A large eye sculpture in a park surrounded by trees.

Holiday Homes in Northeast Missouri

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

In two weeks
2 Oct - 4 Oct
In two months
13 Nov - 15 Nov
In three months
11 Dec - 13 Dec
In four months
8 Jan - 10 Jan

Our top choices for Northeast Missouri holiday homes

A living room with a brown sofa, a wooden coffee table, a television on a stand, and a bookshelf.

1. Unwind on Vine

Unwind on Vine
Macon
9.6 out of 10, Exceptional, (36 reviews)
"We have stayed twice at Unwind on the Vine and have enjoyed our stays. The owners are very attentive to any needs we have had during our stays."
United States
Nancy E.
The price is AU$242
includes taxes & fees
16 Sept - 17 Sept
Unwind on Vine
A modern kitchen with stainless steel appliances, a stone accent wall, and a bar area.

2. Aunt Lele's Cozy Cottage

Aunt Lele's Cozy Cottage
Quincy
9.8 out of 10, Exceptional, (46 reviews)
"Perfect place for our family of 5 to enjoy a weekend visiting my wife’s family."
United States
Matt B.
The price is AU$221
includes taxes & fees
20 Sept - 21 Sept
Aunt Lele's Cozy Cottage
A room with a brick wall, shelves with plants, a framed painting, and a patterned bench.

3. Historic brick 2-bedroom house in downtown Hannibal with off street parking WiFi

Historic brick 2-bedroom house in downtown Hannibal with off street parking WiFi
Hannibal
9.6 out of 10, Exceptional, (65 reviews)
"Great location for downtown exploring."
United States
Lisa B.
The price is AU$259
includes taxes & fees
16 Sept - 17 Sept
Historic brick 2-bedroom house in downtown Hannibal with off street parking WiFi
A modern kitchen with white cabinets, a stainless steel refrigerator, and a dining area with a wooden table and white chairs.

4. Peaceful, Country Cottage with Open Floor Plan

Peaceful, Country Cottage with Open Floor Plan
Quincy
9.8 out of 10, Exceptional, (223 reviews)
"Only there for a one night stay, but very beautiful and comfortable!"
United States
Vicki W.
The price is AU$343
includes taxes & fees
16 Sept - 17 Sept
Peaceful, Country Cottage with Open Floor Plan
A dining area with a wooden table and chairs, a chandelier, and a red sofa in the background.

5. Vibey home a few blocks from downtown Hannibal

Vibey home a few blocks from downtown Hannibal
Hannibal
9.8 out of 10, Exceptional, (15 reviews)
"Very Nice house!!! Enjoyed my stay there."
United States
Shaun P.
The price is AU$376
includes taxes & fees
17 Sept - 18 Sept
Vibey home a few blocks from downtown Hannibal
A covered patio with string lights, a seating area, and a small table.

6. TJ’s Country Getaway- Dog Friendly

TJ’s Country Getaway- Dog Friendly
Union
10.0 out of 10, Exceptional, (51 reviews)
"This was such a cozy and comfortable property. The host provided everything we needed and she was so welcoming. We will stay here again!"
United States
Angela S.
The price is AU$225
includes taxes & fees
22 Sept - 23 Sept
TJ’s Country Getaway- Dog Friendly
A living room with a grey sofa, a white coffee table, and teal chairs. A kitchen is visible through an open door.

7. Modern and comfy home five minutes from downtown

Modern and comfy home five minutes from downtown
Hannibal
10.0 out of 10, Exceptional, (21 reviews)
"House was perfect for our stay."
United States
Brent W.
The price is AU$388
includes taxes & fees
16 Sept - 17 Sept
Modern and comfy home five minutes from downtown

8. Charming 1-bedroom house in nice Imperial with AC. Attn! Traveling Contractors

Charming 1-bedroom house in nice Imperial with AC. Attn! Traveling Contractors
Imperial
9.8 out of 10, Exceptional, (8 reviews)
"Thank you we enjoyed the place but we would like to get some more nights if all possible"
United States
Tommy H.
The price is AU$155
includes taxes & fees
16 Sept - 17 Sept
Charming 1-bedroom house in nice Imperial with AC. Attn! Traveling Contractors
A dining area with a wooden table, grey upholstered chairs, a bench, a patterned rug, a brick wall, a framed picture, and a potted plant.

