
Matlacha Isles Holidays
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Your Matlacha Isles Holiday
Make planning your travels simple by locking in a holiday package to Matlacha Isles. We'll look after the details, so you can focus on soaking up everything this neighbourhood has to offer. If you'd love to sightsee during your trip to Matlacha Isles, don't miss nearby attractions such as Royal Tee Golf Club. Don't just wish for it — make it a reality! Lock in your perfect Matlacha Isles holiday with Expedia and get to where you're going your way.
Our guide on where to stay in Matlacha Isles

Pelican
While visiting Pelican, you might make a stop by sights like Tarpon Point and Chabad Jewish Center.
Our pick of the best Matlacha Isles Hotel Deals

Marriott Sanibel Harbour Resort & Spa
Nice room and perfect location
Reviewed on 1 Feb 2026

Margaritaville Beach Resort Fort Myers
Very clean
Reviewed on 3 Feb 2026

Sanibel Island Beach Resort
Great beach hotel! Room is clean and bed comfortable. All the staff are friendly and accommodating. Tiki hut fun by the pool. The restaurant is great for a lite bite and a full meal. The beach is steps from the hotel. Perfect get away even during the cold spell.
Reviewed on 4 Feb 2026
Frequently asked questions
Discover the most popular places to visit in Matlacha Isles

Sun Splash Water Park
Enjoy a fun-filled day at Sun Splash Water Park during your visit to Cape Coral. Stroll along the beautiful beaches or discover the beautiful sunsets in this family-friendly area.
Mike Greenwell's Bat-A-Ball & Family Fun Park
Take the family on an outing to Mike Greenwell's Bat-A-Ball & Family Fun Park during your trip to Cape Coral. Stroll along the beautiful beaches or discover the area's beautiful sunsets.
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