Top Hotels Near Mayo Clinic Florida in Jacksonville from AU$155

Start date: Check-in selected.
To Date
End date: Check-out

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

Tonight
7 Dec - 8 Dec
Tomorrow
8 Dec - 9 Dec
Next weekend
12 Dec - 14 Dec
In two weeks
19 Dec - 21 Dec

Filter by

Guest rating
Guest rating
Star rating

Accommodation near Mayo Clinic Florida

Reception
Residence Inn By Marriott Jacksonville - Mayo Clinic Area

Residence Inn By Marriott Jacksonville - Mayo Clinic Area

3.0 star property
1.1 km from Mayo Clinic Florida
9.4 out of 10, Exceptional, (445)
"Great facility to stay."
United States
Gary
The price is AU$255
includes taxes & fees
19 Dec - 20 Dec
Residence Inn By Marriott Jacksonville - Mayo Clinic Area
Terrace/patio
TownePlace Suites by Marriott Jacksonville East

TownePlace Suites by Marriott Jacksonville East

3.0 star property
Golden Glades - The Woods, 3.1 km from Mayo Clinic Florida
9.2 out of 10, Wonderful, (546)
"Very good hotel"
United States
Careli
The price is AU$195
includes taxes & fees
18 Dec - 19 Dec
TownePlace Suites by Marriott Jacksonville East
Terrace/patio
Hampton Inn & Suites Jacksonville - Beach Blvd/Mayo Clinic

Hampton Inn & Suites Jacksonville - Beach Blvd/Mayo Clinic

2.5 star property
Golden Glades - The Woods, 3.1 km from Mayo Clinic Florida
9.0 out of 10, Wonderful, (1002)
"Staff was super friendly and professional...rooms super clean and comfy"
United States
Brian
The price is AU$176
includes taxes & fees
13 Dec - 14 Dec
Hampton Inn & Suites Jacksonville - Beach Blvd/Mayo Clinic
Lobby sitting area
Holiday Inn Express & Suites Jacksonville SE- Med Ctr Area by IHG

Holiday Inn Express & Suites Jacksonville SE- Med Ctr Area by IHG

2.5 star property
2.7 km from Mayo Clinic Florida
8.6 out of 10, Excellent, (1002)
"Good location for a family vacation "
United States
Angel
The price is AU$179
includes taxes & fees
19 Dec - 20 Dec
Holiday Inn Express & Suites Jacksonville SE- Med Ctr Area by IHG
Terrace/patio
Courtyard by Marriott Jacksonville at Mayo Clinic Campus/Beaches

Courtyard by Marriott Jacksonville at Mayo Clinic Campus/Beaches

3.0 star property
0.3 km from Mayo Clinic Florida
8.4 out of 10, Very good, (751)
"Nice hotel, close to shops and mayo clinic."
United States
Judy
The price is AU$275
includes taxes & fees
20 Dec - 21 Dec
Courtyard by Marriott Jacksonville at Mayo Clinic Campus/Beaches
Lobby
Hilton Jacksonville At Mayo Clinic

Hilton Jacksonville At Mayo Clinic

4.5 star property
0.8 km from Mayo Clinic Florida
9.4 out of 10, Exceptional, (47)
"Beautiful hotel. Close to Mayo Clinic."
United States
Patty
The price is AU$209
includes taxes & fees
20 Dec - 21 Dec
Hilton Jacksonville At Mayo Clinic
BBQ/picnic Area
Salt Air Inn & Suites

Salt Air Inn & Suites

2.5 star property
7.8 km from Mayo Clinic Florida
9.8 out of 10, Exceptional, (403)
"A cute little gem with some of the best hospitality in the area. "
United States
Windy
Salt Air Inn & Suites
Property amenity
TownePlace Suites by Marriott® Jacksonville Mayport

TownePlace Suites by Marriott® Jacksonville Mayport

3.0 star property
10.8 km from Mayo Clinic Florida
9.8 out of 10, Exceptional, (63)
"This was an awesome place to stay."
United States
Christine
The price is AU$198
includes taxes & fees
15 Dec - 16 Dec
TownePlace Suites by Marriott® Jacksonville Mayport
Lobby
Element Jacksonville Beach

