
Matlacha Isles Holidays
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Your Matlacha Isles Holiday
Make planning your travels simple by locking in a holiday package to Matlacha Isles. We'll look after the details, so you can focus on soaking up everything this neighbourhood has to offer. If you'd love to sightsee during your trip to Matlacha Isles, don't miss nearby attractions such as Royal Tee Golf Club. Don't just wish for it — make it a reality! Lock in your perfect Matlacha Isles holiday with Expedia and get to where you're going your way.
Our guide on where to stay in Matlacha Isles

Pelican
While visiting Pelican, you might make a stop by sights like Tarpon Point and Harbour View Gallery.
Our pick of the best Matlacha Isles Hotel Deals

Marriott Sanibel Harbour Resort & Spa
Great view from mini suite. Only real issue is self-parking is a nightmare. If you don't mind $35 per day plus tips, use the valet parking. The quality and presentation of the buffet breakfast is not on par with the rest of the facility, which is beautiful!
Reviewed on 7 Dec 2025

Lani Kai Beachfront Resort
Not bad.Clean room. Friendly staff. nice location
Reviewed on 17 Dec 2025

Margaritaville Beach Resort Fort Myers
The staff was amazing. It is a wonderful
Reviewed on 14 Dec 2025
Frequently asked questions
Discover the most popular places to visit in Matlacha Isles
Sun Splash Water Park
Enjoy a fun-filled day at Sun Splash Water Park during your visit to Cape Coral. Stroll along the marina or discover the beautiful sunsets in this family-friendly area.
Activities

Fort Myers Beach 90 Minute Round Tiki Boat Cruise