9. Centrally located in the Tower Grove East neighborhood!

Centrally located in the Tower Grove East neighborhood!
Tower Grove East
9.8 out of 10, Exceptional, (175 reviews)
"Great place!"
United States
Arthur S.
The price is AU$217
includes taxes & fees
20 Sept - 21 Sept
Centrally located in the Tower Grove East neighborhood!
A wooden pergola with a 'GARDEN' sign, a pathway leading to a house, and a lush garden with various plants and flowers.

10. Cozy little house blocks from the Park & Fair Grounds.

Cozy little house blocks from the Park & Fair Grounds.
Washington
10.0 out of 10, Exceptional, (75 reviews)
"Super cute spot in Washington. Very clean and stocked with all the things you need for cooking and entertainment."
United States
Blair O.
The price is AU$353
includes taxes & fees
16 Sept - 17 Sept
Cozy little house blocks from the Park & Fair Grounds.
A spacious living area with a leather sofa, a cowhide rug, and a staircase leading to an upper level.

11. Unique Tiny Home! Lakefront ~ BBQ Grill ~ Couple's Retreat

Unique Tiny Home! Lakefront ~ BBQ Grill ~ Couple's Retreat
Bourbon
10.0 out of 10, Exceptional, (4 reviews)
"Very charming lil cabin! It was perfect for a solo trip. I’d love to come back with my husband for a romantic weekend getaway."
United States
Wendy L.
The price is AU$489
includes taxes & fees
29 Sept - 30 Sept
Unique Tiny Home! Lakefront ~ BBQ Grill ~ Couple's Retreat
A modern kitchen with wooden cabinets, stainless steel appliances, and a large island with bar stools.

12. Shouse Near Mark Twain Lake!

Shouse Near Mark Twain Lake!
Monroe City
10.0 out of 10, Exceptional, (12 reviews)
"This was our second stay, and it was just as great as the first time! Plenty of room to play, huge TVs for family movie night, and a well equipped kitchen for serving meals. Thank you! "
United States
Christina H.
The price is AU$428
includes taxes & fees
4 Oct - 5 Oct
Shouse Near Mark Twain Lake!
A kitchen with wooden cabinets, a central island with chairs, and a ceiling fan.

13. Spacious Family Retreat / Sleeps 9 / Fenced Yard

Spacious Family Retreat / Sleeps 9 / Fenced Yard
Macon
10.0 out of 10, Exceptional, (2 reviews)
"Nice house in great location,would definitely stay again"
United States
Bert A.
The price is AU$574
includes taxes & fees
16 Sept - 17 Sept
Spacious Family Retreat / Sleeps 9 / Fenced Yard
A white house with a porch and a large tree in front.

14. Our 80-Acre Farm, Lake, Nature Trail, Bonfires, Starry Nights 2 Miles Grafton

Our 80-Acre Farm, Lake, Nature Trail, Bonfires, Starry Nights 2 Miles Grafton
Grafton
10.0 out of 10, Exceptional, (149 reviews)
"My wife and I stayed there for a few days for her birthday. It was so peaceful there. The host keeps the place very clean and includes many additional thoughtful items. The trail is a nice touch and worth exploring. It was super hot during our stay and the A/C kept us nice and cool."
United States
Alex
The price is AU$425
includes taxes & fees
16 Sept - 17 Sept
Our 80-Acre Farm, Lake, Nature Trail, Bonfires, Starry Nights 2 Miles Grafton
A cozy living room with a wooden staircase, a chessboard on a round table, and a lamp on a side table.