Element Jacksonville Beach

3.0 star property
5.4 km from Mayo Clinic Florida
9.6 out of 10, Exceptional, (517)
"Clean room and friendly staff."
United States
Lucia
The price is AU$202
includes taxes & fees
4 Jan - 5 Jan 2026
Element Jacksonville Beach
Exterior
Holiday Inn Express & Suites Jacksonville - Town Center by IHG

Holiday Inn Express & Suites Jacksonville - Town Center by IHG

2.5 star property
Southside, 7.8 km from Mayo Clinic Florida
9.6 out of 10, Exceptional, (1005)
"Nice refurbished rooms.. "
United States
David
The price is AU$227
includes taxes & fees
24 Dec - 25 Dec
Holiday Inn Express & Suites Jacksonville - Town Center by IHG
Standard Room, 2 Queen Beds, Non Smoking
The Hotel Palms

The Hotel Palms

3.5 star property
7.8 km from Mayo Clinic Florida
9.6 out of 10, Exceptional, (291)
"stayed here for an event and it was awesome"
United States
clayton
The price is AU$289
includes taxes & fees
1 Jan - 2 Jan 2026
The Hotel Palms
Reception
Ponte Vedra Inn & Club

Ponte Vedra Inn & Club

5.0 star property
6.3 km from Mayo Clinic Florida
9.4 out of 10, Exceptional, (812)
"Wonderful place to visit to relax. Very clean, very friendly and courteous staff. Great view from the balcony."
United States
Greg
The price is AU$714
includes taxes & fees
4 Jan - 5 Jan 2026
Ponte Vedra Inn & Club
Beach/ocean view
The Lodge and Club at Ponte Vedra Beach

The Lodge and Club at Ponte Vedra Beach

5.0 star property
6.3 km from Mayo Clinic Florida
9.4 out of 10, Exceptional, (686)
"Clean room, excellent service and only steps from the ocean. The facility could use some TLC but, all in all, a wonderful place to stay. We’ll be back for sure. "
United States
Robert
The price is AU$634
includes taxes & fees
4 Jan - 5 Jan 2026
The Lodge and Club at Ponte Vedra Beach
Lounge
AC Hotel Jacksonville St Johns Town Center

AC Hotel Jacksonville St Johns Town Center

2.5 star property
Southside, 8.1 km from Mayo Clinic Florida
9.4 out of 10, Exceptional, (161)
"Staff was excellent...highly recommend this Hotel"
Canada
Robert
The price is AU$280
includes taxes & fees
19 Dec - 20 Dec
AC Hotel Jacksonville St Johns Town Center
Studio, 2 Queen Beds, Accessible, Non Smoking | Living area
Hampton Inn & Suites Jacksonville Deerwood Park

Hampton Inn & Suites Jacksonville Deerwood Park

2.5 star property
Southside, 11.2 km from Mayo Clinic Florida
9.4 out of 10, Exceptional, (1004)
"Great stay"
United States
Mary Jean
The price is AU$155
includes taxes & fees
28 Dec - 29 Dec
Hampton Inn & Suites Jacksonville Deerwood Park
Sports facility
Hyatt Place Jacksonville / St. Johns Town Center

Hyatt Place Jacksonville / St. Johns Town Center

3.0 star property
Southside, 8.6 km from Mayo Clinic Florida
9.2 out of 10, Wonderful, (1003)
"Good location, friendly staff, clean "
United States
john
The price is AU$204
includes taxes & fees
12 Dec - 13 Dec
Hyatt Place Jacksonville / St. Johns Town Center
Property amenity
Sheraton Jacksonville Hotel

Sheraton Jacksonville Hotel

4.0 star property
Deerwood, 9.6 km from Mayo Clinic Florida
9.2 out of 10, Wonderful, (1005)
"The Sheraton is a very nice hotel!"
United States
Grace
The price is AU$178
includes taxes & fees
21 Dec - 22 Dec
Sheraton Jacksonville Hotel
Exterior
Hotel Indigo Jacksonville-Deerwood Park by IHG

