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Our top choices for Mill Creek hotels

Rockwood Inn

Rockwood Inn
2.0 star property
Cape Girardeau
10.0 out of 10, Exceptional, (19)
"My stay was cozy, warm and inviting, and absolutely wonderful shower. I will definitely be returning! "
United States
Kim
The price is AU$256
includes taxes & fees
1 Jan - 2 Jan 2026
Rockwood Inn

Town House Inn Cape Giradreau

Town House Inn Cape Giradreau
2.5 star property
Cape Girardeau
6.0 out of 10, (206)
"Along a main street but not a lot of noise, especially in the rooms. Rooms exit to the outdoors."
United States
Gary
The price is AU$96
includes taxes & fees
4 Jan - 5 Jan 2026
Town House Inn Cape Giradreau

Drury Inn & Suites Cape Girardeau

Drury Inn & Suites Cape Girardeau
3.0 star property
Cape Girardeau
9.4 out of 10, Exceptional, (1004)
"Awesome stay!"
United States
Breckin
The price is AU$152
includes taxes & fees
5 Jan - 6 Jan 2026
Drury Inn & Suites Cape Girardeau

Hampton Inn Cape Girardeau I 55 East

Hampton Inn Cape Girardeau I 55 East
2.5 star property
Cape Girardeau
9.6 out of 10, Exceptional, (785)
"Excellent stay"
United States
Christina
The price is AU$178
includes taxes & fees
8 Jan - 9 Jan 2026
Hampton Inn Cape Girardeau I 55 East

Candlewood Suites Cape Girardeau by IHG

Candlewood Suites Cape Girardeau by IHG
2.5 star property
Cape Girardeau
8.2 out of 10, Very good, (886)
"Room was clean and spacious."
United States
George
The price is AU$126
includes taxes & fees
25 Jan - 26 Jan 2026
Candlewood Suites Cape Girardeau by IHG

Fairfield Inn & Suites by Marriott Cape Girardeau

Fairfield Inn & Suites by Marriott Cape Girardeau
2.5 star property
Cape Girardeau
9.4 out of 10, Exceptional, (145)
"Lovely staff clean hotel comfortable beds "
United States
Kastriot
The price is AU$148
includes taxes & fees
8 Jan - 9 Jan 2026
Fairfield Inn & Suites by Marriott Cape Girardeau

Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
2.5 star property
Cape Girardeau
9.4 out of 10, Exceptional, (1000)
"We like to stay at this hotel on our way to New Orleans and on our return trip to Wisconsin. It is convenient, clean, breakfast options are excellent and the 8 pm cookie time is always a hit. Staff are also very friendly. "
United States
Brian
The price is AU$153
includes taxes & fees
11 Jan - 12 Jan 2026
Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

The Riverview

The Riverview
4.0 star property
Cape Girardeau
9.4 out of 10, Exceptional, (480)
" Excellent stay. Will come again"
United States
joydeep
The price is AU$157
includes taxes & fees
11 Jan - 12 Jan 2026
The Riverview

Courtyard by Marriott Cape Girardeau Downtown

Courtyard by Marriott Cape Girardeau Downtown
3.0 star property
Cape Girardeau
9.6 out of 10, Exceptional, (471)
"Very nice hotel within walking distance to many good restaurants "
United States
Vicky
The price is AU$193
includes taxes & fees
25 Jan - 26 Jan 2026
Courtyard by Marriott Cape Girardeau Downtown

Pear Tree Inn Cape Girardeau Near the Medical Center

Pear Tree Inn Cape Girardeau Near the Medical Center
2.5 star property
Cape Girardeau
9.0 out of 10, Wonderful, (1004)
"Nice place for a stay at a reasonable price."
United States
Arthur
The price is AU$118
includes taxes & fees
5 Jan - 6 Jan 2026
Pear Tree Inn Cape Girardeau Near the Medical Center

Quality Inn Cape Girardeau North

Quality Inn Cape Girardeau North
2.5 star property
Cape Girardeau
7.2 out of 10, Good, (689)
"The room was clean and nice. The breakfast was really good."
United States
Kalani
The price is AU$100
includes taxes & fees
8 Jan - 9 Jan 2026
Quality Inn Cape Girardeau North

Drury Plaza Hotel Cape Girardeau Conference Center

Drury Plaza Hotel Cape Girardeau Conference Center
3.0 star property
Cape Girardeau
9.6 out of 10, Exceptional, (1004)
"This Drury is our preferred place to stay when visiting family in Cape Girardeau. The hotel Staff is always warm and small town friendly! The hotel is nice and the breakfast buffet is outstanding!! "
United States
Michael
The price is AU$152
includes taxes & fees
5 Jan - 6 Jan 2026
Drury Plaza Hotel Cape Girardeau Conference Center

Hotel 7 Inn Anna

Hotel 7 Inn Anna
2.5 star property
Anna
6.6 out of 10, (217)
"The staff was wonderful"
United States
Donna
The price is AU$138
includes taxes & fees
4 Jan - 5 Jan 2026
Hotel 7 Inn Anna

Pear Tree Inn Cape Girardeau West

Pear Tree Inn Cape Girardeau West
2.5 star property
Cape Girardeau
9.0 out of 10, Wonderful, (1001)
"Very clean and updated bathroom, clean room; outstanding hot breakfast and friendly staff."
United States
Colleen
The price is AU$118
includes taxes & fees
5 Jan - 6 Jan 2026
Pear Tree Inn Cape Girardeau West
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top Mill Creek Hotel Reviews

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Frequently asked questions

Where is the best place to stay in Mill Creek?
Drury Plaza Hotel Cape Girardeau Conference Center, located 18.1 mi (29.2 km) from the heart of Mill Creek, is a top choice for your stay, based on our traveller data. Other good options for your visit to the area are The Riverview and Drury Inn & Suites Cape Girardeau. See all available top hotels, or vacation rentals in Mill Creek.
What are some of the best holiday rentals that Mill Creek has to offer?
Little Blue Cottage on Spanish: This holiday home rental outside of Mill Creek comes with WiFi so that you can feel at home during your trip. See all vacation rentals in Mill Creek.
If I need to cancel my hotel reservation in Mill Creek, will I receive a refund?
Yes! You'll find that most hotel reservations are refundable if you cancel prior to the accommodation's cancellation deadline, which often is within 24-48 hours of check in. If your reservation is non-refundable, you might be able to cancel it and receive a refund within 24 hours of your booking. Filter your search by fully refundable to find flexible hotel deals in Mill Creek.
What's it like to stay in Mill Creek?
Those travelling to Mill Creek will definitely enjoy the sights to see and things to do. There are 156 hotels and other accommodation options in the surrounding area. Find out more about Mill Creek.
What should I do while I'm visiting Mill Creek?
Places to visit in the wider area include StarView Vineyards, Trail of Tears State Park and Isle Casino Cape Girardeau. You'll also find Show Me Center and Grassy Lake in the area. Take a look at what more there is to see and do in Expedia's Mill Creek guide.
What's the weather like in Mill Creek?
The hottest months are usually July and August, with an average temperature of 24°C, while the coldest months are January and February, with an average of 4°C. Average annual precipitation for Mill Creek is 1431 mm.

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