15. The John Sydney House - Family and Pet Friendly Historic Home Downtown

The John Sydney House - Family and Pet Friendly Historic Home Downtown
Hannibal
9.8 out of 10, Exceptional, (23 reviews)
"Rooms were clean and the decor was very well done! We loved our stay here and the hosts were responsive to all our needs."
United States
Brian H.
The price is AU$356
includes taxes & fees
16 Sept - 17 Sept
The John Sydney House - Family and Pet Friendly Historic Home Downtown
A porch with two turquoise Adirondack chairs and a small table, surrounded by well-maintained greenery and a white house with black shutters.

16. WELCOME TO THE OWL'S NEST - 2 BEDROOM HOME IN AUGUSTA, WINERIES & THE KATY TRAIL

WELCOME TO THE OWL'S NEST - 2 BEDROOM HOME IN AUGUSTA, WINERIES & THE KATY TRAIL
Augusta
10.0 out of 10, Exceptional, (39 reviews)
"Comfortable place to stay. We appreciated the snacks and that there is a pack n play!"
United States
Samantha E.
The price is AU$410
includes taxes & fees
20 Sept - 21 Sept
WELCOME TO THE OWL'S NEST - 2 BEDROOM HOME IN AUGUSTA, WINERIES & THE KATY TRAIL
An outdoor patio with a pergola, wicker furniture, and a view of the landscape.

17. Gipfel Suite - Himmel Haus Bed & Breakfast

Gipfel Suite - Himmel Haus Bed & Breakfast
Hermann
10.0 out of 10, Exceptional, (135 reviews)
"Everything was wonderful! It was a great room, a beautiful view from the terrace and a great breakfast."
United States
Kristin V.
The price is AU$229
includes taxes & fees
28 Sept - 29 Sept
Gipfel Suite - Himmel Haus Bed & Breakfast
A living room with a TV, wooden furniture, a fireplace, and a cozy seating area.

18. Charming 2-bedroom, cozy bungalow with sunroom in fabulous St. Louis with WiFi

Charming 2-bedroom, cozy bungalow with sunroom in fabulous St. Louis with WiFi
Bevo Mill
9.0 out of 10, Wonderful, (34 reviews)
"We enjoyed our stay, very quaint house and Julie was an amazing host "
United States
Lori O.
The price is AU$328
includes taxes & fees
16 Sept - 17 Sept
Charming 2-bedroom, cozy bungalow with sunroom in fabulous St. Louis with WiFi
A modern kitchen with white cabinets, a stainless steel refrigerator, a gas stove, and a microwave.

19. Settle into Soulard! 6 beds 2 full baths!

Settle into Soulard! 6 beds 2 full baths!
Soulard
8.6 out of 10, Excellent, (19 reviews)
"Clean, convenient and satisfied our needs for this stay. "
United States
Michael L.
The price is AU$390
includes taxes & fees
17 Sept - 18 Sept
Settle into Soulard! 6 beds 2 full baths!
A kitchen with a view to a patio, a refrigerator, and a trash can.

20. Private Entry Basement Suite • Pond & Farm View • Pet Friendly • St Peters

Private Entry Basement Suite • Pond & Farm View • Pet Friendly • St Peters
St. Peters
10.0 out of 10, Exceptional, (16 reviews)
"Excellent place to stay while visiting. Pet friendly a HUGE plus. The host was very pleasant to work with and the place really is thoughtfully outfitted. Would definitely stay here again"
United States
Chris B.
The price is AU$353
includes taxes & fees
22 Sept - 23 Sept
Private Entry Basement Suite • Pond & Farm View • Pet Friendly • St Peters
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties
Save an average of 15% on thousands of hotels when you're signed in
Sign in
Sign up, it's free

Top Northeast Missouri Hotel Reviews

Drury Plaza Hotel St. Louis Union Station

Drury Plaza Hotel St. Louis Union Station

10/10 Excellent
"Breakfast and evening kickback was adequate, room was large with microwave and fridge."
Kevin 3-night trip
Posted 1 hour ago
Drury Plaza Hotel St. Louis Union Station

Find out more about Northeast Missouri

Northeast Missouri Holiday Homes information

Number of reviews
13,051
Accommodation
630 Holiday Homes
Lowest Price
AU$122
Highest Price
AU$210