attached Garage
Quincy
10.0 out of 10, Exceptional, (55 reviews)
"The place was immaculate and beautifully finished. Josh was great to work with, always responded quickly and very attentive. Highly recommend this property!!"
United States
Jeff C.
The price is AU$336
includes taxes & fees
15 Nov - 16 Nov
Spacious & Modern 2BR Home with Attached Garage
A modern kitchen with stainless steel appliances, a stone accent wall, and a bar area.

2. Aunt Lele's Cozy Cottage

Aunt Lele's Cozy Cottage
Quincy
9.8 out of 10, Exceptional, (48 reviews)
"Perfect place for our family of 5 to enjoy a weekend visiting my wife’s family."
United States
Matt B.
The price is AU$263
includes taxes & fees
11 Nov - 12 Nov
Aunt Lele's Cozy Cottage
A living room with a brown sofa, a wooden coffee table, a television on a stand, and a bookshelf.

3. Unwind on Vine

Unwind on Vine
Macon
9.6 out of 10, Exceptional, (38 reviews)
"We enjoy our stay in Macon and the location was perfect."
United States
Amy S.
The price is AU$381
includes taxes & fees
14 Nov - 15 Nov
Unwind on Vine
A modern kitchen with white cabinets, a stainless steel refrigerator, and a dining area with a wooden table and white chairs.

4. Peaceful, Country Cottage with Open Floor Plan

Peaceful, Country Cottage with Open Floor Plan
Quincy
9.8 out of 10, Exceptional, (227 reviews)
"The cottage was in a quiet location, clean, and with easy access to both Quincy, IL and Hannibal, MO. The property owner was available and easy to contact."
United States
Jodi
The price is AU$349
includes taxes & fees
3 Nov - 4 Nov
Peaceful, Country Cottage with Open Floor Plan
A room with a brick wall, shelves with plants, a framed painting, and a patterned bench.

5. Historic brick 2-bedroom house in downtown Hannibal with off street parking WiFi

Historic brick 2-bedroom house in downtown Hannibal with off street parking WiFi
Hannibal
9.8 out of 10, Exceptional, (72 reviews)
"Very nice experience, and close to all the historical sites!"
United States
Steve G.
The price is AU$268
includes taxes & fees
9 Nov - 10 Nov
Historic brick 2-bedroom house in downtown Hannibal with off street parking WiFi
A spacious living area with a leather sofa, a cowhide rug, and a staircase leading to an upper level.

6. Unique Tiny Home! Lakefront ~ BBQ Grill ~ Couple's Retreat

Unique Tiny Home! Lakefront ~ BBQ Grill ~ Couple's Retreat
Bourbon
10.0 out of 10, Exceptional, (4 reviews)
"Very charming lil cabin! It was perfect for a solo trip. I’d love to come back with my husband for a romantic weekend getaway."
United States
Wendy L.
The price is AU$506
includes taxes & fees
11 Nov - 12 Nov
Unique Tiny Home! Lakefront ~ BBQ Grill ~ Couple's Retreat
A cozy living room with a wooden staircase, a chessboard on a round table, and a lamp on a side table.

7. The John Sydney House - Family and Pet Friendly Historic Home Downtown

The John Sydney House - Family and Pet Friendly Historic Home Downtown
Hannibal
9.6 out of 10, Exceptional, (28 reviews)
"Rooms were clean and the decor was very well done! We loved our stay here and the hosts were responsive to all our needs."
United States
Brian H.
The price is AU$333
includes taxes & fees
2 Nov - 3 Nov
The John Sydney House - Family and Pet Friendly Historic Home Downtown
A dining area with a wooden table and chairs, a chandelier, and a red sofa in the background.

8. Vibey home a few blocks from downtown Hannibal

Vibey home a few blocks from downtown Hannibal
Hannibal
9.8 out of 10, Exceptional, (17 reviews)
"Had a great time in Hannibal."
United States
Terry
The price is AU$405
includes taxes & fees
2 Nov - 3 Nov
Vibey home a few blocks from downtown Hannibal
Property grounds

9. Charming 2-bedroom house in nice Imperial with AC. Attn! Traveling Contractors

Charming 2-bedroom house in nice Imperial with AC. Attn! Traveling Contractors
Imperial
9.8 out of 10, Exceptional, (8 reviews)
"Thank you we enjoyed the place but we would like to get some more nights if all possible"
United States
Tommy H.
The price is AU$184
includes taxes & fees
4 Nov - 5 Nov
Charming 2-bedroom house in nice Imperial with AC. Attn! Traveling Contractors
A modern kitchen with wooden cabinets, stainless steel appliances, and a large island with bar stools.

10. Shouse Near Mark Twain Lake!

Shouse Near Mark Twain Lake!
Monroe City
10.0 out of 10, Exceptional, (13 reviews)
"This was our second stay, and it was just as great as the first time! Plenty of room to play, huge TVs for family movie night, and a well equipped kitchen for serving meals. Thank you! "
United States
Christina H.
The price is AU$458
includes taxes & fees
1 Nov - 2 Nov
Shouse Near Mark Twain Lake!
A covered patio with string lights, a seating area, and a small table.

11. TJ’s Country Getaway- Dog Friendly

TJ’s Country Getaway- Dog Friendly
Union
10.0 out of 10, Exceptional, (54 reviews)
"The property was great, cozy touches, clean and simply lovely. It was great to be able to travel with my dog!"
United States
Sherry
TJ’s Country Getaway- Dog Friendly
A living room with a grey sofa, a white coffee table, and teal chairs. A kitchen is visible through an open door.