Hotel Indigo Jacksonville-Deerwood Park by IHG

3.5 star property
Southside, 10.8 km from Mayo Clinic Florida
9.2 out of 10, Wonderful, (1006)
"Very nice stay "
United States
Timmothy
The price is AU$195
includes taxes & fees
21 Dec - 22 Dec
Hotel Indigo Jacksonville-Deerwood Park by IHG
On the beach, white sand, surfing, kayaking
Margaritaville Jacksonville Beach

Margaritaville Jacksonville Beach

2.5 star property
5.9 km from Mayo Clinic Florida
9.0 out of 10, Wonderful, (3414)
"Excellent location & property "
United States
Doris
The price is AU$245
includes taxes & fees
8 Dec - 9 Dec
Margaritaville Jacksonville Beach
Free daily buffet breakfast
Holiday Inn Express Jacksonville Beach by IHG

Holiday Inn Express Jacksonville Beach by IHG

3.0 star property
4.6 km from Mayo Clinic Florida
9.2 out of 10, Wonderful, (1001)
"The check in was simple and a room was ready for us before check out time. We were able to rest and sleep well during our stay in Jacksonville Beach."
United States
David
The price is AU$190
includes taxes & fees
14 Dec - 15 Dec
Holiday Inn Express Jacksonville Beach by IHG
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties

Top Mayo Clinic Florida Hotel Reviews

Margaritaville Jacksonville Beach

Margaritaville Jacksonville Beach

10/10 Excellent
"Nice room. Nice relaxed Tropical feel and decorations. Food was good. Beautiful views! "
James 3-night trip
Posted 4 days ago
Margaritaville Jacksonville Beach

Hotels near other Mayo Clinic Florida attractions

Adventure Landing

4.1/5 (157 reviews)
This amusement park east of Jacksonville is a fun daytrip for the whole family with thrilling rides, exciting attractions for kids and a shipwreck-themed waterpark.
See properties

Windsor Parke Golf Club

Enjoy a round of golf in Jacksonville at Windsor Parke Golf Club. Amble around the area's beautiful beaches or attend a sporting event.
See properties

Frequently asked questions

What's the area like around Mayo Clinic Florida?
Mayo Clinic Florida is located in a welcoming area of Jacksonville known for its beautiful beaches and surfing. If you're looking for a convenient place to stay, take a look at the 41 hotels and other accommodation options you'll find within a mile.
Where is the best place to stay close to Mayo Clinic Florida?
Adjacent to Mayo Clinic Florida, Courtyard by Marriott Jacksonville at Mayo Clinic Campus/Beaches is one of the top choices for your stay based on our traveller data, and this hotel offers a restaurant and an outdoor pool. Other good choices close by include Hilton Jacksonville At Mayo Clinic and Residence Inn By Marriott Jacksonville - Mayo Clinic Area.
How many hotels are there near Mayo Clinic Florida?
Expedia has 41 hotels and other accommodation options within a mile from Mayo Clinic Florida.
If I need to cancel the hotel reservation for my stay near Mayo Clinic Florida, will I receive a refund?
Yes! You'll find that most hotel bookings are fully refundable as long as you cancel before the accommodation's cancellation deadline, which is usually within 24-48 hours of your arrival date. If you have a non-refundable reservation, you may still be able to cancel and get a refund within a 24-hour period of your booking. Enter your dates, click on "Search", then use the "fully refundable" filter to view the top deals on offer near Mayo Clinic Florida.
What can I see and do near Mayo Clinic Florida?
You can enjoy live performances at Players by the Sea and Wilson Center For the Arts. Spend some time exploring the the natural beauty of Oceanfront Park, Cradle Creek Preserve and Huguenot Park. Lounge by the water at Northeast Florida Beaches and Ponte Vedra Beach.

Explore a world of travel with Expedia