12. Modern and comfy home five minutes from downtown

Modern and comfy home five minutes from downtown
Hannibal
10.0 out of 10, Exceptional, (22 reviews)
"House was perfect for our stay."
United States
Brent W.
The price is AU$418
includes taxes & fees
1 Nov - 2 Nov
Modern and comfy home five minutes from downtown
A porch with two turquoise Adirondack chairs and a small table, surrounded by well-maintained greenery and a white house with black shutters.

13. WELCOME TO THE OWL'S NEST - 2 BEDROOM HOME IN AUGUSTA, WINERIES & THE KATY TRAIL

WELCOME TO THE OWL'S NEST - 2 BEDROOM HOME IN AUGUSTA, WINERIES & THE KATY TRAIL
Augusta
10.0 out of 10, Exceptional, (42 reviews)
"This is a fantastic place to stay. We will return in the future."
United States
Mike S.
The price is AU$413
includes taxes & fees
1 Nov - 2 Nov
WELCOME TO THE OWL'S NEST - 2 BEDROOM HOME IN AUGUSTA, WINERIES & THE KATY TRAIL
A dining area with a wooden table, grey upholstered chairs, a bench, a patterned rug, a brick wall, a framed picture, and a potted plant.

14. Centrally located in the Tower Grove East neighborhood!

Centrally located in the Tower Grove East neighborhood!
Tower Grove East
9.8 out of 10, Exceptional, (180 reviews)
"Great place!"
United States
Arthur S.
The price is AU$220
includes taxes & fees
2 Nov - 3 Nov
Centrally located in the Tower Grove East neighborhood!
A living room with a TV, wooden furniture, a fireplace, and a cozy seating area.

15. Charming 2-bedroom, cozy bungalow with sunroom in fabulous St. Louis with WiFi

Charming 2-bedroom, cozy bungalow with sunroom in fabulous St. Louis with WiFi
Bevo Mill
9.0 out of 10, Wonderful, (38 reviews)
"We enjoyed our stay, very quaint house and Julie was an amazing host "
United States
Lori O.
The price is AU$352
includes taxes & fees
3 Nov - 4 Nov
Charming 2-bedroom, cozy bungalow with sunroom in fabulous St. Louis with WiFi
A two-story house with a covered porch, a stone facade, and a well-maintained lawn.

16. Kid and pet friendly 2 nd floor duplex

Kid and pet friendly 2 nd floor duplex
Pacific
9.0 out of 10, Wonderful, (32 reviews)
"Very clean, nicely decorated."
United States
Amanda Q.
The price is AU$283
includes taxes & fees
12 Nov - 13 Nov
Kid and pet friendly 2 nd floor duplex
A two-story house with a blue exterior, a front porch, and a small front yard.

17. Hickory Lake House

Hickory Lake House
3.0 star property
Wright City
The price is AU$624
includes taxes & fees
9 Nov - 10 Nov
Hickory Lake House
A modern living room with a sofa, a wooden dining table with stools, a kitchen area with cabinets and a TV, and a hallway leading to a door.

18. Family friendly 3 bedroom home in Kahoka MO

Family friendly 3 bedroom home in Kahoka MO
Kahoka
9.4 out of 10, Exceptional, (13 reviews)
"Absolutely friendly and welcoming hosts. "
United States
Jay M.
The price is AU$314
includes taxes & fees
8 Nov - 9 Nov
Family friendly 3 bedroom home in Kahoka MO
A residential building with a patio area featuring outdoor furniture and string lights.

19. Private Entry Basement Suite • Pond & Farm View • Dog Friendly • St Peters

Private Entry Basement Suite • Pond & Farm View • Dog Friendly • St Peters
St. Peters
10.0 out of 10, Exceptional, (20 reviews)
"What a great place to stay! Clean, well stocked, and very spacious. Would definitely book again."
United States
Lynn D.
The price is AU$408
includes taxes & fees
1 Nov - 2 Nov
Private Entry Basement Suite • Pond & Farm View • Dog Friendly • St Peters
Eat in Kitchen for 6 with granite counters and stainless appliances

20. Historic Craftsman • Hot Tub • Walk to Wineries • Katy Trail

Historic Craftsman • Hot Tub • Walk to Wineries • Katy Trail
AUGUSTA
10.0 out of 10, Exceptional, (7 reviews)
"We had a great stay! The property is within walking distance of several shops & a cute cafe. The owner was very responsive."
United States
Claire M.
The price is AU$614
includes taxes & fees
9 Nov - 10 Nov
Historic Craftsman • Hot Tub • Walk to Wineries • Katy Trail
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties
Save an average of 15% on thousands of hotels when you're signed in
Sign in
Sign up, it's free

Top Northeast Missouri Hotel Reviews

Forest Park Hotel by MDR

Forest Park Hotel by MDR

10/10 Excellent
"Our stay was perfectly fine considering the price. I have nothing to complain about. It’s nothing fancy, but staff was very friendly and helpful, the room was clean, and the bed was soft. If I just needed a room to sleep in for the night, I would have no problem staying here again."
Isabelle 1-night trip
Posted 2 hours ago
Forest Park Hotel by MDR

Find out more about Northeast Missouri

Northeast Missouri Holiday Homes information

Number of reviews
880
Accommodation
630 Holiday Homes
Lowest Price
AU$184
Highest Price
AU$624